Abstract: An intracerebral current simulation method including a first step of providing head image data; a second step of forming a three-dimensional brain model including micro-polyhedron units; a third step of providing first information which includes conditions under which a coil is placed on a patient's head, an electric current is applied to the coil, and the patient's reaction to the magnetic stimulation is observed, the conditions including a position and orientation of the coil, an electric current applied to the coil, and a structure relating to a generated magnetic field of the coil; and a fourth step of calculating an eddy current or electric field induced inside each of the micro-polyhedron units on the basis of the first information provided in the third step and second information which includes conductivity assigned to each micro-polyhedron unit. Also disclosed is a transcranial magnetic stimulation device and system.

Abstract: In some embodiments, a cell collection device includes a sample brush including a proximal end, a distal end, and outwardly extending bristles provided at the distal end, and an outer sleeve adapted to receive the sample brush, the sleeve including a proximal end and a distal end, wherein the sleeve can be linearly slid along the length of the brush to encapsulate the bristles after they have been used to collect cells from a patient.

Abstract: In one embodiment, a hybrid foil bearing includes a bearing sleeve, multiple inner foils provided within the sleeve, the foils having gas outlets from which pressurized gas can be injected into an interior of the bearing, and integrated gas flow paths that radially extend through the bearing sleeve and deliver the gas to the gas outlets.

Abstract: A computer-implemented method for the label-free classification of cells using image cytometry is provided. In some exemplary embodiments of the computer implemented method, the classification is the classification of the cells, such as individual cells, into a phase of the cell cycle or by cell type. A user computing device receives as an input one or more images of a cell obtained from a image cytometer. The user computing device extracts features form the one or more images, such as brightfield and/or darkfield images. The user computing device classifies the cell in the one or more images based on the extracted features using a cell classifier. The user computing device then outputs the class label of the cell, as defined by the classifier.

Abstract: Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure, restoring glucose tolerance and/or preventing glucose intolerance and/or maintaining glucose homeostasis and/or increasing insulin sensitivity and/or preventing weight gain and/or inducing or enhancing weight loss, treating dyslipidemia, treating hypertestosteronism or hyperandrogenism, and/or treating type 2 diabetes in an individual in need thereof are provided.

Abstract: Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for using this enzyme are described.

Abstract: An adhesive composition that is capable of functioning alone as an adhesive component without using a curable resin, and adhering to integrate an inorganic material and an organic material, and a composite material using the same. The adhesive composition contains an adduct containing an acidic phosphate ester comprising one or more kinds of compounds represented by General Formulae (1) and (2), and a metal. The composite material includes one material, the other material, and an adhesive composition disposed between the materials to adhere to the materials, the one material and the other material being integrated by the adhesive composition. P(?O)(—OR1)(—OH)2 . . . (1), and P(?O)(—OR1)2(—OH) . . . (2), where R1 represents an aliphatic hydrocarbon group having 4 to 30 carbon atoms, and has one or more branched chain structures, or one or more carbon-carbon double bond structures.

Abstract: The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and/or prevention of a metastatic cancer wherein the agent an extracellular matrix (ECM) protein carried on a polycarbonate polyurethane matrix. The invention also relates to a product, comprising an agent for modulating metastatic tumor cell dissemination, and to a method of treatment or prevention of cancer.

Abstract: A DC/DC power converter provides high voltage gain using integrated boost and voltage multiplier (VM) stages. The boost cell operates according to a switching sequence to alternately energize and discharge a primary winding. A VM cell electrically coupled to the primary winding of the boost cell charges a multiplier capacitor to a DC output voltage greater than the input voltage when the primary winding is energized and discharges the multiplier capacitor when primary winding is discharged.

Abstract: (E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.

