Abstract: The disclosure relates to the identification of salivary biomarkers for diagnosis and monitoring of type 2 diabetes in a subject. Also provided are methods for noninvasively diagnosing and monitoring type 2 diabetes in a subject. More particularly, the expression of salivary biomarkers, including MUC-1, MUC-2, MUC-4, and MUC-5B, are highly associated with A1C level in African American patients with type 2 diabetes.
Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing or eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged bone and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering from delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.
Abstract: A system for measuring microfluctuation of accommodation comprises a measuring module and a processing module. The measuring module includes at least one first sensing element attached to the area around an eye of a testee for measuring an EMG signal. The processing module is coupled with the measuring module for picking up a specific frequency range of the EMG signal as a measurement index of microfluctuation of accommodation, wherein the specific frequency range is between 0.1 Hz and 100 Hz. The system allows the testee to be tested in an open field of view and exempts the testee from experiencing fatigue in the muscle around the eyes. The system is compact and convenient to carry. A method for measuring microfluctuation of accommodation is also disclosed.
Abstract: Methods and compositions are provided for inducing phagocytosis of a target cell, treating an individual having cancer, treating an individual having an intracellular pathogen infection (e.g., a chronic infection), and/or reducing the number of inflicted cells (e.g., cancer cells, cells infected with an intracellular pathogen, etc.) in an individual. Methods and compositions are also provided for predicting whether an individual is resistant (or susceptible) to treatment with an anti-CD47/SIRPA agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent (e.g., co-administration of an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent). Kits are also provided for practicing the methods of the disclosure.
Type:
Grant
Filed:
October 23, 2015
Date of Patent:
June 11, 2019
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Roy Louis Maute, Kipp Andrew Weiskopf, Aaron Michael Ring, Irving L. Weissman
Abstract: The present inaveation relates to prophylactic and/or therapeutic vaccines thatpoatairj Newcastle disease Virus (NDV) virus-like particles (VLPs) comprising one or more Epstein-Barr Virus (EBV) antigens, in one embodiment, the invention provides a recombinant virus-like particle (V'UP) comprising, i is operable combination, a) Newcastle disease virus? iNDVj matrix (M) protein, and b) one or more Epstein-Barr Virus (BBV) antigens. The im'eniion's prophylactic and/or therapeutic vacclrses are useful for preventing asc/or treatmg, infection with EBY aixi/or disease associated Epstein-Barr Virus, such as cancer.
Abstract: The disclosure provides a non-orthogonal multiple access data transmission method and a transmission device using the same. The method includes: performing channel encoding for a plurality of data and a plurality of identifiers respectively corresponding to the plurality of data by using Raptor code so as to generate a Raptor codeword, wherein the plurality of identifiers respectively correspond to a plurality of receiving terminals; and modulating the Raptor codeword to generate a plurality of modulation symbols and broadcasting the plurality of modulation symbols.
Abstract: The method for measuring of quick changes of low surface conductivity of dielectrics under electromagnetic interference of line voltage is based on a comparison measurement on a voltage divider and synchronization of measuring pulses with periodic sinusoidal course of interference when voltage with pre-set parameters of square pulse is brought to the tested dielectric surface and potential is sampled in the voltage divider consisting of the measured dielectric surface and a resistor with preselected resistivity in certain time intervals both before application of the measuring pulse and immediately before its end, and then based on a difference between the values measured using a differential amplifier, the value corresponding to that measured without effect of electromagnetic interference 60 Hz is derived and the result is the possibility to measure quick changes of low surface conductivity of dielectric surface.
Abstract: A bubble continuous positive airway pressure system may include an adjustable flow generator configured to control a flow rate of air to be delivered to a patient. A pressure-regulated delivery system is configured to control a pressure delivered to the patient interface. The delivery system is operatively connected to a pressure control tube. One end of the pressure control tube is submerged in a liquid. A patient interface is configured to transfer pressure from the pressure control tube to the patient's airway.
