Abstract: This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxa-diazole-5-carboxamide compound, salt, or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N-benzylidene-acetohydrazide compound is 3-(3,5-dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide.

Abstract: Zeolites having highly dispersed bimetallic clusters, uniformly distributed in size and composition, encapsulated therein are disclosed. Metal encapsulation and alloying is conferred by introducing ligated metal cation precursors into zeolite synthesis gels, which are subsequently crystallized hydrothermally to form zeolites with metal cations occluded in the pores. The ligated cations are anchored to the zeolite framework via siloxane bridges which enforces their uniform dispersion throughout the zeolite crystals. Treatment of the crystallized zeolites in O2 and then H2 forms bimetallic clusters, which remain narrowly distributed in size and composition.

Abstract: A ligand-responsive hammerhead ribozyme is provided. In some embodiments, the ribozyme comprises: i. a first loop that has been replaced by an RNA aptamer that binds to a ligand; and ii. a second loop comprising a modified sequence, wherein the aptamer and the second loop interact in a ligand-dependent manner and autocatalytic cleavage of the ribozyme is ligand-responsive.

Abstract: A protection system capable of safely quenching a high temperature superconductor (HTS) magnet coil. The protection circuit provides for a frequency loss induced quench design that advances the protection technology for HTS magnet coils and provides a protection system that is capable of quickly distributing the heat energy uniformly in all the coil sections when a localized hot-spot is created.

Abstract: The present invention provides a method for self-replication of multimers of nucleic acid origami tiles by exponentially amplifying the multimer from initial seeds of monomeric units of nucleic acid origami tiles and also provides for the selective exponential amplification of a designated multimer, such as with specific properties or characteristics, over one or more competing multimers in the presence of a mixture of monomers for each of the possible multimers. The selection of the designated multimer based on an environmental change allows the designated multimer to outgrow all competing multimers.

Abstract: The present invention relates to nanoparticle compositions and, in particular, to composite polymeric nanoparticle compositions. A composite nanoparticle described herein comprises a photoluminescent polymeric component and a photo-thermal polymeric component. The photoluminescent polymeric component and the photo-thermal polymeric component can each comprise a single polymeric species or multiple polymeric species.

Abstract: A method for detecting rare genomic variants in a population of cells is disclosed. The method can detect de novo mutations in bacteria and analyze the impact of various physiological conditions on mutation rate, even though such effects would be too subtle to detect using other methods. The method can be used for detection of low-frequency subpopulations in the microbiome or in cancer.

Abstract: A system and method for increasing the capacity of a Multiple-Input Multiple-Output (MIMO) system at desired user's locations and reducing the capacity at locations, other than that of the desired user, while also providing secrecy. Knowing the channel coefficient between each transmitter and receiver antenna pair at the transmitter, the method of the present invention calculates the artificial signal that minimizes the Euclidean distance between the desired and received data symbols if the precoding/combining matrix pair from the set that has the minimum Euclidean distance to the singular value decomposition (SVD) of the channel matrix is used for transmission and reception. The artificial signal may be fed to the precoder, instead of the actual desired data symbols, or may be transmitted directly to reduce computational complexity, power consumption and processing delay if the hardware configuration allows.

Abstract: A beamformer for performing analog beamforming of ultrasound signals received from a plurality of transducer devices, the beamformer includes: first analog devices configured to output first ultrasound signals by delaying or transmitting the ultrasound signals based on a predetermined delay time; second analog devices configured to store first sub-ultrasound signals from among the first ultrasound signals, and to output the first sub-ultrasound signals depending on whether the first sub-ultrasound signals are repeatedly used; and a processor configured to control the delay time, and to perform the analog beamforming by summing the first ultrasound signals which correspond to the plurality of transducer devices and which are outputted depending on the delay time.

Abstract: Presenting a visualization of antenna radiation patterns may include sending a request to a server for up-to-date information regarding an antenna mode; receiving the request at the server and reading a register value for the antenna mode; responding, by the server, with updated antenna mode information; and overlaying antenna radiation patterns on an image based on the mode information.

Abstract: The present disclosure discloses the laminated ceramic chimp component including an element part having a ceramic main body and an internal electrode placed in the ceramic main body; an external electrode part having a first external electrode and a second external electrode, the first and second external electrodes being provided with side electrodes covering both side surfaces of the ceramic main body, respectively, upper electrodes covering portions of both sides of an upper surface of the ceramic main body, respectively, and lower electrodes covering portions of both sides of a lower surface of the ceramic main body, respectively; and a nano thin film layer formed of electric insulation material and applied to a region including the upper electrodes, the method for manufacturing the same and the atomic layer deposition apparatus for the same.

