Abstract: Systems and methods for clinical neuronavigation in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a brain stimulation target, including obtaining functional magnetic resonance imaging (fMRI) image data of a patient's brain, were brain imaging data describes neuronal activations within the patient's brain, determining a brain stimulation target by mapping at least one region of interest to the patient's brain, locating functional subregions within the at least one region of interest based on the fMRI image data, determining functional relationships between at least two brain regions of interest, generating parameters for each functional subregion, generating a target quality score for each functional subregion based on the parameters and selecting a brain stimulation target based on its target quality score and the patient's neurological condition.

Abstract: This document relates to materials and methods for treating cancer (e.g., prostate cancer). For example, methods for using one or more androgen receptor variant (AR-V) inhibitors (e.g., morpholinos) to treat a mammal having prostate cancer (e.g., castration-resistant prostate cancer) are provided.

Abstract: In compounding pharmaceuticals at the outset, the medications are typically arrive in their mass produced form (pills, creams, syrups, etc.) and are individually packaged. Some packaging forms, particularly tubes, take an excessive amount of time to empty for the medication to be used in later compound medications. Presently in this industry, human workers will squeeze the medication out of each individual tube into large bucket containers for storage until the medication is ready for mixing. The disclosed invention provides a novel apparatus and method for emptying multiple tubes at a time with limited human interaction. The apparatus uses a roller and cap-pressing method that can empty several tubes at one time, significantly increasing efficiency. The apparatus is then connected with a novel software package which controls the operation of the device and can provide a counting mechanism for contract monitoring and predicting the lifespan of the device.

Abstract: Disclosed herein are systems and methods for specifying treatment criteria and treatment planning parameters for patient specific radiation therapy planning. According to an aspect, a method includes receiving data about a patient, computing geometric characterization of one or more organs at risk proximate to a target volume of a patient or vice versa, and selecting relevant treatment knowledge and experience. The method also includes generating, based on the received data, computed geometric characterization, and available knowledge and experience, a first set of radiation treatment planning parameters that will lead to a high quality plan for the patient. Further, the method includes model-based prediction, based on the data, a second set or more of radiation treatment planning parameters that will lead to alternative achievable plans with different organ sparing objectives for treating the patient. The multiple sets for parameters can be used separately or in conjunction to generate treatment plans.

Abstract: The invention relates to compounds, compositions, and methods that can inhibit the biosynthesis of mycotoxins.

Abstract: Systems and methods for backscatter communications are provided that employ a backscatter reader to transmit a carrier signal to multiple backscatter tags having heterogeneous hardware and specifications. In response to receiving the carrier, the tags encode data into the received signal and, concurrently, transmit their respective backscattered signal to the reader. The concurrent signals are received by the reader as a combined signal. The reader detects edges in the received signal, based on the corresponding in-phase (I) and quadrature (Q) signals. The edges are then assigned to streams based on the offset or transmission rate of the tags. In some cases, the reader can detect edge collisions. These collisions can be resolved by causing the colliding signals to be retransmitted or by separating the colliding signals. The individual streams corresponding to each of the tags can then be decoded to identify the originally transmitted data from each tag.

Abstract: Embodiments herein report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating a construct of use in pharmaceutically acceptable compositions to treat a subject in need of alpha-1 antitrypsin therapy or treatment. In other embodiments, compositions and methods disclosed herein concern linking alpha-1 antitrypsin or derivative thereof to an immune fragment.

Abstract: Embodiments of the present invention relate to methods of preparing a cell, tissue, organ or plant for cryopreservation, wherein the method includes contacting the cell, tissue, organ or plant with a composition including sucrose and/or sucralose.

Abstract: Provided are transporters based on polymyxin B. Also provided are methods of using the transporters for intracellular delivery of cargo and methods of enhancing intracellular uptake of cargo.

Abstract: The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing chemokine related conditions, typically prevention or treatment of viral infections such as HIV or for managing cancer.

