Patents Assigned to University
  • Ion current use for combustion resonance detection, reduction and engine control
    Patent number: 10443535
    Abstract: A system and method for detection, reduction of combustion resonance and engine control is provided. The system senses ion current within one or each cylinder of a multi-cylinder engine and determines combustion resonance from the ion current signal. In addition, the system may determine an engine control strategy to reduce combustion resonance based on the feedback from the ion current signal.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: October 15, 2019
    Assignee: Wayne State University
    Inventors: Tamer H. Badawy, Naeim A. Henein
  • Mobile device system for dispensing oral consumables
    Patent number: 10442601
    Abstract: A system for dispensing oral consumables includes a mobile device and an oral consumables dispenser attached to the device. The dispenser can include a retractable holder for storing the oral consumables. As mobile electronic devices and their associated accessories are carried by most people for lengthy periods throughout the day, the system for dispensing oral consumables can facilitate timely consumption of oral consumables.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: October 15, 2019
    Assignee: King Saud University
    Inventor: Sulieman Saleem B. Al-Johany
  • Cleavage resistant photoluminescent proteins and applications thereof
    Patent number: 10442842
    Abstract: Photoluminescent proteins resistant to protein cleavage reagents are described herein. In being resistant to cleavage reagents, such photoluminesncent proteins can reduce the number of digestion or cleavage products, thereby simplifying quantification and purification of recombinant protein compositions. In some embodiments, a photoluminescent protein described herein comprises an amino acid sequence having an absence of internal methionine residues.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: October 15, 2019
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Robert R. Beitle, Rudra Palash Mukherjee, Suresh K. Thallapuranam, Joshua Sakon, David S. McNabb
  • Controlled stimulation delivery from neurostimulator
    Patent number: 10441803
    Abstract: A system for providing neurostimulation includes an external device (“external exciter”) and an implanted device. The external exciter includes an energy source which inductively powers the implanted device. Examples of such external exciters include devices having at least one of: ultrasonic transducers, Radio Frequency (RF) transmitters, and solar cells. The implanted device includes circuitry that limits its maximum energy output to a predetermined saturation threshold such that excess stimulation from the external exciter does not raise the output of the implanted device beyond the saturation threshold. The output signal of the external exciter is then pulse-width modulated in order to produce a desired amount of output stimulation from the implanted device to stimulate the bioelectrically excitable tissue at a desired level.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: October 15, 2019
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Bruce C. Towe, Daniel Gulick
  • Fuel-cell system and method of generating energy from crude fuel
    Patent number: 10446852
    Abstract: The present invention relates to a fuel-cell system. This system includes an anode electrode; a cathode electrode; a separator positioned between the anode electrode and the cathode electrode, wherein the separator is not an ion exchange membrane; an anode catalyst; and a cathode catalyst, wherein the cathode catalyst is a non-precious metal catalyst or metal-free catalyst. The present invention also relates to a method of generating energy from crude fuel. This method involves providing a fuel-cell system and contacting the fuel-cell system with a crude fuel under conditions effective to generate energy from the crude fuel.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: October 15, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Wenzhen Li, Neeva Benipal, Ji Qi, Yang Qiu
  • Controlled tunnel gap device for sequencing polymers
    Patent number: 10444220
    Abstract: The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: October 15, 2019
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Stuart Lindsay, Shuai Chang, Jin He, Peiming Zhang, Shuo Huang
  • Early intervention knee implant device and methods
    Patent number: 10441428
    Abstract: A replacement knee implant has a femoral implant and a tibial implant, each of which are inset in a bone surface. The tibial implant is generally elongated with one end rounded and an opposite end conforming to the shape of the tibia, and is made of a metal alloy or a ceramic. The upper surface is dished while the lower surface is planar and can be parallel or sloped relative to the upper surface, and can have a keel for fixation. The femoral implant for implementation in a femoral condyle is rounded such that, when implemented, the femoral implant is flush at the anterior and posterior sides and protruding away from the femur between the anterior and posterior ends. The femoral implant can have an elongated keel for extending into the femur, and can be made from a highly cross-linked polyethylene.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: October 15, 2019
    Assignee: New York University
    Inventors: Peter Stanley Walker, Joseph A. Bosco
  • Substituted heterocycles for targeting HSP90
    Patent number: 10442806
    Abstract: Described herein are substituted indazoles comprising formula (II) that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. Formula (II) may link to detection moieties such as fluorophores that may allow for selective detection of Hsp90 in a sample.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: October 15, 2019
    Assignee: Duke University
    Inventors: Timothy Haystead, Philip Floyd Hughes, Christopher D. Lascola
  • Methods and compositions for treating bacterial infection
    Patent number: 10441588
    Abstract: The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic agents against bacterial infections (e.g., biofilms). The present disclosure also provides topical formulations for use in methods for treating bacterial infections.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: October 15, 2019
    Assignees: Curators of the University of Missouri, Nanova, Inc.
