Abstract: Certain embodiments provide a GPCR fusion protein. In particular embodiments, the GPCR fusion protein comprises: a) a G-protein coupled receptor (GPCR); and b) an autonomously folding stable domain, where the autonomously folding stable domain is N-terminal to the GPCR and is heterologous to the GPCR. The GPCR fusion protein is characterized in that is crystallizable under lipidic cubic phase crystallization conditions. In certain embodiments, the GPCR fusion protein may be crystallizable in a complex with a G-protein or in a complex with an antibody that binds to the IC3 loop of the GPCR.

Abstract: A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8. Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8.

Abstract: The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).

Abstract: A bottom feed cavity aperture antenna is provided. The bottom feed cavity aperture antenna includes a patch and a ground structure. The patch feeds a signal to the bottom feed cavity aperture antenna. The ground structure includes a continuous wall, and a top end and a bottom end, wherein the continuous wall surrounds the patch, a thickness of the ground structure is formed between the top end and the bottom end, a patch height is formed between the patch and the bottom end, and a ratio of the patch height to the thickness is substantially lower than 1/2, and a magnetic field is formed at the top end, and magnetic resonance directions of the magnetic field are parallel to a first axis.

Abstract: Compositions of fluorapatite derivative crystals are disclosed herein. Also disclosed are methods of using these compositions to treat tooth sensitivity, to use as an anticaries treatment, to use as a restorative material, to use as a tooth surface whitener, and to combat or lessen the side effects of tooth whitening.

Abstract: A gallium nitride (GaN) based light emitting diode (LED), wherein light is extracted through a nitrogen face (N-face) of the LED and a surface of the N-face is roughened into one or more hexagonal shaped cones. The roughened surface reduces light reflections occurring repeatedly inside the LED, and thus extracts more light out of the LED. The surface of the N-face is roughened by an anisotropic etching, which may comprise a dry etching or a photo-enhanced chemical (PEC) etching.

Abstract: A Space Division Multiple Access transmission method based on a statistical characteristic pattern including configuring multiple receiving and transmitting antennae at a base station side into one or more antenna arrays; comparing a diagonalization performance among the unitary matrixes for a correlation matrix of subscriber channels, with a long-time statistical correlation matrix of the subscriber channels at the base station side; calculating an optimal diagonalized correlation matrix, and then performing characteristic pattern clustering for the subscribers in a cell with the space resource divisions of the subscribers; grouping the subscribers that belong to a same characteristic pattern cluster into space division subscriber groups; carrying out SDMA transmission, by the subscribers in a same space division subscriber group, with their space resource divisions; dynamically performing subscriber characteristic pattern clustering and space division subscriber grouping described above to generate updated

Abstract: A method is provided for making “smart” paper and “smart” microfibers by means of nanotechnology layer-by-layer techniques. The method comprises forming an aqueous pulp of lignocellulose fibers and nanocoating it by alternatively adsorbing onto the fibers multiple consecutively-applied layers of organized ultra thin and oppositely-charged polyelectrolytes, at least one of which is an electrically conductive polymer or nanoparticle (or a magnetically active polymer or nanoparticle, or an optically active polymer or nanoparticle), and another one of which has a charge opposite of said electrically conductive polymer or nanoparticle (or magnetically active polymer or nanoparticle, or optically active polymer or nanoparticle), thereby making a modified aqueous pulp of electrically conductive (or magnetically active, or optically active) multi-layer nanocoated lignocellulose fibers.

Abstract: Disclosed in this specification is a method for aligning nanostructures. A substrate is coated with a liquid solution comprising particles. Before the solution is cured, circularly-polarized light is applied to the substrate to induce a magnetic field in the particles. A low strength magnetic field is then applied. The induced magnetic field of the particles aligns with the applied magnetic field. The solution is permitted to cure while simultaneously exposed to both the circularly-polarized light and the applied magnetic field. The resulting composite retains the particle alignment.

Abstract: A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

Abstract: An apparatus for providing input to a processor includes a sensor pad having a surface and a sensor array for sensing pressure at the surface and producing signals corresponding to the pressure at the surface. The sensor array having columns and rows of electrodes that are covered with resistive material which fills in the spaces between the electrodes and acts as a linear resistor between the electrodes and measures pressure on the pad surface between the electrodes. The apparatus includes an interface in contact with the sensor pad and in communication with the sensor array which couples to the processor to communicate the signals to the processor. A method for providing input to a processor includes the steps of sensing pressure with a sensor pad having a surface and a sensor array for sensing the pressure at the surface. There is the step of producing signals corresponding to the pressure at the surface with the sensor array.

