Abstract: The disclosure provides a method for quantification of hepatic function in a subject comprising measuring the clearance of an orally administered isotopically labeled cholic acid in a subject with, or suspected of having or developing, a hepatic disorder, for example, chronic hepatitis C. The disclosure further provides methods and kits for assessment of hepatic function.

Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.

Abstract: Provided is an assembly including a block co-polymer film and a plurality of nano-rods; where the plurality of nano-rods are oriented at the surface of the block co-polymer film, substantially perpendicular to at least one interface between block co-polymer domains. Further provided are methods of assembly formation and devices including such assemblies.

Abstract: We disclose the synthesis and use of chiral ionic liquids based on a substituted pentose, furanose, hexose, or pyranose sugar. The compounds and processes to make or use them are provided.

Abstract: Methods are provided for enhancing properties, including polarization, of thin-film ferroelectric materials in electronic devices. According to one embodiment, a process for enhancing properties of ferroelectric material in a device having completed wafer processing includes applying mechanical stress to the device, independently controlling the temperature of the device to cycle the temperature from room temperature to at or near the Curie temperature of the ferroelectric material and back to room temperature while the device is applied with the mechanical stress, and then removing the mechanical stress. Certain of the subject methods can be performed as part of a back end of line (BEOL) process, and may be performed during the testing phase at wafer or die level.

Abstract: Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.

Abstract: Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator and a serotonin reuptake inhibitor. Pharmaceutical composition comprising a serotonin reuptake inhibitor and a glutamate modulator are also provided.

Abstract: It is an object of the present invention to provide a method for efficient differentiation into blood cells. Specifically, in the present invention, when blood cells are produced from pluripotent stem cells such as ES cells or iPS cells in vitro, the cells are cultured under a low oxygen partial pressure to increase the efficiency of differentiating the pluripotent stem cells into hematopoietic progenitor cells, erythroid progenitor cells, and the like, so as to increase the number of finally obtained, desired blood cells.

Abstract: The invention provides a porous sensor and sensing methods that use a porous sensor with a porous nanostructure having an optical response and having a portion of the porous nanostructure filled with a fiducial marker that is non-reactive to an analyte of interest. In a preferred sensing method, reflectance spectra from both the fiducial marker and reactive portions of the porous structure are acquired simultaneously. The fiducial marker provides an internal reference that permits compensation for humidity, as well as off angle measurements. In addition, simple visual observations can reveal the presence of an analyte, including human observations.

Abstract: A method and system for providing a magnetic junction usable in a magnetic device are described. The magnetic junction includes a pinned layer, a nonmagnetic spacer layer, and a free layer. The nonmagnetic spacer layer is between the pinned layer and the free layer. The free layer has a magnetic anisotropy, at least a portion of which is a biaxial anisotropy. The magnetic junction is configured such that the free layer is switchable between a plurality of stable magnetic states when a write current is passed through the magnetic junction.

Abstract: The strut and tie method for waffle slabs relates to computer modeling of waffle slabs to predict strength and mode of failure. The waffle slab strut and tie method utilizes a three-dimensional strut-and-tie model, which is applied to distinct structural features of waffle slabs. Individual ribs in the slab form two-dimensional trusses, which are connected with perpendicular trusses at rib intersections. The geometry of the slab defines the location of nodes for finite element analysis.

Abstract: An axial-centrifugal flow catheter pump for cavopulmonary assistance is provided, incorporating a rotor providing both an axial fluid flow and a centrifugal fluid flow. The rotor includes a first terminal impeller configured to provide a centrifugal and axial fluid flow in a first direction, a second terminal impeller configured to provide a centrifugal and axial fluid flow in a second direction opposite to the first direction, and a central impeller configured to provide a predominantly centrifugal fluid flow. The first and second terminal impellers each include blade arrangements configured to provide a centrifugal and axial fluid flow directed toward the rotor central impeller. Cavopulmonary assistance devices are provided including the axial-centrifugal flow catheter pump.

Abstract: The present disclosure provides a precise performance three-dimensional ultrasound scanner that is lightweight for an easy hold by suggesting a novel constitution of a swing mechanism wherein an arrangement of the drive motor perpendicular to the swing axis requires a smaller capacity motor and eliminating a backlash. The swing mechanism includes: an arm holder connected to a rotational axis of the motor; an arm connected to the arm holder so that the arm swings within a certain angular range; a link, attached to the arm, for moving in unison with the arm; a shaft, connected to the link, for transmitting a rotary power of the arm to the transducer unit. The swing mechanism can be operated using the smaller capacity motor and eliminates the need for a pulley, gear or belt eliminating backlashes to promote implementation of lightweight precision three-dimensional ultrasound scanners.

