Abstract: The present disclosure provides recombinant T cells that include a vector encoding one or more of peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1-alpha (PGC1?), mitochondrial transcription factor A (Tfam), GA binding protein transcription factor alpha subunit (GABPA), and estrogen-related receptor alpha (ERR? ). Such recombinant T cells can also include a chimeric antigen receptor (CAR) or a recombinant T cell receptor (TCR). Methods of using these recombinant T cells in cancer immunotherapy are provided. Also provided are kits and compositions that can be used with such methods.

Abstract: The present disclosure relates to a surgical tool for cutting and hemostasis of biological tissues. The surgical tool includes a hollow blade comprising a cutting implement residing within a hollow cavity configured to provide high-pressure steam through an apical surface. The cutting implement can operate independently or in cooperation with the provided high-pressure steam. The surgical tool of the present disclosure applies a directionally-controlled, high-pressure steam flow to a tissue region of interest. A control unit provides temperature-controlled steam at a flow-rate determined in accordance with tissue type and intended procedure.

Abstract: Provided are multi-drug lipid nanoparticles that stably incorporate multiple small molecule drugs with divergent hydrophobic and water solubility characteristics and related methods of making and using the same, The disclosed compositions and methods provide for enhanced stability of lipid nanoparticle drug formulations that can reliably provide drugs addressing different mechanistic targets with prolonged presence in the body for more efficacious treatment and avoidance of single drug resistance.

Abstract: This invention relates to magnetocaloric materials comprising ternary alloys useful for magnetic refrigeration applications. The disclosed ternary alloys are Cerium, Neodymium, and/or Gadolinium based compositions that are fairly inexpensive, and in some cases exhibit only 2nd order magnetic phase transitions near their curie temperature, thus there are no thermal and structural hysteresis losses. This makes these compositions attractive candidates for use in magnetic refrigeration applications. The performance of the disclosed materials is similar or better to many of the known expensive rare-earth based magnetocaloric materials.

Abstract: A system for stimulating a sympathetic chain includes an electrode assembly that is configured to attach to a bone in proximity to a targeted portion of the sympathetic chain. The electrode assembly includes a cathode and an anode. The system also includes a power supply connected to the electrode assembly and configured to deliver power to the electrode assembly. The electrode assembly generates an electrical field between the cathode and the anode when power is delivered to the electrode assembly. The electrical field reaches the targeted portion of the sympathetic chain to provide electrical stimulation to the targeted portion of the sympathetic chain.

Abstract: This disclosure describes a novel PRACH scheme based on an Analog Bloom Filter, in which user equipment is allowed to transmit multiple sequences to a base station, instead of only one sequence as is the case with the current LTE. A new decoding algorithm is disclosed, which copes with the unique challenges in the signal generated with ZC sequences, such as peak shifting and multiple peaks. In addition, when CFO can be removed the new scheme allows the UE to piggyback log 2 7 bits of information along with the signal. Evaluation shows that the new scheme outperforms the existing PRACH of LTE by more than an order of magnitude in many cases, and therefore is a good candidate as the PRACH for future wireless networks (e.g., 5G).

Abstract: The present invention relates to the technical field of synthetic aperture radar, and in particular to a ground-based interference synthetic aperture radar-based atmospheric phase compensation method. The present invention first uses the inverse fast Fourier transform algorithm to rapidly and effectively realize the focusing in the range and cross-range dimension. Then a triple threshold method which combines coherence coefficient, amplitude, and amplitude dispersion index is used to select reliable PS points. Finally, under a full consideration of the spatial correlation of the atmospheric phase, the atmospheric phase is estimated by using a two-dimensional-polynomial model. The present invention can rapidly and accurately estimate and compensate the atmospheric phase, is helpful in improving the accuracy of GB-InSAR real-time measurement, and valuable and universal in practical application.

Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for modulating the expression of genes in plants.

Abstract: An organic hydride production apparatus includes: an electrolyte membrane having proton conductivity; a cathode that includes a cathode catalyst layer used to hydrogenate a hydrogenation target substance using protons to produce an organic hydride and also includes a cathode chamber; an anode that includes an anode catalyst layer used to oxidize water to produce protons and also includes an anode chamber; and a gas introduction unit that introduces, into the anolyte at a certain position, a certain gas used to remove at least one of the hydrogenation target substance and the organic hydride that have passed through the electrolyte membrane and been mixed into the anolyte.

