Patents Assigned to University
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Patent number: 10449230Abstract: Provided are transporters based on polymyxin B. Also provided are methods of using the transporters for intracellular delivery of cargo and methods of enhancing intracellular uptake of cargo.Type: GrantFiled: October 6, 2017Date of Patent: October 22, 2019Assignee: The Regents of the University of CaliforniaInventors: Kristina Hamill, Jeffrey D. Esko, Lisa McCoy, Yitzhak Tor
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Patent number: 10450293Abstract: The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for managing chemokine related conditions, typically prevention or treatment of viral infections such as HIV or for managing cancer.Type: GrantFiled: May 15, 2015Date of Patent: October 22, 2019Assignee: Emory UniversityInventors: Bryan D. Cox, Lawrence J. Wilson, Anthony Prosser, Dennis C. Liotta, James P. Snyder
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Patent number: 10448631Abstract: Embodiments of the present invention relate to methods of preparing a cell, tissue, organ or plant for cryopreservation, wherein the method includes contacting the cell, tissue, organ or plant with a composition including sucrose and/or sucralose.Type: GrantFiled: September 22, 2016Date of Patent: October 22, 2019Assignee: East Carolina UniversityInventors: Anthony Kennedy, Jean-Luc Scemama, Jitka Virag, Edward R. Pennington
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Patent number: 10451752Abstract: A system, method, and apparatus for simulating the detection of radiation comprise at least one simulated radioactive source, a simulated radiation detector, and an emulating module configured to simulate a detection level for the at least one simulated radioactive source according to a radiation level associated with the simulated radioactive source, wherein the simulated detection level is provided on the simulated radiation detector.Type: GrantFiled: October 3, 2018Date of Patent: October 22, 2019Assignee: Texas Tech University SystemInventor: Robert Stump
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Patent number: 10449763Abstract: An amorphous thin metal film can include a combination of metals or metalloids including: 5 at % to 74 at % of a metalloid selected from the group of carbon, silicon, and boron; 5 at % to 74 at % of a first metal; 5 at % to 74 at % of a second metal; and 5 at % to 70 at % of a dopant. The first and second metals can be independently selected from the group of titanium, vanadium, chromium, iron, cobalt, nickel, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium, hafnium, tantalum, tungsten, osmium, iridium, or platinum, wherein the first metal and the second metal can be different metals. The dopant can be selected from the group of oxygen, nitrogen, or combinations thereof. The metalloid, first metal, second metal, and dopant can account for at least 70 at % of the amorphous thin metal film.Type: GrantFiled: June 24, 2016Date of Patent: October 22, 2019Assignees: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P., Oregon State UniversityInventors: James Elmer Abbott, Jr., John M McGlone, Kristopher Olsen, Roberto A Pugliese, Greg Scott Long, Douglas A Keszler, John Wager
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Patent number: 10449866Abstract: A coil alignment method performed in a coil alignment apparatus coupled to a VA controller includes: sensing magnetic field intensities induced from a ground assembly (GA) coil through a first auxiliary coil and a second auxiliary coil which are fixedly coupled to a VA coil; comparing a first magnetic field intensity sensed through the first auxiliary coil with a second magnetic field intensity sensed through the second auxiliary coil; moving the VA coil or the GA coil to a position where there is a predetermined difference or less between the first magnetic field intensity and the second magnetic field intensity; and moving at least one of the VA coil and the GA coil in a direction facing each other, so that a center point of the VA coil and a center point of the GA coil are located within a shortest distance of each other or within a certain error range of the shortest distance, while maintaining the predetermined difference or less between the first magnetic field intensity and the second magnetic field inType: GrantFiled: June 2, 2017Date of Patent: October 22, 2019Assignees: Hyundai Motor Company, Kia Motors Corporation, Konkuk University Industrial Cooperation Corp.Inventors: Jae Yong Seong, Won Shil Kang, Hyun Chul Ku, Jong Gyun Lim
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Patent number: 10450652Abstract: A method of forming a carbonized composition includes providing an organic composition, forming a protective layer over the organic composition, increasing temperature to carbonize the organic composition and for a period of time to form the carbonized composition, and removing the protective layer from the carbonized composition.Type: GrantFiled: April 14, 2017Date of Patent: October 22, 2019Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Haitao Liu, Feng Zhou
