Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: A CDMR memory cell, includes a first bitcell which is used to store a current data level and a second bitcell which is used to store the complementary data level. When a read operation is performed, a comparator compares the data levels read from the two bitcells. If these two levels are not complementary, the comparator outputs an indicator. This indicator serves as an alert that a storage error has, or may have, occurred.

Abstract: A method of fabricating an anode material for a secondary battery includes following steps. A carbon-containing biomass material is provided. The carbon-containing biomass material is mixed with a solid-state nitrogen-containing precursor via a solid-phase mixing method to form a mixture. A sintering process is performed on the mixture to form a nitrogen-doped biomass carbon.

Abstract: A home medication management system and method are provided comprise a home medication management device, a computing device associated with a user of medication management system, and a server in communication with the home medication management device and the computing device. The server comprises memory storing an application program interface (API) that is configured to manage the home medication of a patient including the registration of prescriptions, transmission of the registered prescriptions to the home medication management device, association of medications of the registered prescriptions with recesses of the home medication management device, presentation of alerts to the patient at scheduled times to take the medications based on the prescriptions, monitoring the patient for compliance with the alerts, determining whether the patient has taken the medication as scheduled, and presenting the determination to the user via the computing device.

Abstract: Embodiments of the present disclosure pertain to methods of opening a lipid bilayer by associating the lipid bilayer with a molecule that includes a moving component capable of moving (e.g., rotating) in response to an external stimulus; and exposing the molecule to an external stimulus before, during or after associating the molecule with the lipid bilayer. The exposing causes the moving component of the molecule to move and thereby open the lipid bilayer (e.g., by pore formation). The external stimuli may include an energy source, such as ultraviolet light. The opened lipid bilayer may be a component of cell membranes in vitro or in vivo. The opening of the lipid bilayer may allow for the passage of various materials (e.g., active agents, such as peptide-based drugs) through the lipid bilayer and into cells. Additional embodiments of the present disclosure pertain to the aforementioned molecules for opening lipid bilayers.

Abstract: A method of identifying an epileptogenic zone of a subjects brain includes: receiving a plurality N of physiological brain signals that extend over a duration, each of the plurality N of physiological brain signals acquired from the subjects brain; calculating within a time window a state transition matrix based on at least a portion of each of the plurality N of physiological brain signals, wherein the state transition matrix is a linear time invariant model of a network of N nodes corresponding to the plurality N of physiological brain signals; calculating a minimum norm of a perturbation on the state transition matrix that causes the network to transition from a stable state to an unstable state; and assigning a fragility metric to each of the plurality N of physiological brain signals based on the minimum norm of the perturbation for that physiological brain signal.

Abstract: Various embodiments are directed to a high temperature superconducting (HTS) synchronous machine having a rotating armature and methods for fabricating the same. The HTS synchronous machines described herein solve the rotating seal system complications which plague conventional HTS synchronous machines by eliminating entirely the need for any such system. Instead, it is proposed here to rotate the AC armature windings, which are stationary (i.e., normally the “stator”) in conventional HTS synchronous machines, while allowing the superconducting field windings to remain stationary.

Abstract: Methods are provided of generating functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT) and using mitochondrial replacement techniques to circumvent mother-to-child mtDNA disease transmission.

Abstract: Provided herein are methods and compositions for the targeted delivery to myometrial tissue of one or more agents capable of regulating contractility of myometrial tissue, wherein the one or more agents are contained or encapsulated within a polymeric delivery vehicle conjugated with one or more molecules that recognizes and/or is capable of binding, directly or indirectly, to the oxytocin receptor.

Abstract: The present invention provides for a method of engineering a plant having an increased content of a target compound in the plant's seed, the method comprising introducing into the plant a first nucleic acid construct that encodes a seed-specific promoter operatively linked to a transcription factor wherein expression of the transcription factor increases the production of the target compound. A genetically modified plant cell engineered by the method.

