Abstract: An amorphous thin metal film can include a combination of metals or metalloids including: 5 at % to 74 at % of a metalloid selected from the group of carbon, silicon, and boron; 5 at % to 74 at % of a first metal; 5 at % to 74 at % of a second metal; and 5 at % to 70 at % of a dopant. The first and second metals can be independently selected from the group of titanium, vanadium, chromium, iron, cobalt, nickel, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium, hafnium, tantalum, tungsten, osmium, iridium, or platinum, wherein the first metal and the second metal can be different metals. The dopant can be selected from the group of oxygen, nitrogen, or combinations thereof. The metalloid, first metal, second metal, and dopant can account for at least 70 at % of the amorphous thin metal film.

Abstract: A fiber fluidic system may be used to produce particles (e.g., NPs and/or microparticles). The fiber fluidic system may include a cylinder with a plurality of elongated fibers oriented along a length of the cylinder. The cylinder may have a first opening at or near a first end of the cylinder and a second opening downstream of the first opening. A constrained phase fluid may be provided through the first opening and a free phase fluid may be provided through the second opening to produce particles (e.g., NPs and/or microparticles) through a second end of the cylinder. The fiber fluidic system may be used to continuously produce the particles at high throughput.

Abstract: The present invention relates to a nanoparticle composition which is prepared by a process which is characterized by dissolving a poorly water-soluble compound or the like under a high temperature and a high pressure, and milling a suspension or the like containing a uniform crystal obtained by cooling the obtained solution.

Abstract: A system and method for obtaining magnetic resonance images are provided. The system is programmed to control the RF system to apply a saturation pulse at a reference frequency that saturates a selected labile spin species of the subject. The system is programmed to control the RF system to apply an inversion pulse after a variable delay. The system is programmed to control the RF system and the plurality of gradient coils to apply a motion sensitized driven equilibrium (MSDE) preparation pulse. The system is programmed to control the plurality of gradient coils to read imaging data during an acquisition time period. The system is programmed to reconstruct a T1 mapping image of the subject with black-blood contrast.

Abstract: Halogenated phenylethynyl-substituted heterocycles that possess either an N-alkylamino or N,N-dialkylamino group attached to the heterocycle or halogenated phenylethynyl-substituted benzenes that a nitrogen-containing heterocycle attached to the benzene inhibit the proliferation cancer cells and are useful antineoplastic agents.

Abstract: Described herein is a previously unknown function of XBP1 in controlling anti-tumor immunity. It is shown that inhibiting XBP1 in tumor-associated dendritic cells inhibits tumor growth and induces protective anti-tumor immune responses.

Abstract: Smart hot water heater control can be improved by departing from the conventional approach of monitoring hot water demand at a single point (i.e., the water heater output). Instead, hot water demand is monitored at each location in the building where hot water is used. With this approach, the controller can provide hot water at a temperature suitable for the intended use, e.g., warm water for a bath or shower, and much hotter water for a dishwasher. This advantageously avoids inefficiency due to mixing hot and cold water at a tap to provide temperature control.

Abstract: The current invention pertains to a molecular conjugate comprising an antagonist of a cell surface receptor specific to a target cell and an immune effector, such as a T cell modulator, conjugated to the antagonist. The target cell can be a cell responsible for development of a disease in a subject, for example, a cancer cell. In certain embodiments, the immune effector is an immune effector protein or an immune effector fragment thereof. The current invention also pertains to a method of treating a disease in a subject, the method comprising administering to the subject a pharmaceutically effective amount of the molecular conjugates of the current invention to the subject. The methods of the current invention can be used to treat cancer, such as breast cancer, ovarian cancer, prostate cancer, lung cancer, pancreatic cancer, or melanoma.

Abstract: A coil alignment method performed in a coil alignment apparatus coupled to a VA controller includes: sensing magnetic field intensities induced from a ground assembly (GA) coil through a first auxiliary coil and a second auxiliary coil which are fixedly coupled to a VA coil; comparing a first magnetic field intensity sensed through the first auxiliary coil with a second magnetic field intensity sensed through the second auxiliary coil; moving the VA coil or the GA coil to a position where there is a predetermined difference or less between the first magnetic field intensity and the second magnetic field intensity; and moving at least one of the VA coil and the GA coil in a direction facing each other, so that a center point of the VA coil and a center point of the GA coil are located within a shortest distance of each other or within a certain error range of the shortest distance, while maintaining the predetermined difference or less between the first magnetic field intensity and the second magnetic field in