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Patent number: 10449633Abstract: The present invention discloses a gas pressure forming method of an ellipsoid. The formability of a closed polyhedral shell including polar plates, ellipsoidal side flap plates, and welded joints is improved, and the closed polyhedral shell is pressurized into an ellipsoid by using compressed gas under a heating condition, specifically comprising: assembling and welding two polar plates and ellipsoidal side flap plates into a closed polyhedral shell; disposing an electrode on the closed polyhedral shell, energizing and heating to a preset temperature, and then inflating compressed gas into the shell; deforming the closed polyhedral shell under the action of internal gas pressure, stopping inflating gas until a desired curvature shell is obtained, discharging gas, and removing the electrode to obtain a formed ellipsoid.Type: GrantFiled: April 23, 2019Date of Patent: October 22, 2019Assignee: Dalian University of TechnologyInventors: Shijian Yuan, Xiaobo Fan
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Patent number: 10450365Abstract: Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.Type: GrantFiled: August 16, 2017Date of Patent: October 22, 2019Assignees: Neurimmune Holding AG, University of ZurichInventors: Jan Grimm, Roland Martin, Benoit Combaluzier, Ivan Jelcic
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Patent number: 10448920Abstract: Examples of the present invention utilize principal component analysis (PCA) to detect cough sounds in an audio stream. Comparison of all or portions of the audio stream with a cough model may be conducted. The cough model may include a number of basis vectors may be based on initial portions of known coughs. The initial portions may be non-user specific, and accordingly the cough model may be used to detect coughs across individuals. Moreover, examples of the present invention may reconstruct the cough sounds from stored features such that the cough sounds are reconstructed but the reconstruction techniques used may be insufficient to reconstruct speech sounds that may also have been recorded, which may increase user privacy.Type: GrantFiled: September 14, 2012Date of Patent: October 22, 2019Assignee: University of WashingtonInventors: Shwetak N. Patel, Eric Cooper Larson, Tien-Jui Lee, Shih-Yen Liu
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Patent number: 10453211Abstract: The present disclosure discloses an imaging system, method, and apparatus for identifying information of a hidden object. A light source generates a first beam of narrow-band light and a second beam of narrow-band light that has temporal fluctuations correlated with the first beam. The first beam is directed towards a first scattering surface and the second beam is directed towards a second scattering surface. The first scattering surface scatters the first beam to a scattered light that illuminates a hidden object, the hidden object reflects at least a portion of the scattered light towards the second scattering surface, the reflected light interferes with the second beam and produces an interference pattern on the second scattering surface. An image sensor detects irradiance of the interference pattern on the second scattering surface.Type: GrantFiled: July 25, 2017Date of Patent: October 22, 2019Assignee: Southern Methodist UniversityInventors: Marc P. Christensen, Prasanna Rangarajan
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Patent number: 10453668Abstract: A spectrometer device for analysis of aerosol particles, dusts, and other microparticles and/or nanoparticles includes an electrospray ionization source supplying a particle stream to an aerodynamic lens that focuses and collimates a beam of particles. An electrostatic trap accepts the beam of particles and traps a single trapped particle at a time in the electrostatic trap to oscillate with a measurable amplitude and frequency. A sensor senses the amplitude and frequency, and a processor determines a calculated mass to charge ratio from the amplitude and frequency of oscillation of the trapped particle in real time. A method creates a focused stream of micro or nanoparticles, traps a single particle at a time in an electrostatic trap. The amplitude and frequency of the oscillation of the trapped particle is sensed. The mass to charge ratio is determined from the amplitude and frequency of oscillation. Particles can be accelerated into a target.Type: GrantFiled: February 28, 2018Date of Patent: October 22, 2019Assignee: The Regents of the University of CaliforniaInventors: Robert Continetti, Morgan Miller, Brian Adamson
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Patent number: 10450601Abstract: A buffer composition for hybridization of a target nucleic acid is provided. The nucleic acid can include a nucleotide to be detected with a nucleic acid probe. The probe can contain a nucleotide sequence complementary to the target nucleic acid. The buffer can include a blocking nucleic acid having a nucleotide sequence complementary to a non-target nucleic acid having a nucleotide not to be detected corresponding to the nucleotide to be detected. The buffer composition can suppress non-specific hybridization to the nucleic acid probe even when a non-target nucleic acid is present. The use of the buffer composition can achieve excellent detection efficiency of the target nucleic acid.Type: GrantFiled: September 1, 2014Date of Patent: October 22, 2019Assignees: Toyo Kohan Co., Ltd., Yamaguchi UniversityInventors: Shuichi Kamei, Mayuko Hosoya, Masaaki Oka, Shoichi Hazama, Ryouichi Tsunedomi
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Patent number: 10453988Abstract: A method of creating cadmium telluride films is presented. The method demonstrates heterogeneous nucleation of CdTe directly on a substrate through sequential deposition of aqueous precursor solutions containing cadmium and telluride ions, respectively. The method can include (i) applying a cadmium precursor solution to the substrate to form a cadmium precursor film on the substrate, (ii) applying a telluride precursor solution to the cadmium precursor film. The telluride precursor solution includes Te2? in solution such that a CdTe film is adherently formed directly on the substrate.Type: GrantFiled: June 5, 2017Date of Patent: October 22, 2019Assignee: University of Utah Research FoundationInventors: Carina Hahn, Dennis Pruzan, Michael Scarpulla
