Abstract: Conductivity-selective lateral etching of III-nitride materials is described. Methods and structures for making vertical cavity surface emitting lasers with distributed Bragg reflectors via electrochemical etching are described. Layer-selective, lateral electrochemical etching of multi-layer stacks is employed to form semiconductor/air DBR structures adjacent active multiple quantum well regions of the lasers. The electrochemical etching techniques are suitable for high-volume production of lasers and other III-nitride devices, such as lasers, HEMT transistors, power transistors, MEMs structures, and LEDs.

Abstract: A semiconductor device has gate-all-around devices formed in respective regions on a substrate. The gate-all-around devices have nanowires at different levels. The threshold voltage of a gate-all-around device in first region is based on a thickness of an active layer in an adjacent second region. The active layer in the second region may be at substantially a same level as the nanowire in the first region. Thus, the nanowire in the first region may have a thickness based on the thickness of the active layer in the second region, or the thicknesses may be different. When more than one active layer is included, nanowires in different ones of the regions may be disposed at different heights and/or may have different thicknesses.

Abstract: Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.

Abstract: A crop yields sensing system comprises a first sensor of a first type associated with a portion of a harvester to output first signals facilitating determination of crop yield and a second sensor of a second type different than the first type to output second signals facilitating determination of crop yield for the portion of the harvester. The system further comprises a processing unit to receive the first signals and the second signals and determine crop yield for the portion of the harvester based on a combination of the first signals and the second signals.

Abstract: Tracers that can be used for PET or SPECT imaging of the distribution of Pgp are disclosed. The tracers are metalloprobes that can comprise a radioactive metal ion such as 67Ga or 68Ga. Methods of synthesizing the tracers, and methods of imaging heart and other tissues are also disclosed. The tracers can be used to obtain high signal-to-background ratios for imaging tissues in vivo such as heart or tumor tissue. In various embodiments, disclosed tracers can exhibit, a) enhanced first pass extraction into heart tissue compared to presently available probes, b) linearity with true blood flow, c) enhanced detection of myocardial viability compared to presently available probes, d) reduced liver retention compared to presently available probes, and e) more efficient clearance from non-cardiac and adjoining tissues compared to presently available probes.

Abstract: The present method includes a data acquisition process and tomographic image generation processes. In the data acquisition process, holograms of an object light and so forth are acquired for each light with a wavelength by changing the wavelengths of the illumination light, off-axis spherical wave reference light, and inline spherical wave reference light. In the tomographic image generation process, a reconstructed light wave of the object light and a reconstructed light wave of the illumination light on a reconstruction surface are generated from these holograms. A reconstruction light wave with adjusted phase is added up for each wavelength to generate a tomographic hologram. From this, an accurate and focused tomographic image without distortion can be generated.

Abstract: Provided herein is a method for diagnosing/prognosing a metastatic cancer in a subject by measuring and detecting one or more of CS-ANXA2, DCAMKL, Lgr5 or CS-ANAX2 and DCAMKL or CS-ANXA2 and Lgr5 positive circulating tumor stem cells in the subject's blood or plasma. Also provided is a method for distinguishing the presence of early stage primary cancer from advanced stage metastatic cancer in the subject by measuring and detecting AnnexinA2, CS-ANXA2 and DCAMKL?1 or Lgr5 in the blood or plasma. In addition, there is provided a method for distinguishing the presence of benign, pre-cancerous tumorous growths or cancerous tumors in the subject by measuring and detecting AnnexinA2 and circulating tumor stem cells positive for CS-ANXA2 and DCAMKL or CS-ANXA2 and Lgr5 in the blood or plasma.

Abstract: Intravenous ferumoxytol is used to effectively label mesenchymal stem cells (MSCs) in vivo and is used for in vivo tracking of stem cell transplants with magnetic resonance (MR) imaging. The method eliminates risk of contamination and biologic alteration of MSCs associated with ex-vivo-labeling procedures.

Abstract: A neuroinhibitory substance for use in a method for treating or preventing headache comprising injecting a neuroinhibitory substance such as botulinium toxin in close proximity to the sphenopalatine ganglion or otic ganglion wherein an injection device comprising said neuroinhibitory substance is brought into close proximity to the sphenopalatine ganglion or otic ganglion by inserting said injection device into the patient transnasally or infrazygomatically and the neuroinhibitory substance injected in close proximity to the SPG or OG.

Abstract: The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also describes methods of screening for compounds that can be used to prevent or treat periodontitis or diseases associated with periodontitis.

