Abstract: A freeform extrusion fabrication process for producing three-dimensional ceramic, metal and functionally gradient composite objects, including the steps of filling a plurality of paste sources with a respective plurality of aqueous paste compositions, operationally connecting respective syringes containing respective aqueous paste compositions to a mixing chamber, moving a first aqueous paste composition from a first respective paste source into the mixing chamber, moving a second aqueous paste composition from a second respective paste source into the mixing chamber, mixing the first and second aqueous paste compositions to define a first admixture having a first admixture composition, extruding the first admixture onto a surface to define an extruded layer having a first admixture composition, surrounding the sides of the extruded layer with an oil bath, radiatively drying the extruded layer.

Abstract: A semiconductor vertical resonant cavity light source includes an upper and lower mirror that define a vertical resonant cavity. An active region is within the cavity for light generation between the upper and lower mirror. At least one cavity spacer region is between the active region and the upper mirror or lower mirror. The cavity includes an inner mode confinement region and an outer current blocking region. An index guide in the inner mode confinement region is between the cavity spacer region and the upper or lower mirror. The index guide and outer current blocking region each include a lower and upper epitaxial material layer thereon with an epitaxial interface region in between. At least a top surface of the lower material layer includes aluminum in the interface region throughout a full area of an active part of the vertical light source.

Abstract: A lighting system includes various ballasts or LED drivers having respective dimming interface circuits coupled in parallel to an external dimming device. Each device includes a controller regulating output to a lighting load based on desired dimming output. Dimming interface circuits coupled are between the controller and the external dimming device, each configured to dynamically adapt a level of constant current sourced from the dimming interface circuit to the external dimming device via first and second interface terminals, based on a determined analog mode or digital mode associated with the external device. The dimming interface circuit generates dimming control signals to the controller based on dimming input signals received via the first and second interface terminals, and in a digital mode, the interface circuit generates digital pulse signals to the external dimming device via the interface terminals for bidirectional communications therewith.

Abstract: The invention provides a prophylactic agent or therapeutic agent for fibrodysplasia ossificans progressiva, containing as an active ingredient a binding inhibitor that inhibits interaction between activin and activin A receptor type I (ACVR1), or an expression suppressor that suppresses expression of activin.

Abstract: Techniques are disclosed for producing a drop of a viscoelastic fluid. A separation volume of viscoelastic fluid that is to form a drop from a larger remnant volume of viscoelastic fluid is moved from through an interface and into a cross-channel. Movement subjects the viscoelastic fluid to shear that may cause a reduction in viscosity. Movement of the viscoelastic fluid is then reduced or stopped (i.e., the rate at which shear is applied is reduced), such that the viscosity of the viscoelastic fluid may increase as the viscoelastic fluid experiences relaxation. The separation volume of viscoelastic fluid is then moved down the cross-channel in a first direction by the flow of an immiscible fluid, which separates the separation volume from a remnant volume. The separation volume may then be dispensed from the cross-channel as a drop.

Abstract: There is provided a method for manufacturing a nitride crystal substrate, including: arranging a plurality of seed crystal substrates made of a nitride crystal in a planar appearance, so that their main surfaces are parallel to each other and their lateral surfaces are in contact with each other; growing a first crystal film using a vapor-phase growth method on a surface of the plurality of seed crystal substrates arranged in the planar appearance, and preparing a combined substrate formed by combining the adjacent seed crystal substrates each other by the first crystal film; growing a second crystal film using a liquid-phase growth method on a main surface of the combined substrate so as to be embedded in a groove that exists at a combined part of the seed crystal substrates, and preparing a substrate for crystal growth having a smoothened main surface; and growing a third crystal film using the vapor-phase growth method, on the smoothed main surface of the substrate for crystal growth.

Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.

Abstract: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

Abstract: Systems and methods for low-power single-wire communication are provided. In some embodiments, a method of operation of a transmitter to transmit a data word to a receiver using low-power single-wire communication includes receiving the data word to be transmitted to the receiver. The method also includes encoding the data word to be transmitted in a Pulsed Index Communication (PIC) format to produce a PIC data word and transmitting the PIC data word to the receiver. In this way, the transmitter may be able to transmit an increased amount of data while maintaining a simple communication protocol that uses low power and does not require a Clock-Data Recovery circuit.

