Abstract: The present invention relates to a method of transporting a stem cell population, the method comprising transporting the stem cell population contacted with a liquid carrier. In addition, the present invention concerns a method of treating a subject having a disease, the method comprising topically administering a defined mesenchymal stem cell population to the subject, wherein the mesenchymal stem cell population is administered within about 96 hours from the time point the mesenchymal stem cell population has been harvested. Also concerned is a unit dosage comprising about 20 million cells, of about 15 million cells, of about 10 million cells, of about 5 million cells, of about 4 million cells, of about 3 million cells, of about 2 million cells, of about 1 million cells, of about 0.5 million cells, of about 0.25 million cells or of less than 0.25 million cells of a defined mesenchymal stem cell population.
Type:
Application
Filed:
April 9, 2019
Publication date:
October 10, 2019
Applicants:
Cellresearch Corporation Pte. Ltd., The Regents of the University of Colorado
Abstract: The present invention provides for a genetically modified host cell and related methods and materials for the biocatalytic production of an ?,?-dicarboxylic acids (DCAs) and/or mono-methyl ester derivatives of dicarboxylic acids (DCAMMEs).
Type:
Application
Filed:
May 28, 2019
Publication date:
October 10, 2019
Applicant:
The Regents of the University of California
Abstract: The subject invention provides methods, assays and products for detecting small-molecules in a sample, in particular, in both clinical and field settings. The method for detecting a small-molecule target in a sample comprises providing a sample, contacting the sample with an aptamer-based sensor selective for the small-molecule target, and sensitively and rapidly detecting the small-molecule target in the sample. Specifically, the method utilizes EATR-amplified small-molecule sensors based on cooperative binding split aptamers (CBSAs).
Type:
Application
Filed:
April 6, 2018
Publication date:
October 10, 2019
Applicant:
The Florida International University Board of Trustees
Abstract: The disclosed embodiments provide a method for integrating an optical interposer with one or more electronic dies and an optical-electronic (OE) printed circuit board (PCB). This method involves first applying surface-connection elements to a surface of the optical interposer, and then bonding the one or more electrical dies to the optical interposer using the surface-connection elements. Next, the method integrates the OE-PCB onto the surface of the optical interposer, wherein the integration causes the surface-connection elements to provide electrical connections between the optical interposer and the OE-PCB.
Type:
Application
Filed:
April 4, 2019
Publication date:
October 10, 2019
Applicant:
The Regents of the University of California
Abstract: The present invention belongs to the field of advanced manufacturing technology and relates to one set-up and method of electrohydrodynamic jet 3D printing based on resultant effect of electric field and thermal field. This method is used to fabricate micro/nano 3D structure, under the resultant effects of electro hydrodynamic force and thermal field. First of all, the ink reaches needle orifice at a constant speed under the resultant effect of fluid field and gravity field. Then a high voltage electric field is applied between needle and substrate. And the ink is dragged to form stable micro/nano scale jet which is far smaller than the needle size using the electric field shear force generated at needle orifice. The solvent evaporation rate of ink increases combined with the radiation of thermal field at the same time. Finally, the micro/nano scale 3D structure is fabricated on substrate with the accumulation of jet layer by layer.
Type:
Application
Filed:
February 5, 2018
Publication date:
October 10, 2019
Applicant:
Dalian University of Technology
Inventors:
Dazhi WANG, Kai LI, Tongqun REN, Junsheng LIANG
Abstract: A repulsive-attractive-force electrostatic actuator according to some embodiments of the invention includes a first actuator layer including a first substrate, a first electrode pattern, and a second electrode pattern. The actuator further includes a second actuator layer including a second substrate, a third electrode pattern, and a fourth electrode pattern. The actuator further includes a first voltage source connected to the first and second electrode patterns such that the first electrode pattern is at a relative voltage of V1 to the second electrode pattern, and a second voltage source connected to the third and fourth electrode patterns such that the third electrode pattern is at a relative voltage of V2 to the fourth electrode pattern. The applied relative voltages V1 and V2 are selectable to provide one of a selected repulsive force or a selected attractive force between the first and second actuator layers.
