Abstract: This disclosure relates to methods of immunization comprising administering an effective amount of an immunogenic composition comprising an antigen or vaccine and an adjuvant disclosed herein to a subject in need thereof. In certain embodiments, the adjuvant is 1,8-dihydroxy-9,10-dihydroanthracen-9-one or derivative thereof. In certain embodiments, the adjuvant is N-(3,5-bis-trifluoromethyl-phenyl)-5-chloro-2-hydroxy-benzamide or derivatives thereof. In certain embodiments, the adjuvant is a fullerene or derivatives thereof, e.g., Fullerene-C60. In certain embodiments, the disclosure relates to compositions and devices comprising adjuvants disclosed herein.

Abstract: The present invention relates to the substantially non-invasive diagnosis of liver disease, especially to enable intervention in the progression of such disease at an early stage. This invention further relates to the use of plasma biomarkers to differentiate nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver (NAFL) and non-nonalcoholic fatty liver disease (NAFLD), and normal controls. Specifically, the invention relates to the use of free eicosanoids and other polyunsaturated fatty acid (PUFA) metabolite levels in plasma to differentiate NASH from NAFL and non-NAFLD normal controls.

Abstract: In at least one illustrative embodiment, a system may include a basin that includes an index plate positioned at a bottom of the basin. The basin is configured to receive a liquid analyte, such as a liquid food product or a nutrient broth. The index plate includes an array of multiple wells. Each well opens into an interior of the basin and is sized to receive a magnetostrictive sensor in a predetermined orientation. One or more sensor coils is positionable beneath each well. The basin may be filled with liquid analyte and magnetostrictive sensors may be positioned in the wells. The liquid analyte may be allowed to incubate at a controlled temperature. A controller may position a sensor coil beneath a well, apply a varying magnetic field to a magnetostrictive sensor in the well, and detect a frequency response of the magnetostrictive sensor. Other embodiments are described and claimed.

Abstract: A high-order optical fiber multi-wavelength filter includes a polarization beam splitter configured to form a polarization-diversity loop configuration by splitting light received from a broadband light source into two polarization components, combining circulated and input light of the two polarization components, and outputting the combined light, a pair of polarization controllers each including at least one wave plate in combination, and configured to change a polarization state of input light, and a pair of polarization-maintaining fibers configured to form interference spectrums by assigning phase differences through birefringence.

Abstract: The invention relates to a substrate intended in use to contact a fouling agent, the substrate including a coating comprising polysaccharide, which coating serves to reduce or prevent fouling of the substrate caused by contact from the fouling agent, in comparison to an equivalent uncoated substrate. The invention also relates to the anti-fouling coating, to apparatus comprising such coating and to related methods of reducing or preventing fouling of a substrate intended in use to contact a fouling agent.

Abstract: The application describes plants, plant cells, and seeds that express WRINKLED1 transcription factors and/or 14-3-3 proteins that are useful for increasing production of oils in plants and seeds. Also described are expression systems and cassettes that encode and express such WRINKLED1 transcription factors and/or 14-3-3 proteins.

Abstract: The present disclosure relates to a method of disinfecting a fluid comprising at least one live microbial organism. The method includes contacting the fluid comprising the at least one microbial organism with an effective amount of a photo-catalyst while exposing the fluid and the photo-catalyst to light from at least one light source with a wavelength of about 300-550 nm to reduce the number of the at least one live microbial organism to a predetermined level. The photo-catalyst comprises tungsten trioxide nanoparticles doped with palladium nanoparticles, and the palladium nanoparticles are present in an amount of about 0.1-5% of the total weight of the tungsten trioxide nanoparticles and the palladium nanoparticles.

Abstract: Exemplary systems, methods and computer-accessible mediums can secure split manufacturing of an integrated circuit by modifying a previous location of at least one pin to a further location of the at least one pin based on a fault analysis procedure. A determination of the further location can include an iterative procedure that can be a greedy iterative procedure. The modification of the location of the at least one partition pin can be performed by swapping at least one further partition pin with the at least one partition pin.

Abstract: The current invention is directed to a class of compounds that inhibit the function of Thymidylate synthase. Thymidylate synthase inhibition was noted to result in inhibition of tumor cell grow and killing of tumor cells. Thymidylate synthase inhibition is, thus, useful for treatment of various types of cancers, including but not limited to, acute lymphoblatic leukemia (ALL), acute myelogenous leukemia (AML), acute promyelocytic leukemia, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute monocytic leukemia (AMOL), hairy cell leukemia, large cell immunoblastic lymphoma, plasmacytoma, multiple myeloma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, leukemia, brain cancer, lung cancer, central nervous system (CNS) cancer, melanoma, renal cancer, prostate cancer, colon cancer, ovarian cancer and breast cancer. The compounds disclosed herein can be used alone or in combination with other cancer treatment regimens (e.g.

