Abstract: Systems and methods for computational analysis of chemical data to predict binding targets of a chemical are provided. A plurality of chemical pairs is established, each including a first chemical for which binding targets are to be predicted and a respective one of the second chemicals. For each chemical pair, values of at least two datatypes of the first chemical can be compared to values of the at least two datatypes of the respective one of the plurality of second chemicals in the chemical pair to generate a similarity score. The similarity scores can be converted to a likelihood value. For each chemical pair, a total likelihood value can be determined based on respective likelihood values for each of the at least two datatypes of the chemical pair. A candidate binding target is predicted to bind to the first chemical, based on the total likelihood value of each chemical pair.

Abstract: The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1? in neurons. The invention also provides HSV vectors for expressing PP1? within neurons and compositions comprising such vectors.

Abstract: An integrated controller of a powertrain of a vehicle and a control method thereof, to determine an optimum shifting stage of the vehicle, may include a cost function having a driving distance per fuel consumption amount obtained through the simulation of a vehicle model by use of the demand power of the engine as an input value, wherein an optimum shifting stage is determined using the cost function to control an engine throttle in addition to controlling a transmission based on the optimum shifting stage.

Abstract: Methods and compositions for improving photosynthesis by eliminating a sustained photoprotective mechanism by mutating or silencing the Chloroplastic Lipocalin (CHL) gene whereby photosynthesis of the plants increases. The sustained photoprotective mechanism negatively regulated by the Suppressor of Quenching 1 protein involves the chloroplastic lipocalin and occurs in the peripheral antenna of photosystem II.

Abstract: A method and associated access point for processing data for transmission to communication devices, the method comprising determining or receiving channel state information, CSI, relating to a plurality of the communication devices; for each of one or more sub-carriers, determining which communication devices can communicate using the respective subcarrier according to, or based on, the channel state information or data derived therefrom; allocating communication devices to sub-carriers upon which each communication device can communicate; and providing data for at least one or more or each communication device on the sub-carriers to which the respective communication device has been allocated. Preferably, the method uses an adaptive bit loading algorithm to allocate communication devices to sub-carriers.

Abstract: Methods and apparatus for providing dispersion-managed dissipative Kerr solitons on-chip are provided. Microresonators are also provided for producing such solitons. The solitons may be enabled by real-time dynamical measurements on frequency combs. Methods are further provided to determine the temporal structure of the intracavity field in both the fast time axis, with ultrafast time-lens magnifiers at 600 fs timing resolutions, and the slow time axis via optical sampling with a synchronized fiber frequency comb reference. An order-of-magnitude enlarged stability zone of the dispersion-managed dissipative Kerr solitons is achieved versus the static regimes.

Abstract: Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.

Abstract: Provided are nucleic acid-based sensors, kits that include such sensors, and methods for making and using such sensors. The sensors permit detection of a broad array of target agents, such as nucleic acids (e.g., DNA and RNA), proteins, cells, and small molecules (e.g., toxins and metals). In some examples, the sensors determine the activity of a protein, such as an enzyme's activity. The assays provide easy-to-read signals for point-of-care diagnosis. The sensors control the conformational switch for recognizing targets and to trigger the subsequent assembly of enzyme/cofactor structures for producing and amplifying signals.

Abstract: According to the present invention, various diseases, such as viral diseases, cancer, and multiple sclerosis, can be prevented and improved by using an immunostimulatory factor production-promoting composition comprising genomic double-stranded RNA of a plant-derived endornavirus.

Abstract: Provided is a method of detecting the presence of an anti-Zika virus (ZIKV) antibody in a sample, including contacting a sample with a suspension having a plurality of microspheres wherein individual microspheres are conjugated to a peptide and the peptide includes a ZIKV peptide selected from the group including ZIKV NS1, ZIKV NS5, and ZIKV envelope protein, forming a first incubated suspension by incubating said sample with said suspension to permit binding of anti-ZIKV antibodies present in the sample to said microspheres, forming a second incubated suspension by contacting said first incubated suspension with an anti-ZIKV antibody detecting-reagent to permit binding of the anti-ZIKV antibody detecting reagent to said microspheres, removing from the second incubated suspension anti-ZIKV antibody detecting-reagent molecules that are not bound to said microspheres, and detecting the presence of anti-ZIKV antibody detecting-reagent molecules in the second incubated suspension.

Abstract: The disclosure relates to the field of fusion proteins. In some aspects, the disclosure relates to artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes and uses thereof. In some aspects, the disclosure relates to corn-pounds produced by artificial cytochrome P450 enzymes.

