Patents Assigned to University
  • SYSTEMS AND METHODS FOR MIXING DRAWN FLUIDS
    Publication number: 20190282151
    Abstract: In one embodiment, a mixing device includes a sleeve that forms an inner space configured to receive a sample container, a housing associated with the sleeve, a mixing element contained within the housing that is configured to mix liquid contained within the sample container, and an activation element configured to activate the mixing element when the activation element is triggered.
    Type: Application
    Filed: March 19, 2019
    Publication date: September 19, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventor: Christopher John Zahner
  • REVERSIBLY PROTECTED THIOLATED ELECTROPHILIC FATTY ACIDS AS PRODRUGS
    Publication number: 20190282527
    Abstract: Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
    Type: Application
    Filed: October 4, 2017
    Publication date: September 19, 2019
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Bruce A. Freeman, Nicholas Khoo, Francisco Jose Schopfer, Steven Woodcock
  • COMPOSITION FOR INDUCING PROLIFERATION OR ACCUMULATION OF REGULATORY T CELLS
    Publication number: 20190282635
    Abstract: It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.
    Type: Application
    Filed: May 29, 2019
    Publication date: September 19, 2019
    Applicant: The University of Tokyo
    Inventors: Kenya Honda, Koji Atarashi, Kikuji Itoh, Takeshi Tanoue
  • MEDICINAL USE OF SERRULATANE DITERPENES
    Publication number: 20190282514
    Abstract: The invention relates to terpenes and uses thereof.
    Type: Application
    Filed: September 7, 2017
    Publication date: September 19, 2019
    Applicant: The University of Sydney
    Inventors: Colin Charles DUKE, Rujee Kyokajee DUKE, Van Hoan TRAN
  • NOVEL REVERSIBLE NITROXIDE DERIVATIVES OF NITROALKENES THAT MEDIATE NITROSATING AND ALKYLATING REACTIONS
    Publication number: 20190282528
    Abstract: Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include reversible nitroxide derivatives of nitroalkenes. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
    Type: Application
    Filed: October 4, 2017
    Publication date: September 19, 2019
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Marco Fazzari, Bruce A. Freeman, Francisco Jose Schopfer
  • TEMPERATURE-ACTUATED VALVE, FLUIDIC DEVICE, AND RELATED METHODS OF USE
    Publication number: 20190285187
    Abstract: Temperature-actuated valves, devices including temperature-actuated valves, and related methods are described. In an embodiment, the temperature-actuated valve includes a heat-shrink film defining a perforation extending at least partially in a first direction. In an embodiment, the temperature-actuated valve is configured to open when a portion of the heat-shrink film including the perforation is heated above a threshold temperature to contract the heat-shrink film along a second direction perpendicular to the first direction to define an aperture, in an open configuration, providing a fluid a path through the heat-shrink film. In an embodiment, the temperature-actuated valve includes a leakage-mitigation feature configured to limit fluid flow through the perforation when the valve is in a closed configuration.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 19, 2019
    Applicant: University of Washington
    Inventors: Paul Yager, Joshua Bishop, Michael Purfield
  • METHOD OF ETCHING MICROELECTRONIC MECHANICAL SYSTEM FEATURES IN A SILICON WAFER
    Publication number: 20190287810
    Abstract: A method of etching features in a silicon wafer includes coating a top surface and a bottom surface of the silicon wafer with a mask layer having a lower etch rate than an etch rate of the silicon wafer, removing one or more portions of the mask layer to form a mask pattern in the mask layer on the top surface and the bottom surface of the silicon wafer, etching one or more top surface features into the top surface of the silicon wafer through the mask pattern to a depth plane located between the top surface and the bottom surface of the silicon wafer at a depth from the top surface, coating the top surface and the one or more top surface features with a metallic coating, and etching one or more bottom surface features into the bottom surface of the silicon wafer through the mask pattern to the target depth plane.
    Type: Application
    Filed: March 13, 2018
    Publication date: September 19, 2019
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Feng Zhou, Ki Wook Jung, Ercan Mehmet Dede, Mehdi Asheghi, Kenneth E. Goodson
  • COMPOSITIONS AND METHODS FOR RAPID IN VITRO SYNTHESIS OF BIOCONJUGATE VACCINES IN VITRO VIA PRODUCTION AND N-GLYCOSYLATION OF PROTEIN CARRIERS IN DETOXIFIED PROKARYOTIC CELL LYSATES
    Publication number: 20190284600
    Abstract: Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated carrier proteins. The glycosylated carrier proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated carrier proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated carrier proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.