Abstract: Disclosed herein are biomaterials that include a plurality of fibers embedded in a matrix of hydrogel material. The plurality of fibers and hydrogel material are formed during one process step. In one embodiment, the plurality of fibers and hydrogel materials are formed using a multilayer coextrusion process step. Additional process steps can be performed to form a tissue engineering scaffold. Such a scaffold can be used to grow biological matter. In one embodiment, stem cells are applied to the scaffold to grow biological material. Process steps can be controlled to determine certain mechanical properties of the resulting biomaterial. In one embodiment, the process steps are controlled to determine the stiffness of the resulting biomaterial. In such an embodiment, the stiffness of the resulting biological material determines physical properties of the biological material grown on the scaffold.

Abstract: An object is to provide a thermotolerant yeast capable of assimilating xylose to produce ethanol or a mutant strain thereof and a method for producing ethanol by assimilation of xylose. There is used a yeast, Kluyveromyces marxianus strain No. 21 (accession number: NITE BP-01739), or a mutant strain thereof that has xylose assimilation ability and ethanol production ability when cultured at 30° C. under aerobic conditions using a culture medium containing xylose as a sugar source. Also performed is a method for producing ethanol, comprising culturing the yeast or the mutant strain thereof under aerobic conditions using a culture medium containing xylose as a sugar source.

Abstract: Provided is a method for producing a polyisoprenoid, which can increase natural rubber production by enhancing the rubber synthesis activity of rubber particles. The present invention provides methods for producing a polyisoprenoid using a gene coding for a cis-prenyltransferase (CPT) family protein, a gene coding for a Nogo-B receptor (NgBR) family protein and a gene coding for a rubber elongation factor (REF) family protein, specifically a method for producing a polyisoprenoid in vitro using rubber particles bound to proteins coded for by these genes, and a method for producing a polyisoprenoid in vivo using a recombinant organism (plant) having these genes introduced therein.

Abstract: An actuator (12) includes a moving member (18) pivotally connected to a base unit (14) for rotation about an axis. The driving force for rotation of the moving member (18) relative to the base unit (14) is provided by a pair of antagonistically operating shape memory alloy (SMA) wires (48, 50) and transmitted via a torsional spring (56). An endoscope, or a snake-like robot (66), may include one or more of the actuators (12).

Abstract: A smart sensor network for power grid health monitoring includes a plurality of spaced sensors that are magnetically coupled to the power transmission line to be monitored. The sensors include a signal injection unit and a signal sensing unit. As such, one of the sensors acts to inject, via its signal injection unit, a high frequency signal through the magnetic coupling into the power transmission line, while sensors on either side of the signal injecting sensor act to block the injected signal, which is then detected by the signal sensing unit of the injecting sensor, and is used to measure the impedance of the power transmission line segment being analyzed. Based on the difference between a pre-measured impedance of the power transmission line being monitored and the actual impedance value of the power transmission line being measured by the sensor, the health of the power line can be obtained.

Abstract: Methods, media, and systems for securing communications between a first node and a second node are provided. In some embodiments, methods for securing communication between a first node and a second node are provided. The methods comprising: receiving at least one model of behavior of the second node at the first node; and authorizing the first node to receive traffic from the second node based on the difference between the at least one model of behavior of the second node and at least one model of behavior of the first node.

Abstract: Provided herein are compositions, kits and methods related to permitting a human or non-human primate subject to receive multiple doses of recombinant adeno-associate virus (rAAV) vectors. In some aspects, provided herein are methods comprising administering an anti-CD20 antibody, optionally in combination with an mTOR inhibitor, to the subject to permit multiple doses of an rAAV vector to be administered.

Abstract: Novel antimicrobial compounds and associated methods of development are presented herein.

Abstract: A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also may include a stimulus delivery mechanism positioned between the proximal end and the distal end and an induction coil operably coupled to the stimulus delivery mechanism. Further, the device may include an external controller wirelessly coupled to the induction coil for inductively transferring energy to the induction coil.

Abstract: A compound having the formula: wherein n, y, R1 and R2 are defined herein, and others, methods of making of and using, and compositions made thereby which have an antimicrobial resistance effect are described.