Abstract: Techniques are described for data transfer in spin-based systems where digital bit values are represented by magnetization states of magnetoresistive devices rather than voltages or currents. For data transmission, a spin-based signal is converted to an optical signal and transmitted via an optical transport. For data reception, the optical signal is received via the optical transport and converted back to a spin-based signal. Such data transfer may not require an intervening conversion of the spin-based signal to charge-based signal that relies on voltages or currents to represent digital bit values. In addition, techniques are described to use magnetoresistive devices to control the amount of current or voltage that is delivered, where the magnetization state of the magnetoresistive device is set by an optical signal.
Abstract: Several methods for prediction and detection of neurological events are proposed based on spatiotemporal patterns in recorded neural signals. The methods are illustrated with examples from neural data recorded from human and non-human primates.
Type:
Grant
Filed:
December 5, 2011
Date of Patent:
October 22, 2019
Assignees:
Brown University, The General Hospital Corporation, The United States Government as Represented by the Department of Veterans Affairs
Inventors:
Wilson Truccolo, Leigh R. Hochberg, John P. Donoghue, Sydney S. Cash
Abstract: The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
Type:
Grant
Filed:
August 24, 2018
Date of Patent:
October 22, 2019
Assignee:
The Regents of the University of California
Inventors:
Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva
Abstract: In one embodiment, a system includes apparatus for monitoring hand or wrist movement, the apparatus including a magnetic ring adapted to be worn on a finger of a patient and a data acquisition unit adapted to be worn on a wrist of the patient, the data acquisition unit including a magnetic sensor that can measure the strength and orientation of magnetic fields generated by the ring.
Type:
Grant
Filed:
March 10, 2014
Date of Patent:
October 22, 2019
Assignee:
The Regents of the University of California
Inventors:
Nizan Friedman, Justin Rowe, David J. Reinkensmeyer, Mark G. Bachman
Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.
Type:
Grant
Filed:
April 11, 2017
Date of Patent:
October 22, 2019
Assignee:
The Regents of the University of Michigan
Inventors:
Mark E. Meyerhoff, Nicolai Lehnert, Yu Qin, Andrew P. Hunt, Elizabeth J. Brisbois, Hang Ren
Abstract: Factors affecting the fragmentation pattern of cell-free DNA (e.g., plasma DNA) and the applications, including those in molecular diagnostics, of the analysis of cell-free DNA fragmentation patterns are described. Various applications can use a property of a fragmentation pattern to determine a proportional contribution of a particular tissue type, to determine a genotype of a particular tissue type (e.g., fetal tissue in a maternal sample or tumor tissue in a sample from a cancer patient), and/or to identify preferred ending positions for a particular tissue type, which may then be used to determine a proportional contribution of a particular tissue type.
Abstract: A therapeutically effective composition for treating Alzheimer's disease includes a pharmaceutically acceptable dosage form comprising melatonin, resveratrol, EGCG, and vitamin B12 combined in a therapeutically effective amount. A combinatorial treatment method for Alzheimer's disease includes administering to a human having Alzheimer's disease a therapeutically effective combination of melatonin, resveratrol, EGCG, and vitamin B12. A method of treating Alzheimer's disease includes administering to a human having Alzheimer's disease a therapeutically effective amount of a pharmaceutically acceptable dosage form comprising melatonin, resveratrol, EGCG, and vitamin B12.
Type:
Grant
Filed:
June 28, 2016
Date of Patent:
October 22, 2019
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: Methods and apparatus automatically classify intravascular plaque using features extracted from intravascular optical coherence tomography (IVOCT) imagery. One example apparatus includes an image acquisition circuit that accesses a set of IVOCT images, a pre-processing circuit that generates a blood vessel mask based on the IVOCT images, a feature extraction circuit that defines a three dimensional (3D) volume of interest centered on a location in a member of the set of IVOCT images, a classification circuit that generates a classification based on a probability that a voxel represents a type of plaque, and a visualization circuit that provides a visualization, substantially in real time, of a member of the set of IVOCT images and the classification, where the visualization includes a sector classification image, a labeled image, or a 3D visualization. A prognosis or treatment plan may be provided based on the visualization or the classification.
Type:
Grant
Filed:
April 19, 2017
Date of Patent:
October 22, 2019
Assignee:
Case Western Reserve University
Inventors:
Ronny Y. Shalev, David L. Wilson, Soumya Ray
Abstract: A device for making a carbon nanotube array includes a chamber, a gas diffusing unit and a gas supplying pipe. The gas diffusing unit and the gas supplying pipe are in the chamber. The gas diffusing unit is a hollow structure and defines a hole and an outlet. The gas supplying pipe includes a first end and a second end opposite to the first end. The first end extends out of the chamber. The second end is in the chamber and connected to the hole.