Abstract: Provided herein is a device related to imaging. In one embodiment, the device includes a side illumination unit, two window sample chamber, and refractive index matching. Also provided herein is an imaging apparatus comprising: a microscope; and a device comprising a side illumination unit, a two window sample chamber, and a refractive index matching. Further provided herein is a method of imaging a sample comprising: providing an apparatus comprising a microscope and a device comprising a side illumination unit, a two window sample chamber, and a refractive index matching; and imaging the sample in the apparatus.

Abstract: Embodiments disclosed herein are directed to surgical cannulas and methods relating thereto. In some embodiments, a method includes cutting one or more lines in a tubular member to form a tubular body and a hinge of a surgical cannula. In some embodiments, a surgical cannula includes a fiber brag grating (FBG) reflector mounted to a tendon for deflecting a distal tip of the surgical cannula. A controller is coupled to the FBG reflector and is configured to determine a tension in the tendon based on reflected light from the FBG reflector. In some embodiments, a surgical cannula includes a tubular body including a plurality of apertures extending therethrough.

Abstract: Provided are feeder cell lines that can be used to expand and differentiate B cells in vitro, a method for expanding B cells in vitro comprising culturing the B cells with the feeder cell line, and a method for producing monoclonal antibody in vitro comprising culturing a single B cell with the feeder cell line under sufficient conditions and for sufficient time to induce expansion and differentiation of the B cell into a B cell done secreting antibody.

Abstract: A three-dimensional model of a reconstructed bone framework is obtained using an iterative, surface interpolating algorithm. A reference and a target three-dimensional model are provided. The reference model is non-rigidly registered to the target model based upon positional constraints, so as to produce a registered reference model. An initial reconstructed model is set as the registered reference model. A first correspondence search is iteratively conducted to identify a first set of corresponding points on the reconstructed and target models. During each iteration, the reconstructed model is incrementally and non-rigidly registered to the target model based upon the corresponding points. A second correspondence search is conducted to identify a second set of corresponding points on the reconstructed and target models.

Abstract: Provided herein are recombinant constructs, vectors and expression cassettes including a first promoter which is suitably a tRNA promoter operably connected to a first polynucleotide encoding a first single guide RNA and a second promoter operably connected to a second polynucleotide encoding a Cas9 polypeptide. The first single guide RNA includes a first portion complementary to a strand of a target sequence of a DNA virus and a second portion capable of interacting with the Cas9 polypeptide. Also provided are codon optimized Staphylococcus aureus derived Cas9 polynucleotides and polypeptides with nuclear localization signals and optionally an epitope tag. Also provided are constructs for production of sgRNAs including a tRNA. Methods of inhibiting viral replication, inhibiting expression of a target sequence from a virus or treating a viral infection or viral induced cancer using the compositions are also provided.

Abstract: A medical device containing a sensor, a motor, one or more plates, and a control unit, for treating diabetes. The medical device vibrates the pancreas thereby improving blood and secretory hormone circulation and enhancing the production of insulin.

Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

Abstract: The invention provides an alternating current electrospray technology that can generate micron sized droplets in oil at very high throughput for emulsion or digital PCR (Polymerase Chain Reaction). This technology outperforms the throughput of the current gold standard in droplet generation using flow-focusing technology by at least a factor of 100. The design is simple and can generate a billion to a trillion monodispersed droplets in about one hour. This is much faster than flow-focusing which is limited to a few million droplets per hour. The droplet size and generation rate can also be easily adjusted by changing the voltage of the AC electric field. The range of produced droplet sizes is about 1-100 microns, wherein the droplets are monodispersed in size.

Abstract: The present disclosure provides for isolated non-naturally occurring, mutant-human IAPP polypeptides, which are more soluble at neutral pH than the wild-type hIAPP protein. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject in a single injection with an insulin agent. The present disclosure also provides methods and pharmacological compositions for treating an abnormal condition, such as an amyloid-based disease or type-1 diabetes in a subject.

Abstract: Provided herein are methods for treating a bone-related disorder in a subject. At least one of a microtubule altering drug, for example, a microtubule disrupting drug or a microtubule stabilizing drug, a TRPV4 agonist or a NOX2 activator is administered to the subject. Also provided are related methods for treating a bone-related disorder in the subject, by further administering at least one of an anti-sclerostin agent, a parathyroid hormone agonist, a bisphosphonate, an estrogen mimic, or a selective estrogen receptor modulator is further administered to the subject with the at least one of a microtubule altering drug, a TRPV4 agonist or a NOX2 activator.

Abstract: A interply hybrid composite based single crystal alpha-aluminium oxide fiber includes single crystal alpha-aluminium oxide fiber, glass fiber and a resin compatibilizer; a hybrid ratio of the single crystal alpha-aluminium oxide fiber to the glass fiber is 1:40 to 3:53.