Abstract: In the method, a pre-selected working area of a graphene film with a linear dimension of 2,000 nm, which working area is divided into sections having a dimension of 50-100 nm, is subjected to the effect of a pulsed alternating magnetic field with a frequency of 3 terahertz that corresponds to the transition from the ground energy level, corresponding to the non-excited state of spin density, to a fourth working energy level of the excited state of spin density in the graphene film, thus causing spin density pumping. A spatially localized external magnetic field is generated around the edges of the working area, which resonantly reflects spinons having a working frequency of 0.5-1 terahertz that corresponds to the transition from a third working energy level to a second working energy level of the excited state of spin density, said spinons causing the induced coherent radiation of working frequency spin waves as they pass thorough the working area.

Abstract: On a lower image display panel 141, a game result of rearranged of symbols 501 is randomly determined. When the result is winning of a bonus game, individual indication data and common indication data associated with the type of the bonus game are specified. After an indication effect starts based on the common indication data, an indication effect is executed based on the individual indication data.

Abstract: A pipelined processor comprising a cache memory system, fetching instructions for execution from a portion of said cache memory system, an instruction commencing processing before a digital signature of the cache line that contained the instruction is verified against a reference signature of the cache line, the verification being done at the point of decoding, dispatching, or committing execution of the instruction, the reference signature being stored in an encrypted form in the processor's memory, and the key for decrypting the said reference signature being stored in a secure storage location. The instruction processing proceeds when the two signatures exactly match and, where further instruction processing is suspended or processing modified on a mismatch of the two said signatures.

Abstract: A processor comprising: an instruction processing pipeline, configured to receive a sequence of instructions for execution, said sequence comprising at least one instruction including a flow control instruction which terminates the sequence; a hash generator, configured to generate a hash associated with execution of the sequence of instructions; a memory configured to securely receive a reference signature corresponding to a hash of a verified corresponding sequence of instructions; verification logic configured to determine a correspondence between the hash and the reference signature; and authorization logic configured to selectively produce a signal, in dependence on a degree of correspondence of the hash with the reference signature.

Abstract: In accordance with an embodiment of the disclosure, a method of making a supercapacitor includes impregnating a foam electrode substrate with an active material precursor, wherein the foam electrode substrate includes a plurality of pores and the active material precursor is dispersed into the pores. The method further includes reacting the active material precursor infiltrated foam substrate with a reductant under conditions sufficient to convert the active material precursor to an active material, wherein the active material is based on a nitride, an oxynitride, a carbide, or an oxycarbide of a metal selected from Groups III, IV, V, VI, or VII of the Periodic Table.

Abstract: This invention provides compounds that are true antagonists of the leptin receptor, in the presence and the absence of native leptin or another leptin receptor binder. These compounds may be used to inhibit leptin receptor activity, promote growth arrest or death of leptin receptor-positive cancer cells, or monitor or detect a leptin receptor-positive cell, in vitro or in vivo. These compounds may also be used to treat a weight-loss nutritional disorder, osteoporosis, rheumatoid arthritis, osteoarthritis, or inflammatory bowel disease. Also included in the invention are methods for detecting leptin receptor-positive cells, for arresting cell growth or killing cancer cells in vivo, for monitoring or detecting a leptin receptor-positive cell in vitro or in vivo, for treating a weight-loss nutritional disorder, for treating osteoporosis, for treating rheumatoid arthritis, for treating osteoarthritis, or for treating inflammatory bowel disease.

Abstract: A fixture-compatible, dimmable illumination driving apparatus including: a rectifying unit rectifying a phase-controlled waveform of an alternating current (AC) power; a comparing unit comparing an output waveform of the rectifying unit with a first voltage according to a preset reference clock; a reference voltage generating unit generating a reference voltage corresponding to the number of high signals higher than the first voltage among outputs of the comparing unit during one cycle of the output waveform; and a pulse width modulation (PWM) signal generating unit generating a PWM signal from the reference voltage and a feedback voltage.