Abstract: This invention provides a method of treating, suppressing, inhibiting, or preventing chronic rhinosinusitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. This invention also provides a method of treating, suppressing, inhibiting, or preventing nasal polyps in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.
Type:
Grant
Filed:
October 27, 2011
Date of Patent:
October 14, 2014
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem
Abstract: A high peak intensity laser amplification system and the method therein implemented are provided. In a first aspect of the invention, the laser system includes at least one optical member (27) operably introducing a phase function into a high peak intensity laser pulse (25). A further aspect includes introducing destructive interference in an unchirped laser pulse prior to amplification and reconstructive interference in the output laser pulse after amplification. Dynamic pulse shaping is employed in another aspect of the present invention.
Type:
Grant
Filed:
February 26, 2010
Date of Patent:
October 14, 2014
Assignee:
Board of Trustees of Michigan State University
Abstract: The multiphase flow detector detects the different fractions of different phases of fluids, i.e., oil, water, and/or gas, flowing through a pipeline or the like. The detector includes a plurality of capacitive and resistive probes extending radially into an oil delivery pipeline. The probes preferably have various different lengths from one another to detect differences in fluid phases at differing distances from the pipe wall as the fluid flows randomly therethrough. The capacitive and resistive probes are preferably evenly spaced from one another in an alternating circumferential array. Two rings or stations of such probes are preferably installed in the pipe to measure the velocity of flow in the pipe, as well as the fluid fractions flowing therethrough. Appropriate algorithms enable a central controller to determine the fraction differences between oil and water and between oil and gas, and therefore to determine the fraction difference between water and gas.
Type:
Grant
Filed:
September 4, 2012
Date of Patent:
October 14, 2014
Assignees:
King Fahd University of Pretroleum and Minerals, King Abdulaziz City for Science and Technology
Inventors:
Wael H. Ahmed, Abdel Salam Al Sarkhi, Meamer El Nakla
Abstract: A computer-assisted method for quantitative characterization and treatment of ventricular fibrillation includes preprocessing a time series of an atrial fibrillation signal obtained from a patient, segmenting the time series of the AF signal into activation segments by the computer system, obtaining local activation waveforms (LAW) from the activation segments, determining degrees of similarity between the LAWs, and identifying one or more critical regions in the patient's atria if the LAWs have degrees of similarity exceeding a first threshold value.
Type:
Grant
Filed:
July 26, 2012
Date of Patent:
October 14, 2014
Assignee:
National Central University
Inventors:
Men-Tzung Lo, Yenn-Jiang Lin, Shih-Ann Chen, Yi-Chung Chang, Chen Lin, Ke-Hsin Hsu, Wan-Hsin Hsieh, Hung-Yi Lee, Norden E. Huang
Abstract: Dual suppression of the MAP kinase and PI3K/Akt pathways showed synergistic or greatly enhanced anti-melanoma cell effects, compared to suppression of a single pathway, including the inhibition of cell proliferation, transformation and invasion, induction of G0/G1 cell cycle arrest and, importantly, cell apoptosis. Remarkably, suppression of either pathway induces the expression of thyroid iodide-handling genes and dual suppression of the two pathways synergistically and robustly induces expression of these genes, accompanied by uptake of radioiodine in the cells. These genes include sodium/iodide symporter, thyroid-stimulating hormone receptor, thyroglobulin, thyroperoxidase, pendrin gene, thyroid transcription factors (e.g., TTF-1, TTF-2, PAX8) and other thyroid genes.
Abstract: Described herein are polypeptides, polynucleotides and methods involving a ?-utrophin region or an anti-dystrophinopathic fragment thereof operationally linked to a second region effective to transduce the fusion protein into mammalian muscle cells.
Abstract: Provided is a stethoscopy training system which is inexpensive and has a simple configuration, without using a device which measures a respiratory operation of a simulated patient. The stethoscopy training system for this objective is formed from: a simulated stethoscope (1) having a sound acquisition unit further comprising a location display means (1d), a tube, and ear pipes; a location sensing means (2) for sensing the location of the sound acquisition unit; biological sound database (3); a biological sound reproducing means (4); and a timing display means (5) for displaying a timing of a repetition of a reproduced respiratory sound. The database retains as information biological sounds which are prerecorded from actual patients in correspondence with chest locations.
Type:
Application
Filed:
May 11, 2012
Publication date:
October 9, 2014
Applicants:
Kenzmedico Co., Ltd., National University Corporation Chiba University
Abstract: A method is disclosed for recycling asphalt roofing shingles and incorporating them into hot mix asphalt for use in applications such as asphalt pavement construction. Unlike previous methods, the asphalt from ground shingles is mixed with and becomes an integral component of the asphalt binder, instead of acting primarily as part of the aggregate. The asphalt content of the shingles mixes with heated asphalt binder to produce a single asphalt phase, and the asphalt from the shingles acts as asphalt in the final composite.
Type:
Application
Filed:
February 27, 2014
Publication date:
October 9, 2014
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: The disclosure provides a method of regulating fatty acid or glucose metabolism in a cell by contacting the cell with a modulator of miR-208a and/or miR-208b activity or expression. The disclosure also provides a method of treating or preventing a metabolic disorder, such as obesity, diabetes, or metabolic syndrome, in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression. Also provided is a method of enhancing or improving mitochondrial function and/or redox-homeostasis in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression.
Type:
Application
Filed:
October 9, 2012
Publication date:
October 9, 2014
Applicants:
The Board of Regents, The University of Texas System, Miragen Therapeutics, Inc.