    Type: Application
    Filed: March 19, 2019
    Publication date: September 19, 2019
    Applicants: Northwestern University, Cornell University
    Inventors: Michael Christopher Jewett, Jessica Carol Stark, Matthew P. DeLisa, Thapakorn Jaroentomeechai
  • SYNTHETIC DISUGAR HYDROCARBONS AS NATURAL ANALOGS TO CONTROL MICROBIAL BEHAVIORS
    Publication number: 20190282597
    Abstract: Synthetic disaccharide hydrocarbons (DSHs) that reactive bacterials swarming motility and inhibit bacterial adhesion and biofilm formation. A library of DSHs were tested in several experiment for the impact on various Pseudomonas aeruginosa populations and compared against existing compounds to determine efficacy and utility. Certain DSHs were also to determine the ability to clear bacteria in a mouse pneumonia model.
    Type: Application
    Filed: May 28, 2019
    Publication date: September 19, 2019
    Applicants: Syracuse University, The Research Foundation for the State University of New York
    Inventors: Yan-Yeung Luk, Guirong Wang
  • COMPOSITION FOR INDUCING PROLIFERATION OR ACCUMULATION OF REGULATORY T CELLS
    Publication number: 20190282634
    Abstract: It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.
    Type: Application
    Filed: April 19, 2019
    Publication date: September 19, 2019
    Applicant: The University of Tokyo
    Inventors: Kenya Honda, Koji Atarashi, Kikuji Itoh, Takeshi Tanoue
  • Non-Invasive Passive Interstitial Fluid Collector
    Publication number: 20190282149
    Abstract: A microfluidic device for non-invasively and passively accessing interstitial fluid from a patient includes a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.
    Type: Application
    Filed: October 20, 2017
    Publication date: September 19, 2019
    Applicant: Georgetown University
    Inventor: Makarand Paranjape
  • LAYER-BY-LAYER ASSEMBLY OF GRAPHENE OXIDE MEMBRANES VIA ELECTROSTATIC INTERACTION AND ELUDICATION OF WATER AND SOLUTE TRANSPORT MECHANISMS
    Publication number: 20190283388
    Abstract: A method for synthesizing a water purification membrane is presented. The method includes stacking a plurality of graphene oxide (GO) nanosheets to create the water purification membrane, the stacking involving layer-by-layer assembly of the plurality of GO nanosheets and forming a plurality of nanochannels between the plurality of GO nanosheets for allowing the flow of a fluid and for rejecting the flow of contaminants. The method further includes cross-linking the plurality of GO nanosheets by 1,3,5-benzenetricarbonyl trichloride on a polydopamine coated polysulfone support.
    Type: Application
    Filed: March 25, 2019
    Publication date: September 19, 2019
    Applicant: University of Maryland, College Park
    Inventors: Baoxia Mi, Meng Hu
  • Smart Rutting and Cracking Resistant Asphalt Pavement Incorporating Shape Memory Polymers
    Publication number: 20190284396
    Abstract: The low temperature cracking and high temperature rutting of polymer-modified asphalt concrete pavement can be reduced. The composite includes asphalt and at least one polymer that expands at low temperature, triggered by cooling-induced tensile stress, to reduce thermal cracking. The composite includes at least one polymer that expands at high temperature, so that the composite recovers after compression induced by traffic loading at higher temperatures, thereby reducing rutting. The system reduces thermal stress, and reduces or even eliminates thermal cracking and rutting. Shape memory polymers (SMPs) are used to improve asphalt compositions so that they better resist both thermal cracking and rutting. The SMP(s) can be incorporated into the asphalt, or a portion of fine aggregates can be replaced with SMP particles or SMP fibers, or aggregate replacement and asphalt modification can be combined.
    Type: Application
    Filed: March 12, 2019
    Publication date: September 19, 2019
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Guoqiang Li
  • MATERIALS AND METHODS FOR DETECTING SOURCE BODY FLUIDS
    Publication number: 20190284643
    Abstract: The invention pertains to analyzing the levels of DNA methylation at specific genetic loci to detect specific body fluids, for example, vaginal secretions or vaginal epithelial cells, semen or sperms, saliva or buccal epithelial cells, or blood or blood cells. Particularly, the levels of methylation of DNA at the genetic loci corresponding to SEQ ID NOs: 1, 6, 11, and 16 are used to detect vaginal secretions or vaginal epithelial cells, semen or sperms, saliva or buccal epithelial cells, and blood or blood cells, respectively. The level of methylation at the specific loci can be determined by high-resolution melt analysis (HRM) or sequencing of the amplicons produced using specific primers designed to amplify the specific loci. Kits containing the primers and reagents for carrying out the methods disclosed herein are also provided.
