Patents Assigned to University
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Patent number: 8822462Abstract: Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds of the general Formulas A-J, and pharmaceutically acceptable salts, esters, prodrugs or derivatives thereof are disclosed.Type: GrantFiled: January 28, 2010Date of Patent: September 2, 2014Assignee: Emory UniversityInventors: Stephen F. Traynelis, Dennis C. Liotta, Rose M. Santangelo, Ethel C. Garnier
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Patent number: 8822671Abstract: A 2?-modified ribonucleoside having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. A modified form of RNA having a halogen-substituted alkoxymethyl protective group exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2?-O-methyl modified nucleic acid.Type: GrantFiled: November 28, 2011Date of Patent: September 2, 2014Assignees: The University of Tokyo, Chiralgen, Ltd.Inventors: Mamoru Shimizu, Takeshi Wada, Kouichiro Arai
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Patent number: 8823045Abstract: A light emitting diode includes a graphene layer, a first semiconductor layer, an active layer, a second semiconductor layer, a first electrode and a second electrode. The first semiconductor layer, the active layer, and the second semiconductor layer are stacked with each other in sequence. The first electrode is located on and electrically connected with the second semiconductor layer. The second electrode is located on and electrically connected with the first semiconductor layer. The graphene layer is located on at least one of the first semiconductor layer and the second semiconductor layer.Type: GrantFiled: November 29, 2012Date of Patent: September 2, 2014Assignees: Tsinghua University, Hon Hai Precision Industry Co., Ltd.Inventors: Yang Wei, Shou-Shan Fan
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Patent number: 8825132Abstract: An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetization. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.Type: GrantFiled: July 4, 2012Date of Patent: September 2, 2014Assignees: Bruker BioSpin GmbH, The University of YorkInventors: Joost Lohman, Simon Benedict Duckett, Gary George Green, Antonio Giuseppe Gianotti
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Patent number: 8822187Abstract: This application relates to the polypeptides, nucleic acid molecules, vectors, transfected cells, and methods for synthesis of triterpenes, including botryococcene.Type: GrantFiled: April 27, 2012Date of Patent: September 2, 2014Assignee: University of Kentucky Research FoundationInventors: Joe Chappell, Thomas D. Niehaus, Shigeru Okada, Timothy P. Devarenne, David S. Watt
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Patent number: 8822367Abstract: Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment, the WOC is a polyoxometalate WOC which is hydrolytically stable, oxidatively stable, and thermally stable. The WOC oxidized waters in the presence of an oxidant. The oxidant can be generated photochemically, using light, such as sunlight, or electrochemically using a positively biased electrode. The hydrogen ions are subsequently reduced to form hydrogen gas, for example, using a hydrogen evolution catalyst (HEC). The hydrogen gas can be used as a fuel in combustion reactions and/or in hydrogen fuel cells. The catalysts described herein exhibit higher turn over numbers, faster turn over frequencies, and/or higher oxygen yields than prior art catalysts.Type: GrantFiled: March 17, 2010Date of Patent: September 2, 2014Assignee: Emory UniversityInventors: Craig L Hill, Yurii V Gueletii, Djamaladdin G. Musaev, Qiushi Yin, Bogdan Botar
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Patent number: 8822411Abstract: The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject.Type: GrantFiled: August 23, 2010Date of Patent: September 2, 2014Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 8822418Abstract: The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; diseases or conditions associated with an abnormal level or activity of collagen VI; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); and disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation.Type: GrantFiled: May 24, 2010Date of Patent: September 2, 2014Assignee: Brown UniversityInventors: Justin R. Fallon, Michael Rafii, Mark A. Bowe, Beth McKechnie, Alison Amenta, Mary Lynn Mercado, Hiroki Hagiwara
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Patent number: 8822421Abstract: The instant invention provides amino acid sequences competing with E2F for DNA binding. Methods of using said amino acid sequences for treatment of hormone-refractory prostate cancer are also provided.Type: GrantFiled: October 14, 2011Date of Patent: September 2, 2014Assignee: Rutgers, The State University of New JerseyInventors: Joseph R. Bertino, Debabrata Banerjee, Tamara Minko, Olga B. Garbuzenko, Xiaoqi Xie, John E. Kerrigan, Emine E. Abali, Kathleen W. Scotto
