Patents Assigned to University
  • Subunit selective NMDA receptor potentiators for the treatment of neurological conditions
    Patent number: 8822462
    Abstract: Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds of the general Formulas A-J, and pharmaceutically acceptable salts, esters, prodrugs or derivatives thereof are disclosed.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: September 2, 2014
    Assignee: Emory University
    Inventors: Stephen F. Traynelis, Dennis C. Liotta, Rose M. Santangelo, Ethel C. Garnier
  • 2'-O-modified RNA
    Patent number: 8822671
    Abstract: A 2?-modified ribonucleoside having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. A modified form of RNA having a halogen-substituted alkoxymethyl protective group exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2?-O-methyl modified nucleic acid.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: September 2, 2014
    Assignees: The University of Tokyo, Chiralgen, Ltd.
    Inventors: Mamoru Shimizu, Takeshi Wada, Kouichiro Arai
  • Light emitting diode with graphene layer
    Patent number: 8823045
    Abstract: A light emitting diode includes a graphene layer, a first semiconductor layer, an active layer, a second semiconductor layer, a first electrode and a second electrode. The first semiconductor layer, the active layer, and the second semiconductor layer are stacked with each other in sequence. The first electrode is located on and electrically connected with the second semiconductor layer. The second electrode is located on and electrically connected with the first semiconductor layer. The graphene layer is located on at least one of the first semiconductor layer and the second semiconductor layer.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: September 2, 2014
    Assignees: Tsinghua University, Hon Hai Precision Industry Co., Ltd.
    Inventors: Yang Wei, Shou-Shan Fan
  • Field cycling method for magnetic resonance
    Patent number: 8825132
    Abstract: An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetization. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.
    Type: Grant
    Filed: July 4, 2012
    Date of Patent: September 2, 2014
    Assignees: Bruker BioSpin GmbH, The University of York
    Inventors: Joost Lohman, Simon Benedict Duckett, Gary George Green, Antonio Giuseppe Gianotti
  • Polypeptides, nucleic acid molecules, and methods for synthesis of triterpenes
    Patent number: 8822187
    Abstract: This application relates to the polypeptides, nucleic acid molecules, vectors, transfected cells, and methods for synthesis of triterpenes, including botryococcene.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: September 2, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Joe Chappell, Thomas D. Niehaus, Shigeru Okada, Timothy P. Devarenne, David S. Watt
  • Polyoxometalate water oxidation catalysts and methods of use thereof
    Patent number: 8822367
    Abstract: Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment, the WOC is a polyoxometalate WOC which is hydrolytically stable, oxidatively stable, and thermally stable. The WOC oxidized waters in the presence of an oxidant. The oxidant can be generated photochemically, using light, such as sunlight, or electrochemically using a positively biased electrode. The hydrogen ions are subsequently reduced to form hydrogen gas, for example, using a hydrogen evolution catalyst (HEC). The hydrogen gas can be used as a fuel in combustion reactions and/or in hydrogen fuel cells. The catalysts described herein exhibit higher turn over numbers, faster turn over frequencies, and/or higher oxygen yields than prior art catalysts.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: September 2, 2014
    Assignee: Emory University
    Inventors: Craig L Hill, Yurii V Gueletii, Djamaladdin G. Musaev, Qiushi Yin, Bogdan Botar
  • Truncated activin type II receptor and methods of use
    Patent number: 8822411
    Abstract: The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: September 2, 2014
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Treatment of muscular dystrophies and related disorders
    Patent number: 8822418
    Abstract: The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; diseases or conditions associated with an abnormal level or activity of collagen VI; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); and disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: September 2, 2014
    Assignee: Brown University
    Inventors: Justin R. Fallon, Michael Rafii, Mark A. Bowe, Beth McKechnie, Alison Amenta, Mary Lynn Mercado, Hiroki Hagiwara
  • E2F as a target of hormone refractory prostate cancer
    Patent number: 8822421
