Abstract: Provided herein are methods for treatment of a neurodegenerative disease, such as neuronal ceroid lipofuscinosis including administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of an agent that mediates upregulation of TPP1.
Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
Type:
Application
Filed:
July 15, 2019
Publication date:
November 7, 2019
Applicants:
Immunolight, LLC., Duke University
Inventors:
Frederic A. BOURKE, JR., Tuan VO-DINH, Harold WALDER
Abstract: Methods are disclosed for inhibiting the development of a tumor in a subject. The methods include administering to a subject a therapeutically effective amount of a dominant negative tumor necrosis factor (DN-TNF)-? protein and/or a nucleic acid encoding the DN-TNF-? protein. The DN-TNF-? protein and/or a nucleic acid encoding the DN-TNF-? protein can be administered alone or in combination with other agents.
Type:
Application
Filed:
December 14, 2016
Publication date:
November 7, 2019
Applicant:
University of Pittsburgh - Of the Commonwealth System of Higher Education
Abstract: The presently disclosed subject provides a biomimetic eye model, and methods of its production and use. In one exemplary embodiment, the biomimetic eye model can include a scaffold having a convex curvature, a fluidic device coupled to the scaffold, a fabricated eyelid coupled to the fluidic device and a motor coupled to the fabricated eyelid. In certain embodiments, the scaffold can be impregnated with one or more keratocytes and a surface of the convex curvature of the scaffold can be covered with one or more layers of epithelial cells.
Type:
Application
Filed:
July 11, 2019
Publication date:
November 7, 2019
Applicant:
The Trustees of the University of Pennsylvania
Abstract: The invention features compositions and methods for identifying orthogonal transcriptional switches derived from Tet repressor homologs for Saccharomyces cerevishiae regulated by 2,4-diacetylphloroglucinol (DAPG) and other ligands.
Type:
Application
Filed:
December 7, 2017
Publication date:
November 7, 2019
Applicants:
The Johns Hopkins University, The Johns Hopkins University
Abstract: A multi-pixel x-ray source is provided. The x-ray source includes a plurality of transmission target assemblies. The transmission target assembly includes a tungsten target and a diamond substrate. The substrate includes a first transmission surface and a second transmission surface opposite first transmission surface. The substrate further includes a first side surface and a second side surface disposed between the first and second transmission surfaces. The target covers the first transmission surface of the substrate. The transmission target assembly further includes a base. The base surrounds the first and second side surfaces of substrate, exposing a collimator surface of the second transmission surface and the target. The transmission target assembly is configured to transmit x-ray generated by the target through the target and the substrate.
Abstract: Compounds comprising phosphorescent metal complexes comprising cyclometallated imidazo[1,2-f]phenanthridine and diimidazo[1,2-a:1?,2?-c]quinazoline ligands, or isoelectronic or benzannulated analogs thereof, are described. Organic light emitting diode devices comprising these compounds are also described.
Type:
Application
Filed:
July 15, 2019
Publication date:
November 7, 2019
Applicant:
Universal Display Corporation
Inventors:
David KNOWLES, Chun LIN, Peter MACKENZIE, Jui-Yi TSAI, Robert W. WALTERS, Scott BEERS, Cory S. BROWN, Walter YEAGER
Abstract: Provided are a compound of chemical formula 1 or 2 and a use thereof. The compound can be advantageously used in the prevention or treatment of metabolic diseases including type 2 diabetes, insulin resistance, or obesity, on the basis of a mechanism of autophagy activation through the promotion of lysosome production.
Type:
Application
Filed:
June 29, 2017
Publication date:
November 7, 2019
Applicants:
Industry-Academic Cooperation Foundation, Yonsei University, Gwangju Institute of Science and Technology
Inventors:
Myung-Shik LEE, Hyejin LIM, Young Eui JEON, Jin Hee AHN, H.S. PAGIRE
Abstract: The present disclosure provides a mutated form of AP4 that is more resistant to degradation relative to wild-type AP4. The disclosure also provides T cells expressing the mutated form of AP4 and methods of using the T cells in adoptive cellular immunotherapy.
Abstract: Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands of individual binding events across a multiplex solid phase sensor with a large area. A dynamic tracking procedure is used to measure the duration of each event. From this, the total rates of binding and de-binding as well as the distribution of binding event durations are determined. Systems and components for performing the kinetic assay are also described.
Abstract: A slope-adaptive inclined special elevator includes a bumper, an elevator car system, a slope guide rail system, a counter-weight system, a traction machine, a governing rope governor, and a traction rope guiding wheel. The two ends of the traction rope are connected to the elevator car system and the counter-weight system respectively, and the traction rope is towed and lifted under the driving action of the traction machine and the guiding action of the traction rope guiding wheel; over-speed protection is realized by means of the governing rope governor and a safety gear linkage and the bumper; to adapt to slope variations, the car body is leveled automatically by an automatic leveling assembly, the traction rope is guided forcibly via traction rope lifting devices and traction rope pressing devices, and the governing rope is guided forcibly via governing rope lifting devices and governing rope pressing devices.