Abstract: Strains of human-derived bacteria have been obtained from complex fecal samples and shown to induce accumulation of Th17 cells in the intestine and promote immune functions. Pharmaceutical compositions containing these bacteria can be used as anti-infectives and as adjuvants in mucosal vaccines.

Abstract: An apparatus for processing multi-type sensor signals on the basis of multi-modal deep learning, the apparatus including: an individual sensor failure diagnosis unit configured to measure a normality of a sensor output of a single modal sensor at each sampling period, and sense an abnormal operation of the sensor on the basis of the measured normality; an inter-sensor mutual failure diagnosis unit including a multi-modal deep auto encoder, and configured to learn a correlation existing between multi-modalities, extract shared representation between modalities from multi-modal inputs on the basis of the learned correlation, and perform an inter-sensor mutual failure diagnosis; and a reconstruction target sensor output value reconstructing unit configured to, when an output value of a specific sensor is missing, predict and reconstruct the output value of the sensor using other sensor information using the shared representation extracted from other modal sensors.

Abstract: Compositions and methods for mitochondria genome editing are provided. Also provided are methods for treating mitochondrial disorders by the disclosed compositions.

Abstract: The present disclosure relates to a method of analysis by an optical marker, including: irradiating a broadband light source onto a spherical dielectric material; measuring an interference spectrum of reflected light from the spherical dielectric material; and analyzing the reflected light using thin-film interference theory.

Abstract: The present invention provides a pharmaceutical composition that can improve the survival time and the survival rate of a patient after onset of hemorrhagic shock. The present invention provides a gaseous pharmaceutical composition comprising hydrogen gas for improving and/or stabilizing circulatory dynamics after onset of hemorrhagic shock. The pharmaceutical composition of the present invention can be administered when blood transfusion therapy cannot be given, and can increase the survival rate after onset of hemorrhagic shock or extend the survival time compared to when the pharmaceutical composition of the present invention is not administered.

Abstract: Clostridium difficile infection is the leading cause of hospital acquired antibiotic-associated diarrhea in the US (Bartlett, in 2006). The increased prevalence of circulating C. difficile strains poses a significant health threat to US health care facilities. Strains expressing the toxin C. difficile Transferase (CDT), in addition to Toxins A and B (TcdA and TcdB), are more virulent and are associated with higher mortality rates (Bacci et al., 2011). We recently identified a protective role for eosinophils against C. difficile pathogenesis (Buonomo et al., 2016). We have also defined CDT's ability to increase host inflammation and suppress protective eosinophils through a TLR2 dependent mechanism (Cowardin et al., 2016). How CDT promotes virulence and eosinophil suppression via TLR2 is still under investigation.

Abstract: A medical suction & irrigation system used for removing bodily fluid and debris from a surgical site and particularly a hand-held medical device that utilizes suction tips and suction/irrigation tips during medical procedures. The system features use of a fully disposable suction and irrigation devices. This system comprises a series of devices which includes a universal handle member, interchangeable tip members, a storage member, and a receptacle member. This system will improve the workflow of users at all skill levels while integrating seamlessly into existing common practice. It is a fully integrated and optimized system which recognizes and utilizes the interaction between two distinct user groups with the overall benefit of reducing procedural times and increasing patient safety.

Abstract: A method of ammonia synthesis is described that includes contacting a nitrogen gas-containing plasma with an aqueous solution, thereby forming ammonia from the nitrogen gas and water. The nitrogen gas-containing plasma is present in an electrochemical cell. The electrochemical cell includes a container including an acidic liquid electrolyte. The electrochemical cell also includes a source of nitrogen gas, a metal electrode at least partially immersed in the electrolyte, a metal tube electrode spaced apart from a surface of the electrolyte by a predetermined spacing. The electrochemical cell is configured to provide a plasma spanning the predetermined space from the metal tube electrode to contact the surface of the electrolyte when power is applied to the metal tube electrode.

Abstract: A physiological information detection system may include an add-on device in electronic communication with a computing device. The add-on device includes a body and a first light filter retained in the body. The first light filter filters light emitted by the light source of the computing device. A lens is also retained in the body proximate the first light filter. The lens directs light exiting the first light filter out a surface of the first lens. The body retains a second lens that receives into a surface of the second lens light exiting the first lens. The surface of the first lens and the surface of the second lens are substantially coplanar. A second light filter is also retained in the body proximate the second lens. The sensor detects the light exiting the second light filter.