Abstract: Disclosed herein is a material comprising a functionalized solid support surface, wherein the functionalization comprises a thioalkylene linker bound to the support surface and the thioalkylene linker is coupled to a moiety derived from a ligand, wherein the ligand includes a terminal alkenyl and at least one first functional group configured to bind to at least one predetermined target species.

Abstract: Described herein are methods for treating B cell proliferative disorders, in an individual in need thereof. The methods include administering to an individual in need thereof a Btk inhibitor (e.g., ibrutinib), in combination with a CDK4 inhibitor (e.g., palbociclib).

Abstract: Systems and methods for relationship recommendations systems in accordance with embodiments of the invention are illustrated. In one embodiment, a relationship recommendation server system includes a processor wherein a relationship recommendation program configures the processor to obtain a graph database including a set of nodes including node attribute data and a set of edges including edge attribute data and describing relationships between nodes in the set of nodes, determine a set of motif data, where the motif data describes at least one subgraph including a subset of the nodes and a subset of the edges within the graph database, obtain a search node, generate additional edges between the search node and a subset of the nodes within the graph database, where the additional edges form subgraphs including the search node that are isomorphic to a subset of the motif data, and recommend relationships based on the generated additional edges.

Abstract: A multicomponent nanomaterial AuNP(DTDTPA)(Ga), where DTDTPA is an amino-carboxylate ligand (diethylene triamine pentaacetic acid, DTPA) linked to the surface of the Au nanoparticle (NP) via dithiol (DT) linkage. Another embodiment is a multicomponent nanomaterial AuNP(DTDTPA)(Ga) with a biomolecule attached. In preferred embodiments, the Ga is Ga-67 or Ga-68. Preferred synthesis methods are conducted at room temperature.

Abstract: Methods of processing MRI image data to reduce or eliminate motion-related artifacts in MRI images includes: electronically repeatedly acquiring sets of 2D or 3D k-space data of a target region of a subject using at least one MRI pulse sequence; electronically applying a bootstrapping procedure to produce a large number of images from the acquired k-space data; then electronically evaluating the images produced by the bootstrapping procedure; and electronically identifying an image with a minimal motion-related artifact level from the evaluation of the images produced by the bootstrapping procedure.

Abstract: Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.

Abstract: A power converter as disclosed herein includes circuitry to reduce switching current spikes as conventionally appear at startup, and control the current spikes in a predictable way, thereby improving reliability of the power converter. A controller generates drive signals to half-bridge switching elements, an output therefrom corresponding to a frequency of the gate drive signals. A resonant tank comprises a resonant capacitor, DC blocking capacitor, a resonant inductor, and a load. Pre-charge circuitry is coupled to the resonant tank and, after initially receiving power from the DC power source and prior to controller startup, pre-charges at least the DC blocking capacitor to a steady state operating value. By pre-charging the DC blocking capacitor to its steady state voltage even before startup of the controller, AC current is introduced into the resonant inductor after the low-side switching element is first turned on and soft switching is provided throughout.

Abstract: A system for providing auto-focus augmented reality (AR) viewing of real and virtual objects includes a frame for holding AR viewing components on a user's head and optically in front of the user's eyes. The AR viewing components include an internal virtual objects display for displaying virtual objects to a user. Internal and external focus correction modules respectively adjust focal distances of virtual and real objects, are respectively configurable to adjust the focal distances of the virtual and real objects differently based on the different user vision types, and operate to respectively adjust the focal distances of the virtual and real objects such that the virtual and real objects are simultaneously in focus based on the vision type of the user.

Abstract: The present disclosure describes luminescent solar concentrators that include photoluminescent nanoparticles. The photoluminescent nanoparticles include a semiconductor nanocrystal that sensitizes the luminescence of a defect. The defect can include, for example, an atom, a cluster of atoms, or a lattice vacancy. The defect can be incorporated into the semiconductor nanocrystal, adsorbed onto, or otherwise associated with the surface of the semiconductor nanocrystal.

Abstract: This disclosure relates to managing conditioned fear and conditions induced by experiencing or witnessing an extreme traumatic event using neurokinin receptor antagonists. In certain embodiments, the disclosure relates to methods of treating or preventing conditioned fear comprising administering an effective about neurokinin 3 receptor antagonist to a subject in need thereof. In certain embodiments, the subject is diagnosed with Post-Traumatic Stress Disorder. In certain embodiments, the neurokinin 3 receptor antagonist is (R)—N-{{3-[1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl}-4-phenylpiperidin-4-yl}-N-methylacetamine or salts thereof.

