Abstract: A spray-capillary device is configured to process ultra low-volume samples. The spray-capillary device includes a spray capillary that includes an inlet end and a discharge end. The spray capillary includes a porous section at the discharge end. A downstream connector provides an interface between the porous section of the spray capillary, a conductive fluid, and a high voltage electrical source. The application of voltage to the downstream connector causes electrospray ionization, which can be used to draw ultra law volume samples into the inlet end. A gas injection assembly can be used to increase the pressure on the inlet end of the spray capillary to encourage movement of the sample through the spray capillary. The spray-capillary device is well suited for providing ultra low samples to a mass spectrometer detection device.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences especially for use as to nucleotide repeat disorders. Provided are delivery systems and tissues or organ which are targeted as sites for delivery especially for use as to nucleotide repeat disorders. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex or system especially for use as to nucleotide repeat disorders, as well as methods for the design and of such. Also provided are methods of directing CRISPR complex or system formation in eukaryotic cells especially for use as to nucleotide repeat disorders including with consideration of specificity for target recognition and avoidance of toxicity and editing or modifying a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: To have convenient and highly precise prediction of the shape of a human body after a treatment by calculation processing that includes extracting a feature vector Fnew from face data of a patient as an evaluation subject, selecting a plurality of case patients having feature vectors Fpre(i), extracted from the face data of a plurality of previous patients, obtaining pre-orthodontic facial shape models Hpre(i) and a post-orthodontic facial shape models Hpost(i) in which the faces of the selected previous case patients before and after a treatment have been normalized, obtaining a facial shape model Hnew, and obtaining a three-dimensional predicted facial shape model Hprd, by modifying the facial shape model Hnew of the patient as an evaluation subject, using a vector average difference AVEpost?AVEpre between the pre-treatment and post-treatment facial shape models.

Abstract: The present invention provides a method and a system for detecting the presence of an analyte in a sample. In particular, the present invention provides a system, such as a diagnostic kit, for detecting the presence of an analyte in a sample, comprising (a) a recombinant bacterium or spore expressing one or more recombinant proteins on the surface thereof, wherein the recombinant protein specifically binds to the analyte directly or through a binding agent that specifically binds to the recombinant protein and the analyte, and (b) a signal-producing substance that can be detected.

Abstract: Rapid assessment of microcirculation in tissue to realize closed-loop systems is provided. Microcirculatory assessment systems according to embodiments described herein allow a user to assess changes in local blood flow in microvasculature in real-time using conventional electrical techniques. Some embodiments provide a closed-loop system that allows calibrated doses of electrical stimulation to be delivered in a deep brain stimulation (DBS) system depending on blood flow changes (in specific regions of the brain) being fed back to a controller. The approach described here is readily translatable with very minimal changes to existing hardware. Such closed-loop systems will improve the accuracy of electrode placement in DBS surgery and potentially reduce surgery time, optimize the delivery of electrical stimulation, increase battery life of implantable DBS systems, reduce post-surgical visits to medical practitioners and improve the quality of life of patients.

Abstract: No drug has been available for treating a peripheral sensory neuropathy caused as a side effect by a drug, in particular, by an anticancer drug such as oxaliplatin. A composition for ameliorating peripheral sensory neuropathy, which is characterized by including a Lentinus edodes mycelium extract, ameliorates symptoms induced by the drug such as the anticancer drug, including numbness of extremities, a pain in extremities, a reduction in deep tendon reflection, a reduction in muscle force, allodynia, hyperalgesia, impaired finger fine movement, impaired walking, stumbling, falling, impaired flexion (being difficult or impossible to sit on one's heels, sit cross-legged, sit with one's legs out to one side, sit on a chair, or the like), or paralysis of extremities.

Abstract: A movement-synchronized wellbore inspection system and a movement-synchronization control method thereof are disclosed. The wellbore inspection system comprises a rope-climbing robot, a wire rope, a ground wire rope moving device, a ground wire rope moving track, an underground wire rope moving device, an underground wire rope moving track, an inertial sensor and a control device. An upper end of the wire rope is connected to the ground wire rope moving device, and an lower end of the wire rope passes through the rope-climbing robot and is then connected to the underground wire rope moving device. The control device controls the underground and ground wire rope moving devices to move in synchronization, and then the inertial sensor carried on the rope-climbing robot detects posture data of the wire rope and transmits the data to the control device.

Abstract: A system to provide circadian-friendly lighting for nighttime hospital care comprising a lighting module and a transmitter tag that interface wirelessly wherein the lighting module comprises red-shifted light spectra, which is proven to be less disruptive to melatonin production than current blue-shifted hospital lighting; wherein the light output of the devices is modulated by the proximity of a tag to the device, with light intensity increasing with closer proximity between these two components and decreasing with increased distance, thereby providing hands-free lighting to caregivers in the specific locations where they need light to perform care tasks.

