Abstract: The disclosure relates to a method for creating a nanoscale structure. The method includes forming a window in a semiconductor structure, the semiconductor structure comprising a substrate, a first semiconductor layer, and a mask layer; depositing a second semiconductor layer within the window such that a gap remains between the second semiconductor and a portion of the window; and regrowing the first semiconductor layer such that the first semiconductor layer fills the gap.

Abstract: The present invention discloses a core-shell structure supported tungsten composite catalyst and a preparation method and use thereof. Most of the existing synthesis methods of the main ring of quinolone drugs have the defects of many synthesis steps, cumbersome operation, large amount of three wastes, higher costs and the like. The present invention prepares a magnetic separable core-shell supported tungsten composite catalyst, WO3/SiO2/Fe3O4, by preparing Fe3O4 colloid and SiO2/Fe3O4 composite nano-particles. This magnetic separable core-shell supported tungsten composite catalyst, WO3/SiO2/Fe3O4, is used to catalyze and synthesize quinolone compounds. The present invention provides an efficient preparation method of quinolone compounds using a catalyst which can be recovered by magnetic separation and recycled.

Abstract: A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

Abstract: A disclosed system quantifies the power distribution of a wireless signal within a constrained environment using non-sequential ray tracing. For each ray, one or more ray-reflecting surface is prescreened to identify collision-eligible surfaces and identify a collision surface from the collision-eligible surfaces, wherein the collision surface is the first ray-reflecting surface that a ray collides with. A power distribution component, indicating the position and power of a ray at a particular elevation within the environment, is added to a cumulative power distribution. If a reflected ray corresponding to each collision is calculated and satisfies ray eligibility conditions, a collision surface may be determined for the reflected ray. Collision surfaces may be identified by evaluating a target function for a number of ray positions, where the target function evaluates to zero when displacement between the ray and the ray-reflecting surface is zero.

Abstract: Embodiments of the invention include a coating or film assembly and a method of making the assembly which has a first layer at least partially infused with at least one antifreeze material, and a second layer at least partially coupled to at least a portion of the first layer. In some embodiments, at least a portion of the second layer includes pores with a defined spacing. In some embodiments, at least a portion of the second layer is rendered hydrophilic in the presence of absorbed moisture or phases of ice including frost, rime, and/or glaze. Further, in some embodiments, at least a portion of the first layer enables the antifreeze material to migrate through and out of the first layer into at least a portion of a hydrophilic region of the second layer.

Abstract: Described here is a method for improving the catalytic activity of an electrocatalyst, comprising subjecting the electrocatalyst to 1-10 galvanostatic lithiation/delithiation cycles, wherein the electrocatalyst comprises at least one transition metal oxide (TMO) or transition metal chalcogenide (TMC). Also described here is an electrocatalyst and a water-splitting device comprising the electrocatalyst.

Abstract: Disclosed are highly scalable fabrication methods for producing electronic circuits, devices, and systems. In one aspect, a fabrication method includes attaching an electronic component at a location on a substrate including a flexible and electrically insulative material; forming a template to encase the electronic component by depositing a material in a phase to conform on the surfaces of the electronic component and the substrate, and causing the material to change to solid form; and producing a circuit or electronic device by forming openings in the substrate to expose conductive portions of the electronic component, creating electrical interconnections coupled to at least some of the conductive portions in a selected arrangement on the substrate, and depositing a layer of an electrically insulative and flexible material over the electrical interconnections on the substrate to form a flexible base of the circuit, in which the produced circuit or electronic device is encased.

Abstract: The present invention provides a film for attaching a nanostructured material to a surface of a substrate, comprising: (a) a removable support; (b) an attaching layer for attaching the film to the surface of a substrate; and (c) the material directly coupled to the support and the attaching layer. Methods for making the film, methods for attaching the material to the surface of a substrate are also provided. The present invention further provides a surface having a material attached thereto by means of the attaching layer. Using the methods disclosed herein, a material having a high specific surface area (SSA) and having particular proper ties (e.g. super-hydrophobicity) can be applied to a substrate including a fuel cell, a conductive electrode, a dye sensitized solar cell, a diffuse reflective mirror, eyewear, a window and a vehicle (e.g. car) windscreen, for example to provide a self-cleaning surface.

Abstract: Provided are therapeutic methods for treating a patient with lymphedema, or prophylactically treating an individual susceptible to lymphedema, by inhibiting synthesis activity of leukotriene B4.

