Abstract: Novel CUR— and CUR—BF2 compounds as well as novel bis and mono-NSAID/CUR—BF2 and NSAID/CUR hybrids exhibiting anti-tumor properties are presented. CUR compounds bearing fluorinated moieties with selective fluorine introduction into the ?-carbonyl moiety as well as CUR—BF2 adducts and CURs with diverse substitution patterns in the phenyl rings including fluorinated substituents (SCF3, OCF3, and F) and/or bulky activating groups (OMe, OAc, and OBz) are presented. Fluorinated aryl-pyrazoles and isoxazoles as well as novel CUR and CUR—BF2 compounds with monocyclic aromatic and bicyclic-heteroaromatic lateral rings, bearing fluorine(s), OCF3, CF3, and SCF3 groups, and their alpha-carbonyl-fluorinated analogs, as well as their pyrazole and isoxazole derivatives are presented. The CUR-pyrazoles embody analogs that are fluorinated at the phenyl-pyrazole moiety. The hybrids, compounds, and their derivatives exhibited exceptional cytotoxic and anti-proliferative activity against several cancer cell-lines.

Abstract: Provided are compositions and methods for detecting a target DNA (double stranded or single stranded) in a sample. In some embodiments, a subject method includes: (a) contacting the sample with: (i) a type V CRISPR/Cas effector protein (e.g., a Cas12 protein such as Cas12a, Cas12b, Cas12c, Cas12d, Cas12e); (ii) a guide RNA (comprising a region that binds to the type V CRISPR/Cas effector protein, and a guide sequence that hybridizes with the target DNA); and (iii) a detector DNA that is single stranded (i.e., a “single stranded detector DNA”) and does not hybridize with the guide sequence of the guide RNA; and (b) measuring a detectable signal produced by cleavage (by the type V CRISPR/Cas effector protein) of the single stranded detector DNA. Also provided are compositions and methods for cleaving single stranded DNAs (e.g., non-target ssDNAs), e.g., inside of a cell.

Abstract: The invention provides microbeads comprising chitosan, a magnetic nanoparticle, and an agent, and methods for using such microbeads for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection or disease.

Abstract: Janus particles, including biodegradable, biocompatible, anisotropic, amphiphilic Janus nanocolloids, and their use in stabilizing emulsions and cleansing are described.

Abstract: The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity and few side effects which can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. The problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin but neutralizes the neurite outgrowth inhibiting activity of RGMa, preferably by providing an anti-RGMa antibody which has complementarity determining regions having amino acid sequences of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in Sequence Listing, and SFG.

Abstract: Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.

Abstract: A method of producing submicron carbon particles from oil ash. The method comprises pyrolyzing the oil ash to produce a pyrolyzed oil ash and milling the pyrolyzed oil ash to produce carbon particles having a mean particle size in the submicron regime. The method produces submicron carbon particles which have a very high carbon content (90 to 99 atom %) and a very low content of oxygen, the particles having a ratio of carbon to oxygen ratio of 10:1 to 99:1. The size of the particles may be controlled by the duration of the milling. The submicron carbon particles are devoid of functionalities containing carbon-oxygen double bonds as measured by Raman spectroscopy and X-ray photoelectron spectroscopy (XPS).

Abstract: The present invention discloses a cold start operation device and control method for a diesel engine in a plateau region under a low ambient temperature, allowing a starter to drive a piston to compress the low-temperature air, by using the heated air as the fresh inlet air to introduce it into the cylinder, so that the in-cylinder temperature at the compressing TDC is increased to obtain the ignition temperature, and finally achieving the cold start of diesel engines in plateau regions. The present invention avoids complicated preheating devices, and has simple structure and reliable performance, can achieve effective cold start in different low ambient temperature environments.

Abstract: The present disclosure relates to a message transmission requesting apparatus and method for requesting message transmission from a terminal located within a predetermined range from the message transmission requesting apparatus, a message transmission management server, and a base station. Specifically, the message transmission requesting apparatus comprises: an uplink resource allocation information acquisition unit for acquiring uplink resource allocation information; at least one uplink signal reception unit for receiving an uplink signal on the basis of the uplink resource allocation information; a control unit for determining, on the basis of the uplink signal, information on a terminal which has transmitted the uplink signal, the information including identifier information of the terminal and location information of the terminal; and a message transmission request unit for transmitting the information on the terminal to a base station.

Abstract: A heat recovery apparatus, system and method of using the same. The heat recovery apparatus includes a particulate inlet, a particulate distributor in fluid communication with the particulate inlet, a cavity in fluid communication with the particulate distributor, a plurality of pipes contained within the cavity and configured for transmission of a heat transfer fluid therethrough, and a particulate outlet in fluid communication with the cavity.

Abstract: An electrochemical device includes an electrolyte, a cathode contacting the electrolyte, and an oxygen evolution reaction (OER) electrode operating as an anode contacting the electrolyte. The OER electrode includes an iron-containing substrate and a layer that includes a metal-containing layer disposed over the iron-containing substrate. The metal-containing layer includes a metal and iron, the metal being selected from the group consisting of nickel, cobalt, manganese, and combinations thereof.

