Abstract: A wind turbine platform configured to float in a body of water and support a wind turbine thereon includes a buoyant hull platform. A wind turbine tower is centrally mounted on the hull platform and a wind turbine is mounted to the wind turbine tower. An anchor is connected to the hull platform and to the seabed, and a weight-adjustable mass is suspended from the hull platform.

Abstract: A mixture of carbazole and triazine derivatives that can be thermally evaporated from one crucible to fabricate thin films for electroluminescent devices is disclosed.

Abstract: Conjugated polymer-based organic field-effect transistors have garnered attention since the solution processability of the semiconductor material raises the possibility of lower device fabrication costs, and considerable progress has been made on achieving high mobility systems. Further improvements in charge carrier mobility while using non-specialized deposition techniques and minimizing the volume of semiconductor used in the fabrication process are important considerations for practical implementation. Here, a method of fabricating devices is disclosed that uses a technique (for example, a scalable blade-coating technique) to cast polymer thin film devices from blend solutions with one component being the polymer semiconductor and the other being a commodity polymer. Even when mixing the semiconducting polymer with 90% polystyrene by weight, an average mobility of 2.7±0.4 cm2V?1s?1 can be obtained.

Abstract: A method for making an implantable lead is related. A pipe is provided. The pipe includes a first end portion, a second end portion opposite to the first end portion, and a middle portion connecting the first end portion and the second end portion. A flexible conductive layer is formed on the middle portion of the pipe. At least one contactor is applied on the first end portion of the pipe. At least one connector is applied on the second end portion of the pipe. At least one wire is placed in the pipe to electrically connect the at least one contactor and the at least one connector.

Abstract: The present disclosure includes: a data processing method of a software defined network (SDN) controller included in a SDN, wherein the SDN controller is connected to legacy network access equipment, an edge switch, and base network access equipment, and includes: (a) receiving an access request of user equipment transmitted by the legacy network access equipment through the edge switch connected to the legacy network access equipment; (b) setting initial access of the user equipment through a legacy network service module included in the SDN controller in response to the access request of the user equipment; (c) generating an access path for a base network on the basis of a base network service module included in the SDN controller upon completion of the initial access setup; and (d) requesting the edge switch to generate an entry for the access path upon generation of the access path.

Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

Abstract: Ocular diseases affecting the macula or the vasculature of the eye affect a wide variety of individuals. In particular, Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a significant genetic predisposition. Methods of analyzing one or more mutations in the HtrA1 gene in order to identify individuals with a presusceptability to development of an ocular disease and a pathologic condition of the eye and diagnose those currently suffering from an ocular disease or a pathologic condition of the eye are provided. The methods of the present invention may further include analysis of the CFH gene in order to identify individuals with a presusceptability to development of an ocular disease and a pathologic condition of the eye and diagnose those currently suffering from an ocular disease or a pathologic condition of the eye. Compositions and methods for treating ocular disease and pathologic conditions of the eye are also provided.

Abstract: Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

Abstract: Disclosed herein are novel amine-functionalized porphyrin compounds, as wells as pharmaceutically acceptable salts or esters thereof. The disclosed compounds can be used to impart antioxidant, anti-inflammatory, anti-microbial, and/or cell-adhesion specificity to a surface or material in need thereof, such as a surface of an indwelling medical implant, or a marine surface.

Abstract: The present disclosure provides a full-duplex wireless communication method, an antenna device and a full-duplex wireless communication system. The method includes steps of: within a training period, acquiring a relevant parameter for cancelling a self-interference signal from an antenna itself as a first estimated value, and a relevant parameter for cancelling a cross-interference signal between the antenna and the other antenna as a second estimated value; and within a data transmission period, receiving and transmitting signals simultaneously by the antenna using an identical frequency, cancelling the self-interference signal from the antenna itself in accordance with the first estimated value, and cancelling the cross-interference signal between the antenna and the other antenna in accordance with the second estimated value.

