Patents Assigned to University
  • Compositions and methods for targeting stromal cells for the treatment of cancer
    Patent number: 10329355
    Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: June 25, 2019
    Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology
    Inventors: Carl H. June, Ellen Pure, Liang-Chuan Wang, Steven Albelda, John Scholler
  • RUNX2 transcription factor inhibitors and uses thereof
    Patent number: 10329246
    Abstract: Provide herein are compounds with a general chemical structure of: Substituents R1 and R2 independently are H, Cl, F, Br, CH3, CF3, SH, —N(C1-3alkyl)2, —NHC(O)C1-3alkyl, or —NHC(O)C5-7cycloalkyl, substituent R3 is H or C1-3 alkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast cancer, or metastatic cancers, to inhibit RUNX2 activity, such as protein expression, in a cancer cell and to increase survival of a subject with breast cancer.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: June 25, 2019
    Assignees: University of Maryland, Baltimore, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Antonino Passaniti, MacKerell D. Alexander, Jr.
  • Structure evaluation system, structure evaluation apparatus, and structure evaluation method
    Patent number: 10330646
    Abstract: According to an embodiment, a structure evaluation system includes a plurality of AE sensors, a signal processor, a position locator, a velocity calculator, and an evaluator. The AE sensors detect an elastic wave generated from a structure. The signal processor extracts an AE signal including information on the elastic wave by performing signal processing on the elastic wave detected by the AE sensor. The position locator derives a wave source distribution indicating a distribution of sources of the elastic waves generated in the structure on the basis of the AE signals. The velocity calculator derives a propagation velocity of the elastic wave generated in the structure on the basis of the AE signal. The evaluator evaluates the soundness of the structure on the basis of the wave source distributions and the propagation velocity of the elastic waves.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: June 25, 2019
    Assignees: Kabushiki Kaisha Toshiba, Kyoto University
    Inventors: Kazuo Watabe, Hidefumi Takamine, Tomoki Shiotani
  • Pot seedling feeding system for transplanter
    Patent number: 10327379
    Abstract: The present invention provides a pot seedling feeding system for a transplanter, including a conveyor unit, a detection sensor, a controller, a seedling separation unit, side plates, and support stands. The conveyor unit includes a step motor, a transmission shaft, a conveyor belt, a tensioning shaft, and bearings. The seedling separation unit includes a seedling separation rod, a reset spring, a guide post, and a support seat. The controller is used to control the step motor which drives the conveyor belt in order to move the pot seedling. When a seedling receiving barrel of the planter rises to a seedling receiving position, the planter is controlled by using a brake cable, the seedling separation rod is then ejected which in turn drives the step motor to carry a pot seedling to move forward. The pot seedling is then dropped in a seedling receiving cup of the planter.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: June 25, 2019
    Assignee: Jiangsu University
    Inventors: Lili Dong, Jing Luo, Li Ma, Junyi He
  • Degradable polycarbonate sport fishing materials
    Patent number: 10329381
    Abstract: Degradable polycarbonates network based bulk materials are provided. The bulk materials of the present disclosure may be produced having a wide range of tunable mechanical, physical, and thermal properties and are hydrolytically degradable. The bulk materials of the present disclosure may be suitable for the manufacture of a variety of sport fishing equipment or other equipment for water use or that may benefit from hydrolytic degradation in the environment.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: June 25, 2019
    Assignee: The Texas A&M University System
    Inventors: Karen L. Wooley, Simcha E. Felder, Brooke A. Versaw, Ashlee A. Jahnke, Lauren A. Link, Mark W. Wooley, Charles A. Hinton, William R. Howell, Jr.
