Abstract: The present invention relates to the use of secreted proteins from mesenchymal stem cells and other cells for the treatment of myocardial infarction. In particular, the invention provides compositions and methods based on secreted proteins from mesenchymal stem cells and the genes encoding them.
Type:
Application
Filed:
June 25, 2012
Publication date:
August 28, 2014
Applicant:
National University of Ireland, Galway
Inventors:
Timothy O'Brien, Frank Barry, Claire Kavanagh
Abstract: Disclosed are an apparatus, a method, and a recording medium for controlling a portable communication terminal and a smart watch of the portable communication terminal, which control an operation of a display unit only when a user obtains information on a movement of the smart watch from a sensor installed in the smart watch and view the smart watch.
Type:
Application
Filed:
February 20, 2014
Publication date:
August 28, 2014
Applicant:
University of Seoul Industry Cooperation Foundation
Abstract: The invention describes antibodies having a high affinity for aggregated forms of ?-synuclein and a low affinity for monomeric forms of ?-synuclein. The antibodies are useful in the diagnosis of neurodegenerative diseases.
Abstract: A nanostructure is described. The nanostructure includes a nanoparticle, a shell encompassing the nanoparticle, and a gap having a width ranging from 1.0 nm to 6.0 nm and located between the nanoparticle and the shell to enable the nanostructure to generate a fluorescence.
Abstract: Provided is an electrolyte solution for a magnesium battery, containing a mesoionic compound represented by the following general formula (1): (in general formula (1), R1 and R2 are each independently a C1-7 hydrocarbyl group or oxygen-containing hydrocarbyl group and X is O or S).
Type:
Application
Filed:
February 27, 2014
Publication date:
August 28, 2014
Applicants:
TOYOTA JIDOSHA KABUSHIKI KAISHA, National University Corporation Nagoya Institute Of Technology
Abstract: The invention is directed to polymers that self-crosslink at acidic pH or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs, where they will cross link in situ, thus increasing their viscosity and/or form a gel and blocking thief zones. Methods of making and using such polymers are also provided.
Type:
Application
Filed:
February 6, 2014
Publication date:
August 28, 2014
Applicants:
University of Kansas, ConocoPhillips Comapny
Inventors:
Huili GUAN, Cory BERKLAND, Ahmad MORADI-ARAGHI, Jenn-Tai LIANG, Terry M. CHRISTIAN, Riley B. NEEDHAM, James H. Hedges, Min CHENG, Faye L. SCULLY
Abstract: The process disclosed herein produces macroscopic quantities of semiconducting arsenic sulfide nanofibers within one to three days. The process is biotically influenced by the bacteria Shewanella sp. Strain ANA-3. The fibers are semiconductors with bandgaps between 2.2 and 2.5 eV. Newly measured semiconducting and bandgap properties can lead to applications in the semiconductor, transistor, and solar energy fields. A faster and more robust biological component makes the overall process more commercially feasible than it would have been otherwise. The faster rate allows for larger yields of nanofibers in a predetermined period of time.
Abstract: The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions comprise a nitrated lipid and an inhibitor of the renin-angiotensin-aldosterone system. The methods comprise administering a nitrated lipid in combination with an inhibitor of the renin-angiotensin-aldosterone system to a subject in need thereof, in an amount effective to treat diabetic nephropathy, chronic kidney disease, and/or end-stage renal disease. The use of a nitrated lipid with an inhibitor of the renin-angiotensin-aldosterone system exhibits a synergistic effect in treating chronic kidney disease and diabetic nephropathy.
Type:
Application
Filed:
February 18, 2014
Publication date:
August 28, 2014
Applicant:
The University of Utah Research Foundation
Abstract: An organic electrical device can include a first dielectric substrate including a PVDF-TrFe-CFE terpolymer, a first semiconductor region coupled to a first surface of the first dielectric substrate, and a first gate region coupled to a second surface of the first dielectric substrate, the second surface opposite the first surface and opposite the first semiconductor region. The organic electrical device can include an organic field-effect transistor (OFET), comprising the first gate region, the first dielectric substrate, a first source region, and a first drain region respectively electrically coupled to the first semiconductor region. An electrostrictive actuator or mechanical sensor can be co-integrated on the first dielectric substrate, the actuator or sensor including first and second conductive regions located on opposite surfaces of the first dielectric substrate. The actuator or sensor can be electrically coupled to the OFET, and controlled at least in part by the OFET.
Type:
Application
Filed:
April 5, 2012
Publication date:
August 28, 2014
Applicant:
The Trustees of Columbia University in the City of New York
Inventors:
Zhang Jia, Nadia Pervez, Fabio Carta, Ioannis Kymissis
Abstract: This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed.
Type:
Application
Filed:
September 13, 2011
Publication date:
August 28, 2014
Applicant:
The Trustees of Columbia University in the City of New York
Inventors:
Scott Alan Snyder, Daniel S. Treitler, Alexandria P. Brucks, Andreas Gollner, Maria I. Chiriac, Nathan E. Wright, Jason J. Pflueger, Steven P. Breazzano
Abstract: A photoplethysmograph device includes a light source for illuminating a target object. A modulator drives the light source such that the output intensity varies as a function of a modulation signal at a modulation frequency. A detector receives light from the target object and generates an electrical output as a function of the intensity of received light. A demodulator with a local oscillator receives the detector output and produces a demodulated output, insensitive to any phase difference between the modulation signal and the oscillator, indicative of blood volume as a function of time and/or blood composition. A number of demodulators may be provided to derive signals from multiple light sources of different wavelengths, or from an array of detectors. The plethysmograph may operate in a transmission mode or a reflectance mode. When in a reflectance mode, the device may use the green part of the optical spectrum and may use polarising filters.