Abstract: The integrity verification system includes a client and an RCE server. The client requests an RCE service to the RCE server using a pointer of a return function as a parameter of a service call function and transmits a memory code of the return function to the RCE server when Reverse-RCE for obtaining the memory code of the return function is requested from the RCE server. The RCE server generates a first hash key of the transmitted memory code, compares the first hash key to a stored second hash key of the memory code of an original return function, generates a return value according to a compared result between the first hash key and the second hash key and transmits the generated return value to the client using the generated return value as a parameter of the service call function. The client executes the return function using the return value as a parameter of the return function.

Abstract: This disclosure describes devices, system, and a method for the prediction and prevention of acute decompensated heart failure or other patient conditions involving fluid accumulation in legs or hands. In one example, a wearable device contains a drift-free leg-size sensor and a tissue-elasticity sensor. Both sensors may be relatively inexpensive and developed using innovative new sensing ideas. Preliminary tests with the sensor prototypes show promising results: the leg-size sensor is capable of measuring 1 mm changes in leg diameter and the tissue-elasticity sensor can detect 0.15 MPa differences in elasticity. In another example, a wearable system includes sensors for measuring a variety of physiological parameters, a processing module, and a communication module. A low-profile instrumented sock, e.g., a wearable device, with multiple sensors can provide an indication of heart failure status for a patient.

Abstract: The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ?95% of them contain the identical mutation.

Abstract: This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3?-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods of nucleic acid sequencing employing the nucleotide analogue.

Abstract: The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine, oxcarbazepine or another carbamazepine-like compound. It is based, at least in part, on the discovery that, in cells having a genetic defect in ?1-antitrypsin, carbamazepine was able to decrease levels of the mutant protein. Furthermore, carbamazepine reduced the hepatic load of mutant ?1-antitrypsin and the toxic effect of that mutant protein accumulation, hepatic fibrosis, in vivo using a mouse model of the disease. As patients having this defect in ?1-antitrypsin exhibit toxic accumulations of the protein, treatment according to the invention may be used to ameliorate symptoms and signs of disease.

Abstract: Provided according to embodiments of the invention are methods of monitoring air obstruction in an individual that include obtaining at least one calibration photoplethysmography (PPG) signal stream from the individual while the individual spontaneously breathes through at least one resistor having a known resistance; using a processing device to determine changes in the at least one calibration PPG signal stream in response to an increase in resistance to the individual's breathing; obtaining a monitoring PPG signal stream from the individual during spontaneous breathing; and using the monitored PPG signal stream to determine a calibrated resistance value, and using the calibrated resistance value to determine a level of obstruction of the individual's breathing. Related devices are also provided herein.

Abstract: Disclosed herein are devices comprising a solid state gas sensor comprising a catalyst and a detection component capable of sensing halogenated gases through an increase or decrease in electrical conductivity. Further disclosed herein are methods of detecting one or more halogenated organic compounds, comprising providing a device comprising a solid state gas sensor comprising a catalyst and a detection component capable of sensing halogenated gases through an increase or decrease in electrical conductivity, and using the device to detect one or more small solid state halogenated organic compounds. Also disclosed herein are various methods of treating asthma in an individual.

Abstract: Various arrangements for identifying and grading cancer in tissue samples are presented. A digital image of a stained tissue sample may be acquired. A Shearlet transform may be performed on the digital image of the stained tissue sample. Shearlet coefficients may be calculated based on the performed Shearlet transform of the normalized digital RGB image of the stained tissue sample. A trained neural network may be applied to create a plurality of feature maps using the digital image and Shearlet coefficients, wherein the trained neural network was trained using a plurality of images and Shearlet coefficients of a plurality of digital images. A classifier may be applied to an output of the trained neural network to identify whether cancer is present in the stained tissue sample. A notification may be output that is indicative of a grade of detected cancer in the sample.

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.