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Patent number: 10450289Abstract: Provided herein are compounds having the general formula compositions, and methods useful for treating cancer and neurodegeneration. The compounds comprise a mitochondria-targeting moiety linked to ?-lapachone or a ?-lapachone derivative.Type: GrantFiled: June 8, 2016Date of Patent: October 22, 2019Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Peter Wipf, Bennett Van Houten, Wei Qian, Chaemin Lim
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Patent number: 10451486Abstract: A polarization and color sensitive pixel device and a focal plane array made therefrom. Each incorporates a thick color/polarization filter stack and microlens array for visible (0.4-0.75 micron), near infrared (0.75-3 micron), mid infrared (3-8 micron) and long wave infrared (8-15 micron) imaging. A thick pixel filter has a thickness of between about one to 10× the operational wavelength, while a thick focal plane array filter is on the order of or larger than the size or up to 10× the pitch of the pixels in the focal plane array. The optical filters can be precisely fabricated on a wafer. A filter array can be mounted directly on top of an image sensor to create a polarization camera. Alternatively, the optical filters can be fabricated directly on the image sensor.Type: GrantFiled: December 7, 2017Date of Patent: October 22, 2019Assignee: Arizona Board of Regents on Behalf of the University of ArizonaInventor: Stanley Pau
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Patent number: 10449232Abstract: The present invention relates to a viral vector for expression of the cell death-inducing PUMA protein, for use in gene therapy, for example for the treatment of rheumatoid arthritis. This vector consists in particular of a recombinant adenovirus expressing the gene encoding the PUMA protein and of a recombinant baculovirus containing a coxsackie-adenovirus receptor (CAR).Type: GrantFiled: October 7, 2014Date of Patent: October 22, 2019Assignees: Hospices Civils de Lyon, The Regents of the University of California, Universite Claude-Bernard-Lyon 1, Institut D'Enseignement Superieur et de Recherche en Alimentation, Sante Animale, Sciences Argonomiques et de l'Environnement, Institut National de la Sante et de la Recherche MedicaleInventors: Pierre Miossec, Saw-See Hong, Gary Firestein
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Patent number: 10449391Abstract: Systems comprising a processor in electrical communication with a tangible, non-transitory memory that, in response to an execution by the processor, cause the processor to measure a relative biological effectiveness of a beam on a region of a human body, and a beam applicator in electrical communication with the processor, wherein a characteristic of the beam can be adjusted based on the measured relative biological effectiveness are disclosed. Methods of treatment comprising measuring, by a processor capable of detecting potential biological hot spots, a relative biological effectiveness of a beam on a region of a human body, designing a beam therapy treatment plan based on the measured relative biological effectiveness, and applying a beam to a patient with a region in need of beam therapy with a beam applicator in electrical communication with the processor capable of detecting potential biological hot spots are also disclosed.Type: GrantFiled: July 24, 2015Date of Patent: October 22, 2019Assignee: Indiana University Research and Technology CorporationInventor: Jeffrey Buchsbaum
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Patent number: 10454166Abstract: In some embodiments, a beam scanning antenna includes a lens having a focal surface and a microfluidic beam scanning focal plane array associated with the focal surface, the array including: an elongated microfluidic channel that contains an electrically conductive antenna element suspended within a dielectric fluid that is provided within the channel, the channel including multiple microfluidic chambers that are positioned at discrete locations along a length of the channel, wherein the antenna element can be selectively positioned within selected chambers, and means for moving the position of the antenna element along the channel to change a direction along which electromagnetic waves are transmitted or received.Type: GrantFiled: July 6, 2017Date of Patent: October 22, 2019Assignee: University of South FloridaInventors: Gokhan Mumcu, Rasim Oytun Guldiken, Ahmad Adel Gheethan
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Patent number: 10454114Abstract: A method of forming metallic particles, comprising: providing precursor particles comprising a transition metal alloy; supplying carbon monoxide (CO) under reaction conditions which differentially remove a first alloy metal from the precursor particles at a faster rate than a second alloy metal; and, maintaining the reaction conditions until the precursor particles are converted to the particles. The precursor particles may comprise PtNi4, and the particles may be Pt3Ni, formed as hollow nanoframes on a carbon support.Type: GrantFiled: December 21, 2017Date of Patent: October 22, 2019Assignee: The Research Foundation for the State University of New YorkInventors: Jiye Fang, Yiliang Luan