Abstract: The invention provides compositions and methods for treating conditions associated with decreased activity of hydrogen sulfide.

Abstract: The present invention relates to a composition for preventing or treating cellular senescence-associated diseases comprising homoharringtonine as an active ingredient, and it was confirmed that the composition comprising homoharringtonine as an active ingredient exhibits a senolytics effect of selectively killing aging-induced fibroblasts and renal tubular cells, whereas aging-induced vascular endothelial cells and epithelial melanocytes and retinal pigmented epithelial cells, and exhibits a senomorphics effect of restoring the function and morphology of cells, and thus the homoharringtonine acts differently depending on the type of cells to effectively prevent or treat senile eye disease, tissue fibrosis disease, atherosclerosis, osteoarthritis, degenerative brain disease, chronic skin damage, obesity and diabetes caused by cellular aging and can be provided as a composition for whitening skin and life extension.

Abstract: The present invention relates generally to a compound having both agonist activity at opioid receptor(s) and antagonist activity at NK1 receptor, and methods for producing and using the same. This combination of activities provides several synergistic and/or beneficial effects such as enhanced potency in analgesic effect and reduction or inhibition of tolerance.

Abstract: A method of identifying properties of microorganisms using ODEP force includes obtaining a sample solution of microorganisms including microorganisms having predetermined properties; pre-processing the sample solution of microorganisms to obtain a sample solution of microorganisms to be tested having predetermined electrical properties; placing the sample solution of microorganisms to be tested on a channel of a chip member; activating a light image module having combinations of different strengths of ODEP force to analyze the sample solution of microorganisms to be tested on the channel in which microorganisms in the sample solution of microorganisms to be tested are configured to generate a predetermined distribution and a predetermined presentation due to the predetermined electrical properties; and identifying properties of the microorganisms based on the predetermined distribution and the predetermined presentation.

Abstract: A system is disclosed that enables the automated measurement of cellular mechanical parameters at high throughputs. The microfluidic device uses intersecting flows to create an extensional flow region where the cells undergo controlled stretching. Cells are focused into streamlines prior to entering the extensional flow region. In the extensional region, each cell's deformation is measured with an imaging device. Automated image analysis extracts a range of independent biomechanical parameters from the images. These may include cell size, deformability, and circularity. The single cell data that is obtained may then be used to in a variety of ways. Scatter density plots of deformability and circularity may be developed and displayed for the user. Mechanical parameters such as deformability and circularity may be gated or thresholded to identify certain cells of interest or sub-populations of interest. Similarly, the mechanical data obtained using the device may be used as cell signatures.

Abstract: The present disclosure provides a backlight module, a liquid crystal display, and an electronic device. The backlight module includes: a backplane; at least one light source arranged on the backplane; and at least one diffractive optical element arranged above the light source, and a central axis of the diffractive optical element and a central axis of the light source are on a same straight line.

Abstract: The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.

Abstract: Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.

Abstract: A method for batch handover authentication and key agreement oriented to a heterogeneous network generally includes the following steps: A, system establishment and participant registration: users participating in authentication register on the LTE-A network to obtain their respective identity information; B, access authentication: when a large number of users request access to the WLAN, the target network WLAN is discovered by using the ANDSF, and the leader sends a complete group authentication message to the AAA server of the WLAN to request identity authentication; if the authentication succeeds, the AAA server of the WLAN returns an identity authentication response; C, if the authentication fails, the continued execution of the protocol is terminated. The method effectively realizes batch authentication of users during handover from the LTE-A network to the WLAN, and thus has high authentication efficiency, small signaling overheads, and high security.

Abstract: Amine substituted morpholino oligonucleotides, other than the classical N,N-dimethylamino PMO analogue, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. Morpholino oligonucleotides having thiophosphoramidate, phosphoramidate, and alkyl phosphoramidate linkers. Chimeras containing unmodified DNA/RNA and other analogs of DNA/RNA can be prepared. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous applications.

