Patents Assigned to University
  • PROTEIN-INDUCED PLURIPOTENT CELL TECHNOLOGY AND USES THEREOF
    Publication number: 20140242695
    Abstract: A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof.
    Type: Application
    Filed: May 2, 2012
    Publication date: August 28, 2014
    Applicant: Wayne State University
    Inventors: Jianjun Wang, Qianqian Li
  • NANOFLUIDIC DEVICES WITH INTEGRATED COMPONENTS FOR THE CONTROLLED CAPTURE, TRAPPING, AND TRANSPORT OF MACROMOLECULES AND RELATED METHODS OF ANALYSIS
    Publication number: 20140238856
    Abstract: Devices for controlling the capture, trapping, and transport of macromolecules include at least one fluidic transport nanochannel that intersects and is in fluid communication with at least one transverse nanochannel with (shallow) regions and/or with integrated transverse electrodes that enable fine control of molecule transport dynamics and facilitates analyses of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Application
    Filed: February 26, 2014
    Publication date: August 28, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Laurent Menard
  • LITHIUM COMPOSITIONS
    Publication number: 20140242193
    Abstract: 2:1 cocrystals of amino acids and Li+ salts crystallize from hot water to afford water stable cationic networks based upon tetrahedral lithium cations: bilayered square grids, a lithium zeolitic metal-organic material (LiZMOM) and several lithium diamondoid metal-organic materials (LiDMOMs). The compositions may be used as a pharmaceutical for the treatment of suicidality and other disorders that require lithium to penetrate the blood brain barrier and exert therapeutic effects in the CNS. Advantageously, the novel cocrystal forms described herein may be used to lower the oral dose required to achieve therapeutic concentrations of lithium in the brain, thus reducing the peripheral toxicity and potentially broadening the therapeutic index in comparison to conventional lithium forms.
    Type: Application
    Filed: March 26, 2012
    Publication date: August 28, 2014
    Applicant: University of South Florida
    Inventors: Michael John Zaworotko, Roland D. Shytle, Tien Teng Ong, Padmini Kavuru, Ryan N. Cantwell, Tranhha Nguyen, Adam John Smith
  • POROUS THIN FILM HAVING HOLES AND A PRODUCTION METHOD THEREFOR
    Publication number: 20140242331
    Abstract: The present application relates to a porous thin film having holes, wherein the holes are formed in the top part and/or the bottom part of the thin film and the holes are linked to the pores of the thin film; and the present invention also relates to a production method for a porous thin film having holes, comprising the use of a particle alignment layer as a mould.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicant: Industry-University Cooperation Foundation Sogang University
    Inventors: Kyung Byung Yoon, Hyun Sung Kim, Myunpyo Hong, Na Pi Ha
  • SYNTHESIS OF OIL-SOLUBLE NEW COMPOSITIONS USED FOR DSERSING PIGMENT NANOPARTICLES AND THEIR APPLCATION ON ELECTROWETTING DISPLAY
    Publication number: 20140239241
    Abstract: The present invention provides a macromolecular dispersant and a synthesis method thereof, and the dispersant is synthesized by reacting polyisobutylene-g-succinic anhydride with amine compounds. In addition, the present invention also provides an oil-soluble dispersant composition with nano particle pigments and the manufacturing method thereof. The oil-soluble dispersant composition is manufactured by milling a macromolecular dispersant with a pigment and a grinding media. The oil-soluble dispersant composition is adequate for various pigments, shows the excellent immiscibility of oil/water interface, and owns the low viscosity of ?4 cps and the optical density of ink ?1.1. Therefore, the oil-soluble dispersant of the present invention for the nano particle pigment can be acted as the material of the electrowetting display.
    Type: Application
    Filed: January 3, 2014
    Publication date: August 28, 2014
    Applicant: National Taiwan University
    Inventors: Jiang-Jen Lin, Chih-Wei Chiu, Tzu-Chien Lee, Ling-Yu Chang
  • Galectin-3C Combination Therapy for Human Cancer
    Publication number: 20140243275
    Abstract: The present invention provides a novel composition of matter useful for the treatment of neoplastic diseases. The novel composition is synergistic and comprised of galectin-3C in combination with a proteosome inhibitor, the combination having a pharmacologic activity greater than the expected additive effect of its individual components. Other embodiments of the invention provide novel synergistic compositions of galectin-3C with a proteasome inhibitor capable of reducing or overcoming resistance that develops to the proteasome inhibitor or reducing the adverse side effects from the proteasome inhibitor through increasing the therapeutic efficacy of lower doses.