Abstract: A method for measurement of an information-security-controlling status in accordance with the present disclosure includes receiving actual inspection data obtained by actually inspecting whether each domain complies with each security-controlling item, computing security-controlling status measurement scores for each domain on the basis of a significance grade of each control item, the degree of compliance with a corresponding control item, and a weighting set by a measurement manager, computing a final security-controlling status measurement score for a parent organization to which each domain belongs on the basis of an average of the security-controlling status measurement scores for each domain, and outputting the computed security-controlling status measurement scores and final security-controlling status measurement score.

Abstract: Provided are methods and compositions for cartilage repair. The method involves performing a surgical procedure at the site of a cartilage defect and administering a composition comprising a receptor for hyaluronan mediated motility (RHAMM)-mimetic peptide, and a high molecular weight hyaluronan.

Abstract: A simultaneous wireless information and power transfer relaying network system includes a source, a relay and a destination node. An overall time slot constituting a relaying protocol of the system includes a first time slot assigned for the source and a second time slot assigned for the relay, where at least a part of the first time slot is assigned for an information transmission from the source to the relay. A time duration of the second time slot is greater than a time duration of the at least part of the first time slot assigned for the information transmission from the source to the relay. A method of communication for the SWIPT relaying network system includes determining a structure of the overall time slot including ratios of time durations of subparts of the overall time slot.

Abstract: A method of forming a carbonized composition includes providing an organic composition, forming a protective layer over the organic composition, increasing temperature to carbonize the organic composition and for a period of time to form the carbonized composition, and removing the protective layer from the carbonized composition.

Abstract: A device and method is described for electronic human prosthetics, and specifically a skull- and/or spine implantable bi-directional neural-communication/brain-machine interface (BBMI) device where the input, output and on-board computing are combined into a single unit to form a compact neuro-prosthetics device. This invention is also directed to a fully implantable wireless spinal electronic recording and stimulation system using the BBMI in a human. The bi-directional devices (BBMIs) communicate with other bi-directional brain-machine interface devices (BBMI) and/or with external controllers wirelessly. The compact implantable stimulator has ultrasonic secondary battery charging system. One or more BBMI can be wirelessly connected so that a closed loop of BBMIs, or a BBMI and an external controller, can wirelessly send trigger pulses to this fully implanted stimulator over the spinal cord.

Abstract: A substance measurement device includes: a container portion configured to receive a substance; a sensing device configured to measure a property of the substance related to at least one of a flow rate of the substance into the container portion, a level of the substance within the container portion, and a volume of the substance within the container portion; and at least one shield positioned within the container portion and configured to provide at least one of: a mechanical buffer between the substance entering the container portion and the sensing device; and an electrical shield between the substance entering the container portion and the sensing device.

Abstract: An example non-destructive method for estimating a length of a member, which may be embedded, is described herein. The method can include impacting the member, recording a respective signal at each of a plurality of sensors attached to the member, and transforming the respective signals into a frequency domain. The respective signals can include dispersive waves generated by the impact. The method can also include determining an effective wavenumber of dispersive wave propagation based on the respective frequency-domain signals, determining theoretical wavenumber of dispersive wave propagation using a dispersion relation for the member, and estimating the length of the member based on the relationship between the effective wavenumber of dispersive wave propagation and theoretical wavenumber of dispersive wave propagation.

Abstract: The present invention discloses a gas pressure forming method of an ellipsoid. The formability of a closed polyhedral shell including polar plates, ellipsoidal side flap plates, and welded joints is improved, and the closed polyhedral shell is pressurized into an ellipsoid by using compressed gas under a heating condition, specifically comprising: assembling and welding two polar plates and ellipsoidal side flap plates into a closed polyhedral shell; disposing an electrode on the closed polyhedral shell, energizing and heating to a preset temperature, and then inflating compressed gas into the shell; deforming the closed polyhedral shell under the action of internal gas pressure, stopping inflating gas until a desired curvature shell is obtained, discharging gas, and removing the electrode to obtain a formed ellipsoid.

Abstract: Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.

Abstract: A system, method, and apparatus for simulating the detection of radiation comprise at least one simulated radioactive source, a simulated radiation detector, and an emulating module configured to simulate a detection level for the at least one simulated radioactive source according to a radiation level associated with the simulated radioactive source, wherein the simulated detection level is provided on the simulated radiation detector.