Patents Assigned to University
  • MicroRNA-140-5p as a tumor suppressor and sensitizing agent for chemotherapy
    Patent number: 8765707
    Abstract: The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-140-5p or an agent that mimics the effects of microRNA-140-5p. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA-140-5p or an agent that enhances the expression of microRNA-140-5p.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: July 1, 2014
    Assignees: University of Houston System, Baylor College of Medicine
    Inventors: Preethi H. Gunaratne, Jason M. Shohet
  • Metal complex, light emitting element, and display device
    Patent number: 8765952
    Abstract: The present invention provides a metal complex containing a cation represented by [(MII)2(MI)2(LC)2(LB)4]2+ [in the aforementioned formula, MII is PtII or PdII, MI is H+, AuI, AgI, CuI, HgI, TlI or PbI, and LC and LB are ligands]. The metal complex of the present invention is useful as a light emitting material of an organic EL device.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: July 1, 2014
    Assignee: Nagasaki University
    Inventors: Keisuke Umakoshi, Ami Higashitani, Kazutoyo Kimura, Shoji Ishizaka, Noboru Kitamura
  • Litter receptacle
    Patent number: 8763840
    Abstract: A litter receptacle system, including: a support frame; a container for receiving and storing litter; a coupler; and a retention device; wherein the coupler rotatably couples the container to the support frame; the retention device is in communication with the support frame and the container; and the retention device is operable to releasably secure the container to the support frame, and a method of using the same.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: July 1, 2014
    Assignee: University of Georgia Research Foundation
    Inventors: Michael Oliveri, Deirdre L. Dunphy, Robert Carl Martin, Lou Ellen Kregel, Michael S. Lachowski, Carol Elisabeth John
  • System and method for removal of hazardous substances from liquid crystal displays
    Patent number: 8764503
    Abstract: A process for removing hazardous substances from a LCD display (1) includes incision through off set lines (10) around the front of the panel (3). Top components are then removed to expose the fluorescent tubes (5) which contain hazardous substances. The incisions are parallel to the recessed lips, at a distance in the range of 0 to 20 mm from the recessed lips. The cuts are to a depth of 20 mm to 50 mm. Preferably, at least two incisions are made simultaneously. The fluorescent tubes (5) are crushed after the access operation, by rollers, chains or by plates. During crushing there is suction of the particles and gases which are released, thereby removing the hazardous substances by filtration.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: July 1, 2014
    Assignee: University of Limerick
    Inventors: Lisa O'Donoghue, Huw Lewis, Alan Ryan
  • Contoured elastomeric barrier for bowel retention and method of use
    Patent number: 8764625
    Abstract: The invention provides a device for bowel packing having an essentially elliptical shape that is essentially symmetrical along a minor axis of the ellipse, and the device includes a notch located on the minor axis below the major axis. The device is composed of material comprising an elastomeric polymer and the device is appropriately sized for retaining the intestines of a mammal. The invention further provides methods of use of the devices of the invention for bowel packing. The invention further provides methods for increasing bowel packing speed, increasing effectiveness of bowel retention, decreasing the formation of post-operative intraperitoneal adhesions, and increasing temperature of the abdominal cavity during surgery by use of the device.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: July 1, 2014
    Assignee: The Johns Hopkins University
    Inventors: Antonio Santillan, Robert E. Bristow, Joshua Liu, Gayathree Murugappan, Anshuman Gupta, Brian G. Liu, Sameer S. Manek, Michael R. Bisogno, Kevin Yeh, Vicki Zhou
  • Method for making lithium-ion battery electrode material
    Patent number: 8765213
    Abstract: The present disclosure relates to a method for making an electrode material of lithium-ion batteries. In the method, a carbon source compound is dissolved into a solvent to form a liquid phase solution. A number of titanium dioxide particles are provided and are dispersed into the liquid phase solution. The carbon source compound is pyrolyzed, thereby forming a number of carbon coating titanium dioxide particles. A lithium source solution is provided. The lithium source solution and the carbon coating titanium dioxide particles are mixed, according to a molar ratio in a range from about 4:5 to about 9:10, of lithium element to titanium element, thereby forming a sol. The sol is spray dried to form a number of precursor particles. The precursor particles are heated to form a lithium titanate composite electrode material.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: July 1, 2014
    Assignees: Tsinghua University, Hon Hai Precision Industry Co., Ltd.
    Inventors: Li Wang, Xiang-Ming He, Jian-Guo Ren, Jian Gao, Jian-Jun Li, Wei-Hua Pu
  • Therapeutic drug for adult T-cell leukemia
    Patent number: 8765719
    Abstract: An object is to provide a novel therapeutic drug for adult T-cell leukemia having an ATL cell specific antitumor effect. The therapeutic drug for adult T-cell leukemia according to the invention is characterized by containing a compound represented by the formula I or a prodrug thereof, wherein R1 is H, OH, an alkoxy group, an acyl group, or a thioacyl group, R2 is an acyl group, a thioacyl group, CONR7R8, or CSNR7R8 (R7 and R8 being each independently H, an alkyl group containing 1 to 3 carbon atoms, or a phenyl group), or R1 and R2 together may form a ring, X1 and X2 may be the same or different and are each —CR3R4—, —SiR3R4— or oxygen, and R3 and R4 may be the same or different and are each an alkyl group containing 1 to 6 carbon atoms.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: July 1, 2014
    Assignee: Kagoshima University
    Inventors: Masanori Baba, Yuichi Hashimoto
  • Tumor necrosis factor inhibitors
    Patent number: 8765810
    Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: July 1, 2014
    Assignees: The Trustees Of The University Of Pennsylvania, Cephalon, Inc.