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Patent number: 8824036Abstract: A thermally stabilized, high speed, micrometer-scale silicon electro-optic modulator is provided. Methods for maintaining desired temperatures in electro-optic modulators are also provided. The methods can be used to maintain high quality modulation in the presence of thermal variations from the surroundings. Direct current injection into the thermally stabilized electro-optic modulator is used to maintain the modulation performance of the modulator. The direct injected current changes the local temperature of the thermally stabilized electro-optic modulator to maintain its operation over a wide temperature range.Type: GrantFiled: March 19, 2010Date of Patent: September 2, 2014Assignee: Cornell UniversityInventors: Sasikanth Manipatruni, Rajeev Dokania, Alyssa B. Apsel, Michal Lipson
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Patent number: 8825257Abstract: An autonomous navigation method is a method of causing a mobile body (100) to autonomously navigate while comparing environmental magnetism data obtained in advance by measuring magnetism generated along a navigation path on which the mobile body (100) navigates and measured magnetism detected by actually measuring the magnetism generated along the navigation path when the mobile body (100) navigates along the navigation path. The method includes a step (a) of detecting first measured magnetism and second measured magnetism in different positions on the mobile body (100) and a step (b) of causing the mobile body (100) to autonomously navigate on the basis of the second measured magnetism detected by a magnetism sensor (103), which is not affected by unexpected magnetism (G) not included in the environmental magnetism data, and the environmental magnetism data.Type: GrantFiled: November 16, 2010Date of Patent: September 2, 2014Assignee: Utsunomiya UniversityInventors: Koichi Ozaki, Rahok Samann
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Patent number: 8823154Abstract: An article and method of using spacer layer regions is provided, containing a gas compound, to reduce gas permeation through barrier films overlying a substrate comprising creating a spacer layer between one or more of the barrier films, wherein the spacer layer comprises at least one inert gaseous compound. In another embodiment, an article and method is provided comprising creating alternating thin films of hybridized sol-gel spin-on glass and PDMS based and olefin based elastomers.Type: GrantFiled: May 7, 2010Date of Patent: September 2, 2014Assignee: The Regents of The University of CaliforniaInventors: Craig J. Hawker, Jimmy Granstrom, Luis M. Campos, Jeffrey A. Gerbec, Motoko Furukawa
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Patent number: 8823596Abstract: The present invention pertains to a monopole slot antenna for multiple input and multiple output comprising a substrate. An antenna module is disposed on the first surface of the substrate and includes a first antenna and a second antenna disposed symmetrically with each other. A first inner monopole slot and a first outer monopole slot are disposed on the first antenna. The first inner monopole slot is formed by connecting a first straight section with a plurality of first bended sections. The first outer monopole slot surrounds the outer periphery of the first inner monopole slot. The second antenna is disposed symmetrical to the first antenna. An isolation unit is defined between the first antenna and the second antenna and has a third straight section and a third bended section. Furthermore, two feeding units are defined on the second surface of the substrate.Type: GrantFiled: October 11, 2012Date of Patent: September 2, 2014Assignee: Southern Taiwan University of Science and TechnologyInventors: Wen-Shan Chen, Chi-Huang Lin
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Patent number: 8822513Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.Type: GrantFiled: August 24, 2011Date of Patent: September 2, 2014Assignees: GTX, Inc., University of Tennessee Research FoundationInventors: Yan Lu, Chien-Ming Li, Zhao Wang, Jianjun Chen, Wei Li, James T. Dalton, Duane D. Miller, Charles Duke, Sunjoo Ahn