  • Method for electrochemical reduction of carbon dioxide
    Patent number: 10329677
    Abstract: A method of electrochemically reducing CO2 to form at least one alcohol, preferably ethanol. The method includes (a) contacting an electrode system with an aqueous solution comprising at least one electrolyte and CO2, wherein the electrode system comprises a working electrode, a counter electrode, and a reference electrode, wherein the working electrode comprises a base electrode and a coating of a composite comprising graphene nanosheets and Cu2O nanoparticles disposed on a surface of the base electrode, and (b) applying a negative potential to the working electrode to reduce the CO2 and form the at least one alcohol.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: June 25, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Ramadan A. Geioushy, Mazen M. Khaled
  • Memristive neuromorphic circuit and method for training the memristive neuromorphic circuit
    Patent number: 10332004
    Abstract: A neural network is implemented as a memristive neuromorphic circuit that includes a neuron circuit and a memristive device connected to the neuron circuit. An input voltage is sensed at a first terminal of a memristive device during a feedforward operation of the neural network. An error voltage is sensed at a second terminal of the memristive device during an error backpropagation operation of the neural network. In accordance with a training rule, a desired conductance change for the memristive device is computed based on the sensed input voltage and the sensed error voltage. Then a training voltage is applied to the memristive device. Here, the training voltage is proportional to a logarithmic value of the desired conductance change.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: June 25, 2019
    Assignees: DENSO CORPORATION, The Regents of the University of California
    Inventors: Irina Kataeva, Dmitri B. Strukov, Farnood Merrikh-Bayat
  • Method for molecule detection
    Patent number: 10330601
    Abstract: The disclosure relates to a method for detecting single molecules on an object. The method includes: providing a carrier; attaching the carrier on a surface of the object so that the surface of the object is indirect contact with the carrier; and detecting the single molecules on the object with a detector. The carrier includes a flexible substrate and a metal layer on the flexible substrate. The flexible substrate includes a base and a bulge pattern located on a surface of the base. The bulge pattern includes a number of strip-shaped bulges intersecting with each other to form a net and define a number of recesses. The metal layer is located on the bulge pattern. The carrier has a relative higher SERS and can enhance the Raman scattering.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: June 25, 2019
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Ying-Cheng Wang, Yuan-Hao Jin, Qun-Qing Li, Shou-Shan Fan
  • Retrofit/repair technique for asphalt shingle roofs that exhibit premature adhesive tab seal failures
    Patent number: 10329771
    Abstract: Devices, systems and methods for providing a retrofit and repair technique and device for asphalt shingle roof coverings or roofing systems that exhibit premature adhesive tab seal failures. A device can have a handle at one end and a blade tip end at the other end has the blade tip inserted under a shingle to be repaired. The device can dispense a row of “dabs” at a selected location under roof shingle(s). The dispenser can dispense a row of individual “dabs” by a volume container. Alternatively, the dispenser can have a roll with a plurality of rows of pre-made “dabs” of adhesive on removable type paper. Once the blade tip end of the tool device is inserted between upper and lower shingles, the dabs are dispensed by removing the release paper, and the device is pulled out with the release tape is wound up, advancing the adhesive cylinders. Next, the worker can press down on the upper shingle.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: June 25, 2019
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: David O. Prevatt, Kurtis R. Gurley, Craig R. Dixon
  • Compact microscope
    Patent number: 10330904
    Abstract: A compact microscope including an enclosure, a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, an illumination section, an objective lens system, a sample stage mounted on the primary optical support element, an illumination optical system to direct an illumination light beam from the illumination section to the sample stage, and a return optical system to receive returned light from sample stage and transmit returned light to a detection apparatus, wherein the illumination optical system and return optical system are mounted on the primary optical support element.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: June 25, 2019
    Assignee: Oxford University Innovation Limited
    Inventors: Achillefs Kapanidis, Bo Jing, Robert Crawford
  • Post-processing reduction of fixed pattern artifacts and trigger jitter in swept-source optical coherence tomography
    Patent number: 10327631
    Abstract: Disclosed herein are methods and systems for aligning swept-source optical coherence tomography (SS-OCT) spectral interferograms to a reference spectral interferogram based on signal information (e.g., amplitude or phase) at a fixed-pattern noise location to reduce residual fixed-pattern noise and improve the phase stability of SS-OCT systems.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: June 25, 2019
    Assignee: Oregon Health & Science University
    Inventors: David Huang, Gangjun Liu
  • Intracorporal ultra high purity calcium sulfate cast mixed with antimicrobials for the treatment of penile implant infections
    Patent number: 10328177
    Abstract: The present invention includes a method for treating penile implant infections that uses a synthetic high-purity calcium sulfate mixed with antimicrobials, which is capable of providing prolonged exposure of antimicrobials to the infection site and capable of acting as an intracorporal filler preventing fibrosis and loss of phallic length. The technique is especially useful for high-risk patients, and provides another medium for which antimicrobial agents can be delivered to a surgical infection site while at the same time acting as a filler, preventing fibrosis, and loss of the space. The antimicrobial cast lasts 4-6 weeks, making timely re-implantation easier, and preventing intracorporal fibrosis and loss of phallic length.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: June 25, 2019
    Assignee: University of South Florida
    Inventors: Rafael Carrion, Daniel Roberto Martinez, Eihab Akary, Tariq Said Hakky
  • Synthetic nanostructures including nucleic acids and/or other entities
    Patent number: 10328026
    Abstract: Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 25, 2019
    Assignee: Northwestern University