Type:
Grant
Filed:
May 27, 2015
Date of Patent:
June 11, 2019
Assignee:
William Marsh Rice University
Inventors:
Rebecca Richards-Kortum, Z. Maria Oden, Jocelyn Kaye Brown, Robert H. J. Miros, Elizabeth Molyneux
Abstract: A controllable adhesive for non-flat surfaces is provided. The device has a conformable (i.e. flexible) film and directly cast thereto a synthetic dry adhesive film. The synthetic dry adhesive film has elastomeric wedges. The conformable film is capable to deform to a non-flat surface. In one embodiment, the controllable adhesive has a first loading mechanism at one end of the controllable adhesive to apply load to the controllable adhesive. In another embodiment, forming a gripper, the controllable adhesive has a second controllable adhesive with a second loading mechanism, such that the first and second loading mechanism face each other and join a common point of loading.
Type:
Grant
Filed:
January 12, 2016
Date of Patent:
June 11, 2019
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Elliot W. Hawkes, David L. Christensen, Srinivasan Arul Suresh, Mark R Cutkosky
Abstract: A container for a food and/or beverages is provided. The container is designed such that it may have the capability of absorbing excess thermal energy from the food or beverage, thereby cooling the consumable material to a desired temperature and maintaining the material at the desired temperature for a considerable period of time. The container typically includes an outer insulating shell; an inner heat conducting liner and a phase change material (PCM). To facilitate heat transfer to and from a food or beverage stored in the container, the PCM is commonly disposed between the outer insulating shell and the inner heat conducting liner and positioned in thermal contact with the inner heat conducting liner. The PCM may include a diol diester having a melting point of about 30 to 90° C.
Type:
Grant
Filed:
January 26, 2015
Date of Patent:
June 11, 2019
Assignee:
Trent University
Inventors:
Suresh S. Narine, Michael C. Floros, Michael Tessier
Abstract: Disclosed is an apparatus for decreasing a thrust of a radial flow turbine. The apparatus includes a rotary shaft having an axial through-hole in the interior thereof, a rotor assembled in the rotary shaft and having a rotor hub and rotor blades formed on an outer peripheral surface thereof, a casing configured to isolate the rotary shaft and the rotor from the outside, and a shaft seal configured to maintain a seal between the rotary shaft and the casing.
Type:
Grant
Filed:
June 29, 2016
Date of Patent:
June 11, 2019
Assignee:
Korea Maritime University Industry-Academic Cooperation Foundation
Inventors:
You Taek Kim, Do Yeop Kim, Jun Seong Kim
Abstract: The disclosure provides a method for enhancing memory of a subject, lowering blood glucose levels in a subject, and treating schizophrenia, the methods comprise intranasally administering to the subject an amount of a oxytocin peptide or analog thereof having a beneficial effect.
Type:
Grant
Filed:
February 28, 2017
Date of Patent:
June 11, 2019
Assignee:
The Regents of the University of California
Abstract: Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions.
Type:
Grant
Filed:
December 23, 2014
Date of Patent:
June 11, 2019
Assignees:
argenx BVBA, The Board of Regents of the University of Texas System
Inventors:
Peter Ulrichts, Christophe Blanchetot, Torsten Dreier, Johannes de Haard, E. Sally Ward Ober, Nicolas G. H. Ongenae
Abstract: A composition includes a first population of strongly plasmonic nanorods and a second population of strongly plasmonic nanorods. The two populations each have a size range of the nanorods, creating a size range gap between the two populations. This size range gap creates a transparency window that can be seen in an extinction spectrum of the composition, which is characterized by the sizes of the nanorods in both populations. The composition may be included in a filter providing a transparency to a defined wavelength characterized by the size range gap of the nanorods.
Abstract: The disclosure relates to an electronic beam machining system. The system includes a vacuum chamber; an electron gun located in the vacuum chamber and used to emit electron beam; a holder located in the vacuum chamber and used to fix an object; a control computer; and a diffraction unit located in the vacuum chamber; the diffraction unit includes a two-dimensional nanomaterial; the electron beam transmits the two-dimensional nanomaterial to form a transmission electron beam and a plurality of diffraction electron beams; the transmission electron beam and the plurality of diffraction electron beams radiate the object to form a transmission spot and a plurality of diffraction spots.
