Abstract: The disclosed embodiments include systems, methods, and computer readable media for applying DR tags using a computing device, comprising: loading a plurality of documents for review into a memory of the portable computing device; displaying, via a display of the portable computing device, a first document of the plurality of documents; receiving, via the display, a first touchscreen user drag-and-drop input related to the first document, wherein the first touchscreen user drag-and-drop input corresponds to a first tag and a first tag value associated with the first tag; upon initiation of the first touchscreen user drag-and-drop input related to the first document, displaying as an overlay to the first document a first visual indicator corresponding to the touchscreen user drag-and-drop input; in response to completion of the first touchscreen user drag-and-drop input, applying to the first document the first tag value corresponding to the first tag; storing, in the memory, the first tag value associated wit

Abstract: The non-coherent ultra-wideband receiver receives an ultra-wideband (UWB) signal, consisting of pulses (or “symbols”) and uses on-off keying (OOK) modulation so that when a binary “0” is transmitted, the receiver collects noise-only samples. The receiver collects samples during the symbol (pulse) duration and sorts the samples by magnitude of voltage or energy. The receiver uses the known transmission rate and the estimated signal-to-noise ratio to retrieve a sample index from a look-up table. The receiver then compares the signal sample at the index value with a predetermined threshold voltage (or energy). If the selected sample exceeds the threshold, then it is assumed that all succeeding samples also exceed the threshold (assuming the sort is in ascending magnitude) and the pulse is present and binary “1”. Otherwise, the pulse is absent in the sampling period, and binary “0”. The process is repeated for the signal duration.

Abstract: A method of controlling a fluid flow using momentum and/or vorticity injections. Actively controlling an actuator allows for direct, precise, and independent control of the momentum and swirl entering into the fluid system. The perturbations are added to the flow field in a systematic mater providing tunable control input, thereby modifying behavior thereof in a predictable manner to improve the flow characteristics.

Abstract: Provided according to embodiments of the invention are photoplethysmography (PPG) sensors, systems and accessories, and methods of making and using the same. In some embodiments of the invention, the PPG sensors include a clip body that includes a first end portion and a second end portion; a flex circuit attached or adjacent to the clip body, and an elastomeric sleeve that envelops (1) at least part of the first end portion and at least part of the flex circuit attached or adjacent thereto; or (2) at least part of the second end portion and at least part of the flex circuit attached or adjacent thereto.

Abstract: The present invention provides for polycrystalline superconducting permanent magnets which are synthesized of doped superconducting (AE) Fe2As2 compounds, where AE denotes an alkaline earth metal, such as Ba, Sr, Mg or Ca. The superconducting permanent magnets of the present invention can be magnetized in their superconducting state by induced currents, resulting in trapped magnetization that scales with the size of the bulk material. The magnitude of the trapped field has been demonstrated to be over 1 T and is predicted to be over 10 T if the technology is scaled, which is much higher than the capabilities of permanent magnets and other superconducting polycrystalline bulks currently known in the art.

Abstract: A single-chain insulin comprises a C-domain of 6 to 11 amino acid residues comprising at least two acidic residues at the N-terminal side of the C-domain and at least two basic residues at the C-terminal side of the C-domain peptide, a basic amino acid residue at the position corresponding to A8 of human insulin, and an acidic amino acid residue at the position corresponding to A14 of human insulin. The C-domain may contain a 2 to 4 amino acid joint region between the acidic and basic residues. Residues C1 and C2 may have a net negative charge of ?1 or ?2; and the remaining C-domain segment may culminates with two basic residues. A pharmaceutical composition comprises the single-chain insulin, formulated at a pH within the range 7.0 to 8.0, and may be formulated at a concentration of 0.6 mM to 5.0 mM and/or at a strength of U-100 to U-1000.

Abstract: A method for extracting protein from a fat sample is described comprising the steps of separating solidified fat and solid residues from a centrifuged mixture of protein, fat, other solid materials and aqueous solution of phosphate buffered saline to form an aqueous phase containing the protein. The aqueous phase is then filtered through a filter to separate a clear protein extract from the mixture.

Abstract: The disclosure of the present application presents a multiple-ring coupled ring oscillator design that employs multiple-ring coupling to achieve improved phase noise by minimizing noise injection from tail current and adjacent rings, while providing additional output phases for multiphase signal generation. In one non-limiting exemplary prototype embodiment, a 1.5 GHz triple-ring coupled ring oscillator achieved measured phase noise of ?110.5 dBc/Hz at 1 MHz offset, demonstrating phase noise reduction of 7 dB compared with its single-ring oscillator counterpart. The MROs couple multiple rings with proper phase shifting to achieve improved phase noise. Common source coupling benefits from tail current noise reduction, and introducing phase delays in the coupling paths minimizes noise coupling from the adjacent cores. The overall effect leads to improved phase noise performance as demonstrated in quadrature voltage controlled VCO designs.