Abstract: The present invention belongs to the technical field of composite materials, and disclosed are a xylan-based double network nanocomposite hydrogel and the preparation and application thereof. The method includes: (1) adding a graphite oxide powder into deionized water, and ultrasonically dispersing to obtain a GO water dispersion; (2) adding xylan into deionized water, heating and stiffing to obtain a xylan solution; (3) adding a water-soluble calcium salt, a reaction monomer and the xylan solution into the GO water dispersion, stiffing and dispersing uniformly under an ice-bath condition, adding an initiator, a cross-linking agent and an accelerator, and stiffing to mix well so as to obtain a mixed solution; (4) subjecting the mixed solution of step (3) to a drying reaction, to obtain the xylan based double network nanocomposite hydrogel. The composite hydrogel obtained in the present invention has high mechanical properties, is biodegradable and has good biocompatibility.

Abstract: A biopharmaceutical agent including a 37 kDa/67 kDa laminin receptor precursor/high affinity laminin receptor (LRP/LR) and/or a fragment thereof for use in treatment and/or prevention of atherosclerosis and/or obesity and/or insulin resistance and/or diabetes. The biopharmaceutical agent may be encapsulated by functionalized or non-functionalized nanoparticles, and further may be formulated to include a carrier to provide a pharmaceutical composition for parental or non-parental administration. In use, the biopharmaceutical agent reduces lipid content in target cells. Also, a method of decreasing lipid concentration in a target cell of a human or animal subject.

Abstract: The disclosure provides a deep parallel fault diagnosis method and system for dissolved gas in transformer oil, which relate to the field of power transformer fault diagnosis. The deep parallel fault diagnosis method includes: collecting monitoring information of dissolved gas in each transformer substation and performing a normalizing processing on the data; using the dissolved gas in the oil to build feature parameters as the input of the LSTM diagnosis model, and performing image processing on the data as the input of the CNN diagnosis model; building the LSTM diagnosis model and the CNN diagnosis model, respectively, and using the data set to train and verify the diagnosis models according to the proportion; and using the DS evidence theory calculation to perform a deep parallel fusion of the outputs of the softmax layers of the two deep learning models.

Abstract: A perovskite-silicon tandem cell capable of absorbing solar radiation with energy lower than that of 1.12 eV, i.e., the bandgap of crystalline silicon—corresponding to the wavelength of 1100 nm. Ho3+ can absorb photons of wavelength range 1120 to 1190 nm, Tm3+, 1190 to 1260 nm, and Er3+, 1145 to 1580 nm, but up-conversion can be achieved using Ho3+, Tm3+, and Er3+-doped metal oxide, such as ZrO2, in perovskite-silicon tandem solar cells. Doped metal oxides, such as ZrO2 can also work as selective contacts. Such perovskite-silicon tandem structures can achieve over 30% solar energy conversion efficiency.

Abstract: Methods of screening cancerous cells for nutritional weaknesses and methods of treating cancer nutritionally are disclosed. Certain cancers depend on being supplied with one or more nutrients that are non-essential for normal cells. In particular, the invention relates to methods of treating cancer by identifying nutritional weaknesses of cancer cells and using nutritional therapy to suppress cancer by putting a subject on a diet that deprives cancerous cells of a nutrient needed for cancer proliferation and growth. Nutritional therapy can be used to enhance the effectiveness of current cancer treatments.

Abstract: Methods of forming graphene hard mask films are disclosed. Some methods are advantageously performed at lower temperatures. The substrate is exposed to an aromatic precursor to form the graphene hard mask film. The substrate comprises one or more of titanium nitride (TiN), tantalum nitride (TaN), silicon (Si), cobalt (Co), titanium (Ti), silicon dioxide (SiO2), copper (Cu), and low-k dielectric materials.

Abstract: Provided are a method for producing a lithium secondary battery thick film and a method for producing a lithium secondary battery, by using electrostatic slurry spraying of slurry containing a sulfide-based solid electrolyte. Particularly, the method for producing a lithium secondary battery thick film comprises: a step of preparing slurry in which the powder of a sulfide-based solid electrolyte is mixed with at least one solvent selected between a dichloroethane and a dichlorobenzene, at the weight ratio of 1:10 to 1:100; and a step of depositing a lithium secondary battery thick film by electrostatically spraying the slurry on a current collector under a nitrogen atmosphere in the cone-jet mode.

Abstract: Systems and methods to determine an electrochemical impedance spectrogram (EIS) rapidly in real time are provided. Embodiments described herein provide an approach to determine an EIS rapidly (e.g., much less than one second) over a wide band of frequencies. Since the EIS is a foundational diagnostic that is used in a wide variety of applications involving electrochemical events, the proposed approach will significantly impact a wide range of applications. Novel waveforms and systems analysis techniques are used to determine the electrochemical impedance over a wide range of frequencies simultaneously. Embodiments can be readily integrated into conventional electrochemical workstations and embedded devices. Other embodiments can be instantiated into custom-made hardware depending on the needs of a given application. The speed and resolution of the EIS obtained using this approach can be tailored to a wide variety of applications.

Abstract: Systems and methods for a six-primary color system for display. A six-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. The six-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.