Abstract: The present disclosure discloses an active matrix organic light-emitting diode display device and a manufacturing method thereof. The method includes forming a sacrificial layer on a carrier layer; forming a flexible substrate on the sacrificial layer; forming a first insulating layer on the flexible substrate; forming at least one transition metal chalcogenide based backplane on the first insulating layer; and forming an opening unit after forming a capping layer on the at least one transition metal chalcogenide based backplane; and forming at least one active matrix organic light-emitting diode unit which is electrically connected to the at least one transition metal chalcogenide based backplane in the opening unit.

Abstract: Disclosed is a crop yield prediction method and device. The method includes: transmitting an image acquisition instruction to a preset aircraft terminal to acquire a ground image; transmitting a driving instruction at the same time, wherein a distance between a first rail vehicle and a second rail vehicle is inversely proportional to the driving time, a plurality of light channels are embedded between a first rail and a second rail, and a light transmittance of the light channels is able to be affected by the external environment to change; transmitting a light emitting instruction and recording initial data when multiple beams of light are emitted; transmitting a light receiving instruction and recording final data when the multiple beams of light are received; and inputting the ground image, the initial data and the final data into a crop yield prediction model for processing.

Abstract: Methods and systems are described for producing non-invasive and targeted neuronal lesions using magnetic resonance and acoustic energy. Imaging data corresponding to a region of interest is obtained, the region of interest within an imaging subject. Information indicative of a target region within the region of interest is received from the obtained imaging data. Focused acoustic energy directed to the target region within the region of interest is generated to disrupt a barrier between a therapeutic agent and parenchymal tissue in response to insonification by the focused acoustic energy, the therapeutic agent comprising a neurotoxin and microbubbles.

Abstract: The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.

Abstract: The subject invention provides methods of treating neurological disease or disorder, such as brain injuries, such as stroke, traumatic brain injury (TBI), or other ischemic events that cause brain injury by inhibiting or down-regulating Let-7i activity or function. The disclosed methods may have the potential to extend the “window of opportunity” for treatment of such injuries and enhance the effectiveness of existing therapeutics.

Abstract: Systems and methods of encrypted communication between a server and client devices using keyless encryption schemes are disclosed. Client devices with arrays of physical-unclonable-function devices respond to challenges from a server. Characteristics of the arrays are stored by the server during a secure enrollment process. Subsequently, the server issues challenges to the clients. The clients derive a ciphertext according to a variable cipher scheme determined using responses to the challenges issued by the server using characteristics of portions of the arrays specified by the challenges. The server and clients may independently determine encryption and decryption procedures using characteristics of the arrays.

Abstract: Disclosed herein is a new type of fully-connected, hybrid beamforming transceiver architecture. The transceiver described herein is bi-directional and can be configured as a transmit beamformer or a receive beamformer. A method and apparatus are described that allows the beamformer to operate in “carrier aggregated” mode, where communication channels in multiple disparate frequency bands can be simultaneously accessed.

Abstract: A DC-DC voltage converter includes an input circuit, a parallel linked leg (PLL), an output circuit and a controller. The PLL includes an active leg switch, a leg inductor, a leg capacitor and a leg diode. The controller is configured to i) turn on the active input switch and the active leg switches while maintaining the active output switch at a turn off state for the first duty cycle period ii) turn off the active input switch and the active leg switches, and turn on the active output switch for a second duty cycle period following the first duty cycle period, and iii) turn off the active output switch while maintaining also turn off states of the active input switch and the active leg switches for a remaining period following the second duty cycle period. A method of controlling the DC-DC converter includes steps of i) to iii).

Abstract: A novel organic sulfur compound, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer or inflammatory diseases, containing the same as an active ingredient are provided. The novel organic sulfur compound is capable of excellently inhibiting histone deacetylated (HDAC) enzymes in a concentration of nanomolar or micromolar units and has been found to have an excellent effect against inflammatory diseases, and has been found to be capable of inhibiting the proliferation of cancer.

Abstract: A semiconductor device includes a III-nitride buffer layer and a III-nitride barrier layer. A boron nitride alloy interlayer interposed between the III-nitride buffer layer and the III-nitride barrier layer. A portion of the III-nitride buffer layer includes a two-dimensional electron gas (2DEG) channel that is on a side of the III-nitride buffer layer adjacent to the boron nitride alloy interlayer.