Abstract: Disclosed herein are recombinant baculoviruses suitable for introducing an exogenous gene into a pest insect, particularly, disease-transmitting mosquitos. The recombinant baculovirus is characterized in having a promotor that is any of a HzNV-1 viral early expressing gene pag1, a ceropin gene b1, a defensin gene a4, or hp70 gene; and an exogenous gene operably linked thereto the promoter. Also disclosed herein is a method of introducing an exogenous gene into a pest insect. The method includes transducing the pest insect with a recombinant baculovirus without suppressing the production of microRNAs (miRNAs) in the pest insect, wherein the recombinant baculovirus comprises a promoter of pag1, cecropin b1, defensin gene a, or hp70.

Abstract: An improved hyperspectral Raman imaging system and device that obtains full scale Raman images from a sample surface in seconds, wherein the dichromic mirror is located between the objective lens and sample surface. The laser is delivered to the sample surface and the Raman image is collected and transmitted through optic fiber to a camera after filtration. By delivering the laser to the sample without going through the objective lens, a high-power laser can safely illuminate the full field of view of the objective lens, allowing for safe Raman imaging within seconds. This fast and safe Raman imaging system can be used for, among other applications, the early detection of dental caries in practical settings.

Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.

Abstract: Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and biochemical properties. The culture system can be utilized to study the effect of microenvironmental factors on cancer cell response, and in particular on cancer stem cell (CSC) response. Cancer cells can be encapsulated in a crosslinked gel system having a narrow range of predetermined gel stiffness. One or more biochemical factors including peptides that can affect the growth, development, and/or proliferation of CSCs can be incorporated in the system to examine the effects of the factor(s) on the encapsulated cells with regard to growth, proliferation, size, etc.

Abstract: This disclosure provides systems, methods, and apparatus related to energy management in a building. In one aspect, a method includes providing a plurality of apparatus. Each apparatus of the plurality of apparatus includes a controller, a light, and a heating/cooling device. The controller is in communication with a control system, and the control system controls the electrical system of a building. A power price is received from the control system at a first apparatus of the plurality of apparatus. The power price is compared to a set point power price. Power supplied to at least one of the light of the first apparatus, the heating/cooling device of the first apparatus, a lighting device in a region proximate the first apparatus, and a heating/cooling device in the region proximate the first apparatus is adjusted based on comparing the power price to the set point power price.

Abstract: Methods and kits for performing polymerase chain reaction (PCR) and melting analyses to determine copy number variation and/or gene expression are disclosed herein. Related uses of such methods and analyses are also disclosed herein.

Abstract: The disclosure provides for MOF heterolites comprised of ordered superlattices of MOFs, the manufacture thereof, and the use of the MOF heterolites for various applications, such as gas separation and/or storage, catalysis, light harvesting, and meta-materials.

Abstract: Improved neuromodulation control of neurological abnormalities associated with effector organs in vertebrate beings using direct current stimulation for modulating spinal cord excitability, having a peripheral-current supplying component for providing direct current peripheral nerve stimulation and a spinal-current supplying component providing direct current for spinal stimulation, and a controller managing such functions.

Abstract: An energy aware gas detection system can include relay nodes and gas sensor nodes operating based on an adaptive sleep cycle, each of the gas sensor nodes can include gas sensors configured to detect methane, carbon monoxide, and hydrogen sulfide. Additionally, the system can also include actuator nodes to operate gas valves and a gateway node to be a bridge between the relay nodes and a remote device communicably coupled to a network.

Abstract: In one embodiment, a method for fabricating a ceramic phase change material capsule includes forming a solid phase change material pellet, coating the pellet with a green ceramic material, and sintering the green ceramic material while on the pellet to form a ceramic outer shell of the capsule.

Abstract: The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes.