    Inventors: Mark I. Greene, Ramachandran Murali, Xin Cheng, Raphael Ottenbrite, Yingxin Xiaio
  • Nanomanipulation coupled nanospray mass spectrometry (NMS)
    Patent number: 8766177
    Abstract: A coupled nanomanipulation and nanospray mass spectrometry (NMS) system for single cell, single organelle, and ultra-trace molecular analysis is disclosed herein. The system primarily comprises a bio-workstation coupled to a NMS. The bio-workstation primarily comprises of a nanomanipulator stage with a plurality of nano-positioners attached to a cabinet with a piezo voltage source and a pressure injector. The present invention further describes a fingerprint lift method that when coupled with the system disclosed herein can be used for retrieval and analysis of trace amounts of drug and explosive residues. The system described herein has been used in the areas of trace and document analysis within the forensic field, trace fiber analysis, and electrostatic lifts for illicit drugs, as well as document and painting analysis.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: July 1, 2014
    Assignee: University of North Texas
    Inventor: Guido Fridolin Verbeck, IV
  • Star polymers, methods of preparation thereof, and uses thereof
    Patent number: 8765098
    Abstract: A composition of matter comprising an amphiphilic star polymer, the star polymer comprising a crosslinked microgel core and 6 or more independent polymer arms covalently linked to the core, the 6 or more arms each comprising a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; wherein each individual metal selected from the group consisting of beryllium, magnesium, calcium, strontium, barium, radium, aluminum, gallium, indium, thallium, germanium, tin, lead, arsenic, antimony, bismuth, tellurium, polonium, and metals of Groups 3 to 12 of the Periodic Table has a concentration in the star polymer of greater than or equal to 0 parts per million and less than or equal to 100 parts per million.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: July 1, 2014
    Assignees: International Business Machines Corporation, The Board of Trustees of The Leland Stanford Junior University
    Inventors: Eric Andrew Appel, James Lupton Hedrick, Victor Yee-Way Lee, Robert Dennis Miller, Joseph Sly
  • RNA interference mediating small RNA molecules
    Patent number: 8765930
    Abstract: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAI. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3? ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: July 1, 2014
    Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V., Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, University of Massachusetts
    Inventors: Thomas Tuschl, Sayda Mahgoub Elbashir, Winfried Lendeckel
  • Computer-implemented method of preoperatively determining the optimized external shape of a prosthetic femoral hip stem
    Patent number: 8768674
    Abstract: Computer-implemented method of preoperatively determining the optimized external shape of a prosthetic femoral hip stem for use in partial cementing hip replacement procedures and of a reamer for reaming a cavity in the femur of a patient for implanting the prosthetic femoral hip stem, comprising: a) setting an initial external shape of the prosthetic femoral hip stem based on the reconstructed femur anatomy of a patient, b) generating an associated initial reamer by negatively offsetting the initial external shape of the prosthetic femoral hip stem by an uniform offset value ?, c) calculating contact stresses at the interface of the prosthetic femoral hip stem and the patient's femur when reamed by the initial reamer and d) optimizing the offset value ?, so that the contact stresses are within a predetermined acceptable range.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 1, 2014
    Assignee: King Saud University
    Inventors: Saied Mohamed Hassan Darwish, Mohamed Zoubir A. Bendjaballah
  • LASER
    Publication number: 20140177667
    Abstract: A laser includes a total reflective mirror, an output mirror, a discharge lamp, and an active laser medium. The total reflective mirror, the output mirror, and the discharge lamp define a resonant cavity. The active laser medium is filled in the resonant cavity. The total reflective mirror includes a body, a metal film, and at least one microstructure. The at least one microstructure has a height and a lateral size, and both the height and the lateral size are in a range from about 0.5? to about 2?, while ? is a working wavelength of the laser.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., Tsinghua University
    Inventors: JUN ZHU, JING-LEI ZHU, QUN-QING LI, KAI-LI JIANG, CHEN FENG, GUO-FAN JIN, SHOU-SHAN FAN
  • TOPOLOGICAL INSULATOR STRUCTURE
    Publication number: 20140178674
    Abstract: A topological insulator structure includes an insulating substrate and a magnetically doped TI quantum well film located on the insulating substrate. A material of the magnetically doped TI quantum well film is represented by a chemical formula of Cry(BixSb1-x)2-yTe3. 0.05<x<0.3, 0<y<0.3, and 1:2<x:y<2:1. The magnetically doped TI quantum well film is in 3 QL to 5 QL.