Inventors:
Eva van Rooij, Eric Olson, Chad Grueter
Abstract: The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a GLI polypeptide. The disclosed compositions and pharmaceutical preparations may comprise one or more pyrazolyl-containing compounds, or an analog or derivative thereof.
Type:
Application
Filed:
July 20, 2012
Publication date:
October 9, 2014
Applicant:
The Regents of the University of California
Inventors:
Biao He, Michael Mann, David M. Jablons
Abstract: The present invention relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by inhibiting gut-derived serotonin. The inhibition of the gut-derived serotonin is accomplished by inhibiting Tph1, an enzyme responsible for the production of gut-derived serotonin. The present invention also relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by increasing the number, growth and proliferation of osteoblasts.
Type:
Application
Filed:
November 16, 2012
Publication date:
October 9, 2014
Applicant:
The Trustees of Columbia University in the City of New York
Abstract: The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event.
Type:
Application
Filed:
May 15, 2014
Publication date:
October 9, 2014
Applicant:
University of Pittsburgh - Of the Commonwealth System of Higher Education
Abstract: Polysaccharide fibres, such as cellulose or starch, modified by grafting an amino-containing antimicrobial polymer (ACP) onto the fibres or starch using a co-polymerization reaction, exhibits high antimicrobial activity. For example, the presence of 1.0% by weight grafted polymer in the cellulose fibres or starch fibres results in excellent antimicrobial activity (over 99% inhibition). The application further discloses that including triclosan or butylparaben into a novel cationic ?-cyclodextrin polymer or nanocapsule yields a bacteriostat.
Abstract: A handheld-sized infrared thermal imaging device (i.e. IR camera) having a focal plane array (FPA) or other type of infrared sensor array, internal memory for storing saved thermal images, a mini-USB or other communications port, battery power supply, and minimal user interface options such as on/off, IR image capture, and potentially a very basic display. The IR camera provides a highly portable field usable thermal image capture instrument which can later be connected to an external computing device such as a laptop computer, with the computer software providing thermal imaging functionality typical of higher end thermal imaging cameras. A visual image camera may be added whereby corresponding visible and IR images are captured and downloadable to the external computer for subsequent thermal analysis.
Type:
Application
Filed:
March 12, 2014
Publication date:
October 9, 2014
Applicant:
Universal Enterprises, Inc.
Inventors:
Michael John Kane, David Lauren Wheaton, Sean Patrick Tierney
Abstract: The present invention provides mutants of PmST1 for the preparation of sialyl-Lewisx oligosaccharides, and other sialosides with decreased sialidase activity.
Type:
Application
Filed:
August 6, 2012
Publication date:
October 9, 2014
Applicant:
The Regents of the University of California
Abstract: A flexible tactile imager includes an array of sensing cells that measure shear force and normal force. The sensing cells include a first sub-cell and a second sub-cell. Each sub-cell includes multi-fingered capacitors configured to measure shear force in a first or second direction and to measure the normal force. The multi-fingered capacitors include a flexible printed circuit board, a comb-like fingered sense electrode and drive electrode patterned on a layer of the flexible printed circuit board, a deformable dielectric material positioned above the comb-like fingered sense and drive electrodes, the comb-like fingered floating electrode patterned above the deformable dielectric material, a first capacitance formed between the comb-like fingered sense electrode and the comb-like fingered floating electrode, and a second capacitance formed between the comb-like fingered drive electrode and the comb-like fingered floating electrode.
Type:
Application
Filed:
April 4, 2014
Publication date:
October 9, 2014
Applicant:
University of Utah
Inventors:
Rajesh Surapaneni, Carlos H. Mastrangelo
Abstract: Systems and methods are provided for staining tissue with multiple biologically specific heavy metal stains and then performing X-ray imaging, either in projection or tomography modes, using either a plurality of illumination energies or an energy sensitive detection scheme. The resulting energy-weighted measurements can then be used to decompose the resulting images into quantitative images of the distribution of stains. The decomposed images may be false-colored and recombined to make virtual X-ray histology images. The techniques thereby allow for effective differentiation between two or more X-ray dyes, which had previously been unattainable in 3D imaging, particularly 3D imaging of features at the micron resolution scale. While techniques are described in certain example implementations, such as with microtomography, the techniques are scalable to larger fields of view, allowing for use in 3D color, X-ray virtual histology of pathology specimens.
Abstract: A multifunctional neural network system for prediction which includes memory components to store previous values of data within a network. The memory components provide the system with the ability to learn relationships/patterns existent in the data over time.
Abstract: The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
Type:
Application
Filed:
January 24, 2014
Publication date:
October 9, 2014
Applicant:
The Johns Hopkins University
Inventors:
Xinzhong Dong, Qin Liu, David J. Anderson
Abstract: In a surface potential distribution measuring device for an electric field reduction system of a rotating electrical machine, a Pockels crystal is used between a laser and the surface (test location) of the electric field reduction system. Thus, the light Light intensity of a laser beam reflected on a mirror provided between the Pockels crystal and the test location corresponds to an output voltage that is the voltage difference between the first end surface and the second end surface of the Pockels crystal. Even when an inverter voltage is generated, by using a light detector having a frequency band capable of following the high frequency components of the inverter pulse voltage, the light intensity is detected by the light detector. Therefore, from the light intensity (output voltage), the surface potential distribution measuring device can measure the surface potential of the electric field reduction system in which an inverter pulse voltage is generated.
Type:
Application
Filed:
November 21, 2012
Publication date:
October 9, 2014
Applicants:
Toshiba Mitsubishi-Electric Industrial Sys. Corp., The University of Tokyo