Type:
Application
Filed:
April 8, 2019
Publication date:
October 10, 2019
Applicant:
The Regents of the University of California
Abstract: An injection molding apparatus including a mold, an injection device and a specific volume sensing module is provided. The injection device is adapted to inject a material into the mold. At least parts of the specific volume sensing module are disposed at the mold, wherein the specific volume sensing module is adapted to sense an actual specific volume of the material in the mold. In addition, an injection molding method is also provided.
Abstract: An oral device includes an intraoral bolus simulator comprising an exterior surface and having an interior volume Tillable with a fluid. An extraoral user interface extends from the bolus simulator, and can be used to locate or position the intraoral bolus simulator. In various embodiments, the fluid may be a gas or a liquid, or combinations thereof. In other embodiments, an oral device includes an extraoral handle, a shield connected to the handle, a tether extending from the shield, and a bolus simulator connected to the tether.
Type:
Application
Filed:
December 12, 2017
Publication date:
October 10, 2019
Applicants:
Trudell Medical International, The University of Western Ontario
Inventors:
Ruth E. Martin, Marcus Sieffert, Peter Scarrott, Andreas Rifani, Kelly Armstrong
Abstract: A composition comprising mesoporous aggregates of magnetic nanoparticles and free-radical producing enzyme (i.e., enzyme-bound mesoporous aggregates), wherein the mesoporous aggregates of magnetic nanoparticles have mesopores in which the free-radical-producing enzyme is embedded. Methods for synthesizing the enzyme-bound mesoporous aggregates are also described. Processes that use said enzyme-bound mesoporous aggregates for depolymerizing lignin, removing aromatic contaminants from water, and polymerizing monomers polymerizable by a free-radical reaction are also described.
Type:
Application
Filed:
May 29, 2019
Publication date:
October 10, 2019
Applicant:
Cornell University
Inventors:
Stephane C. CORGIE, Patarawan KAHAWONG, Emmanuel P. GIANNELIS, Larry P. WALKER
Abstract: A method for fabricating quantum rods includes: preparing a Cd-precursor; preparing a S-precursor and CdSe seeds; preparing a Zn-precursor; mixing the S-precursor and the CdSe seeds with the Cd-precursor in a reaction mixture; adding the Zn-precursor to the reaction mixture; stopping the reaction; and performing a purification process to obtain the quantum rods.
Type:
Application
Filed:
April 10, 2019
Publication date:
October 10, 2019
Applicant:
The Hong Kong University of Science and Technology
Inventors:
Maksym F. Prodanov, Valerii Vladimirovich Vashchenko, Abhishek Kumar Srivastava, Hoi Sing Kwok
Abstract: Aspects of the subject disclosure may include, for example, upon receiving a request for media content, a first signal quality may be determined, a first quality level may be selected based on the first signal quality, and segments of the first quality level may be retrieved, stored in a buffer, and played from the buffer. When the buffer is sufficiently occupied first inferior segments stored in the buffer may be replaced by determining a second signal quality selecting a second quality level based on the second signal quality, identifying the first inferior segment based on the second quality level, and replacing the first inferior segment with a first replacement segment, the first replacement segment corresponding to the first inferior segment. These processes may be performed iteratively. Other embodiments are disclosed.