Abstract: A boom coaster includes a passenger vehicle, a track, a bogie coupled to the passenger vehicle and the track and configured to move along the track, and a simulated ride surface positioned above the track and beneath the passenger vehicle. The simulated ride surface is configured to imitate a path of the passenger vehicle, the bogie is coupled to a surface of the passenger vehicle via a leg member extending around the simulated ride surface, and the leg member suspends the passenger vehicle above the simulated surface such that the bogie and the track are blocked from a passenger view perspective of the passenger vehicle.

Abstract: The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.

Abstract: Offset-cancellation sensing circuit (OCSC)-based Non-volatile (NV) memory circuits are disclosed. An OCSC-based NV memory circuit includes a latch circuit configured to latch a memory state from an input signal. The OCSC-based NV memory circuit also includes a sensing circuit that includes NV memory devices configured to store the latched memory state in the latch circuit for restoring the memory state in the latch circuit when recovering from a reduced power level in an idle mode. To avoid the need to increase transistor size in the sensing circuit to mitigate restoration degradation, the sensing circuit is also configured to cancel an offset voltage of a differential amplifier in the sensing circuit. In other exemplary aspects, the NV memory devices are included in the sensing circuit and coupled to the differential transistors as NMOS transistors in the differential amplifier, eliminating contribution of offset voltage from other differential PMOS transistors not included.

Abstract: A balanced wideband impedance transformer can include a first conductor layer including a first metal line and a second metal line, a second conductor layer including a first feed line and disposed on the first conductor layer, a third conductor layer including a second feed line and disposed on the second conductor layer, and a fourth conductor layer including a third metal line and a fourth metal line, and disposed on the third conductor layer.

Abstract: A system for illuminating a spatial augmented reality object includes an augmented reality object including a projection surface having a plurality of apertures formed through the projection surface. The system further includes a lenslets layer including a plurality of lenslets and conforming to curved regions of the of the projection surface for directing light through the apertures. The system further includes a camera for measuring ambient illumination in an environment of the projection surface. The system further includes a projected image illumination adjustment module for adjusting illumination of a captured video image. The system further includes a projector for projecting the illumination adjusted captured video image onto the projection surface via the lenslets layer and the apertures.

Abstract: Provided are compositions and methods that relate ex vivo organoids that contain B cells and stromal cells in a three dimensional material includes a hydrogel. The hydrogel can be formed without exposure to ultraviolet light from an electronic ultraviolet light source. The hydrogel contains silicate nanoparticles (SiNPs) that are ionically bonded to a polyampholytic gelatin. The three dimensional material can be held at a temperature of at least 37 degrees Celsius and does not liquefy. The organoids exhibit mechanical properties that are similar to certain lymphoid tissues, and can include a germinal center. Methods of making the organoids are included, as are high throughput screening approaches that use the organoids for screening a variety of test agents. The organoids can synthesize a variety of compounds that can be recovered from the organoids or the organoid culture medium.

Abstract: Provided are a communication system, an abnormality detection device and an abnormality detection method that detects abnormality concerning communication such as information forged by utilizing a difference in timings of sampling between multiple communication devices. For the system configuration where ECUs transmit and receive information through a common communication line, abnormality detection related to communication is performed by a monitoring device connected to the communication line. Each ECU receives information by sampling once at a predetermined timing during a transmission period of one-bit information. The ECUs may also be allowed to perform sampling at different timings.

Abstract: The present invention includes compounds useful in preventing, treating or ameliorating Sigma-related disorders or diseases. The compounds of the invention may modulate cellular protein homeostasis, which includes: translation initiation, folding, processing, transport, and degradation (including ubiquitin selective autophagy) of proteins. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound, further comprising administering an effective amount of a compound that inhibits the ubiquitin proteasome system (UPS) and/or autophagic survival pathways.

Abstract: Reactant materials for use in the synthesis of compounds comprising a non-metal and hydrogen, and methods of making and using the same are provided. The reactant materials generally comprise first and second non-metals, metals, a cation, and a transition metal, and can be formed and used in reactions occurring at relatively low-pressure conditions using heat energy that can be supplied via solar radiation. In particular, the reactant materials can be used in the synthesis of ammonia and various hydrocarbon compounds using air, water, and sunlight.

Abstract: Disclosed is a phase-locked loop having a high bandwidth using the rising edge and falling edge of a signal. The disclosed phase-locked loop controls the frequency of a voltage control oscillator by comparing both a phase difference between rising edge of a reference signal and rising edge of a feedback signal and a phase difference between falling edge of the reference signal and falling edge of the feedback signal.