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Patent number: 8822707Abstract: Sulfonate leaving groups include a cation chelating moiety, e.g. a polyether or crown ether. The chelating moiety stabilizes the sulfonate leaving group by forming a complex with a cation of a cation-nucleophile combination. The stabilized leaving group is more easily displaced under many conditions than are standard arylsulfonate leaving groups such as the toxyl group. The chelating moiety also favors certain cations depending on the identity of the moiety thereby enhancing the reaction rate with nucleophilic salts containing the preferred cation. Use of the inventive leaving groups results in improved yields, decreased reaction times and improved product purity.Type: GrantFiled: November 14, 2005Date of Patent: September 2, 2014Assignee: Florida Atlantic UniversityInventor: Salvatore Lepore
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Patent number: 8822708Abstract: Triphenylene containing benzo-fused thiophene compounds are provided. Additionally, triphenylene containing benzo-fused furan compounds are provided. The compounds may be useful in organic light emitting devices, particularly as hosts in the emissive layer of such devices, or as materials for enhancement layers in such devices, or both.Type: GrantFiled: December 14, 2012Date of Patent: September 2, 2014Assignee: Universal Display CorporationInventors: Bin Ma, Yonggang Wu, Chun Lin, Raymond Kwong
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Patent number: 8824756Abstract: Systems and methods which implement an image reconstruction framework to incorporate complex motion of structure, such as complex deformation of an object or objects being imaged, in image reconstruction techniques are shown. For example, techniques are provided for tracking organ motion which uses raw time-stamped data provided by any of a number of imaging modalities and simultaneously reconstructs images and estimates deformations in anatomy. Operation according to embodiments reduces artifacts, increase the signal-to-noise ratio (SNR), and facilitates reduced image modality energy dosing to patients. The technology also facilitates the incorporation of physical properties of organ motion, such as the conservation of local tissue volume. This approach is accurate and robust against noise and irregular breathing for tracking organ motion.Type: GrantFiled: June 30, 2010Date of Patent: September 2, 2014Assignee: University of Utah Research FoundationInventors: Sarang Joshi, Jacob Hinkle, Bill Salter, Tom Fletcher, Brian Wang
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Patent number: 8821256Abstract: A game system that is capable of performing a game by employing an information card in place of a conventional paper-based system is provided.Type: GrantFiled: July 16, 2009Date of Patent: September 2, 2014Assignees: Universal Entertainment Corporation, Aruze Gaming America, Inc.Inventors: Kazuo Okada, Jun Fujimoto, Takao Nireki, Kunihiro Manabe, Noritoshi Kukita
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Patent number: 8822190Abstract: The present invention relates to eco-friendly compositions and methods for providing plant growth enhancing formulations comprising mixtures of microbial isolates. In particular, numerous bacterial and fungal strains were isolated from a variety of soil types, from rhizospheres and from root nodules of leguminous plants, in designed combinations, for providing plant growth and plant productivity enhancing formulations. These specifically designed polymicrobial formulations would further provide protection against plant pathogens lowering the need for nitrogen containing fertilizers, solubilize minerals, protect plants against pathogens, and make available to the plant valuable nutrients, such as phosphate, thus reducing and eliminating the need for using chemical fertilizers and chemical pesticides.Type: GrantFiled: January 15, 2009Date of Patent: September 2, 2014Assignee: Board of Trustees of Michigan State UniversityInventors: C. Adinarayana Reddy, Lalithakumari Janarthanam
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Patent number: 8822591Abstract: Disclosed is a pigment dispersion containing at least a pigment, a liquid medium and a high-molecular dispersant. The high-molecular dispersant is a block polymer represented by A-B or A-B-C, in which A, B and C each represent a polymer block and the A and C blocks may be the same or different. The block polymer and its production process are also disclosed. The high-molecular dispersant is free of problems of a smell, coloration, a heavy metal and cost, and its use can provide a pigment dispersion excellent in the dispersion stability of a pigment.Type: GrantFiled: August 5, 2009Date of Patent: September 2, 2014Assignees: Dainichiseika Color & Chemicals Mfg. Co., Ltd., Kyoto UniversityInventors: Yoshikazu Murakami, Hiroyuki Shimanaka, Toshiyuki Hitotsuyanagi, Shinya Tsuchida, Atsushi Goto, Yoshinobu Tsujii, Takeshi Fukuda