Type:
Application
Filed:
April 10, 2018
Publication date:
October 10, 2019
Applicants:
AT&T Intellectual Property I, L.P., The Regents of the University of Michigan
Inventors:
Subhabrata Sen, Zhuoqing Morley Mao, Shichang Xu
Abstract: An acoustoelectric image-guided therapy system and method for applying acoustoelectric image-guided therapy are disclosed. Embodiments are directed to therapy systems and methods that utilize and are based on acoustoelectric imaging. The acoustoelectric imaging may be combined with focused therapies such as ultrasound, ablation, or hyperthermia for treatment of, for example, acute or chronic conduction abnormalities (e.g., neuropathy, arrhythmia, epilepsy, etc.). Current-density maps are obtained near the region of interest using acoustoelectric imaging techniques. Targeting of the region of interest is then identified for therapy based on the current-density maps. Treatment of the targeted region of interest is then employed while optionally monitoring bioelectric properties using real-time feedback from the acoustoelectric imaging. Imaging and therapy may be automatically co-registered. Standard electrophysiology (e.g., ENG, ECG, EEG, etc.
Type:
Application
Filed:
June 5, 2017
Publication date:
October 10, 2019
Applicant:
Arizona Board of Regents on Behalf of the University of Arizona
Inventors:
Russell WITTE, Charles M. INGRAM, Qian LI, Yexian QIN
Abstract: The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.
Type:
Application
Filed:
June 18, 2019
Publication date:
October 10, 2019
Applicants:
Emory University, Dana-Farber Cancer Institute, Inc., Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
Inventors:
Gordon Freeman, Arlene Sharpe, David M. Dorfman, Rafi Ahmed, Daniel Barber, E. John Wherry
Abstract: The present invention provides a method and apparatus for the measurement of a pressure differential across a differential pressure flow meter ?P1 and the line pressure drop due to friction ?Pf along a length L of pipe. Subsequently, the quantity (formula) is calculated, enabling the inline calculation of multiple properties of the flow. Calculated flow properties include friction factor, Reynolds number, discharge coefficient, density, viscosity, and corrected flowrate. The present invention further relates to a method of calibration of a differential flow meter and a calibration apparatus for a differential flow meter utilising the same principles.
Abstract: A fabrication method for a flexible bifacial dye-sensitized solar cell is described. The method involves forming a flexible counter electrode of crystalline Pt nanoparticles on a first conductive layer by irradiating a precursor solution with a UV lamp. A flexible photoanode is formed by applying metal oxide particles to a second conductive layer, and then the solar cell is constructed by sandwiching an electrolyte between the counter electrode and photoanode.
Type:
Application
Filed:
December 26, 2018
Publication date:
October 10, 2019
Applicants:
KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS, Imam Abdulrahman Bin Faisal University
Inventors:
Idris Kayode POPOOLA, Muhammad Ashraf Gondal, Jwaher M. Alghamdi, Talal F. Qahtan
Abstract: A neural device to which a conditioned response function is imparted and a driving method thereof are disclosed. Quantum dots and a polymer insulating layer are formed between upper and lower electrodes. Conductive filaments are formed at interfaces between the quantum dots and the polymer insulating layer. When a positive pulse, which is an unconditioned stimulus signal, is applied, the conductive filaments are formed, and a low resistance state is implemented. As the number of applications of a negative pulse, which is a conditioned stimulus signal, increases, the neural device is switched from a high resistance state to the low resistance state. Through this, the neural device having learning ability for the conditioned stimulus signal may be implemented and driven.
Type:
Application
Filed:
August 24, 2017
Publication date:
October 10, 2019
Applicant:
Industry-University Cooperation Foundation Hanyang University
Inventors:
Tae Whan KIM, Chaoxing WU, Dae Uk LEE, Hwan Young CHOI
Abstract: A tactile sensing system includes at least a stretchable strain sensing layer, an inflatable reservoir, and a means for detecting strain in the stretchable strain sensing layer. The tactile sensing layer may be configured as a tumor detection system by configuring the inflatable reservoir to apply pressure to at least part of a tissue in conjunction with an anatomical contact structure and the stretchable strain sensing layer to be in contact with a region of the surface of the tissue.
Type:
Application
Filed:
May 24, 2019
Publication date:
October 10, 2019
Applicants:
University of Maryland, College Park, University of Illinois at Urbana-Champaign
Inventors:
Elisabeth Smela, Miao Yu, Hugh A. Bruck, Thenkurussi Kesavadas