Abstract: Sparse representation of information performs powerful feature extraction on high-dimensional data and is of interest for applications in signal processing, machine vision, object recognition, and neurobiology. Sparse coding is a mechanism by which biological neural systems can efficiently process complex sensory data while consuming very little power. Sparse coding algorithms in a bio-inspired approach can be implemented in a crossbar array of memristors (resistive memory devices). This network enables efficient implementation of pattern matching and lateral neuron inhibition, allowing input data to be sparsely encoded using neuron activities and stored dictionary elements. The reconstructed input can be obtained by performing a backward pass through the same crossbar matrix using the neuron activity vector as input. Different dictionary sets can be trained and stored in the same system, depending on the nature of the input signals.

Abstract: The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.

Abstract: Embodiments classify a region of tissue demonstrating non-small cell lung cancer using quantified vessel tortuosity (QVT). One example apparatus includes annotation circuitry configured to segment a lung region from surrounding anatomy in the region of tissue represented in a radiological image and segment a nodule from the lung region by defining a nodule boundary; vascular segmentation circuitry configured to generate a three dimensional (3D) segmented vasculature by segmenting a vessel associated with the nodule, and to identify a center line of the 3D segmented vasculature; QVT feature extraction circuitry configured to extract a set of QVT features from the radiological image; and classification circuitry configured to compute a probability that the region of tissue will respond to immunotherapy and generate a classification that the region of tissue is a responder or a non-responder based, at least in part, on the probability.

Abstract: The present disclosure provides compositions and methods for binding and/or cleaving a single stranded target nucleic acid. Subject compositions include a Cas9 polypeptide, a guide nucleic acid, and a PAMmer. A subject PAMmer is a single stranded oligonucleotide having a protospacer adjacent motif (PAM) sequence and at least one of: a specifity segment positioned 5? of the PAM sequence, and an orientation segment positioned 3? of the PAM sequence. In some embodiments, the Cas9 polypeptide is a variant Cas9 polypeptide having reduced nuclease activity relative to a corresponding wild type Cas9 polypeptide. In some cases, methods of binding are for visualizing single stranded target nucleic acids using a detectable label. In some cases, methods of binding are for isolating, collecting, and/or analyzing at least one of: (i) bound single stranded target nucleic acids; and (ii) polypeptides associated with bound single stranded target nucleic acids.

Abstract: Human pluripotent stem cells are differentiated in vitro into human cortical spheroids (hCS), which contain astrocytes, as well as cortical progenitors and neurons for use in analysis, screening programs, and the like.

Abstract: Aspects of the present disclosure describe a compact RF driver circuit for Paul traps in trapped ion quantum computers and methods, and structures including same.

Abstract: The present application discloses a method for assembling ANDROID application based on application content. The method includes: 1) a server captures page information of an ANDROID application and creates an index, and saves metadata and index information of the page to a database, wherein the metadata includes the page jump logic of the ANDROID application; 2) a client sends a keyword input by a user to the server; 3) the server obtains an application list matching the keyword from the database and returns the metadata corresponding to the application list to the client; 4) after a target ANDROID application is selected from the application list, the client launches the target ANDROID application and automatically jumps to the page corresponding to the keyword according to the page jumping logic of the target ANDROID application. The invention breaks the isolation of information and provides a more natural assembly service among ANDROID applications.

Abstract: A transceiver circuit may include: a first NMOS transistor suitable for pulling up a transmission line in response to a TX signal in a TX mode and for being turned on or off according to a voltage level of the transmission line in an RX mode; and a first PMOS transistor suitable for pulling down the transmission line in response to the TX signal in the TX mode and for being turned on or off according to the voltage level of the transmission line in the RX mode.

Abstract: A channel propagation emulator includes a radio peripheral configured to receive input radio frequency (RF) data and modify the input RF data according to channel effects including signal delay, propagation loss and Doppler shift effect to generate an RF output, and a host device operably coupled to the radio peripheral. The RF output represents a modification of the input RF data based on a propagation model. The host device operably coupled to an external controller and is configured to define emulation parameters based on the propagation model. The propagation model is selected at the external controller. The external controller is configured to provide instructions for implementing the Doppler shift effect to include spreading that is multiplicative in frequency.