Abstract: Immunogenic compositions and methods of using them include a biodegradable or bioerodible polyanhydride nanoparticle comprising 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and 1,6-bis(p-carboxyphenoxy)hexane (CPH) copolymers, an immunogenic protein of an Influenza Virus and an adjuvant entrapped within an interior of the nanoparticle, and an excipient. The immunogenic composition may be administered to a subject to confer both local and systemic immunity to the Influenza Virus.

Abstract: Methods and apparatus for a three-stage atrial cardioversion therapy that treats atrial arrhythmias within pain tolerance thresholds of a patient. An implantable therapy generator adapted to generate and selectively deliver a three-stage atrial cardioversion therapy and at least two leads, each having at least one electrode adapted to be positioned proximate the atrium of the patient. The device is programmed for delivering a three-stage atrial cardioversion therapy via both a far-field configuration and a near-field configuration of the electrodes upon detection of an atrial arrhythmia. The three-stage atrial cardioversion therapy includes a first stage for unpinning of one or more singularities associated with an atrial arrhythmia, a second stage for anti-repinning of the one or more singularities, both of which are delivered via the far-field configuration of the electrodes, and a third stage for extinguishing of the one or more singularities delivered via the near-field configuration of the electrodes.

Abstract: CRISPR/Cas9-mediated genome editing holds clinical potential for treating genetic diseases, such as Duchenne muscular dystrophy (DMD), which is caused by mutations in the dystrophin gene. In vivo AAV-mediated delivery of gene-editing components machinery has been shown to successfully remove mutant sequence to generate an exon skipping in the cardiac and skeletal muscle cells of postnatal mdx mice, a model of DMD. Using different modes of AAV9 delivery, the restoration of dystrophin protein expression in cardiac and skeletal muscle of mdx mice was achieved. Here, a humanized mouse model for DMD is created to help test the efficacy of genome editing to cure DMD. Additionally, to facilitate the analysis of exon skipping strategies in vivo in a non-invasive way, a reporter luciferase knock-in version of the mouse model was prepared. These humanized mouse models provide the ability to study correcting of mutations responsible for DMD in vivo.

Abstract: A miniature antenna device includes a dielectric substrate having an upper side and an opposing lower side and at least one antenna element. The antenna element includes a first half-loop conductor strip disposed on the upper side of the substrate and a second half-loop conductor strip disposed on the lower side of the substrate. The first and second half-loop conductor strips are aligned complementarily one with the other to have a common center of curvature that is void of a ground plane. The antenna element further includes a director element disposed on the upper side of the substrate and spanning the first and second half-loop conductor strips, an input terminal disposed on the upper side of the substrate being electrically coupled to the first half-loop conductor strip, and a ground plane disposed on the lower side of the substrate being electrically coupled to the second half-loop conductor strip.

Abstract: Shielding enzymes are made by modifying the enzyme surface with silica precursors and then depositing silica to a desired thickness while retaining biological activity of the enzyme.

Abstract: Provided is an electrochemical reaction method that includes: immersing an anode and a cathode into a solution that includes azide ion (N3?), an alkene, and a transition metal catalyst; passing a current through the anode; and forming a diazide from the alkene. Related systems are also provided.

Abstract: The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of cancer, for example glioblastoma.

Abstract: Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.

Abstract: There is provided a method of producing a separation membrane in which a zeolite membrane is formed on an inorganic oxide porous substrate. The substrate has amorphous SiO2 as a main component of a zeolite formation portion of the substrate, the method includes: a first step of forming a zeolite seed crystal and an alkaline component including a structure directing agent on a surface of the substrate; and a second step of treating a formed product obtained in the first step under a heated steam atmosphere, and the zeolite membrane is formed on the surface of the substrate.

Abstract: There is provided a zeolite membrane which is an MFI-type zeolite membrane formed on an inorganic oxide porous substrate, in which, in a diffraction pattern obtained by X-ray diffraction measurement using a CuK? ray as an X-ray source, when an intensity of a diffraction peak appearing at diffraction angles of 7.3° to 8.4° at which a crystal lattice plane belongs to 011 and/or 101 planes is used as a reference, an intensity of a diffraction peak appearing at diffraction angles of 8.4° to 9.0° at which a crystal lattice plane belongs to 200 and/or 020 planes is preferably 0.3 or more.

Abstract: A physical layer based technique secures wireless communication between a transmitter and receiver. The technique involves obfuscating the preamble data of the baseband signal through unique keys that are generated at the transmitter and the receiver based on channel characteristics known only to them.