Abstract: The present disclosure provides variant Cas9 proteins, nucleic acids encoding the variant Cas9 proteins, and host cells comprising the nucleic acids. The present disclosure provides systems that include a subject variant Cas9 protein (and/or a nucleic acid encoding the variant Cas9 protein) and a Cas9 guide RNA. In some cases, a subject system includes a PAMmer and/or a donor polynucleotide. The variant Cas9 proteins and the nucleic acids encoding the variant Cas9 proteins are useful in a wide variety of methods, which are also provided. In some embodiments, a variant Cas9 protein includes a RuvC domain, an HNH domain, and a disrupted RuvC/HNH linker region that reduces the RuvC cleavage activity of the protein. In some embodiments, a variant Cas9 protein includes a deletion (of all or a part of the HNH domain) or an insertion (within the HNH domain) that reduces the HNH cleavage activity of the protein.

Abstract: Compositions and methods for inhibiting metastatic cancer cells. The compositions comprise nanoparticles which have incorporated therein leukocyte adhesion molecules and therapeutic molecules exposed on their surface. The nanoparticles may be provided attached to leukocytes. Introduction of these compositions in to the circulation of individuals results in inhibition and reduction of metastatic cancer cells.

Abstract: In some embodiments, an apertured waveguide includes a wall comprising a plurality of apertures and an interior channel along which electromagnetic waves can propagate, the interior channel being defined at least in part by the wall.

Abstract: A solar cell module for an unmanned aerial vehicle is disclosed. The solar cell module includes a carrier base and a solar cell unit. The carrier base is disposed on the unmanned aerial vehicle. The solar cell unit has a plurality of solar cells attached to the carrier body. A ratio of the power provided by the solar cell unit to the weight of the solar cell module is equal to or greater than 0.1 (W/g).

Abstract: The present invention provides isolated dimeric Streptococcus-specific phage lysins having two Streptococcus-specific phage lysin monomers covalently linked to each other, and having killing activity against one or more Streptococcus bacteria. Also provided for are pharmaceutical compositions of dimeric lysins and their use in therapeutic treatment or alleviation of infections or bacterial colonizations. The dimeric lysins may also be used to decontaminate porous and non-porous surfaces or devices.

Abstract: A system and method for processing highly undersampled multi-echo spin-echo data by linearizing the slice-resolved extended phase graph model generates highly accurate T2 maps with indirect echo compensation. Principal components are used to linearize the signal model to estimate the T2 decay curves which can be fitted to the slice-resolved model for T2 estimation. In another example of image processing for highly undersampled data, a joint bi-exponential fitting process can compensate for image variations within a voxel and thus provide partial voxel compensation to produce more accurate T2 maps.

Abstract: Provided are methods for processing milk using one or more procedures that include at least one high pressure treatment, such as High Pressure Jet Processing at a hydrostatic pressure of at least 400 MPa. Food additives and food products that contain processed milk components are also provided, and may be dairy or non-dairy products.

Abstract: A self-regulating gene expression construct comprises a single promoter in operative association with a repressor sequence (e.g., bacterial repressor lacI or gaiR), operator sequence(s) responsive to the expressed repressor protein, and a transgene. A dual-regulating construct comprises a single promoter controlling expression of a bacterial repressor sequence and a transgene, and which, in the presence of a first inducer molecule, transcribes the transgene and repressor; and a ribozyme in association with an aptamer sequence, the aptamer sequence capable of interacting with a second inducer molecule to terminate mRNA degradation by the ribozyme. Also provided are recombinant vectors or viruses containing the self-regulating or dual self-regulating constructs and cells containing the vectors. Such compositions are useful in methods of treating a diseases using gene therapy.

Abstract: A method of etching features in a silicon wafer includes coating a top surface and a bottom surface of the silicon wafer with a mask layer having a lower etch rate than an etch rate of the silicon wafer, removing one or more portions of the mask layer to form a mask pattern in the mask layer on the top surface and the bottom surface of the silicon wafer, etching one or more top surface features into the top surface of the silicon wafer through the mask pattern to a depth plane located between the top surface and the bottom surface of the silicon wafer at a depth from the top surface, coating the top surface and the one or more top surface features with a metallic coating, and etching one or more bottom surface features into the bottom surface of the silicon wafer through the mask pattern to the target depth plane.

Abstract: Devices and methods for controlling reversible chemical reactions at solid-liquid interfaces are disclosed. In particular, the invention relates to a method of increasing reaction rates by concentrating a target molecule in a liquid phase in the region of a reactant or ligand immobilized on a solid followed by removal of the liquid phase and replacement with an immiscible phase, such as an immiscible gas or liquid to impede the reverse reaction. Devices for performing this method to increase the rates and degree of completion of kinetically limited ligand binding or nucleic acid hybridization reactions in affinity chromatography and microarray applications are also disclosed.

Abstract: The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.

Abstract: A method for magnetic resonance imaging (MRI) scans a field of view and acquires sub-sampled multi-channel k-space data U. An imaging model A is estimated. Sub-sampled multi-channel k-space data U is divided into sub-sampled k-space patches, each of which is processed using a deep convolutional neural network (ConvNet) to produce corresponding fully-sampled k-space patches, which are assembled to form fully-sampled k-space data V, which is transformed to image space using the imaging model adjoint Aadj to produce an image domain MRI image. The processing of each k-space patch ui preferably includes applying the k-space patch ui as input to the ConvNet to infer an image space bandpass-filtered image yi, where the ConvNet comprises repeated de-noising blocks and data-consistency blocks; and estimating the fully-sampled k-space patch vi from the image space bandpass-filtered image yi using the imaging model A and a mask matrix.