Abstract: Described is a direct method for the fabrication of resorcinarene nanocapsules by photopolymerization of compounds of formula (I), such as resorcinarene tetraalkene tetrathiol (RTATT), in the absence of any template or preorganization. Further, by varying the polymerization media, a variety of other polymeric architectures like lattices, fibrous networks, and nanoparticles were obtained. The morphology and structure were characterized by transmission electron microscopy, energy dispersive spectroscopy, scanning electron microscopy, dynamic light scattering, infrared and nuclear magnetic resonance spectroscopy. These morphologically distinct resorcinarene polymeric architectures contain residual thiol and ene functional groups offering potential functionalization opportunities.

Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.

Abstract: An asphalt binder includes asphalt and an asphalt binder modifier, which includes bio-oil. The asphalt binder can include a carboxyl additive. The asphalt can optionally include polymer-modified asphalt. An asphalt material includes mineral aggregate, an asphalt material binder including asphalt, and an asphalt binder modifier including bio-oil. A method for making the asphalt binder is disclosed. The asphalt material includes asphalt pavement and roofing shingles. The asphalt binder can be emulsified with water and a surfactant for use as a weatherproofing sealant or as an adhesive.

Abstract: Disclosed herein are methods, systems, and devices that may be implemented by an energy aggregator to control, or regulate, the electric load placed on an electric grid by an aggregation of electrical devices, such as electric vehicles. Generally, the disclosed methods and systems may provide for the bidirectional modulation of the power draw of each electric vehicle around a first power draw, or scheduled power draw. Further, the disclosed methods and systems provide for the determination of a desirable scheduled power draw for a given electric vehicle. In one example, the scheduled power draw may be determined based on, among other things, a respective amount of projected degradation in a given time period of each electrical device from a set of electrical devices.

Abstract: A method for establishing a parametric model of a semiconductor process is provided. A first intermediate result is generated according to layout data and a non-parametric model of the semiconductor process. A first response is obtained according to the first intermediate result. A specific mathematical function is selected from a plurality of mathematical functions, and the parametric model is obtained according to the specific mathematical function. A second intermediate result is generated according to the layout data and the parametric model. A second response is obtained according to the second intermediate result. It is determined whether the parametric model is an optimal model according to the first and second responses.

Abstract: Methods and systems of displaying an image of an object are described. The displayed image is comprised of at least two parts that are displayed so as to present a unified image of the object. One part of the image is derived using a first temporal filter and the other part of the image is derived using a second temporal filter.

Abstract: Disclosed herein are a method and apparatus for representing a bubble effect using metadata. The method for representing a bubble effect using a bubble effect representation apparatus may include generating metadata based on information related to a bubble effect, information about the performance of the bubble effect representation apparatus, and preference information for the bubble effect, generating control instruction information for the bubble effect representation apparatus by analyzing the generated metadata, and representing the bubble effect based on the control instruction information.

Abstract: A gaming machine according to an embodiment of the present invention includes: a first display unit that includes a plurality of reels including a plurality of symbols thereon; and a controller configured to: determine whether a rendering effect activation is selected; execute a game by spinning and stopping the plurality of reels of the display device; and perform a rendering effect on the spinning and stopping of the plurality of reels when it is determined that the rendering effect activation is selected.

Abstract: Cooperative caching systems incorporating Plug-and-Play base stations are described herein. Plug-and-Play base stations with large caching capacities are employed in a wireless network to perform cooperative transmission with macro base stations. Each Plug-and-Play base station can either have wireless backhaul or a low-cost wired backhaul connection to the macro base stations. Cooperative caching systems can direct traffic between the Plug-and-Play base stations and the macro base stations.

Abstract: In the present invention, different strategies are used to improve the bioavailability of triterpene glycosides and triterpenes including, for example, (a) a covalent approach involving modification with polyethylene glycol and (b) a formulation approach involving non-covalent encapsulation in antibody targeted pol(DL-lactic acid) nanoparticles.

Abstract: Aspects of the present disclosure include methods for detecting a low abundance protein and methods for identifying a site of N-glycosylation on a protein. In practicing methods according to certain embodiments, a eukaryotic cell is contacted with an isotopic labeling composition and isotopically labeled N-glycosylated peptides obtained from the eukaryotic cell are assessed by liquid chromatography-tandem mass spectrometry. A predetermined isotopic pattern in the mass spectrum is identified and amino acid sequences of the peptides containing the predetermined isotopic pattern are determined. Systems for identifying a predetermined isotopic pattern in mass spectra and determining amino acid sequences of peptides containing the predetermined isotopic pattern are also described.

Abstract: The invention provides compositions for inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, comprising an effective amount of a redox-sensitive purine compound and an effective amount of a redox agent. The invention further provides methods of inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, by administering compositions of the invention. Methods of screening for compounds that inhibit a redox-sensitive GTPase protein, including compounds that target and inhibit Rho or Rab family GTPases, are further provided.