Abstract: Methods and systems for manufacturing a three-dimensional product. Fabrication of a three-dimensional part from a powder spread over a work table as a powder bed can be initiated. The fabrication process can be paused to cool down the work table to room temperature to obtain access to the three-dimensional part for post-processing operations such as, for example, embedding external artifacts. Fabrication can continue by preheating the powder rather than the work table until fabrication of the three-dimensional part is complete. A damaged part may be placed within the powder bed, wherein the fabrication process can be directly initiated to achieve part repair. Additionally, a material of the same part's composition can be used or a different material utilized to render the part better than new. Access to the three-dimensional part allows embedding of a foreign object in the three-dimensional part within the powder bed while the three-dimensional part remains non-finished.

Abstract: A method for task scheduling on a heterogeneous multi-core reconfigurable computing platform is disclosed, the method includes: determining an execution manner of a target task according to popularity of the to-be-executed target task and usage of a reconfigurable resource of the heterogeneous multi-core reconfigurable computing platform, where the execution manner includes a hardware manner or a software manner, for the target task, there is no corresponding target intellectual property IP core for executing the target task on the heterogeneous multi-core reconfigurable computing platform, the popularity of the target task is used to indicate central processing unit CPU usage of the target task, and the usage of the reconfigurable resource is used to indicate a usage status of the reconfigurable resource; and executing the target task according to the determined execution manner.

Abstract: A semiconductor element includes a semiconductor region (11) of a first conductivity type, a buried charge-generation region (16) of a second conductivity type, buried in an upper portion of the semiconductor region (11) to implement a photodiode (D1) together with the semiconductor region (11) to generate charges, a charge-readout region (15) of the second conductivity type, provided in the semiconductor region (11) to accumulate the charges transferred from the buried charge-generation region (16), and a reset-performing region (12) of the second conductivity type, provided in the semiconductor region (11), a variable voltage is applied to the reset-performing region (12) to change the height of a potential barrier generated in the semiconductor region (11) sandwiched between the charge-readout region (15) and the reset-performing region (12) to exhaust the charges accumulated in the charge-readout region (15).

Abstract: This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the ?-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the ?-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their ?-, ?-, and ?-functionalized derivatives from renewable carbon sources can be achieved.

Abstract: A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.

Abstract: Novel phosphorescent metal complexes containing 2-phenylisoquinoline ligands with at least two substituents on the isoquinoline ring are provided. The disclosed compounds have low sublimation temperatures that allow for ease of purification and fabrication into a variety of OLED devices.

Abstract: Systems comprising a processor in electrical communication with a tangible, non-transitory memory that, in response to an execution by the processor, cause the processor to measure a relative biological effectiveness of a beam on a region of a human body, and a beam applicator in electrical communication with the processor, wherein a characteristic of the beam can be adjusted based on the measured relative biological effectiveness are disclosed. Methods of treatment comprising measuring, by a processor capable of detecting potential biological hot spots, a relative biological effectiveness of a beam on a region of a human body, designing a beam therapy treatment plan based on the measured relative biological effectiveness, and applying a beam to a patient with a region in need of beam therapy with a beam applicator in electrical communication with the processor capable of detecting potential biological hot spots are also disclosed.

Abstract: Provided herein are compounds having the general formula compositions, and methods useful for treating cancer and neurodegeneration. The compounds comprise a mitochondria-targeting moiety linked to ?-lapachone or a ?-lapachone derivative.

Abstract: A method of creating cadmium telluride films is presented. The method demonstrates heterogeneous nucleation of CdTe directly on a substrate through sequential deposition of aqueous precursor solutions containing cadmium and telluride ions, respectively. The method can include (i) applying a cadmium precursor solution to the substrate to form a cadmium precursor film on the substrate, (ii) applying a telluride precursor solution to the cadmium precursor film. The telluride precursor solution includes Te2? in solution such that a CdTe film is adherently formed directly on the substrate.

Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.

Abstract: Examples of the present invention utilize principal component analysis (PCA) to detect cough sounds in an audio stream. Comparison of all or portions of the audio stream with a cough model may be conducted. The cough model may include a number of basis vectors may be based on initial portions of known coughs. The initial portions may be non-user specific, and accordingly the cough model may be used to detect coughs across individuals. Moreover, examples of the present invention may reconstruct the cough sounds from stored features such that the cough sounds are reconstructed but the reconstruction techniques used may be insufficient to reconstruct speech sounds that may also have been recorded, which may increase user privacy.