Type:
Application
Filed:
May 14, 2014
Publication date:
August 28, 2014
Applicant:
The University of Nottingham
Inventors:
John CROWE, Mark GRUBB, Barrie HAYES-GILL, Nicolas MILES
Abstract: A method using optical coherence tomography to capture the microvascular network of the superficial layer of the finger skin for the purpose of fingerprint authentication and liveness detection. At the dermal papilla region, the vascular pattern follows the same pattern of the fingerprint and this vascular pattern forms a live vascular fingerprint. This live vascular fingerprint provides for ultrahigh security and a unique way for fingerprint-based personal verification. Because the system is based on blood flow, which only exists in a living person, the technique is robust against spoof attaching. After performing non-contact in-vivo imaging of a human fingertip, a three dimensional vasculature image is reconstructed from a plurality of vasculature tomography images and at least one vasculature fingerprint image which corresponds to the fingertip is extracted from the three dimensional vasculature image.
Type:
Application
Filed:
February 28, 2014
Publication date:
August 28, 2014
Applicant:
The Regents of the University of California
Abstract: The invention relates to methods of screening to find compounds that are cytotoxic to tumor cells and methods of treating tumor cells using these compounds. In particular, the invention relates to methods of screening for compounds that inhibit mammalian mitochondrial fatty acid synthase (mmFAS) and methods of treating tumor cells using mmFAS inhibitors. This invention also provides methods for inhibiting or preventing cancer cell survival by the administration of mitochondrial fatty acid synthase (FAS) inhibitors. Specifically, this invention describes a method for prohibiting or delaying the development of cancer, the growth of cancer or invasion of cancer from pre-malignant (noninvasive) lesions, or metastasis of cancer based upon the findings that this method compromises energy balance in cancer cells, in turn compromising their basic functions and causing their cell death.
Abstract: The present invention relates to compositions and methods for the prevention and treatment of atrial fibrillation. In particular, the present invention provides therapeutic agents for the treatment and prevention of persistent and permanent atrial fibrillation and prevention of progression of atrial fibrillation to permanent atrial fibrillation.
Type:
Application
Filed:
January 31, 2014
Publication date:
August 28, 2014
Applicant:
The Regents of The University of Michigan
Abstract: Methods are provided for diagnosing pregnancy-associated disorders, determining allelic ratios, determining maternal or fetal contributions to circulating transcripts, and/or identifying maternal or fetal markers using a sample from a pregnant female subject. Also provided is use of a gene for diagnosing a pregnancy-associated disorder in a pregnant female subject.
Type:
Application
Filed:
February 28, 2014
Publication date:
August 28, 2014
Applicant:
The Chinese University of Hong Kong
Inventors:
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Bo Yin Tsui
Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
Type:
Application
Filed:
May 1, 2014
Publication date:
August 28, 2014
Applicants:
Otonomy, Inc., The Regents of the University of California
Inventors:
Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Michael Christopher Scaife, Benedikt Vollrath, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
Abstract: The present invention provides a method for diagnosing hypercoagulability associated with carbon monoxide exposure in a subject. The method comprises obtaining a plasma sample from the subject, dividing the sample into at least two portions, and determining the clot strength of the first portion. The method further comprises exposing the second portion to an organic reductant, determining the clot strength of the second portion after exposure to the organic reductant, and comparing the clot strength of the first portion with the clot strength of the second portion. A diagnosis of hypercogulability associated with carbon monoxide exposure is made when the clot strength of the second portion is decreased compared with the cloth strength of the first portion.
Type:
Application
Filed:
July 19, 2012
Publication date:
August 28, 2014
Applicant:
Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
Abstract: A method, system or device for configuring an optical coupling device including obtaining characteristics of an optical signal and ambient conditions for storage in memory, utilizing a processor for identifying an optimum effective subwavelength area refractive index and a grating period for the input signal and ambient characteristics stored in memory, and utilizing the processor for identifying a preferred filling factor for a transverse polarization.
Type:
Application
Filed:
February 24, 2014
Publication date:
August 28, 2014
Applicant:
Board of Regents, The University of Texas System
Abstract: The invention is directed to methods for generating pancreatic progenitor cells, insulin producing cells or endoderm cells using embryonic stem cells and induced pluripotent stem cells.
Type:
Application
Filed:
January 17, 2014
Publication date:
August 28, 2014
Applicant:
The Trustees of Columbia University in the City of New York
Inventors:
Haiqing HUA, Dieter EGLI, Rudolph L. LEIBEL, Linshan SHANG
Abstract: A method of determining the susceptibility to ventricular arrhythmias in a subject, comprises the steps of: (a) collecting (e.g., by surface EKG or intracardiac EKG) at least one QT and DI interval data set from the subject during a stage of gradually increasing heart rate or a stage of gradually decreasing heart rate; (b) determining (e.g.
Type:
Application
Filed:
June 28, 2012
Publication date:
August 28, 2014
Applicants:
Duke University, University of North Carolina Greensboro
Inventors:
Joseph M. Starobin, Vivek Varadarajan, Wanda Krassowska Neu, Salim F. Idriss