    Abstract: The instant invention provides amino acid sequences competing with E2F for DNA binding. Methods of using said amino acid sequences for treatment of hormone-refractory prostate cancer are also provided.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: September 2, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Joseph R. Bertino, Debabrata Banerjee, Tamara Minko, Olga B. Garbuzenko, Xiaoqi Xie, John E. Kerrigan, Emine E. Abali, Kathleen W. Scotto
  • Apparatus and methods for wide temperature range operation of micrometer-scale silicon electro-optic modulators
    Patent number: 8824036
    Abstract: A thermally stabilized, high speed, micrometer-scale silicon electro-optic modulator is provided. Methods for maintaining desired temperatures in electro-optic modulators are also provided. The methods can be used to maintain high quality modulation in the presence of thermal variations from the surroundings. Direct current injection into the thermally stabilized electro-optic modulator is used to maintain the modulation performance of the modulator. The direct injected current changes the local temperature of the thermally stabilized electro-optic modulator to maintain its operation over a wide temperature range.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: September 2, 2014
    Assignee: Cornell University
    Inventors: Sasikanth Manipatruni, Rajeev Dokania, Alyssa B. Apsel, Michal Lipson
  • Autonomous navigation method and autonomous mobile body
    Patent number: 8825257
    Abstract: An autonomous navigation method is a method of causing a mobile body (100) to autonomously navigate while comparing environmental magnetism data obtained in advance by measuring magnetism generated along a navigation path on which the mobile body (100) navigates and measured magnetism detected by actually measuring the magnetism generated along the navigation path when the mobile body (100) navigates along the navigation path. The method includes a step (a) of detecting first measured magnetism and second measured magnetism in different positions on the mobile body (100) and a step (b) of causing the mobile body (100) to autonomously navigate on the basis of the second measured magnetism detected by a magnetism sensor (103), which is not affected by unexpected magnetism (G) not included in the environmental magnetism data, and the environmental magnetism data.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: September 2, 2014
    Assignee: Utsunomiya University
    Inventors: Koichi Ozaki, Rahok Samann
  • Encapsulation architectures for utilizing flexible barrier films
    Patent number: 8823154
    Abstract: An article and method of using spacer layer regions is provided, containing a gas compound, to reduce gas permeation through barrier films overlying a substrate comprising creating a spacer layer between one or more of the barrier films, wherein the spacer layer comprises at least one inert gaseous compound. In another embodiment, an article and method is provided comprising creating alternating thin films of hybridized sol-gel spin-on glass and PDMS based and olefin based elastomers.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: September 2, 2014
    Assignee: The Regents of The University of California
    Inventors: Craig J. Hawker, Jimmy Granstrom, Luis M. Campos, Jeffrey A. Gerbec, Motoko Furukawa
  • Monopole slot antenna for multiple input and multiple output
    Patent number: 8823596
    Abstract: The present invention pertains to a monopole slot antenna for multiple input and multiple output comprising a substrate. An antenna module is disposed on the first surface of the substrate and includes a first antenna and a second antenna disposed symmetrically with each other. A first inner monopole slot and a first outer monopole slot are disposed on the first antenna. The first inner monopole slot is formed by connecting a first straight section with a plurality of first bended sections. The first outer monopole slot surrounds the outer periphery of the first inner monopole slot. The second antenna is disposed symmetrical to the first antenna. An isolation unit is defined between the first antenna and the second antenna and has a third straight section and a third bended section. Furthermore, two feeding units are defined on the second surface of the substrate.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: September 2, 2014
    Assignee: Southern Taiwan University of Science and Technology
    Inventors: Wen-Shan Chen, Chi-Huang Lin
  • Compounds for treatment of cancer
    Patent number: 8822513
    Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: September 2, 2014
    Assignees: GTX, Inc., University of Tennessee Research Foundation
    Inventors: Yan Lu, Chien-Ming Li, Zhao Wang, Jianjun Chen, Wei Li, James T. Dalton, Duane D. Miller, Charles Duke, Sunjoo Ahn
  • Nucleophile assisting leaving groups
    Patent number: 8822707