Abstract: A dynamic metal-anode flow battery energy-storage system includes a discharge module, a charging module, and a delivery device. The discharge module includes a plurality of discharge reactants to be oxidized to discharge electric energy. The charging module is electrically connected to the discharge module and includes at least one electrolysis device and at least one removal device. The electrolysis device includes a conductive member which is to be energized with electricity, such that a plurality of electrolysis products having the same material with the discharge reactants are adhered to a surface thereof. The removal device includes a scraper adapted to remove the adhered electrolysis products from the surface of the conductive member. The delivery device is adapted to deliver the electrolysis products into the first electrolyte as the discharge reactants, and deliver the discharged products into the second electrolyte as the electrolysis reactants.

Abstract: In one embodiment, the application discloses a method for the treatment of cancer in a patient, the method comprises a vaccination of the patient with a vaccine, wherein the vaccine comprises an effective amount of mammalian pluripotent stem cells obtained from an embryonic source or obtained by reprogramming of somatic cells from the patient, wherein the vaccination comprising the step of administering a mammalian pluripotent stem cells to the patient in need thereof; and vaccine formulations for use in the treatment of cancer.

Abstract: This invention describes vaccine compositions and their methods of use utilizing inactivated fbp1? deletion mutant fungal cells.

Abstract: Synthesis, fabrication, and application of nanocomposite polymers in different form (as membrane/filter coatings, as beads, or as porous sponges) for the removal of microorganisms, heavy metals, organic, and inorganic chemicals from different contaminated water sources.

Abstract: The present invention provides methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in CH1/CL interface, Fabs and IgG bi-specific antibodies produced according to said processes as well as nucleic acids, vectors and host cells encoding the same.

Abstract: Provided is an energy storage system coupling phase change material(s) and dissipation heat pipe(s). The energy storage system includes several energy storage units serially connected along a same central axis. Each of the energy storage units includes a heat charge flow channel, an annular heat release passage, and an annular energy storage passage disposed concentrically from inside to outside. A dissipation pulsating heat pipe is disposed in the energy storage unit, and the dissipation pulsating heat pipe includes several pulsating-heat-pipe branches uniformly arranged in a circumferential direction.

Abstract: The present invention discloses an encoding apparatus using a Discrete Cosine Transform (DCT) scanning, which includes a mode selection means for selecting an optimal mode for intra prediction; an intra prediction means for performing intra prediction onto video inputted based on the mode selected in the mode selection means; a DCT and quantization means for performing DCT and quantization onto residual coefficients of a block outputted from the intra prediction means; and an entropy encoding means for performing entropy encoding onto DCT coefficients acquired from the DCT and quantization by using a scanning mode decided based on pixel similarity of the residual coefficients.

Abstract: In one aspect, a neuromodulation device is described herein. In some embodiments, a neuromodulation device comprises a chamber operable to receive a nerve, at least one electrode disposed in the chamber, and a channel defined by two walls. In some embodiments, the channel of the device is in fluid communication with an interior of the chamber and an external surface of the device. In another aspect, methods of neuromodulation are described herein. In some embodiments, methods described herein can use one or more neuromodulation devices described herein.

Abstract: The invention enables quality of a pinhole image to be improved, any of myopia or hyperopia, astigmatism and presbyopia to be corrected and high functionality to attain.

Abstract: A method for changing acoustics of a performance space may include mounting a plurality of panel assemblies to a ceiling or a portion of a ceiling of the performance space. Each panel assembly of the plurality of panel assemblies may include one or more acoustic panels. The exemplary method may further include changing a distance of the one or more acoustic panels of each panel assembly of the plurality of panel assemblies from the ceiling by coupling the one or more acoustic panels of each panel assembly of the plurality of panel assemblies with a first actuating mechanism, and actuating a linear vertical movement of the one or more acoustic panels of each panel assembly of the plurality of panel assemblies along a first axis perpendicular to the ceiling utilizing the first actuating mechanism.