Type:
Grant
Filed:
December 14, 2018
Date of Patent:
June 11, 2019
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Abstract: Phased array radar systems for unmanned aerial vehicles (UAVs) are disclosed. A disclosed example radar apparatus for a small UAVs includes a transmitter to transmit a transmit signal in the X-band, a receive phased array including at least two receive antennas, wherein the receive phased array provides a field-of-view of at least 100 degrees in a first direction and at least 20 degrees in a second direction perpendicular to the first direction, a first processor programmed to determine a location of an object based on an output from each of the at least two antennas, a second processor programmed to perform collision avoidance based on the location of the object, and a mount to mechanically couple the radar apparatus to the UAV.
Type:
Grant
Filed:
July 20, 2016
Date of Patent:
June 11, 2019
Assignee:
Brigham Young University (BYU)
Inventors:
Karl Foster Warnick, Jonathan Cullinan Spencer
Abstract: An adjustable clamp used for a marine deck welding test includes a supporting device, a guiding and positioning device and a clamping device; the guiding and positioning device comprises a plurality of guiding shafts, a plurality of guiding plates and a plurality of positioning rods, the guiding shafts located at the two sides of a working platform are detachably connected with supporting blocks, the guiding shafts penetrate through the guiding plates, the guiding plates can slide horizontally along the guiding shafts, at least one column of through-holes are formed in each guiding plate in the direction perpendicular to the sliding direction, the through-holes located at the central part are guiding plate bolt holes, the through-holes located at the two sides are guiding plate positioning holes, the positioning rods are placed in the guiding plate positioning holes, and the upper ends of the positioning rods are higher than the guiding plates; the clamping device comprises a plurality of pressing plates loca
Type:
Grant
Filed:
April 30, 2015
Date of Patent:
June 11, 2019
Assignee:
Jiangsu University
Inventors:
Yun Wang, Jinxing Du, Yun Bai, Hao Yu, Zhenying Xu, Sumin Yin, Xuepeng Wang
Abstract: The present invention is directed to an indirect ophthalmoscopic system for imaging of the ocular fundus including a headband configured to hold a digital imaging device and a plus eyepiece lens in front of an eye of the examiner, with the plus eyepiece lens positioned in between the digital imaging device and the examiner's eye, such that the examiner is focused upon the display of the digital imaging device. The aperture of the digital imaging device receives light reflected from the ocular fundus of the patient's eye, emanating from the patient's pupil. The examiner examines the patient and composes the image of the ocular fundus directly in the display screen. In this way, what the examiner sees is captured by the digital imaging device. Stereoscopic imagery is obtained by optical means that create side-by-side virtual images of the aperture of the digital imaging device within the pupil of the eye.
Type:
Grant
Filed:
June 18, 2015
Date of Patent:
June 11, 2019
Assignee:
The Johns Hopkins University
Inventors:
Aaron Wang, John Avallone, David Guyton
Abstract: A thermally releasable adhesive member including a base resin and microcapsules dispersed and disposed in the base resin. The microcapsule includes a core part, a shell part wrapping the core part, and an organic solvent disposed in the core part, and an average diameter of the microcapsules is in a range from about 50 nm to about 500 nm. The adhesive member may maintain high optical transmittance and may be easily detached at a high temperature.
Type:
Grant
Filed:
July 12, 2017
Date of Patent:
June 11, 2019
Assignees:
Samsung Display Co., Ltd., Myongji University Industry and Academia Cooperation Foundation
Inventors:
Byungwook Ahn, Kikyung Youk, Sukwon Jung, Jeongho Hwang, Jongdeok Park, Seungchan Lee, Intae Son, Junhyup Lee
Abstract: Exemplary embodiments include a computer-implemented method for configuring at least one antenna array comprising receiving a plurality of sets of samples corresponding to signals incident on a plurality of antennas; computing a mean of the envelopes of the sums of the respective sets; estimating a direction of arrival of the signals incident on the antennas based on the computed means; and configuring the antenna array based on the estimated direction of arrival. The computing and estimating procedures can be performed for each of a plurality of direction-of-arrival candidates. The estimating procedure can comprise determining a maximum value of the mean and a direction of arrival corresponding to the maximum value. The spatial selectivity of the antenna array can be configured based on the estimated direction of arrival. Other exemplary embodiments can include communication apparatus and computer-readable media embodying one or more of the exemplary computer-implemented methods and/or procedures.
Type:
Grant
Filed:
July 8, 2014
Date of Patent:
June 11, 2019
Assignees:
New York University, Electronics and Telecommunication Research Institute (ETRI)