Type:
Grant
Filed:
May 29, 2018
Date of Patent:
October 22, 2019
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Abstract: A replicating in vitro cell culture of human placental mesenchymal stem cells comprising; cells which maintain a potential to differentiate to derivatives of multiple progenitor cell types throughout the culture. The progenitor cell types may include neuronal cells, oligodendrocytes and beta-cells. A method of treating a disease, disorder, or condition in a human comprising administering a pharmacologically effective dose of human placental mesenchymal stem cells to the human. A method for producing human placental mesenchymal stem cells.
Type:
Application
Filed:
April 16, 2019
Publication date:
October 17, 2019
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: Techniques for a recursive deep-learning approach for performing speech synthesis using a repeatable structure that splits an input tensor into a left half and right half similar to the operation of the Fast Fourier Transform, performs a 1-D convolution on each respective half, performs a summation and then applies a post-processing function. The repeatable structure may be utilized in a series configuration to operate as a vocoder or perform other speech processing functions.
Type:
Application
Filed:
August 22, 2018
Publication date:
October 17, 2019
Applicants:
Adobe Inc., The Trustees of Princeton University
Inventors:
Zeyu Jin, Gautham J. Mysore, Jingwan Lu, Adam Finkelstein
Abstract: An apparatus for simultaneous transmit and receive is provided. The apparatus is capable of rejecting or passing transmitter and receiver signals. The apparatus includes: a transmitter; an antenna (e.g., a shared antenna); a receiver including switches controllable by time varying signals; and a quadrature coupler including first, second, third, and fourth ports, wherein the first port is coupled to the transmitter, wherein the second port is coupled to the antenna, and wherein the third and fourth ports are coupled to the receiver.
Type:
Application
Filed:
April 18, 2018
Publication date:
October 17, 2019
Applicant:
Oregon State University
Inventors:
Arun NATARAJAN, Abhishek AGRAWAL, Sanket JAIN, Robin GARG
Abstract: Gene therapy based combination therapy for malignant pleural mesothelioma (“MPM”) that is resistant to or recurrent after chemotherapy employing a viral vector containing a human interferon transgene, followed by standard first- or second-line cytotoxic chemotherapy. Overall survival rate was significantly higher than historical controls in the second-line group.
Type:
Application
Filed:
June 28, 2019
Publication date:
October 17, 2019
Applicant:
The Trustees of the University of Pennsylvania
Abstract: Systems and methods for utilizing laboratory equipment in a hybrid reality environment or augmented virtual reality environment, are contemplated herein and include: at least one piece of laboratory equipment having at least one feature, wherein the at least one piece of laboratory equipment is tracked; a tracking module for tracking a position and an orientation of the at least one piece of tracked laboratory equipment; a virtual model, stored in a memory, comprising at least one 3-D virtual representation of the at least one feature of the at least one piece of laboratory equipment; and an experimentation module.
Type:
Application
Filed:
April 15, 2019
Publication date:
October 17, 2019
Applicant:
The California State University - San Marcos
Inventors:
Kambiz Hamadani, Ali Ahmadinia, Xin Ye, Yuanyuan Jiang
Abstract: Methods for reverse automated nucleic acid synthesis, and 5?-H-phosphonates suitable for use in the same, as well as methods for making 5?-H-phosphonates, are described.
Abstract: An system for recognition of a translocating polymeric target molecule includes a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. A pair of spaced apart sensing electrodes border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. Each affinity element may be connected to its corresponding electrode via one or more intermediary compounds, such as a linker molecule and/or an electrode attachment molecule. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction. During translocation, the electrodes, affinity elements and first and second portions of the target molecule complete an electrical circuit and allow a measurable electrical current to pass between the first and second electrodes.
Type:
Application
Filed:
April 19, 2019
Publication date:
October 17, 2019
Applicant:
Arizona Board of Regents on behalf of Arizona State University
Abstract: The invention provides a process of maximizing production of chemical raw materials by gaseous phase catalytic cracking crude oil with multi-stages in milliseconds in combination with hydrogenation, comprising: a high-efficiency atomizing nozzle sprays the preheated crude oil into an upper portion of the downflow modification reaction tube, the produced oil mist is mixed with a high temperature heat carrier flowing downward from a first return controller for pyrolysis in milliseconds and then the pyrolysis products are subject to a gas-solid separation; the coked heat carrier obtained by the separation enters into a modification regeneration reactor to conduct a regeneration reaction, the obtained high temperature heat carrier returns to a top of the downflow reaction tube to participate in circulation, the regeneration gas is subject to heat exchange and then output; the high temperature oil and gas produced by the pyrolysis reaction directly flow into the millisecond cracking reactor and conduct a cracking
Type:
Application
Filed:
April 17, 2019
Publication date:
October 17, 2019
Applicant:
China University of Petroleum (East China)
Inventors:
Yuanyu Tian, Yingyun Qiao, Juntao Zhang, Jinhong Zhang, Yuan Jiang, Jie Li
Abstract: ‘NCSX2’ is a new cultivar of hybrid Spiraea that is a triploid, with red-purple new foliage color, red-purple flowers, and continuous blooming throughout the growing season from May to October. The new variety is a Spiraea normally produced as an outdoor garden or container plant.