Abstract: Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes.

Abstract: Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.

Abstract: A time-to-voltage converter (TVC) that includes a 555 timer integrated circuit (IC), and a charging circuit including a constant current source and a capacitor connected in series. The capacitor can be connected to a discharge pin of the 555 timer IC. The TVC can further include a trigger circuit and a reset circuit to receive a start signal and a stop signal, respectively, from an input line, and accordingly generate a trigger signal or a reset signal to trigger or reset the 555 timer IC. A switch can be configured to, under control of an output signal of the 555 timer IC, connect the input line with the reset circuit. A voltage across the capacitor when the 555 timer IC is reset indicates a time interval corresponding to the start and stop signals.

Abstract: Embodiments provide a method of storing a compound using a metal organic framework (MOF). The method includes contacting one or more MOFs with a fluid and sorbing one or more compounds, such as O2 and CH4. O2 and CH4 can be sorbed simultaneously or in series. The metal organic framework can be an M-soc-MOF, wherein M can include aluminum, iron, gallium, indium, vanadium, chromium, titanium, or scandium.

Abstract: The invention discloses an agitation device comprising an impeller, an agitating shaft and a power device. The impeller includes a disc, a hub and concave blades. Each blade consists of a concave surface which extends radially and has an annular sector-like shape, the projections of the upper and lower portions of the blade in the horizontal plane are two annular sectors, and the radian of the annular sector obtained by the projection of the upper portion is larger than that of the lower portion, and the annular sector-like shape and the rotation direction of blades are the same, so that each portion of the blades directly faces an incoming flow, the utilization efficiency of blades is increased and the impeller has low energy consumption and high gas-liquid dispersion efficiency. The device is efficient and energy-saving, has low power consumption, high mixing performance and high gas holdup and mass transfer performance.

Abstract: A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and. a therapeutic agent is provided. A method of delivering a therapeutic agent to a subject in need thereof comprising: administering to the subject an effective amount of a composition comprising: an elastin-like polypeptide (ELP), a kidney targeting agent coupled to the ELP and a targeting agent and/or a drug binding domain coupled to the ELP, wherein the ELP includes an amino acid sequence having at least about repeats of the amino acid sequence GVPGX (SEQ ID NO: 1), and wherein the composition enhances the deposition and retention of the therapeutic agent in the kidney relative to the non-conjugated therapeutic.

Abstract: A self-referencing localized plasmon resonance sensing device and a system thereof are disclosed. The reference optical waveguide element is modified with a noble metal nanoparticle layer. The sensing optical waveguide element is modified with a noble metal nanoparticle layer, which is further modified with a recognition unit. The incident light is guided into the reference and the sensing optical waveguide elements to respectively generate localized plasmon resonance sensor signals. The reference and the sensing optical waveguide elements respectively have a calibration slope. The processor utilizes the calibration slopes to regulate the second difference generated by detecting with the sensing optical waveguide element. The processor utilizes a difference between the first difference, which is generated by detecting with the reference optical waveguide element, and the regulated second difference to obtain a sensor response.

Abstract: A system and method for Machine-to-Machine (M2M) communication over a transmission medium, including a novel random access protocol that is easy to implement, energy efficient, scalable and compatible with the limited-power and low complexity requirements of IoT devices. The proposed protocol utilizes a form of multiple hypothesis testing at the IoT gateway to determine the number of active IoT devices operating in the transmission medium to optimize the power levels of a Successive Interference Cancellation (SIC) receiver in order to distinguish between signals transmitted from different IoT devices on the same time and frequency. The use of beamforming exploits the power and spatial domains without excessively increasing the SIC power levels and address channel access delay problems by reducing the probability of collision and consequently lowering the average back-off delay.

Abstract: This invention is about a cell-penetrating drug carrier and the application thereof. The mentioned cell-penetrating drug carrier can approach the target cell through using a proper recognizable sequence, so that the cell-penetrating drug carrier can be used to specifically delivery wanted drug to target cell. Through carrying wanted drug into the cytoplasm of the target cell by cell-penetrating peptide, the drug accumulation volume in the target cell can be efficiently increased. Preferably, through using proper bioinert polymer, the cell-penetrating peptide and the recognizable sequence can be kept from been digested before approaching the target cell.

Abstract: The invention provides a composition having the formula (I): xXO2.yY2O5, (wherein: 0.5<x<0.7; 0.3<y<0.5; X comprises one or more of silicon, titanium, germanium and zirconium; and Y comprises one or more of phosphorus, vanadium arsenic and antimony), or a hydrate thereof, in which the composition comprises more than 50 wt % or more of crystalline material.

Abstract: This invention provides a redox fuel cell comprising an anode and a cathode separated by an ion selective polymer electrolyte membrane; means for supplying a fuel to the anode region of the cell; means for supplying an oxidant to the cathode region of the cell; means for providing an electrical circuit between the anode and the cathode; a non-volatile catholyte solution flowing in fluid communication with the cathode, the catholyte solution comprising a polyoxometallate redox couple being at least partially reduced at the cathode in operation of the cell, and at least partially re-generated by reaction with the oxidant after such reduction at the cathode, the catholyte solution further comprising vanadium species that result from the speciation of the polyoxometallate at an elevated temperature and/or pressure.

Abstract: A method for estimating parameters of a direct current machine by Laplace transform performed by a computer system. The method includes establishing a transient model of the DC machine and a transfer function based on the transient mode; transforming the transfer function from the time domain to the frequency domain by the Laplace transform to obtain each of an armature current and a rotational speed of the DC machine as a function of frequency; expressing the armature current and the rotational speed as polynomial fractions by polynomial regression, and comparing the functions of the frequency and the polynomial fractions to output values of the armature resistance, the armature inductance, the back electromotive force constant, the moment of inertia and the friction coefficient. As such, the accuracy and operational efficiency in estimating the parameters of the DC machine can be improved.

Abstract: A device for controlling apical flow to a cell culture includes an apical insert that defines at least one inlet channel extending from an inlet port to an apical feed port and at least one outlet channel extending from an apical effluent port to an outlet port. The apical insert includes a projecting portion configured to extend into a cell culture insert to a depth that is less than a depth of the cell culture insert, and a contact surface configured to maintain a spatial relationship between the projecting portion and the cell culture insert.

Abstract: A method of preventing or reducing the level of degradation of an organic substrate is described, wherein a composition is formed that includes the organic substrate together with an effective amount of a sacrificial base and a diarylamine antioxidant.

Abstract: A multi-night titration (MNT) process to find an optimal single therapeutic pressure of a CPAP device. This single therapeutic pressure can then be used on an on-going basis by the patient after the titration period. The MNT process differs from current auto adjusting processes used for titration (or ongoing use) in that the MNT process does not respond locally by adjusting pressures to individual events. With existing devices, the continuous adjustment of supplied air pressure always responds to one or a small number of events and thus fails to compensate for a patient's adaptation thereto, resulting in the supply of a less than optimal therapeutic pressure to the patient. While auto adjusting processes often capture and respond well to short-term and transient conditions, the MNT process of the current disclosure seeks to capture long term trends and find the most suitable average single pressure for a patient.

Abstract: A concentration measurement device including at least one light source; a measurement cell for containing a fluid to be measured; a splitter for dividing light from the light source into incident light being incident into the measurement cell and non-incident light not being incident into the measurement cell; a transmitted-light detector for detecting transmitted light that is the incident light having passed through the measurement cell; a non-incident light detector for detecting the non-incident light; and an arithmetic part for correcting a detection signal of the transmitted-light detector using a detection signal of the non-incident light detector.

Abstract: A mode-locked laser (MLL) that produces ultra-low phase noise optical and RF outputs, includes two nested resonant optical cavities including an optical fiber-based cavity and an etalon, and a three bandwidth Pound-Drever-Hall (PDH) frequency stabilizer assembly incorporating three different optical bandpass filters. The optical fiber-based cavity is characterized by a free spectral range, FSRfiber, and the etalon is characterized by a free spectral range, FSRfilter, wherein FSRfilter/FSRfiber is an integer equal to or greater than 2. A method of generating ultra-low phase noise optical and RF outputs is disclosed. Optical and RF outputs have a phase noise that is less than ?100 dBc/Hz at 1 Hz and less than ?150 dBc at 10 KHz.

Abstract: Described herein are quinazoline-based compounds and formulations thereof. In some embodiments, the compounds and/or formulations thereof can be effective to inhibit and/or kill A. baumannii. Also described herein are methods of treating a subject in need thereof by administering to the subject in need thereof a quinazoline-based compound and/or formulation thereof to the subject in need thereof.

Abstract: A method of detecting and measuring the condition of intraluminal esophageal mucosa. An esophagus is intubated with a catheter including an inflatable and deflatable balloon and one or more impedance sensing electrodes on an exterior surface of the catheter. The balloon is inflated to press the impedance sensing electrode(s) into a mucosa of the interior esophageal wall. An electric current is directed through the mucosa via the impedance sensing electrode(s) while the impedance sensing electrode(s) is/are pressed by the balloon against the mucosa and measure impedance of the mucosa.

Abstract: A plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometer. The dispersion is further also characterized in that the micro-emulsion has a zeta potential of between ?25 mV and ?60 mV.