Abstract: A method of representing visual images by alternative senses is provided herein. The method includes the following stages: obtaining an image of an environment having a background and physical objects distinguishable from the background; slicing the image into a plurality of slices; identifying, for each slice at a time, and slice by slice in a specified order, if at least a portion of the physical objects being contained within the slice; applying, in the specified order, a conversion function to each identified portion of the physical objects for generating a sound or tactile object-dependent signal; associating a sound or tactile location-dependent signal unique for each slice; superpositioning, in the specified order, each object-dependent signal with a respective location-dependent signal for creating a combined object-location signal; and outputting the combined object-location signal to a user via an interface in a form usable for a blind or visually impaired person.

Abstract: Provided is a method for room-pressure and low-temperature preparation of graphene, comprising: heat treating a compound of graphite oxide and sulfuric acid in either room pressure or negative pressure at a temperature between 50 and 400° C., thus converting graphite oxide into graphene. Also provided is a method for low-temperature preparation of a graphene composite material. The acquired graphene and graphene composite material are applicable in optical materials, electrically-conductive materials, sensor materials, catalytic materials, battery materials, and supercapacitor materials.

Abstract: Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The cross-linked polycarbonates can be prepared from allyl or epoxy polycarbonates. Described herein is the formation of functionalized poly(carbonate) particles with an established intermolecular cross-linking process. Six types of ‘nanosponges’ were prepared with the differentiation in crosslinking density and crosslinking chemistry. The intermolecular chain cross-linking process was investigated via the epoxide amine reaction and the thiol-ene click reaction.

Abstract: Provided is a phase change memory device including a graphene layer inserted between a lower electrode into which heat flows and a phase change material layer, to prevent the heat from being diffused to an outside so as to efficiently transfer the heat to the phase change material layer, and a method of fabricating the phase change memory device. The phase change memory device includes a lower electrode; an insulating layer formed to enclose the lower electrode; a graphene layer formed on the lower electrode; a phase change material layer formed on the graphene layer and the insulating layer; and an upper electrode formed on the phase change material layer. Since a phase of the phase change material layer is changed at a small amount of driving current, the phase change memory device is fabricated to have a high driving speed and a high integration.

Abstract: Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

Abstract: A recombinant polypeptide is described including at least one PUF RNA-binding domain capable of specifically binding to a cytosine RNA base. The PUF RNA-binding domain of the polypeptide includes at least one RNA base-binding motif of the general formula X1X2X3X4X5X6X7X8X9X10X11 wherein X1 is selected from a defined group and wherein the RNA base-binding motif is operably capable of specifically binding to a cytosine RNA base.

Abstract: A gas reactor device includes a plurality of microcavities or microchannels defined at least partially within a thick metal oxide layer consisting essentially of defect free oxide. Electrodes are arranged with respect to the microcavities or microchannels to stimulate plasma generation therein upon application of suitable voltage. One or more or all of the electrodes are encapsulated within the thick metal oxide layer. A gas inlet is configured to receive feedstock gas into the plurality of microcavities or microchannels. An outlet is configured to outlet reactor product from the plurality of microcavities or microchannels. In an example preferred device, the feedstock gas is air or O2 and is converted by the plasma into ozone (O3). In another preferred device, the feedstock gas is an unwanted gas to be decomposed into a desired form. Gas reactor devices of the invention can, for example, decompose gases such as CO2, CH4, or NOx.

Abstract: Provided are anti-human ?-synuclein-specific binding molecules, e.g., antibodies or antigen-binding fragments, variants or derivatives thereof, as methods related thereto. Further provided are anti-human ?-synuclein binding molecules which bind to specific N-terminal and C-terminal epitopes on human ?-synuclein. The binding molecules described herein can be used in pharmaceutical and diagnostic compositions for ?-synuclein targeted immunotherapy and diagnosis, respectively.

Abstract: A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.

Abstract: The present invention relates to a method of preparing high crystalline polythiophene nanowire used for organic solar panels, including the following steps: A. a 0.001-40 wt % polythiophene solution is prepared; B. a 0.01-10 wt % carbon nanomaterial suspension is prepared and a 0.001-5 wt % dispersant is added to the suspension to generate a carbon nanomaterial dispersion; C. The foregoing carbon nanomaterial dispersion is added to the polythiophene solution and the resulting mixture is let stand under atmospheric pressure at ?10˜45° C. for 20˜400 min so that polythiophene molecules are able to be adsorbed and stacked up on the surface of carbon nanomaterials to generate polythiophene nanowires. Owing to high alignment order and high crystallinity, the polythiophene nanowire is helpful for elevating light conversion efficiency of organic solar panels.