Abstract: Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.

Abstract: The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a neurodegenerative disease drug, wherein the drug is a substrate of an ABC transporter inhibitor, wherein the mammal is further administered a therapeutically effective amount of an ABC transporter inhibitor, whereby the neurodegenerative disease is treated in the mammal. In certain embodiments, the neurodegenerative disease comprises at least one selected from the group consisting of spinal cord injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, amyotrophic lateral sclerosis, a tauopathy, and chronic traumatic encephalopathy.

Abstract: Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide compounds and pharmaceutical compositions disclosed herein are potent analgesics active in several pain models with generally minimal tolerance and reduced likelihood to induce addiction relative to other known opiates.

Abstract: The present invention provides a lipid extraction device comprising a capillary tube, wherein the capillary tube comprises a first region containing a first filler; and a second region present in a region other than the first region and containing a second filler having polarity different from the first filler. The present invention also provides a system and a method for extracting and analyzing lipids from a biological sample using the lipid extraction device.

Abstract: A composition comprising mesoporous aggregates of magnetic nanoparticles and free-radical producing enzyme (i.e., enzyme-bound mesoporous aggregates), wherein the mesoporous aggregates of magnetic nanoparticles have mesopores in which the free-radical-producing enzyme is embedded. Methods for synthesizing the enzyme-bound mesoporous aggregates are also described. Processes that use said enzyme-bound mesoporous aggregates for depolymerizing lignin, removing aromatic contaminants from water, and polymerizing monomers polymerizable by a free-radical reaction are also described.

Abstract: A processor architecture which partitions on-chip data caches to efficiently cache translation entries alongside data which reduces conflicts between virtual to physical address translation and data accesses. The architecture includes processor cores that include a first level translation lookaside buffer (TLB) and a second level TLB located either internally within each processor core or shared across the processor cores. Furthermore, the architecture includes a second level data cache (e.g., located either internally within each processor core or shared across the processor cores) partitioned to store both data and translation entries. Furthermore, the architecture includes a third level data cache connected to the processor cores, where the third level data cache is partitioned to store both data and translation entries. The third level data cache is shared across the processor cores. The processor architecture can also include a data stack distance profiler and a translation stack distance profiler.

Abstract: The present invention pertains to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and (E)-3-(3,4-dihydroxyphenyl)-N-(prop-2-yn-1-yl)acrylamide of Formula (I): The invention also pertains to a method for stimulating neurite outgrowth by administering to cells in the area where neurite outgrowth is desired a therapeutically effective amount of the compound of Formula (I). Further, the invention pertains to a method for attenuating neuron injury in a subject by contacting a neuron in a subject in need thereof with a therapeutically effective amount of the compound of Formula (I). Furthermore, a method of preparing the compound of Formula (I) are provided.

Abstract: Devices for controlling the capture, trapping, and transport of macromolecules include at least one fluidic transport nanochannel that intersects and is in fluid communication with at least one transverse nanochannel with (shallow) regions and/or with integrated transverse electrodes that enable fine control of molecule transport dynamics and facilitates analyses of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.

Abstract: The present invention provides methods of detecting c-KIT-dependent-melanoma for diagnostic and prognostic purposes. The invention further provides methods of treating such melanoma by inhibiting c-KIT.

Abstract: Disclosed are time synchronization methods for domains based on time information of a vehicle. A time synchronization method performed by a first end node belonging to a first domain of a vehicle includes: receiving a first frame including time information from the vehicle; changing the first end node to a grand master node of the first domain when the time information indicates a time of a universal time domain; and synchronizing a time of the grand master node with the time of the universal time domain.

Abstract: A sign language recognizer is configured to detect interest points in an extracted sign language feature, wherein the interest points are localized in space and time in each image acquired from a plurality of frames of a sign language video; apply a filter to determine one or more extrema of a central region of the interest points; associate features with each interest point using a neighboring pixel function; cluster a group of extracted sign language features from the images based on a similarity between the extracted sign language features; represent each image by a histogram of visual words corresponding to the respective image to generate a code book; train a classifier to classify each extracted sign language feature using the code book; detect a posture in each frame of the sign language video using the trained classifier; and construct a sign gesture based on the detected postures.