Abstract: System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.

Abstract: The present invention provides bio-nanoparticles (BioNPs) for delivering an active agent into hematopoietic stem & progenitor cells (HSPCs). Each BioNP comprises a core and a biological membrane covering the core, which comprises the active agent and a polymer. The biological membrane comprises a phospholipid bilayer and one or more surface proteins of a megakaryocyte (Mk). The active agent remains active after being delivered into the HSPC. Also provided are methods for preparing the BioNPs and uses of the BioNPs for targeted delivery of an active agent into HSPCs and/or treating or preventing a disease or condition in a subject in need thereof.

Abstract: The current disclosure teaches one to achieve PBI membranes with high ionic conductivity and low mechanical creep for the first time. This is in contrast to previous teachings of PBI membrane fabrication methods, which yield PBIs with either high ionic conductivity and high mechanical creep or low ionic conductivity and low mechanical creep. The membranes produced according to the disclosed process provide doped membranes for applications in fuel cells and electrolysis devices such as electrochemical separation devices.

Abstract: Disclosed are an image encoding/decoding method and apparatus. The method and apparatus select at least one reference pixel line from among multiple reference pixel lines and derive a predicted value of a pixel within a current block by using the value of at least one pixel within the selected reference pixel line(s). Alternatively, the method and apparatus derive an intra prediction mode of a reconstructed pixel region on the basis of a reference pixel region of at least one reconstructed pixel region, derive an intra prediction mode of a current block on the basis of the derived intra prediction mode of the reconstructed pixel region, obtain an intra prediction block of the current block by using the derived intra prediction mode, and reconstruct the current block by summing the obtained intra prediction block and a residual block of the current block.

Abstract: Methods, systems, and computer readable media for recognizing one or more hand gestures of a hand-based signal or conversation are described. Some implementations include obtaining one or more unprocessed images of the hand-based signal or conversation including images of at least one of the one or more hand gestures extracting one or more spectral features from the one or more unprocessed images using a Gabor filter bank, receiving the one or more unprocessed images of the one or more hand gestures and the extracted one or more spectral features by a Convolution Neural Network (CNN), and outputting a classification for the at least one of the one or more hand gestures using the Convolution Neural Network (CNN). In some implementations, at least one of the extracted one or more spectral features and at least one of the one or more unprocessed images of the one or more hand gestures are concatenated and input to the Convolution Neural Network (CNN).

Abstract: A method is described for inhibiting marine fouling on a surface. The surface is contacted with a composition comprising a waterborne polyurethane that is crosslinked with an acrylic acid functionalized polysaccharide, water, and a preservative. The composition is then dried to form a deposited film. The polysaccharide may be xanthan.

Abstract: The invention relates to biodegradable, biocompatible materials to promote regeneration of articular surfaces in the temporomandibular joint and, more particularly, to biomaterials and methods for facilitating fibrochondrocyte and chondrocyte growth in in-vitro and in-vivo environments. The materials include magnesium in solid form and polymer. The materials are effective to grow and regenerate fibrochondrocyte and chondrocyte cells, and restore bone cells.

Abstract: The present invention relates to methods of diagnosing traumatic brain injury (TBI) in a subject. The present invention also relates to methods of monitoring the progression of the TBI in a subject.

Abstract: A system includes at least one processor and a memory. The memory stores a dimensionally aware model generated based on a training set and guided by feature dimensions and instructions for execution by the at least one processor. The instructions include, in response to receiving a set of data from a user device, identifying a set of features from the set of data and applying the dimensionally aware model to the set of features by implementing a boundary representation. The instructions include classifying the set of features as acceptable in response to the implementation of the boundary representation indicating the set of features are outside the boundary representation, classifying the set of features as unacceptable in response to the implementation of the boundary representation indicating the set of features are inside the boundary representation, and generating, for display on the user device, an alert based on the classification.

Abstract: According to examples, an apparatus may include a processor and a memory on which is stored machine readable instructions. The processor may execute the instructions to access a first stereoscopic three-dimensional (3D) image of a surface of a layer of build material particles and a second stereoscopic 3D image of the layer surface, the second stereoscopic 3D image being captured at a later time than the first stereoscopic 3D image. The processor may also generate a 3D deformation map of the layer surface from the first stereoscopic 3D image and the second stereoscopic 3D image and may implement an action based on the generated 3D deformation map of the layer surface.

Abstract: Disclosed herein are quinoline-based compounds and method for inhibiting CDK8 or CDK19 for the intervention in diseases, disorders, and conditions. The quinoline-based composition comprise substituents at quinoline ring positions 4 and 6, wherein the substituent at position 4 is selected from a substituted or unsubstituted arylalkylamine or a substituted or unsubstituted arylhetrocyclylamine. Pharmaceutical compositions comprising the substituted qunioline compositions, methods of inhibiting CDK8 or CDK19, and methods of treating CDK8/19-associated diseases, disorders, or conditions are also disclosed.