Abstract: A glucose sensor suitable for measuring glucose levels in human saliva is provided. Systems containing the glucose sensor and methods for making and using the sensor are also provided. The glucose sensor is highly sensitive and can detect glucose levels at least down to 5 ppm. Fabrication of the sensor involves depositing single-walled carbon nanotubes onto the surface of a working electrode in a 3 electrode electrochemical detector and functionalizing the nanotubes by depositing layers of polymers, metallic nanoparticles, and glucose oxidase enzyme onto the nanotubes. The sensor can be used as a disposable, single-use device or as part of an analytical system, such as a microfluidics system, for the analysis of multiple analytes. The sensor enables the diagnosis and monitoring of diabetes to be performed without pain or the need for finger pricks in a home or clinical setting.

Abstract: Provided are a polymer composition on a substrate and a surface modification method which is non-selective to substrate materials. Chemical vapor deposition polymerization is used to deposit a maleimide-functionalized poly-p-xylylene coating on a substrate. The substrate is readily available to perform a thiol-maleimide coupling reaction under mild conditions so as to modify the surface thereof. Furthermore, through a tailored thiol-terminal molecule, a designer surface can be created via thiol-maleimide coupling on a substrate, and the resulting surface can exhibit various desired biological functions for biotechnological applications. Therefore, this modification technique can be applied to biological fields extensively.

Abstract: Ultrasonic imaging apparatus or techniques can include obtaining at least an approximation of samples of reflected ultrasonic energy and constructing a representation of an imaging plane within the tissue region. Such apparatus or techniques can include separately determining, for respective focusing locations respective first sums of at least approximated complex samples of reflected ultrasonic energy obtained via respective first lines of transducers, and separately determining, for the specified focusing location, a second sum of at least some the respective first sums of at least approximated complex samples of reflected ultrasonic energy, the second sum corresponding to a second line of transducers in the ultrasonic transducer array. The separately determining the first or second sums of at least approximated complex samples can include phase-rotating at least some of the complex samples. The second line of transducers can be orthogonal to respective first lines in the transducer plane.

Abstract: A method of normalizing data can comprise globally normalizing at least a first and second data distribution by normalizing the proximal compositional proportionality of the abundance of the analyte using proximity-based intensity normalization. In an example, the proximity-based intensity normalization comprising using the following formula: i jx ? j = 1 n x ? ? i jx / i jy ? j = 1 n y ? ? i jy wherein: ijx is the intensity of ion j in the first distribution x, ijy is the intensity of ion j in the second distribution y, nx is the number of surrogate ions in distribution x, and ny is the number of surrogate ions in distribution y.

Abstract: Disclosed are systems and methods for characterizing interactions or proton beams in tissues. In certain embodiments, charged particles emitted during passage of protons, such as those used for therapeutic and/or imaging purposes, can be detected at relatively large angles. In situations where beam intensity is relatively low, such as in certain imaging applications, characterization of the proton beam with charged particles can provide sufficient statistics for meaningful results while avoiding the beam itself. In situations where beam intensity is relatively high, such as in certain therapeutic applications, characterization of the proton beam with scattered primary protons and secondary protons can provide information such as differences in densities encountered by the beam as it traverses the tissue and dose deposited along the beam path. In certain situations, such beam characterizations can facilitate more accurate planning and monitoring of proton-based therapy.

Abstract: A 10-transistor dual-port SRAM with shared bit-line architecture includes a first memory cell and a second memory cell. The first memory cell has a first storage unit, a first switch set, and a second switch set. The second memory cell has a second storage unit, a third switch set, and a fourth switch set. The second switch set is coupled to a complement first A-port bit line and a complement first B-port bit line, and connected to the first storage unit. The third switch set is connected to a complement second A-port bit line, a complement second B-port bit line, and the second storage unit. Thus, the second memory cell can make use of the third switch set to share the complement first A-port bit line and the complement first B-port bit line with the first memory cell.

Abstract: A surface acoustic wave (SAW) biofilm sensor includes a transmitting electric to acoustic wave transducer defining an upper surface and a lower surface, a receiving acoustic wave to electric transducer defining an upper surface and a lower surface, a piezoelectric film layer defining an upper surface and a lower surface, and a passivation film layer defining an upper surface and a lower surface. Portions of the lower surface of the piezoelectric film layer are disposed on the upper surface of the transmitting electric to acoustic wave transducer and on the upper surface of the receiving acoustic wave to electric transducer, and the lower surface of the passivation film layer is disposed on the upper surface of the piezoelectric film layer such that the upper surface of the passivation film layer is configured to enable contact with a biofilm.

Abstract: The present disclosure provides human Aquaporin 4 (AQP4) peptides and peptides having homology to human Aquaporin 4 (AQP4) peptides. Also provided herein are methods for using human AQP4 peptides and peptides homologous to human AQP4 peptides for diagnosing and/or treating Neuromyelitis Optica.