Type:
Application
Filed:
December 22, 2015
Publication date:
November 7, 2019
Applicants:
Dongnan Elevator Co, Ltd, China University of Mining and Technology
Inventors:
Guohua CAO, Zhencai ZHU, Lei WEI, Jiancong QIN, Xiaoguang BO, Weihong PENG, Yiping MA, Lei WANG
Abstract: Disclosed herein are novel amine-functionalized porphyrin compounds, as wells as pharmaceutically acceptable salts or esters thereof. The disclosed compounds can be used to impart antioxidant, anti-inflammatory, anti-microbial, and/or cell-adhesion specificity to a surface or material in need thereof, such as a surface of an indwelling medical implant, or a marine surface.
Type:
Application
Filed:
July 16, 2019
Publication date:
November 7, 2019
Applicant:
University of Pittsburgh - Of the Commonwealth System of Higher Education
Inventors:
Xinyan Cui, Noah Snyder, Kasey Catt, James Eles
Abstract: Disclosed are a method and apparatus for decoding an image using inter-prediction. The method of decoding an image using inter-prediction includes receiving a bitstream; acquiring a portion of information indicating a motion vector of a current block to be decoded in the received bitstream, obtaining the motion vector of the current block by using the acquired information to determine the remaining information other than the portion, and generating a prediction block for the current block through inter-prediction that uses the motion vector of the current block. Therefore, it is possible to improve image decoding/encoding efficiency.
Type:
Application
Filed:
January 2, 2018
Publication date:
November 7, 2019
Applicant:
Industry-University Cooperation Foundation Hanyang University
Inventors:
Je Chang JEONG, Ki Baek KIM, Do Kyung LEE
Abstract: A novel means that can suppress development of arteriosclerotic lesions and treat arteriosclerosis is disclosed. An antiarteriosclerotic agent according to the present invention comprises, as an active ingredient, a substance which selectively suppresses B2 cells. The substance which selectively suppresses B2 cells is, for example, an anti-CD23 antibody. A first aspect of the method of assisting in determining a condition of arteriosclerosis according to the present invention comprises measuring expression of at least one gene selected from particular gene groups using a sample isolated from a subject. A second aspect of the method comprises measuring the level of IgG3 and/or the level of total IgG in a serum sample isolated from a subject.
Type:
Application
Filed:
October 18, 2017
Publication date:
November 7, 2019
Applicant:
Public University Corporation Yokohama City University
Abstract: A cycloidal rotor air vehicle includes an airframe, a first cycloidal rotor assembly supported by the airframe and configured to rotate about a first axis of rotation relative to the airframe, the first cycloidal rotor assembly including a blade having a longitudinal axis oriented parallel to the first axis of rotation, a first motor configured to rotate the first cycloidal rotor assembly about the first axis of rotation, a first servo coupled to the blade of the first cycloidal rotor assembly and configured to adjust the pitch of the blade, and a control system supported on the airframe and configured to control the operation of the first motor and the first servo.
Type:
Application
Filed:
January 3, 2018
Publication date:
November 7, 2019
Applicant:
The Texas A&M University System
Inventors:
Moble Benedict, Carl C. Runco, David A. Coleman
Abstract: A process for manufacturing an iron-based alloy comprising forming targeted fine oxide and/or carbide dispersoids in a melt, and sequentially precipitating transition-metal nitrides on the dispersoids for heterogeneous nucleation of equiaxed grains. An iron-based cast alloy having a highly equiaxed fine grain structure.
Type:
Grant
Filed:
April 18, 2016
Date of Patent:
November 5, 2019
Assignee:
The Curators of the University of Missouri
Inventors:
Simon Lekakh, Von Richards, Ronald O'Malley, Jun Ge
Abstract: A device is described that can include a probe, a mobile device, and at least one processor. The probe can examine a corresponding anatomical part of a body. The mobile device can have a camera to take an image of the anatomical part of the body. The mobile device can execute a patient-application to process the image. The at least one processor can be configured to transmit the processed image to a server via a communication network. Related apparatuses, systems, methods, techniques and articles are also described.
Type:
Grant
Filed:
February 26, 2018
Date of Patent:
November 5, 2019
Assignee:
The Aga Khan University
Inventors:
Saleem Sayani, Muhammad Abdul Muqeet, Hafiz Imtiaz Ahmed
Abstract: A flow meter (1) comprising a sampling tube (3) through which fluid may flow and a sensor arrangement (9, 25, 27, 39, 41, 43, 44, 45, 46, 47), wherein the sampling tube (3) comprises a first hollow section (51, 53) having a first internal cross-sectional area (A1) and a second hollow section (55, 57) having a second internal cross-sectional area (A2) being less than the first internal cross-sectional area (A1); and the sensor arrangement (9, 25, 27, 39, 41, 43, 44, 45, 46, 47), is for measuring the difference between stagnation and static pressures (P01, P02, P1, P2) within the second hollow section (55, 57).
Type:
Grant
Filed:
December 21, 2015
Date of Patent:
November 5, 2019
Assignee:
University of Surrey
Inventors:
David Birch, Paul Nathan, Praveen Rampersad