    Inventors: C. Shad Thaxton, Chad A. Mirkin, Kaylin M. McMahon, Sushant Tripathy, Raja Kannan Mutharasan, David M. Leander, Andrea Luthi
  • Imaging assemblies with rapid sample auto-focusing
    Patent number: 10330906
    Abstract: Advantageous instruments, assemblies and methods are provided for undertaking imaging techniques (e.g., microscopic imaging techniques). The present disclosure provides improved imaging techniques, equipment and systems. More particularly, the present disclosure provides advantageous microscopy/imaging assemblies with rapid sample auto-focusing (e.g., microscopy/imaging assemblies having instant focusing for rapid sample imaging with auto-focusing). The present disclosure provides for high-throughput whole slide imaging with instant focal plane detection. A whole slide imaging platform/assembly that uses instant focusing systems/methods for high-speed sample autofocusing is provided. Such exemplary platforms/assemblies can be used for digital pathology or the like, and can provide improved, faster and cheaper diagnosis/prognosis of ailments/diseases.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: June 25, 2019
    Assignee: University of Connecticut
    Inventor: Guoan Zheng
  • Solid-lubricated metal cutter and processing method thereof
    Patent number: 10328494
    Abstract: A solid-lubricated metal cutter and processing method relates to the technical field of metal cutters. A surface texture morphology is worked out on a metal cutter, a solid lubricant is filled into the surface texture morphology, and a convex dam is arranged on the cutter surface on which surface texture morphology is located at a chip flow side. The surface texture morphology has micro-pit and micro-boss features, and can exert antifriction effect of a solid lubricant and anti-adhesion effect of micro-protrusions. The convex dam is arranged at an end of the micro-texture region away from the cutting blade, so that a part of the solid lubricant flows back to the texture region and thereby the utilization efficiency and retentiveness of the solid lubricant are improved.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: June 25, 2019
    Assignee: Jiangsu University
    Inventors: Yonghong Fu, Zhengyang Kang, Guowen Zou, Hao Wang, Xijun Hua, Jinghu Ji, Feng Zheng, Hao Fu
  • Method to develop high oleic acid soybeans using conventional soybean breeding techniques
    Patent number: 10329576
    Abstract: The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention is directed to plants where the plants exhibit elevated levels of oleic acid.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: June 25, 2019
    Assignees: The Curators of the University of Missouri, The United States of America, as Represented by the Secretary of Agriculture
    Inventors: Kristin Bilyeu, Grover Shannon, Jeong-Dong Lee, Anh Tung Pham
  • Systems and method for detecting, diagnosing, and/or treatment of disorders and conditions
    Patent number: 10327691
    Abstract: A SoC includes an AFE to receive a plurality of differential input channels and generate digitized data corresponding to the channels, and a classification processor configured to receive the digitized data from the AFE. The AFE includes a Dual-Channel Chopper to perform channel multiplexing of two channels while simultaneously chopping the channels, a Dual Channel Charge Recycled-AFE having an Chopper-Stabilized Capacitive-Coupled IA including bias sampling capacitors that store bias values associated with the first and second channels to enable swapping between the channel, and a DC servo loop (DSL) having a reduced setting time based on a reduction in a resistance of the pseudo-PMOS in response to engaging a system reset. The classification processor includes a Frequency-Time Division Multiplexing (FTDM) Feature Extraction (FE) engine and a Dual-Detector Architecture (D2A) classification processor.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: June 25, 2019
    Assignee: Khalifa University of Science and Technology
    Inventors: Jerald Yoo, Muhammad Altaf, Chen Zhang
  • Matching networks for wireless power transfer and related techniques
    Patent number: 10333485
    Abstract: In one implementation, an analytical approach to determining an improved and/or optimal design of a matching network in a capacitive or inductive WPT system is provided. In one implementation, for example, a framework is provided to enable stage(s) of the network to simultaneously provide gain and compensation. The multistage matching network efficiency can be improved and/or optimized, such as by using the method of Lagrange multipliers, resulting in the optimum distribution of gain and compensation among the L-section stages.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: June 25, 2019
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Sreyam Sinha, Ashish Kumar, Khurram K. Afridi
  • Method of treatment and compounds for use therein
    Patent number: 10328075
    Abstract: The present invention relates generally to a method of therapeutically or prophylactically treating ischaemia-induced myocardial tissue damage, in particular ischaemia-reperfusion-induced myocardial tissue damage. More particularly, the present invention relates to a method of reducing the extent of ischaemia-induced myocardial tissue damage in a mammal by selectively upregulating FPR1-mediated ERK signalling. The method of the present invention is useful, inter alia, in reducing the extent and/or severity of myocardial tissue damage associated with conditions characterized by myocardial ischaemia or myocardial ischaemia and reperfusion, such as acute myocardial infarction caused by atherosclerotic artery occlusion or blood clot-induced artery occlusion.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: June 25, 2019
    Assignees: Baker Heart and Diabetes Institute, Monash University
    Inventors: Rebecca Helen Ritchie, Cheng Xue Qin, Arthur Christopoulos, Patrick Michael Sexton, Jonathan Bayldon Baell
  • Efficient progressive continuous k-nearest neighbor query algorithm for moving objects with a tree-like index
    Patent number: 10331753
    Abstract: Methods and systems for computing continuous k nearest neighbor (CkNN) queries in location based services for moving objects, to produce ordered kNN query results in a continuous and progressive manner, are provided. One method comprises receiving a continuous k nearest neighbor query, computing the initial set comprised of the k interest points nearest to the reference point and a set of remaining nodes stored in a distance-priority queue, generating and storing split points in a min-heap, iteratively moving current reference point to the nearest split point, swapping interest points, updating the corresponding split points in the min-heap, and reporting the kNN result progressively until a termination condition is reached.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: June 25, 2019
    Assignee: The Florida International University Board of Trustees
    Inventor: Jing Tong