    Type: Application
    Filed: March 29, 2012
    Publication date: August 28, 2014
    Applicant: Texas Tech University System
    Inventors: Maurizio Chiriva-Internatí, Everardo Cobos, Constance John
  • SAGITTAL SAW
    Publication number: 20140243832
    Abstract: A sagittal saw includes a blade and an actuator configured to drive the blade. The blade includes a first end, a second end opposed to the first end, and a longitudinal axis extending between the first end and second end. The blade first end extends transverse to the longitudinal axis, and its movement defines a blade path. The blade path comprises a closed plane curve consisting of two loops meeting at a node ie, a figure-eight, whereby the blade path crosses over itself. The actuator includes a gear assembly configured to cyclically drive the blade so that the blade path includes multiple impulsive thrusts along the longitudinal axis in each blade path cycle. In addition, the blade cuts the work piece in both a first direction and a second direction in each blade cycle, the second direction opposed to the first direction.
    Type: Application
    Filed: June 6, 2012
    Publication date: August 28, 2014
    Applicant: Tufts University
    Inventors: Matthew P. Kelly, Timothy B. Lannin, Thomas P. James
  • CONDENSED TANNIN-CONTAINING COMPOSITION TO BE CURED BY APPLYING HEAT/PRESSURE THERETO
    Publication number: 20140238268
    Abstract: Provided are a composition from which a biomass material can be obtained with low energy through a simple process and facility, a formed body obtained from the composition, and a method for producing the formed body. A composition according to the present invention is a composition to be cured by applying heat/pressure thereto, the composition including an element in the form of powder or small pieces, and 8% by weight or more of condensed tannin and 8% by weight or more of a saccharide selected form the group consisting of a monosaccharide and an oligosaccharide. The saccharide is preferably sucrose, glucose, fructose, maltose, xylose, or lactose. Preferably, the composition further includes an acid catalyst.
    Type: Application
    Filed: July 27, 2012
    Publication date: August 28, 2014
    Applicant: Kyoto University
    Inventor: Kenji Umemura
  • NETWORK-CODING BUILDING BLOCKS AND DECOMPOSITION SCHEDULING BASED THEREON
    Publication number: 20140241404
    Abstract: Methods and systems are disclosed involving physical-layer network coding (PNC) atoms as building blocks of PNC networks to solve the scheduling problem in PNC networks using a decomposition framework based on PNC atoms. Ten PNC atoms and their straightforward network coding (SNC) counterparts are disclosed. Performance evaluation results are discussed, which indicate that decomposition based on the ten PNC atoms outperforms the traditional multi-hop (non-NC) scheduling by about 100%. Furthermore, decomposition based on the ten PNC atoms can yield performance gain of 40% or more compared with decomposition based on the TWRC atom alone.
    Type: Application
    Filed: February 27, 2013
    Publication date: August 28, 2014
    Applicant: The Chinese University of Hong Kong
    Inventors: Soung Chang Liew, Jianghao He
  • INACTIVATING PATHOGENS WITH OXIDIZING AGENTS FOR VACCINE PRODUCTION
    Publication number: 20140242115
    Abstract: The present disclosure provides methods for producing a vaccine composition containing a pathogen that is rendered noninfectious by exposure to hydrogen peroxide. The methods disclosed herein are suitable for the preparation of vaccines for a wide variety of pathogens, including viruses, bacteria and parasites. The disclosure also provides vaccine compositions (medicaments) containing a pathogen inactivated by exposure to hydrogen peroxide. Methods for eliciting an immune response in a subject by administering vaccine compositions containing a hydrogen peroxide inactivated pathogen are also provided.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicant: Oregon Health and Science University
    Inventors: Mark K. Slifka, Shirley Villadiego, Erika Hammarlund, Paul Yoshihara
  • METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS
    Publication number: 20140243215
    Abstract: The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease within the patient.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Wake Forest University
    Inventors: Thomas C. Hart, Patricia Suzanne Hart, Michael Gorry, Anthony J. Bleyer
  • COMPOSITION FOR DIAGNOSING OVARIAN CANCER METASTASIS USING CPG METHYLATION STATUS OF GENE PROMOTER AND USE THEREOF
    Publication number: 20140243218
    Abstract: The present invention relates to a composition, a kit and a method for diagnosing ovarian cancer metastasis or predicting the risk of metastasis by detecting methylation levels at CpG sites of one or more gene promoters selected from the group consisting of AGR2 (anterior gradient 2), CA9 (carbonic adj anhydrase 9), GABRP (gamma-aminobutyric acid receptor pi subunit), IFITM1 (interferon-induced transmembrane 1) and MUC13 (mucin 13).
    Type: Application
    Filed: February 20, 2014
    Publication date: August 28, 2014
    Applicant: Ewha University - Industry Collaboration Foundation
    Inventors: Jung-Hyuck AHN, Hye-Youn Sung, Woong Ju
  • NOVEL ANTI-HCV AGENT
    Publication number: 20140242030
    Abstract: Provided is a novel anti-HCV agent including as an active ingredient a peroxide derivative represented by the general formula (I). In the general formula (I), C represents an alicyclic hydrocarbon ring group which may be substituted, n represents an integer of from 1 to 6, and R represents a hydrogen atom or a hydroxyalkyl group. The peroxide derivative exhibits potent anti-HCV activity by remarkably suppressing HCV-RNA replication.