Abstract: The present disclosure relates to a compound represented by Chemical Formula 1, a probe for detecting antibiotic-resistant bacteria, which includes the compound, a composition containing the compound, a kit including the compound and a method for detecting antibiotic-resistant bacteria. A compound probe having a carbapenem structure and including a linker and a fluorophore can detect beta-lactamase or carbapenemase at high sensitivity and, therefore, can be applied to various biochemical researches. In addition, the compound probe can clinically detect carbapenemase-producing antibiotic-resistant bacteria and allows molecular diagnosis of antibiotic-resistant bacterial infectious diseases and analysis of antibiotic-resistant bacteria from a target sample at high sensitivity. Therefore, it can be effectively used for medicinal uses such as in-vitro diagnosis.

Abstract: A method for verifying a drone included in an industrial Internet of Things (IIoT) system, using a petri-net modeling is disclosed. In an embodiment, the method includes a step of modeling the IIoT system as a hierarchical petri-net (modeling step); and a step of verifying whether the drone has security vulnerability on the basis of the hierarchical petri-net model (verification step), wherein the verification step can determine that a drone has security vulnerability when at least one of a plurality of determination factors provided as places to the hierarchical petri-net model determines that the drone is operating abnormally.

Abstract: Compositions and methods for inhibiting fungal pathogen growth in honey bee colonies are provided. In particular, compositions include at least one strain of Parasaccharibacter apium (P. apium), a supernatant of the one or more strains of P. apium, or a combination of the one or more strains of P. apium and the supernatant of the one or more strains of P. apium. One or all of the strains of P. apium can be resistant to one or more antibiotics (e.g., kanamycin), and may include an exogenous antibiotic resistance-conferring transposon, gene, or functional fragment thereof. Also provided are methods, the methods generally including the step of applying an effective amount of a composition to a honey bee colony. Compositions can be fed to the bees, deposited on the hive frame, deposited on at least one surface or element within the hive, or a combination thereof.

Abstract: Systems and methods for monitoring eye health. The systems and methods monitor eye health by measuring scleral strain by way of an implantable monitor, a wearable monitor configured in eyeglasses, or an external monitor using a portable tablet computing device. Certain embodiments of the strain monitor may be utilized to measure the strain on any surface to which it is attached, including, but not limited to, the skin of a patient or the surface of a structure such as a building or a bridge.

Abstract: The present disclosure provides compositions and methods for treating demyelinating conditions. More particularly, the present disclosure relates to compositions comprising a DUOC-01 cell product; methods for preparing such compositions; and methods of using such compositions for treating demyelinating conditions.

Abstract: An apparatus including a controllable fluid-contacting surface is provided. In another aspect, the present apparatus includes a flexible membrane and multiple actuators each having an output shaft or activation member coupled to a water-contacting membrane, with the shafts extending in a direction offset from the nominal outer surface of the membrane. A further aspect of the present apparatus includes an underwater vessel including a propulsion source, a flexible membrane having a water-contacting outer surface and an electronic controller including programmable software for actuating the actuators.

Abstract: Examples of active millimeter-wave imaging systems are described which may utilize modulation schemes to provide illumination signals. The use of modulation techniques may allow for the use of direct-conversion receivers while retaining an ability to separate desired received signal from self-jamming and/or DC offset signal(s) generated by the direct-conversion receivers. In some examples, modulation schemes include the use of balanced orthogonal codes which may support MIMO or massive MIMO imaging systems.

Abstract: A hierarchical porous honeycombed nickel oxide microsphere and a preparation method thereof are disclosed. The method includes mixing nickel sulfate hexahydrate, urea, water and glycerol, to obtain a mixed solution; subjecting the mixed solution to a hydrothermal reaction, to obtain a precursor; and calcining the precursor, to obtain the hierarchical porous honeycombed nickel oxide microspheres.

Abstract: Methods of forming carbon polymer films are disclosed. Some methods are advantageously performed at lower temperatures. The substrate is exposed to a first carbon precursor to form a substrate surface with terminations based on the reactive functional groups of the first carbon precursor and exposed to a second carbon precursor to react with the surface terminations and form a carbon polymer film. Processing tools and non-transitory memories to perform the process are also disclosed.

Abstract: According to various embodiments, an all-optical thresholder device is disclosed. The all-optical thresholder device includes a Mach-Zehnder interferometer (MZI) coupled to a Mach-Zehnder coupler (MZC). The MZI includes at least one microring resonator (MRR) and a first tunable element, where the MRR further includes a second tunable element. The MZC includes a third tunable element. The first, second, and third tunable elements are configured to control biases of the all-optical thresholder device to achieve a desired power transfer function.

Abstract: A driving device is provided. The driving device includes a boost inductor and a resonance circuit. The boost inductor receives a first power via a first terminal of the boost inductor in a first mode and provides a second power via a second terminal of the boost inductor. The resonance circuit stores a stored electric energy from the second power in the first mode, so that the boost inductor does not provide the second power in the second mode and drives a transducer by the stored electric energy in the first mode and the second mode.

Abstract: An anode configured for fast charging a lithium-ion battery includes an anode substrate and a coating provided on a surface of the anode substrate for increasing an overpotential of Li metal to inhibit Li metal plating during extreme fast charging a lithium-ion battery fabricated with the anode. The anode is fabricated by a process of applying a coating to the anode substrate surface that comprises a nanolayer of Cu, or a nanolayer of Ni or a composite nanolayer of Cu and Ni.