    Type: Application
    Filed: August 3, 2018
    Publication date: September 19, 2019
    Applicant: The Florida International University Board of Trustees
    Inventors: Bruce MCCORD, Joana ANTUNES
  • E. COLI MEDIATED siRNA SILENCING OF AVIAN INFLUENZA IN CHICKENS
    Publication number: 20190284559
    Abstract: Products and associated methods are described for the delivery of one or more small interfering RNAs (siRNAs) to an avian cell using a nonpathogenic bacterium for the prevention or treatment of Avian Influenza Virus (AIV). The siRNA is complementary to an mRNA of the AIV NP or PA sequence. In challenge studies with chickens, the siRNA is shown to prevent the onset of clinical symptoms or reduce the severity of disease, including reducing viral titers or virus shedding.
    Type: Application
    Filed: June 4, 2019
    Publication date: September 19, 2019
    Applicant: Colorado State University Research Foundation
    Inventors: Lyndsey M. Linke, Mo D. Salman, Jeffrey Wilusz
  • METHOD AND APPARATUS FOR IMPROVING COGNITIVE PERFORMANCE THROUGH CORTICAL STIMULATION
    Publication number: 20190282815
    Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes a neurostimulation device, such as a signal generator, to affect tissue elements at a lateral temporal lobe of the human brain. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various characteristics of cognition. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation therapy.
    Type: Application
    Filed: July 19, 2017
    Publication date: September 19, 2019
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Michael KAHANA, Daniel Sutton RIZZUTO
  • UNCONSTRAINED EAR RECOGNITION USING A COMBINATION OF DEEP LEARNING AND HANDCRAFTED FEATURES
    Publication number: 20190286891
    Abstract: A system and method for identifying a subject based upon ear recognition using a convolutional neural network (CNN) and handcrafted features, wherein an ear in an image is cropped using ground truth annotations and landmark detection is performed to obtain the information required to normalize pose and scale variations. The normalized images are then described by different feature extractors and matched through distance metrics. Finally, scores are fused and a subject identification decision is made.
    Type: Application
    Filed: December 17, 2018
    Publication date: September 19, 2019
    Applicant: University of South Florida
    Inventors: Sudeep Sarkar, Mauricio Pamplona Segundo, Earnest Eugene Hansley
  • METHOD
    Publication number: 20190287276
    Abstract: The present invention describes a new functional biomarker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional biomarkers of vascular inflammation and disease.
    Type: Application
    Filed: October 31, 2017
    Publication date: September 19, 2019
    Applicant: Oxford University Innovation Limited
    Inventors: Charalambos Antoniades, Keith Channon, Evangelos Oikonomou, Stefan Neubauer
  • ONE-STEP SCALABLE FABRICATION OF MECHANICALLY ROBUST VISIBLE-LIGHT RESPONSIVE OXIDE-MODIFIED METALLIC MULTIFUNCTIONAL MEMBRANES
    Publication number: 20190282970
    Abstract: A universal, scalable, solvent-free, one-step method for thermal annealing a stainless steel membrane to create a superhydrophilic surface. The superhydrophilic membrane itself, and methods for using it to separate oil and water in an oil and water mixture or for photocatalytic degradation of methylene blue and other organic contaminants.
    Type: Application
    Filed: January 11, 2019
    Publication date: September 19, 2019
    Applicant: King Fahd University of Petroleum and Minerals
    Inventors: Mohammed A. GONDAL, Talal F. QATAN, Mohamed A. DASTAGEER
  • Biomarker Panel to Identify Patients at Risk for Peri-Implant Osteolysis
    Publication number: 20190285649
    Abstract: Methods and kits for measuring a panel of biomarkers in a subject suspected of being at risk for peri-implant osteolysis are provided. The method includes obtaining a biological sample from the subject; and measuring a level of at least two biomarkers in a biomarker panel in the sample, wherein the biomarker panel comprises ?-crosslaps (?-CTX), ?-crosslaps (?-CTX), Interleukin-6 (IL-6), Interleukin-8 (IL-8), osteoprotegrin (OPG), deoxypyridinoline (DPD), and cross-linked N-telopeptides (NTX).
    Type: Application
    Filed: March 19, 2019
    Publication date: September 19, 2019
    Applicant: Rush University Medical Center
    Inventors: Ryan D. Ross, Dale Richman Sumner, Joshua J. Jacobs