    Type: Application
    Filed: October 16, 2013
    Publication date: June 26, 2014
    Applicants: Institute of Physics, Chinese Academy of Sciences, Tsinghua University
    Inventors: QI-KUN XUE, KE HE, XU-CUN MA, XI CHEN, LI-LI WANG, CUI-ZU CHANG, XIAO FENG, YAO-YI LI, JIN-FENG JIA
  • MESH ENCLOSED TISSUE CONSTRUCTS
    Publication number: 20140180399
    Abstract: Described is a heart valve leaflet manufactured from a mesh material. The mesh material may have an ability to capture circulatory/stationary/migratory cells of the body to become biologically active. In some cases, the mesh material is coated with a bioactive material, such as a molecule that binds to a cell adhesion molecule (CAM), a growth factor, an extracellular matrix molecule, a subendothelial extracellular matrix molecule or a peptide. The mesh has a stiffness that is comparable to a native heart valve leaflet, such that it functionally mimics a native heart valve.
    Type: Application
    Filed: January 23, 2014
    Publication date: June 26, 2014
    Applicant: The Regents of the University of California
    Inventors: Seyedhamed Alavi, Arash Kheradvar
  • COMPOSITIONS AND METHODS FOR DIAGNOSING COLON DISORDERS
    Publication number: 20140179537
    Abstract: The present invention relates to methods and compositions for diagnosing, monitoring, prognosticating, analyzing, etc., polymicrobial diseases. The present invention also relates to the microbial community present in the digestive tract and lumen in normal subjects, and subjects with digestive tract diseases, especially diseases of the colon, such as inflammatory bowel disease, including ulcerative colitis, Crohn's syndrome, and pouchitis. The present invention especially relates to compositions and methods for diagnosing and prognosticating the mentioned diseases and conditions, e.g., to determine the presence of the disease in a subject, to determine a therapeutic regimen, to determine a therapeutic regimen, to determine the onset of active disease, to determine the predisposition to the disease, etc.
    Type: Application
    Filed: November 25, 2013
    Publication date: June 26, 2014
    Applicants: Rush University, George Mason Intellectual Properties, Inc.
    Inventor: Patrick M. Gillevet
  • EXFILTRATION APPARATUS
    Publication number: 20140175002
    Abstract: An exfiltration apparatus for removing contaminants from a fluid includes a housing, a filter portion positioned within the housing, and a particulate collecting member. The housing defines a fluid flow path extending from a fluid inlet disposed on a first side of the housing to a fluid outlet disposed on a second side of the housing. The particulate collecting member is disposed within the housing between the fluid inlet and the filter portion. The particulate collecting member includes a recessed particulate collecting portion proximate the filter portion and a raised apertured portion proximate the fluid inlet. Fluid flowing along the fluid flow path passes through the particulate collecting member and through the filter portion before exiting through the fluid outlet.
    Type: Application
    Filed: December 16, 2013
    Publication date: June 26, 2014
    Applicant: Ohio University
    Inventors: Shad M. Sargand, Gayle F. Mitchell
  • RAY EMISSION DEVICE AND IMAGING SYSTEM HAVING THE SAME
    Publication number: 20140177802
    Abstract: A ray emission device and an imaging system with the ray emission device are disclosed. The ray emission device comprises: a cylinder; a ray source disposed in the cylinder for emitting a ray; and a collimator disposed in the cylinder. The collimator enables the ray emitted by the ray source to form sectorial ray beams at a plurality of positions in an axial direction of the cylinder. The cylinder has a pencil beam forming part arranged over an axial length of the cylinder corresponding to the plurality of positions. The sectorial ray beams form pencil beams through the pencil beam forming part when the cylinder rotates around a rotation axis.
    Type: Application
    Filed: October 22, 2013
    Publication date: June 26, 2014
    Applicants: Tsinghua University, Nuctech Company Limited
    Inventors: Ziran Zhao, Wanlong Wu, Yingkang Jin, Le Tang, Guangwei Ding, Chenguang Zhu
  • MULITPLE CONTROLLED ELECTROCHROMIC DEVICES FOR VISIBLE AND IR MODULATION
    Publication number: 20140175281
    Abstract: An electrochromic device (ECD) includes an electrochromic cell and, optionally, one or more additional electrochromic cells where all cells are parallel, and where at least one of the electrodes of one of the cells comprises a single-walled carbon nanotube (SWNT) film The electrochromic cells allow the control of transmittance of two or more different portions of the electro-magnetic spectrum through the ECD. One cell can control the transmittance of visible radiation while the other cell can control the transmittance of IR radiation. The ECD can be employed as a “smart window” to control the heat and light transmission through the window. The ECD can be in the form of a laminate that can be added to an existing window.
    Type: Application
    Filed: June 28, 2012
    Publication date: June 26, 2014
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: John R. Reynolds, Ryan M. Walczak, Andrew Gabriel Rinzler, Svetlana V. Vasilyeva, Aubrey Lynn Dyer
  • Therapeutic Nuclease Compositions and Methods
    Publication number: 20140178379
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Application
    Filed: February 6, 2014
    Publication date: June 26, 2014
    Applicant: University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun