Abstract: Systems and methods for depositing complex thin-film alloys on substrates are provided. In particular, systems and methods for the deposition of thin-film Cd1-xMxTe ternary alloys on substrates using a stacked-source sublimation system are provided, where M is a metal such as Mg, Zn, Mn, and Cu.

Abstract: The bioflavonoid luteolin reduces amyloid-? peptide (A?) generation. Luteolin is also a selective GSK-3 inhibitor that 1) decreases amyloidogenic ?-secretase APP processing, and 2) promotes presenilin-1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation. GSK-3? activity is essential for both PS1 CTF phosphorylation states and PS1-APP interaction. To validate The findings were validated in vivo, using a Tg2576 Alzheimer's Disease model system. Luteolin treatment decreased soluble A? levels, reduced GSK-3 activity, and disrupted PS1-APP association.

Abstract: A method for preparing a statin compound by lactonization is disclosed, which comprises the following step: lactonizing a compound of formula II into the compound of formula I in the presence of a strong acid catalyst and a dehydrant in a first solvent, wherein Z represents H, ammonium, or a metal cations; R1 is H or C1-C6 alkyl, preferably H or CH3, R2 is CH3, OH, CH2OH, CH2OC(O)R3, CH2OR3, or COOR4, preferably CH3 or OH, R3 and R4 are independently selected from the group consisting of H and C1-C6 alkyl.

Abstract: Continuous, conducting metal patterns can be formed from metal nanoparticle containing films by exposure to radiation (FIG. 1). The metal patterns can be one, two, or three dimensional and have high resolution resulting in feature sizes in the order of micron down to nanometers Compositions containing the nanoparticles coated with a ligand and further including a dye, a metal salt, and either a matrix or an optional sacrificial donor are also disclosed.

Abstract: The design and refinement of a tethered hovering platform into a feasible working system is presented. To determine a starting point for the design, a detailed historical search was conducted to find the history and the current state of such technology. Real world current needs are analyzed to produce a mission specification and to drive the preliminary vehicle design. Analysis of environmental conditions and decisions about an initial payload package are made in conjunction with motor and propeller sizing. Initial concept testing to discover feasibility and operational issues was performed; from this, instability issues were discovered. Analyzing these instability issues using known rotorcraft and momentum effects, in conjunction with flight testing, yields possible solutions to the problem. The use of constrained layer dampers as a means of passive stabilization is addressed and suggested as the preferred solution. Testing of passive constrained layer damping verifies the stability of the solution.

Abstract: XML parsing (PXP) can be improved using multicore CPUs, enhancing its suitability for scientific data. One approach is to divide the XML document into equal-sized chunks, and parse each chunk in parallel. XML parsing is inherently potentially dependent on all preceding characters. The skeleton, an outline of the document generated during a fast preparse, is used to guide full parallel parsing. The preparse is a sequential phase that limits scalability, and this phase can also be parallelized using a meta-DFA mechanism. For each state q of the original preparser the meta-DFA incorporates a complete copy of the preparser state machine as a sub-DFA which starts in state q running multiple instances of the preparser simultaneously when parsing a chunk, with each possible preparser state at the beginning of a chunk represented by an instance. By pursuing all possibilities simultaneously, the meta-DFA allows each chunk to be preparsed independently in parallel.

Abstract: Described herein are high-throughput methods of monitoring D-serine levels in plasma. The assay involves the use of strong cation solid phase extraction (SPE) to isolate D-serine from plasma, followed by quantitation of D-serine using the D-amino acid oxidase- (DAAO-) catalyzed reaction. Also described are methods of screening for compounds that act as DAAO inhibitors.

Abstract: The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation/phosphorylation of STAT3 induced by IL-6 in cultured neuronal cells. Furthermore, mice treated with diosmin showed a significant reduction of autistic phenotype induced by IL-6 through inhibition of STAT3 activation.

Abstract: Disclosed herein is the production of hydrocarbon based fuel from micro-organisms and algae that comprise algaenan without requiring prior removal of water, as well as the production of hydrocarbon based fuel directly from the algaenan itself. Also disclosed herein are feed material for the processes disclosed herein comprising modified algae and algaenan that selectively produce hydrocarbon of desired chain lengths, along with the process of modifying the algae and algaenan. Also disclosed herein is the production of both hydrocarbon and organic fertilizer from algae without the need to remove the water from the algae prior to processing.

Abstract: Methods and apparatuses for analyzing proteins and other biological materials and xenobiotics within a sample. A specimen is generated, which may include an energy absorbent matrix. The specimen is struck with laser beams such that the specimen releases proteins. The atomic mass of the released proteins over a range of atomic masses is measured. An atomic mass window of interest within the range of atomic masses is analyzed to determine the spatial arrangement of specific proteins within the sample, and those specific proteins are identified as a function of the spatial arrangement. By analyzing the proteins, one may monitor and classify disease within a sample.

Abstract: Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.

Abstract: A direct contact segmented column heater is described. The heater is capable of a broad heating and cooling range, and exhibits a very rapid response, with heating and cooling rates better than 350° C. min?1. In one configuration one or more of the individual heating devices are provided with full independent control and temperature feedback, and developed to provide excellent thermal stability at all temperatures. The heating devices or in other words active thermal transfer devices are capable of bi-directional operation, selectively heating (i.e., providing heat to) or cooling (i.e., withdrawing heat from) a column and/or contents of a column.

Abstract: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3? ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.

Abstract: A six-coordinated ruthenium complex is represented by the following formula (I): RuL1L2L3??(I) wherein L1 represents a 2,2?-bipyridine-based bidentate ligand having at least two functional groups selected from COOH, a carboxylate group and the combination thereof; and L2 and L3 independently represent a 1-(haloalkylpyrazole)-isoquinoline-based bidentate ligand of formula (II) or formula (III).

Abstract: The method of making diethylbenzene selectively produces diethylbenzene by reacting ethylbenzene and ethanol over a zeolite catalyst, such as ZSM-5. The zeolite catalyst is first heated in argon gas within a reaction chamber. The zeolite catalyst is then selectively coked with a precursor mixture of ethylbenzene and ethanol. Argon gas is then flowed over the coked zeolite catalyst, and a reaction mixture of ethylbenzene and ethanol is injected into the reaction chamber to produce diethylbenzene, which is then removed from within the reaction chamber.

Abstract: Techniques, systems and apparatus are disclosed for detecting impedance. In one aspect, a microelectrode sensing device includes a substrate and an array of microelectrode sensors formed on the substrate. Each sensor includes at least one conductive layer formed above the substrate and patterned to include a counter electrode and multiple sensing electrodes to detect an electrical signal in absence and presence of one or more target cells positioned on at least a portion of a surface of each sensing electrode. The sensing electrodes are spaced apart and arranged around the counter electrode to provide a spatially averaged value of the detected electrical signal.

Abstract: A gaming environment is described. If a predetermined number or more marks are displayed, one of progressive chance games will be executed. Also, the progressive chance game to be executed is determined based on the displayed mark. If a progressive bonus is realized in the progressive chance game, jackpot amount corresponding to the progressive bonus will be provided.

Abstract: The present invention relates to compositions that contain a chimeric papillomavirus virus-like particle (VLP) in combination with a DNA molecule encoding a protein or polypeptide epitope. The chimeric papillomavirus VLP is assembled from an L1 protein or polypeptide and a chimeric protein or polypeptide containing at least a portion of the L2 protein and a protein or polypeptide including an immunogenic epitope. The composition is useful for inducing an enhanced immune response against a pathogen or a tumor.

Abstract: A screen in which observation distance may be adjusted while maintaining image brightness and a projection system using the screen. In a light control layer of a screen, a first angle region that determines a diffusion distribution of a reflected light is different according to the screen position in a control direction in which light diffusion control is performed. Accordingly, a diffusion distribution of image light emitted from a screen surface is adjusted to be tilted downward by an upper end and upward by a lower end according to the screen position. Thus, for example, a size of a diffused angle range is maintained to be 30°, and a direction in which the image light is diffusion-emitted corresponds to an assumed position of an observer. The projection image can be observed while maintaining brightness of an image and the observation distance L can be adjusted to be short.

Abstract: Among the methods, compositions, combinations and kits provided herein are those for determining gene expression levels in one or more cell types in heterogeneous cell samples, for identifying genes differentially expressed in different cell types, and for detecting a cell type in a sample from a subject. Also provided herein are methods, compositions, combinations and kits for determining gene expression levels in cells corresponding to phenotypes, and for identifying a phenotype of a subject by detecting differentially expressed genes.