    Abstract: Sulfonate leaving groups include a cation chelating moiety, e.g. a polyether or crown ether. The chelating moiety stabilizes the sulfonate leaving group by forming a complex with a cation of a cation-nucleophile combination. The stabilized leaving group is more easily displaced under many conditions than are standard arylsulfonate leaving groups such as the toxyl group. The chelating moiety also favors certain cations depending on the identity of the moiety thereby enhancing the reaction rate with nucleophilic salts containing the preferred cation. Use of the inventive leaving groups results in improved yields, decreased reaction times and improved product purity.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: September 2, 2014
    Assignee: Florida Atlantic University
    Inventor: Salvatore Lepore
  • Benzo-fused thiophene / triphenylene hybrid materials
    Patent number: 8822708
    Abstract: Triphenylene containing benzo-fused thiophene compounds are provided. Additionally, triphenylene containing benzo-fused furan compounds are provided. The compounds may be useful in organic light emitting devices, particularly as hosts in the emissive layer of such devices, or as materials for enhancement layers in such devices, or both.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: September 2, 2014
    Assignee: Universal Display Corporation
    Inventors: Bin Ma, Yonggang Wu, Chun Lin, Raymond Kwong
  • Image reconstruction incorporating organ motion
    Patent number: 8824756
    Abstract: Systems and methods which implement an image reconstruction framework to incorporate complex motion of structure, such as complex deformation of an object or objects being imaged, in image reconstruction techniques are shown. For example, techniques are provided for tracking organ motion which uses raw time-stamped data provided by any of a number of imaging modalities and simultaneously reconstructs images and estimates deformations in anatomy. Operation according to embodiments reduces artifacts, increase the signal-to-noise ratio (SNR), and facilitates reduced image modality energy dosing to patients. The technology also facilitates the incorporation of physical properties of organ motion, such as the conservation of local tissue volume. This approach is accurate and robust against noise and irregular breathing for tracking organ motion.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: September 2, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Sarang Joshi, Jacob Hinkle, Bill Salter, Tom Fletcher, Brian Wang
  • Game system
    Patent number: 8821256
    Abstract: A game system that is capable of performing a game by employing an information card in place of a conventional paper-based system is provided.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: September 2, 2014
    Assignees: Universal Entertainment Corporation, Aruze Gaming America, Inc.
    Inventors: Kazuo Okada, Jun Fujimoto, Takao Nireki, Kunihiro Manabe, Noritoshi Kukita
  • Polymicrobial formulations for enhancing plant productivity
    Patent number: 8822190
    Abstract: The present invention relates to eco-friendly compositions and methods for providing plant growth enhancing formulations comprising mixtures of microbial isolates. In particular, numerous bacterial and fungal strains were isolated from a variety of soil types, from rhizospheres and from root nodules of leguminous plants, in designed combinations, for providing plant growth and plant productivity enhancing formulations. These specifically designed polymicrobial formulations would further provide protection against plant pathogens lowering the need for nitrogen containing fertilizers, solubilize minerals, protect plants against pathogens, and make available to the plant valuable nutrients, such as phosphate, thus reducing and eliminating the need for using chemical fertilizers and chemical pesticides.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: September 2, 2014
    Assignee: Board of Trustees of Michigan State University
    Inventors: C. Adinarayana Reddy, Lalithakumari Janarthanam
  • Pigment dispersions
    Patent number: 8822591
    Abstract: Disclosed is a pigment dispersion containing at least a pigment, a liquid medium and a high-molecular dispersant. The high-molecular dispersant is a block polymer represented by A-B or A-B-C, in which A, B and C each represent a polymer block and the A and C blocks may be the same or different. The block polymer and its production process are also disclosed. The high-molecular dispersant is free of problems of a smell, coloration, a heavy metal and cost, and its use can provide a pigment dispersion excellent in the dispersion stability of a pigment.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: September 2, 2014
    Assignees: Dainichiseika Color & Chemicals Mfg. Co., Ltd., Kyoto University
    Inventors: Yoshikazu Murakami, Hiroyuki Shimanaka, Toshiyuki Hitotsuyanagi, Shinya Tsuchida, Atsushi Goto, Yoshinobu Tsujii, Takeshi Fukuda