    Inventors: Hongmin Sun, David W. Anderson, Feng Qi
  • Apparatus and method for transmitting and receiving signaling information in digital broadcast system
    Patent number: 10448088
    Abstract: A method for receiving signaling information in a digital broadcast system according to an embodiment of the present invention comprises: a step of receiving a plurality of frames in which signaling information of a second layer is inserted in a signaling area of a first layer or a packet of a first layer; and a step of determining the signaling information of the second layer from the signaling area of the first layer or the packet of the first layer, and receiving service data using at least one of the determined signaling information of the second layer and pre-stored signaling information of a second layer.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: October 15, 2019
    Assignees: Samsung Electronics Co., Ltd., Kyonggi University Industry & Academia Cooperation Foundation
    Inventors: Hyun-Koo Yang, Byoung-Dai Lee, Sung-Hee Hwang, Sung-Oh Hwang
  • Methods and materials for treating cancer
    Patent number: 10441643
    Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-11a antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: October 15, 2019
    Assignees: Mayo Foundation for Medical Education and Research, University of Leeds
    Inventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Rosa Maria Diaz, Christine Marie Pulido, Alan A. Melcher, Peter Selby
  • Lens-based integrated two-dimensional beam steering device
    Patent number: 10444596
    Abstract: A lens-based integrated two-dimensional beam steering device comprising a substrate, an input waveguide, a connecting waveguide, a 1×N optical switch, an electrical interface for the switch, N output waveguides of the switch, N transmitting units, a lens and a controller. The device of the present invention realizes two-dimensional beam steering and has the characteristics of large power capacity, low control complexity, and low electric power consumption.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: October 15, 2019
    Assignee: Shanghai Jiao Tong University
    Inventors: Kan Wu, Xianyi Cao, Chao Li, Jianping Chen
  • Polysaccharide agents and methods of their use for removing solids from water
    Patent number: 10442710
    Abstract: Polysaccharide agents for removing solids from an aqueous suspension and methods for using the polysaccharide agents to remove solids from an aqueous suspension.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: October 15, 2019
    Assignees: Pristana Water LLC, The Texas A&M University System
    Inventors: Rajani Srinivasan, Anuradha Mishra, John McKinney
  • Methods and compositions related to glucocorticoid receptor antagonists and breast cancer
    Patent number: 10441596
    Abstract: Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: October 15, 2019
    Assignee: The University of Chicago
    Inventors: Deng Pan, Masha Kocherginsky, Suzanne D. Conzen
  • Flexible and stretchable electronic systems for epidermal electronics
    Patent number: 10441185
    Abstract: Provided herein are skin-mounted biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided, including electronic devices useful for establishing conformal contact with the skin of a subject. Devices disclosed herein can comprise a plurality of sensing and/or actuating devices provided as part of a skin-mounted flexible or stretchable electronic circuit.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: October 15, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: John A. Rogers, Dae-Hyeong Kim
  • MICROSCALE-BIPOLAR-INTERFACE-ENABLED PH GRADIENTS IN ELECTROCHEMICAL DEVICES
    Publication number: 20190312293
    Abstract: Among the various aspects of the present disclosure is the provision of method of inducing or providing a pH gradient in electrochemical or chemical systems. Briefly, the pH gradient is induced by use of coated particles or films with an ion exchange ionomer.