    Type: Application
    Filed: October 2, 2012
    Publication date: August 28, 2014
    Applicant: National University Corporation Okayama University
    Inventors: Nobuyuki Kato, Masanori Ikeda, Yusuke Wataya, Hye-Sook Kim, Hiroyuki Doi
  • Adeno-Associated Virus Virions with Variant Capsid and Methods of Use Thereof
    Publication number: 20140242031
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Application
    Filed: January 15, 2014
    Publication date: August 28, 2014
    Applicant: The Regents of the University of California
    Inventors: David V. Schaffer, Ryan R. Klimczak, James T. Koerber, John G. Flannery
  • COMPOSITIONS FOR INHIBITION OF INSECT SENSING
    Publication number: 20140242135
    Abstract: In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 28, 2014
    Applicant: Vanderbilt University
    Inventors: Laurence Zwiebel, Gregory M. Pask, David C. Rinker, Ian M. Romaine, Gary A. Sulikowski, Paul R. Reid, Alex G. Waterson, Kwangho Kim, Patrick L. Jones, Robert W. Taylor
  • USE OF NITRITE SALTS IN TREATING TISSUE DAMAGE
    Publication number: 20140242194
    Abstract: Methods of treating a subject who has an tissue damage or who is at risk for tissue necrosis are disclosed. Also disclosed are methods of treating a subject who has an inflammatory disorder. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to reduce the tissue damage. The subject can be diagnosed as having a medical condition that results tissue damage, for example, diabetes, peripheral artery disease, cardiovascular disease, defective wound healing, arthritis, inflammatory bowel disease, ischemia, or a bacterial infection, e.g., Group A staphylococcal infection. The methods can include the step of monitoring the course of treatment.
    Type: Application
    Filed: December 12, 2013
    Publication date: August 28, 2014
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical college
    Inventor: Christopher KEVIL
  • PYRROLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20140243315
    Abstract: The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemia (ALL) cells and a potential cause of ALL chemoresistance. Hence, we investigated whether the development of small molecule Mer inhibitors was possible. A first aspect of the present invention is a compound (sometimes referred to as an “active compound” herein) of Formula I, IA, or IB.
    Type: Application
    Filed: October 1, 2012
    Publication date: August 28, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Xiaodong Wang, Jing Liu, Weihe Zhang, Stephen Frye, Dmitri Kireev
  • SYNTHESIS OF FUNCTIONALIZED OCTAHYDRO-ISOQUINOLIN-1-ONE-8-CARBOXYLIC ESTERS AND ANALOGS, AND THERAPEUTIC METHODS
    Publication number: 20140243333
    Abstract: A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.
    Type: Application
    Filed: May 13, 2014
    Publication date: August 28, 2014
    Applicants: University of Kansas, University of North Carolina
    Inventors: Jeffrey Aube, Bryan L. Roth, Partha Ghosh, Kevin J. Frankowski
  • MICRO-COLUMN WITH DOUBLE ALIGNER
    Publication number: 20140239190
    Abstract: Disclosed herein is a microcolumn with a double aligner. The microcolumn is configured such that when an axis of an aperture of a limiting aperture is spaced apart from an original path of a particle beam, the path of the particle beam can be effectively compensated for in such a way that the path of the particle beam is aligned with the axis of the aperture of the limiting aperture by the double aligner. The microcolumn includes a source lens. The source lens includes at least two aligner layers which compensate for the path of the particle beam.
    Type: Application
    Filed: February 20, 2014
    Publication date: August 28, 2014
    Applicant: Industry-University Cooperation Foundation Sunmoon University
    Inventors: Tae Sik OH, Ho Seob KIM, Dae Wook KIM, Seung Joon AHN
  • GAMING MACHINE RUNNING COMMON GAME
    Publication number: 20140243090
    Abstract: A plurality of gaming terminals each having a terminal display on which a plurality of symbols are provided, a plurality of upper displays forming a single common effect display screen which is constituted by gaming terminal areas corresponding to the respective gaming terminals, and a center controller are provided. When the common game starts, the center controller displays a common game start effect image on a common effect display screen and transmits a common game start effect image display command to the gaming terminals so that the common game start effect image divided for respective gaming terminal areas is displayed on the terminal display of each of the gaming terminals corresponding to the gaming terminal areas.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicants: Universal Entertainment Corporation, Aruze Gaming America, Inc.
    Inventors: Hiroki Munakata, Kenta Sugano, Daisyun Okamoto, Masumi Fujisawa, Takehisa Itagaki