Abstract: The present disclosure relates to a clustering approach for sensor nodes of a wireless sensor network. This clustering approach, equal distance different members, balances the power burden amongst sensor nodes by deriving an optimal number of sensor nodes at each segment of a length. To this end, the present disclosure describes a linear wireless sensor network wherein the distance between adjacent cluster heads is equal while the number of and distance between sensor nodes in each cluster is different. A power consumption model is derived to aid in the determination of the optimal number of sensor nodes within each cluster. Following evaluation of the cluster approach in comparison with previously described approaches, the present disclosure is observed to improve network longevity and reduce power consumption by deliberately increasing the density of sensor nodes nearest a base station.

Abstract: BATS protocols may be utilized for high efficiency communication in networks with burst or dependent type losses. Systematic recoding at intermediate network nodes may be utilized to reduce the computational cost during recoding. A block interleaver based BATS protocol may be utilized to handle burst loss, where batches are recoded to a same number of packets. Adaptive recoding may be utilized to improve the throughput, where a batch with a higher rank is recoded to a larger number of packets. Using adaptive recoding, a non-block interleaver based BATS protocol may be utilized.

Abstract: The present disclosure provides heteroarene-based drug derivatives having a “clickable” ketone group, as well as conjugates of said drug derivatives with targeting moieties capable of binding to extracellular antigens; and pharmaceutical compositions comprising them.

Abstract: Provided herein are cyclodecynes, including chiral cyclodecynes, and methods of making cyclodecynes. The methods may include providing a 1,1?-biaryl compound substituted independently at the 2-position and the 2?-position with a hydroxyl or an amino group; and contacting the 1,1?-biaryl compound with a protected but-2-yne-1,4-diol to form the cyclodecyne.

Abstract: Aspects of the present disclosure relate to binding agents (e.g., antibodies and antigen binding fragments) that bind soluble fms-like tyrosine kinase 1 (sFlt1) in an isoform specific manner. In some embodiments, immunological assay methods utilizing isoform-specific antibodies or antigen binding fragments that bind sFlt1 isoforms are provided for assessing biological samples obtained from pregnant subjects, e.g., for purposes of evaluating preeclampsia status in the subject.

Abstract: An image representation method and processing device based on local PCA whitening. A first mapping module maps words and characteristics to a high-dimension space. A principal component analysis module conducts principal component analysis in each corresponding word space, to obtain a projection matrix. A VLAD computation module computes a VLAD image representation vector; a second mapping module maps the VLAD image representation vector to the high-dimension space. A projection transformation module conducts projection transformation on the VLAD image representation vector obtained by means of projection. A normalization processing module conducts normalization on characteristics obtained by means of projection transformation, to obtain a final image representation vector.

Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.

Abstract: Described herein is a previously unknown function of XBP1 in controlling anti-tumor immunity. It is shown that inhibiting XBP1 in tumor-associated dendritic cells inhibits tumor growth and induces protective anti-tumor immune responses.

Abstract: A sensing electrode, and an electrochemical system and method utilizing same for detecting peroxide-containing compounds in a sample, are provided. The sensing electrode is a carbon electrode having ions of a metal that promotes decomposition of a peroxide absorbed to its surface, optionally along with a solid electrolyte membrane.

Abstract: Provided are optical devices and systems fabricated, at least in part, via printing-based assembly and integration of device components. In specific embodiments the present invention provides light emitting systems, light collecting systems, light sensing systems and photovoltaic systems comprising printable semiconductor elements, including large area, high performance macroelectronic devices. Optical systems of the present invention comprise semiconductor elements assembled, organized and/or integrated with other device components via printing techniques that exhibit performance characteristics and functionality comparable to single crystalline semiconductor based devices fabricated using conventional high temperature processing methods. Optical systems of the present invention have device geometries and configurations, such as form factors, component densities, and component positions, accessed by printing that provide a range of useful device functionalities.

Abstract: The Ce—H2 redox flow cell is optimized using commercially-available cell materials. Cell performance is found to be sensitive to the upper charge cutoff voltage, membrane boiling pretreatment, methanesulfonic-acid concentration, (+) electrode surface area and flow pattern, and operating temperature. Performance is relatively insensitive to membrane thickness, Cerium concentration, and all features of the (?) electrode including hydrogen flow. Cell performance appears to be limited by mass transport and kinetics in the cerium (+) electrode. Maximum discharge power of 895 mW cm?2 was observed at 60° C.; an energy efficiency of 90% was achieved at 50° C. The Ce—H2 cell is promising for energy storage assuming one can optimize Ce reaction kinetics and electrolyte.