Abstract: A technique for processing of data from time-of-flight (TOF) PET scanners. The size of TOF PET data may be reduced without significant loss of information through a process called rebinning. The rebinning may use the Fourier transform properties of the measured PET data, taken with respect to the time-of-flight variable, to perform data reduction. Through this rebinning process, TOF PET data may be converted to any of the following reduced representations: 2D TOF PET data, 3D non-TOF PET data, and 2D non-TOF PET data. Mappings may be exact or approximate. Approximate mappings may not require a Fourier transform in the axial direction which may have advantages when used with PET scanners of limited axial extent. Once TOF PET data is reduced in size using this rebinning, PET images may be reconstructed with hardware and/or software that is substantially less complex and that may run substantially faster in comparison to reconstruction from the original non-rebinned data.

Abstract: A semi-rigid electronic device is disclosed that includes a flexible panel and a housing. The housing may have a physical dimension L, such as length, height, or a diagonal. The minimum bending device radius of the device along the dimension L may be L/pi when held at an edge. The bending radius increases the more rigid the device. The housing, electronic components, and display may each contribute to the flexibility of the overall device. The housing and/or the flexible panel may also include one or more ribs to constrain movement of the semi-rigid device.

Abstract: A method for fabricating semiconductor devices includes: (a) forming a layered structure that includes a temporary substrate, a plurality of spaced apart sacrificial film regions on the temporary substrate, and a plurality of valley-and-peak areas among the sacrificial film regions; (b) growing laterally and epitaxially an epitaxial film layer over the sacrificial film regions and the valley-and-peak areas, wherein gaps are formed among the epitaxial film layer and the valley-and-peak areas; (c) forming a conductive layer to contact the epitaxial film layer; (d) forming a plurality of grooves to divide the epitaxial film layer and the conductive layer into a plurality of epitaxial structures on the temporary substrate; and (e) removing the temporary substrate and the sacrificial film regions from the epitaxial structures by etching the sacrificial film regions through the gaps and the grooves.

Abstract: The present invention relates to a cathode active material for a lithium secondary battery and a process for preparing the same. In accordance with the present invention, the cathode active material having a high packing density was designed and synthesized and thus provided is a cathode active material for a lithium secondary battery exhibiting structural stability such as improved characteristics for charge/discharge, service life and high-rate and thermal stability, by modifying surface of the electrode active material with amphoteric or basic compounds capable of neutralizing acid produced around the cathode active material.

Abstract: Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia.

Abstract: The present invention relates to a mesoporous titania bead and the preparation method thereof, wherein said mesoporous titania bead has a diameter of 200-1000 nm, specific surface area of 50-100 m2/g, porosity of 40-60%, pore radius of 5-20 nm, pore volume of 0.20-0.30 cm3/g, and the titania comprised in the bead is anatase titania.

Abstract: A method for producing a porous thin film with variable transmittance, includes placing a polymer into an oven for an drying process to remove water vapor from the polymer and obtain a dry polymer; mixing the dry polymer, a salt and a solvent in accordance with a mixing ratio so as to obtain a first mixed solution; placing the first mixed solution into an ultrasonic vibrator, dissolving the salt to form a second mixed solution; coating the second mixed solution on a glass plate to form a solution thin film; placing solution thin film into an exhaust cabinet to obtain a composite thin film; and washing the composite thin film to remove the salt from the composite thin film to obtain a porous thin film wherein the polymer is a polyacrylonitrile, the salt is a lithium chloride, the porous thin film changes its transmittance via dry and wet state.

Abstract: Compositions and methods are provided for using tyrosine kinase inhibitors to treat pathogenic infection. In particular, methods for using Abl-family tyrosine kinase inhibitors to treat pathogenic infection are provided. Infections to be treated according to the present invention include, particularly, those caused by microbial pathogens such as bacteria and viruses.

Abstract: This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer, metabolic diseases of bone and lipid storage. The invention is also applicable to infectious diseases where Rab7 is inactivated or its protein-protein interactions are modulated to facilitate intracellular survival of pathogens. The compound described acts as a competitive inhibitor of nucleotide binding and as such also has utility as a scaffold for targeting other small GTPases. In one aspect, methods of treatment of the invention are used to treat or prevent the onset of hereditary sensory neuropathies such as Charcot-Marie-Tooth type 2B disease. Related pharmaceutical compositions, assays, and drug screens are also provided.