Abstract: This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals with metabolic dysfunction, or individuals at risk for metabolic dysfunction.

Abstract: An online precise control method for truncating parameters of microscale abrasive grains includes the steps of: (1) clamping an electrode and a diamond grinding wheel to form a discharge circuit, and communicating a workstation with a power supply and a controller of a numerical control machine tool; (2) feedback controlling movement parameters of the machine tool and parameters of the power supply according to pulse discharge parameters, controlling a discharge current and a discharge voltage, and calculating a number of rotations of the grinding wheel; (3) determining a maximum truncating area of a cutting edge and a maximum effective number of rotations of the grinding wheel according to grinding wheel parameters and pulse discharge parameters, and precisely controlling a truncating area of a cutting edge of abrasive grains online by the calculated number of rotations of the grinding wheel; and (4) after the calculated number of rotations of the grinding wheel reaches a target value, calculating a truncati

Abstract: Fluorescent test paper for detecting mercury ions is firstly prepared, the fluorescent test paper including a fluorescence development area and a standard fluorescent colorimetric card. With reference to an excited color corresponding to a reference channel in the standard colorimetric card, the color corresponding to a carbon quantum dots distribution area on the fluorescent test paper is observed to check the fluorescence detection environment during detection with the fluorescent test paper. In colorimetric detection of the content of mercury ions, the concentration of Hg2+ is detected based on an excited color, in the standard colorimetric card, that corresponds to a standard mercury ion sample and is closest to a color signal in a copper nanoclusters distribution area on the fluorescent test paper.

Abstract: This invention discloses uses for sulindac in preparing anti-lung cancer products. This invention provides uses for sulindac in the preparation of products to treat lung cancer. From carrying out cancer drug repositioning for the FDA- and CFDA-approved drug sulindac, experiments for this invention show, based on screening of non-anti-cancer drugs for various cancer cell lines (tissue types) and mutation sites, that sulindac has a new use as an anti-lung cancer medication, thus achieving a new purpose for an old drug.

Abstract: In the method for preparing single crystal superalloy test bars by using a Ni—W heterogeneous seed crystal, on the premise of ensuring that the single crystal superalloy has the required orientation, by reusing the seed crystal, it is achieved that the trouble caused by the need of preparing a new seed crystal when a single crystal superalloy is produced by the seed crystal method every time is avoided, and the production cost is significantly reduced. In the present disclosure, the formation of the stray grains in mushy zone could be avoided by using a Ni—W heterogeneous seed crystal without mushy zone and a built-in corundum tube.

Abstract: A robotic fish includes a front body, a rear body that includes a first segment and a second segment, and a driving unit. The first segment has a front engaging portion projecting toward and pivotally connected to the front body, and a rear engaging portion formed with a recess that recedes toward the front body and pivotally connected to the second segment. The driving unit includes a motor disposed in the front engaging portion, and a shaft extending along a dorsoventral axis and connecting the motor and the rear connecting portion. A ratio of a distance between the shaft and a foremost edge of the front engaging portion to a distance between the foremost edge and an extreme point of the recess ranges from 0.075 to 0.75.

Abstract: A method for evaluating brittleness of a deep shale reservoir and a computer readable storage medium. The method includes determining a Rickman brittleness index of the deep shale reservoir and determining an effective pressure of the deep shale reservoir according to a pore pressure and an overlying formation pressure of the deep shale reservoir. The Rickman brittleness index is adjusted to obtain the brittleness index of the deep shale reservoir according to an exponential relationship of the brittleness index with the effective pressure of the deep shale reservoir. Inherent properties, such as rock brittle mineral content and the like, are better indicated by the Rickamn brittleness index, and then the brittleness index of the deep shale reservoir is obtained by utilizing the exponential relationship of the brittleness index with the effective pressure of the deep shale reservoir, to realize reasonable evaluation for the brittleness of the deep shale reservoir.

Abstract: An object of the present invention is to provide a novel plant growth inhibiting agent and a plant growth inhibiting method using the same. The plant growth inhibiting agent of the present invention comprises, as an active ingredient, a compound represented by the following formula (I?) and/or a salt thereof. In the formula (I?), R1a represents a substituted or unsubstituted C1 to C20 alkyl group, a substituted or unsubstituted C6 to C14 aryl group, a substituted or unsubstituted C3 to C13 heteroaryl group, or the like; R2 represents a substituted or unsubstituted C1 to C20 alkylene group, a substituted or unsubstituted C6 to C14 arylene group, or the like; R3a represents OH, a substituted or unsubstituted C1 to C6 alkoxy group, or the like; X represents an oxygen atom; Y represents a substituent; q represents any integer of 0 to 3; n represents 0 or 1; and m represents 0 or 1.

Abstract: A medical image data processing apparatus comprises processing circuitry configured to: receive medical image data in respect of at least one subject; receive non-image data; generate a filter based on the non-image data; and apply the filter to the medical image data, wherein the filter is configured to limit a region of the medical image data.