Abstract: An energy system includes a microgrid including a network of at least one distributed energy resource and a plurality of loads, the at least one distributed energy resource being configured to supply power to the plurality of loads. The microgrid is configurable to connect to one of a plurality of feeder circuits of a main power grid at one of a plurality of coupling interface locations, respectively. The microgrid is also configurable to expand or shrink its power supply area according to the available power generation capabilities.

Abstract: Various embodiments are described herein for a system and a method for identifying a region of interest in tissue using mass spectrometry. An agent administration component can be provided to administer an exogenous agent to the tissue. A sampling unit can also be provided to acquire a sample from the tissue. The sample can then be provided to a high sensitivity analysis platform, such as a mass analyzer, to analyze the sample and determine a distribution of the exogenous agent or a by-product of the exogenous agent within the tissue based on the analysis. The analysis platform can then identify the region of interest based on the distribution of the exogenous agent or the distribution of the by-product.

Abstract: The invention relates generally to new prostate cancer markers, and particularly to a class of cancer marked by the presence of missense mutations in SPOP, an E3 ubiquitin ligase component. The invention provides methods and materials for detecting and diagnosing prostate cancer by detecting these mutations and may be useful in predicting disease progression and response to therapy.

Abstract: A timer module including a timer and a compensation circuit coupled to the timer is provided. The timer measures time over a first monitoring period. The timer includes a floating-gate and an energy barrier. The floating-gate stores electrons and has an initial state and a measured state. The measured state includes a current time and a current floating-gate voltage. The energy barrier is positioned adjacent the floating-gate and leaks electrons from an ambient environment of the timer to the floating-gate at a predetermined leakage rate using Fowler-Nordheim (FN) tunneling. The compensation circuit selectably adjusts the first monitoring period to facilitate improved robustness of the timer with respect to fabrication mismatch due to the self-compensating dynamics of FN tunneling.

Abstract: Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.

Abstract: Bio-Inks and methods of using compositions comprising the bio-Inks are disclosed. 3-D tissue repair and regeneration through precise and specific formation of biodegradable tissue scaffolds in a tissue site using the bio-inks are also provided. Specific methylacrylated gelatin hydrogels (MAC) and methacrylated chitosan (MACh) preparations formulated with sucrose, a silicate-containing component (such as laponite), and/or a cross-linking agent (such as a photo-initiator or chemical initiator), as well as powdered preparations of these, are also disclosed. Kits containing these preparations are provided for point-of-care tissue repair in vivo. Superior, more complete (up to 99.85% tissue regeneration within 4 weeks applied in situ), and rapid in situ tissue repair and bone formation are also demonstrated.

Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.

Abstract: Provided is an apparatus for loading a follicular unit to a needle for hair implant including a first slitless needle in which the other end of a hollow body has a wedge shape, one end of the hollow body has a tubular shape to facilitate force transmission, and an end surface of the one end is blunt, so as to be used in a transplantation region in hair transplant procedure, and a first instrument configured to push the follicular unit to an interior of the first needle to load the follicular unit to the interior of the first needle.

Abstract: Starch spherulites are produced by debranching of amylopectin-containing starch into short linear ?-1,4-linked glucans (e.g., short-chain amylose, SCA). The debranched linear glucans are directly converted into spherulites by heating the debranched starch mixture followed by cooling and crystallization to form well-developed spherulites. The spherulites exhibit controlled enzyme digestibility.

Abstract: Methods for label-free characterization of untagged molecules within a biological sample in-situ. The untagged molecules may be constituent of extracellular vesicles, and are excited in the biological sample with at least one wavelength band of light derived from a single stream of optical pulses. Light emitted by the untagged molecules by SHG, THG, 2PAF and 3PAF processes is detected. Separate measures of the biological sample corresponding to light emitted by the untagged molecules in each of the SHG, THG, 2PAF and 3PAF processes are derived. On that basis, normal extracellular vesicles may be differentiated from extracellular vesicles associated with a tumor on the basis of a specified signature of characteristics of images of SHG, THG, 2PAF and 3PAF processes.

Abstract: Expanded performance opportunities for imaging spectrometers are described using ?-polynomial freeform surfaces in reflective and diffractive optics. The imaging spectrometers are generally of a type that include an entrance aperture for admitting radiation over a range of wavelengths, a detector array, a primary reflective optic with optical power, a secondary reflective diffractive optic, and a tertiary reflective optic with optical power for collectively imaging the entrance aperture onto the detector array through a range of dispersed positions. One or more of the primary reflective optic, the secondary reflective diffractive optic, and the tertiary reflective optic can include a ?-polynomial optical surface with no axis of symmetry and represented by a function that depends on both a radial component and an azimuthal component.

Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of a screen of wearable device may be adjusted, where the transparent display portions enable the user to see through the screen of the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. An enhanced video stream derived from the live video stream may be displayed on one or more other display portions of the screen of the wearable device.

Abstract: Ordered (e.g., self-assembled) structures, arranged from peptide nucleic acids and/or analogs thereof, are disclosed. The peptide nucleic acids forming the ordered structures comprise from 1 to 10 PNA backbone units, at least one comprising a guanine nucleobase or an analog thereof. Processes of generating the ordered structures, uses thereof and articles-of manufacturing, devices and systems containing same are also disclosed.

Abstract: Embodiments include operations, apparatus, methods and other embodiments that access a baseline CT image of a region of tissue (ROT) demonstrating non-small cell lung cancer (NSCLC), segment a tumoral region represented in the baseline CT image; define a peritumoral region by dilating the tumoral boundary; extract a set of tumoral radiomic features from the tumoral region, a set of peritumoral radiomic features from the peritumoral region, and a set of clinico-pathologic features from the baseline CT image; provide the set of tumoral radiomic features, peritumoral radiomic features, and clinico-pathologic features to a machine learning classifier; receive, from the machine learning classifier, a time-to-recurrence post trimodality therapy (TMT) prediction, based on the set of tumoral radiomic features, peritumoral radiomic features, and clinico-pathologic features; generate a classification of the ROT as an MPR responder or MPR non-responder based, at least in part, on the time-to-recurrence post-TMT predicti

Abstract: The present invention relates to compounds of formula I shown below: wherein Q is as defined herein. The compounds of formula I act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.

Abstract: This disclosure provides systems, methods, and apparatus related to optical systems. In one aspect, an optical system includes a plurality of optical sources, a first diffractive optical element, and a second diffractive optical element. The plurality of optical sources generates a plurality of pulsed beams that is less than about 1 picosecond in duration. The first diffractive optical element receives and diffracts the plurality of pulsed beams. The second diffractive optical element receives the diffracted plurality of pulsed beams and generates a combined pulsed beam.

Abstract: A hemostatic method is performed as follows: A) An at-puncture hemostatic pressure is applied to a puncture in a blood vessel via a main geometric side, and at least one off-puncture hemostatic pressure is applied to at least one position away from the puncture via at least one auxiliary geometric side, wherein the off-puncture hemostatic pressure acts on the blood vessel either directly or indirectly. B) During the hemostatic process, an ongoing flow velocity of the blood in the blood vessel is obtained and is reduced to lower than a normal flow velocity in the blood vessel by applying the at-puncture and off-puncture hemostatic pressures simultaneously, wherein the at-puncture and off-puncture hemostatic pressures are lower than a systolic pressure in the blood vessel.

Abstract: A sound reproduction system and filter set comprising an array of loudspeakers, comprises a plurality of delay-gain filter elements, and further wherein the filter set comprises a plurality of loudspeaker-specific filter elements (12) which are each associated with different respective speakers of the loudspeaker array, and further comprising a plurality of loudspeaker-independent filter elements (10) which are each common to a plurality of the loudspeakers of the array.

Abstract: Disclosed herein are apparatus, devices, and methods for monitoring marine animals, such as whales, and other marine mammals, and fish groups within a marine environment. A marine animal monitoring system may include an acoustic receiver array having a high-resolution directional sensing capacity using large-aperture densely-sampled coherent ocean acoustic receiver arrays operative to enhance detection range and localization accuracy of marine mammal vocalizations and fish acoustic signals. The acoustic receiver array may generate acoustic signal information based on acoustic signals sensed at the array. The marine monitoring system may operate to generate marine animal information based on the acoustic signal information, such as marine animal location, species, call type, and/or the like.

Abstract: An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to contact the high-frequency cantilever in response to environmental vibrations having a frequency within a near-resonance frequency range associated with said low-frequency cantilever, an a generator that produces electrical power in response to contact between at least one of the plurality of low-frequency cantilevers and the high-frequency cantilever. The energy harvesting device may also include an impact mass coupled to a free end of each of the plurality of low-frequency cantilevers. Some aspects may include a common base to which the high-frequency cantilever and the plurality of low-frequency cantilevers are coupled. Other aspects may include the generator comprising one or more of an induction coil and magnet, a variable distance capacitor, or a piezo-electric material.