    Type: Application
    Filed: April 9, 2019
    Publication date: October 10, 2019
    Applicant: Washington University
    Inventors: Vijay K. Ramani, Zhongyang Wang, Javier Parrondo, Shrihari Sankarasubramanian
  • USE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA (PGC1ALPHA) AGONISTS TO IMPROVE EX VIVO EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES (TILS)
    Publication number: 20190307796
    Abstract: The present disclosure provides methods for expanding tumor-infiltrating lymphocytes (TILs), such as tumor-infiltrating T cells, utilizing an agonist of PGC1? in vivo, ex vivo, or both. Exhausted T cells present in the TIL population fail to effectively proliferate, produce cytokines, or kill target cells. The present disclosure provides methods to correct these defects through the use of pharmacologic agents to reprogram the metabolism of the exhausted intratumoral T cells. Exemplary agonists of PGC1? include proliferator-activated receptor (PPAR)-gamma agonists (e.g., a thiazolidinedione (TZD), aleglitazar, farglitazar, muraglitazar, or tesaglitazar), AMPK activators (e.g., 5-aminoimidazole-4-carboxamide ribonucleotide, AICAR), and sirtuin activators (e.g., resveratrol, SRT1720, SRT2104, SRT2183, SRT1460). Also provided are kits can compositions that can be used with such methods.
    Type: Application
    Filed: June 5, 2017
    Publication date: October 10, 2019
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventor: Greg M. Delgoffe
  • SOIL ANALYZING DEVICE AND SOIL ANALYZING METHOD
    Publication number: 20190310238
    Abstract: A soil analyzing device includes: a sensor having an excitation coil and a detection coil; a measurement unit that generates an excitation signal to be input to the excitation coil, and processes a detection signal output from the detection coil; a storage unit that stores data concerning the correlation between a quantitative value of the soil fertility characteristics including CEC of two or more types of the soil having different components and an estimated value of the soil fertility characteristics including CEC found from the processed detection signal measured by the sensor and the measurement unit; and an estimation unit that estimates the soil fertility characteristics based on the detection signal generated by allowing the sensor to apply the alternating magnetic field to the soil to be analyzed and processed by the measurement unit, and by using the data stored in the storage unit.
    Type: Application
    Filed: June 19, 2017
    Publication date: October 10, 2019
    Applicants: Komatsu Seiki Kosakusho Co., Ltd., National University Corporation Shinshu University
    Inventors: Takafumi Komatsu, Tsunaki Misawa, Naoto Inoue, Eishi Momosaki, Koji Orii
  • MATERIALS AND METHODS FOR RAPID AND SENSITIVE DETECTION OF SMALL-MOLECULE TARGETS
    Publication number: 20190309296
    Abstract: The subject invention provides methods, assays and products for detecting small-molecules in a sample, in particular, in both clinical and field settings. The method for detecting a small-molecule target in a sample comprises providing a sample, contacting the sample with an aptamer-based sensor selective for the small-molecule target, and sensitively and rapidly detecting the small-molecule target in the sample. Specifically, the method utilizes EATR-amplified small-molecule sensors based on cooperative binding split aptamers (CBSAs).
    Type: Application
    Filed: April 6, 2018
    Publication date: October 10, 2019
    Applicant: The Florida International University Board of Trustees
    Inventors: YI XIAO, HAIXIANG YU
  • METHODS FOR TREATING TESTOSTERONE DEFICIENCY IN MEN AND METHODS FOR PRECISE DOSING OF UGT2B17 SUBSTRATE DRUGS
    Publication number: 20190307773
    Abstract: Treatment of testosterone deficiency in men by a precision medicine approach using a biomarker of activity of UGT2B17 that is involved in testosterone urinary elimination. By inhibiting UGT2B17, alone or in combination with administration of testosterone, testosterone deficiency in men can be treatable. Further, a method of dose selection for precise dosing of UGT2B17 substrate drugs is provided. Additionally, methods for safe dosing of pharmaceutical agents that undergo UGT2B17-mediated acyl glucuronidation are provided.
    Type: Application
    Filed: April 10, 2019
    Publication date: October 10, 2019
    Applicant: University of Washington
    Inventors: Bhagwat Prasad, Abdul Basit, Haeyoung Zhang, John K. Amory