Abstract: Disclosed are various embodiments for estimating the flow of blood through a blood vessel in a region of interest. Passage of a bolus of fluid through an imaged blood vessel over a period of time is tracked by a computing device. The computing device fits the tracked passage of the bolus of fluid to a modeled passage of the bolus of fluid. The computing device then estimates a volume of blood flow through the imaged blood vessel based at least in part on a fit of the tracked passage of the bolus of fluid to the modeled passage of the bolus of fluid.

Abstract: A traveling wave parametric amplifier involving a series of Josephson junctions is disclosed. Devices and systems incorporating traveling wave parametric amplifiers, and methods of using and fabricating traveling wave parametric amplifiers are also disclosed. In accordance with one or more aspects, traveling wave parametric amplifiers, devices and systems incorporating traveling wave parametric amplifiers, and methods of using and fabricating traveling wave parametric amplifiers are disclosed.

Abstract: Optical flow is measured between a first image and a second image by evaluating a match quantifying parameter in respect of a set of candidate flow vectors. The set of candidate flow vectors includes one or more flow vectors selected in dependence upon one or more neighbor flow vectors associated with one or more neighboring pixels to the given pixel which have previously calculated respective match quantifying parameters indicative of closest matches for the one or more neighboring pixels. The set of candidate flow vectors also includes adjacent flow vectors corresponding to target pixels surrounding the target pixels identified by the neighbor flow vectors. One or more randomly selected random flow vectors is also added to the set of candidate flow vectors. The calculated match quantifying parameters are weighted in dependence upon whether the corresponding candidate flow vector is similar to any other candidate flow vector.

Abstract: A space vector pulse width modulation (SVPWM) method for suppressing a common-mode voltage of a multiphase motor includes the following steps: (1) dividing all basic vectors of the multiphase motor into q types, and selecting therefrom x types having equal common-mode voltage magnitude of which an absolute value is smallest; (2) for each type in the x types of basic vectors, structuring y classes of auxiliary vectors according to an optimization model; (3) synthesizing reference vectors by virtue of the auxiliary vectors to obtain functioning time of basic vectors functioning in each switching period; and (4) obtaining an optimal functioning sequence of the basic vectors functioning in each switching period with fewest switching operations of a converter as a purpose. The present invention may effectively suppress a magnitude and frequency of the common-mode voltage of the multiphase motor without increasing calculation complexity or reducing other performance indexes.

Abstract: The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional neural tissues for use in methods including regenerative medicine, wound repair and transplantation.

Abstract: Helical carbon nanotubes and the chemical functionalization of helical carbon nanotubes for use in high-performance multifunctional nanocomposite materials are described. Various processes of preparing functionalized helical carbon nanotubes and materials incorporating these nanotubes are also described.

Abstract: A method of forming a one-dimensional nanoarray of In2O3 nanowires on indium foil is disclosed. The nanowires of In2O3 have diameters of 30 nm-50 nm and lengths of 100 nm-200 nm, and are attached to and substantially perpendicular to the surface of the indium foil. The In2O3 nanoarray may have a nanowire density of 200-300 nanowires per ?m2 indium foil and a band gap energy of 2.63-3.63 eV. The In2O3 nanoarray may be formed by anodization of indium foil in an electrochemical cell subjected to a voltage of 15-25 V at room temperature.

Abstract: A lithium ion secondary battery having excellent durability is provided. The lithium ion secondary battery includes: a positive electrode including a current collector made from aluminum; a negative electrode; and an electrolytic solution. The electrolytic solution contains an electrolyte including a lithium salt, and a linear carbonate represented by general formula (2) below, the linear carbonate is contained at a mole ratio of 3 to 6 relative to the lithium salt, and the electrolyte includes a first lithium salt represented by general formula (1) below and an alkali metal salt selected from general formulas (A) to (D) below.

Abstract: A culture system for co-culturing a first cell group consisting of one or more kinds of cells and a cell layer or tissue formed of a second cell group consisting of one or more kinds of cells different from the former cells comprising: a first culture tank for co-culturing under anaerobic conditions the first cell group consisting of one or more kinds of cells and the cell layer or tissue formed of the second cell group consisting of one or more kinds of cells; a second culture tank for pooling a liquid culture medium of aerobic conditions; one or more substance-exchange structures that are disposed so as to connect the first culture tank to the second culture tank; and the aforesaid cell layer or tissue that is disposed so as to cover the surface on the first culture tank side of the substance-exchange structure(s).