Abstract: A method for determining a quotient value from a dividend value and a divisor value in a digital processing circuit is provided. The method includes computing a reciprocal value of the divisor value and multiplying the reciprocal value by the dividend value to obtain a reciprocal product, the reciprocal product having an integer part. The method also includes computing an intermediate remainder value by computing a product of the integer part and the divisor value, and subtracting the resulting product from the dividend value and determining the quotient value based upon the intermediate remainder value.
Abstract: The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.
Type:
Grant
Filed:
December 8, 2010
Date of Patent:
April 8, 2014
Assignees:
Vanderbilt University, The United States of America as represented by the Department of Veterans Affairs
Inventors:
Colleen M. Brophy, Padmini Komalavilas, Joyce Cheung-Flynn, Kyle M. Hocking, Susan S. Eagle
Abstract: Disclosed are mechanically-actuated devices for transporting fluids within a microfluidic circuit and performing diagnostic operations on a sample. Also disclosed are related methods for performing sample analysis effected by the motion of an actuator proximate to a microfluidic system.
Type:
Grant
Filed:
December 14, 2007
Date of Patent:
April 8, 2014
Assignee:
The Trustees Of The University Of Pennsylvania
Inventors:
Zongyuan Chen, Haim H. Bau, Michael Mauk, Xianbo Qiu, Jason Kwa
Abstract: A method for removing germanium suboxide between a germanium (Ge) substrate and a dielectric layer made of metal oxide includes causing a supercritical fluid composition that includes a supercritical carbon dioxide fluid and an oxidant to diffuse into the germanium suboxide such that metal residues in the dielectric layer, the germanium suboxide and the oxidant are subjected to a redox reaction so as to reduce the germanium suboxide into germanium.
Abstract: Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking and methods of making and using thereof.
Type:
Grant
Filed:
July 15, 2011
Date of Patent:
April 8, 2014
Assignee:
University of Utah Research Foundation
Inventors:
Glenn D. Prestwich, Xiao Zheng Shu, Yanchun Liu
Abstract: The present invention provides a pharmaceutical composition for preventing or treating rheumatoid arthritis comprising rebamipide as an active ingredient and a pharmaceutically acceptable carrier. The pharmaceutical composition may be for oral administration, for example an oral solid dosage form of a tablet or capsule form. The pharmaceutical composition may be formulated into a unit dosage form suitable for orally administering rebamipide in a dose ranging from 0.5 to 50 mg/kg, preferably from 0.6 to 6 mg/kg.
Type:
Grant
Filed:
October 8, 2009
Date of Patent:
April 8, 2014
Assignees:
Catholic University Industry Academic Cooperation Foundation, Hanlim Pharmaceutical Co., Ltd.
Inventors:
Jun-Ki Min, Mi-La Cho, Yun-Ju Woo, Hye-Jwa Oh, Joo-Yeon Jhun, Geun-Hyeog Lee, Se-Wan Park, Jin-Ha Park, Eun-Young Kwak
Abstract: Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
Type:
Grant
Filed:
January 24, 2012
Date of Patent:
April 8, 2014
Assignee:
The Regents of the University of Michigan
Inventors:
Shaomeng Wang, Haibin Zhou, Jianfang Chen, Angelo Aguilar, Jennifer L. Meagher, Duxin Sun, Chao-Yie Yang, Liu Liu, Longchuan Bai, Donna McEachem, Jeanne Stuckey, Xiaoqin Li
Abstract: A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.
Type:
Grant
Filed:
September 14, 2012
Date of Patent:
April 8, 2014
Assignees:
Regeneron Pharmaceuticals, Yale University, Institute for Research in Biomedicine (IRB)
Inventors:
Sean Stevens, Andrew J. Murphy, Richard Flavell, Elizabeth Eynon, Jorge Galan, Tim Willinger, Markus Manz, Anthony Rongvaux, George D. Yancopoulos
Abstract: In methods and systems to authenticate systems in a quantum key distribution environment based on limited disclosures and identical, re-usable, pre-provisioned authentication keys, each system constructs an encryption key based on a corresponding one of transmitted events and detected events. Basis-sifting, error detection, error correction, and/or privacy amplification (PA) may be performed on the encryption keys based on limited disclosures (e.g., detection interval information, basis-sifting information, associated detection basis information, and/or parity measures). The authenticated keys may be modified based on disclosed detection information. Error detection and/or PA may be performed with identical pre-provisioned algorithms and pseudo-random values generated from the authenticated keys or modified authenticated keys. Final authenticated encryption keys are selectively constructed depending upon an extent of detected errors.
Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue, either ex vivo or in vivo, and compare the response data with a model configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes.
Type:
Grant
Filed:
May 16, 2012
Date of Patent:
April 8, 2014
Assignee:
The Regents of the University of Michigan
Inventors:
Mary-Ann Mycek, Malavika Chandra, James Scheiman, Robert H. Wilson, Diane Simeone, Barbara McKenna, Jeremy Taylor, Oliver Lee, Leng-Chun Chen, William Lloyd
Abstract: A thin-film manufacturing method includes the steps of: generating a plasma from source gas; extracting ions from the plasma; and depositing a thin film on one side or both sides of a substrate to be deposited with the ions. The method is performed in an apparatus including: a plasma chamber generating the plasma; a film deposition chamber accommodating the substrate to be deposited; an ion transfer path for transferring the ions from the plasma chamber to the film deposition chamber; a branch pipe branching from the ion transfer path; and an exhaust system connected to the branch pipe. The thin film is formed while the source gas except the ions is exhausted from the branch pipe.
Type:
Grant
Filed:
September 23, 2011
Date of Patent:
April 8, 2014
Assignees:
Fuji Electric Co., Ltd., Kyushu University, National University Corporation
Inventors:
Tomonori Katano, Katsumi Taniguchi, Kungen Teii
Abstract: A data-intensive computer includes a processing sub-system formed by a plurality of processing servers, a database sub-system formed by a plurality of database servers configured to form a collective database, and a unifying operating system environment. The unifying operating system environment extends across the processing sub-system and the database sub-system to coordinate operation of the plurality of processing servers and the plurality of database servers to act as components in a single data-intensive computer and presents the database sub-system to an application running in the data-intensive computer as a layer in a memory hierarchy of the data-intensive computer.
Abstract: The present disclosure relates to an example of a method for a first router to adaptively determine status within a network. The network may include the first router, a second router and a third router. The method for the first router may comprise determining status information regarding the second router located in the network, and transmitting the status information to the third router located in the network. The second router and the third router may be indirectly coupled to one another.
Type:
Grant
Filed:
September 13, 2012
Date of Patent:
April 8, 2014
Assignee:
Board of Regents, University of Texas Systems
Inventors:
Paul Gratz, Boris Grot, Steven W. Keckler
Abstract: An Aphis glycines resistance Rag2 gene is provided herein, along with methods for identifying its presence using marker-assisted selection. A cultivar of G. max having resistance to Aphis glycines conferred by the Rag2 gene has been identified. The Rag2 gene, as well as the methods, aphid-resistant varieties, and markers disclosed herein may be used to breed new elite lines expressing soybean aphid resistance.
Type:
Grant
Filed:
January 12, 2011
Date of Patent:
April 8, 2014
Assignees:
The Board of Trustees of the University of Illinois, The United States of America, as represented by the Secretary of Agriculture
Abstract: A nonpolar III-nitride film grown on a miscut angle of a substrate, in order to suppress the surface undulations, is provided. The surface morphology of the film is improved with a miscut angle towards an ?-axis direction comprising a 0.15° or greater miscut angle towards the ?-axis direction and a less than 30° miscut angle towards the ?-axis direction.
Type:
Grant
Filed:
March 22, 2012
Date of Patent:
April 8, 2014
Assignee:
The Regents of the University of California
Inventors:
Asako Hirai, Zhongyuan Jia, Makoto Saito, Hisashi Yamada, Kenji Iso, Steven P. Denbaars, Shuji Nakamura, James S. Speck
Abstract: Use of an isolated peptide comprising an amino acid sequence being no more than 25 amino acids in length, the amino acid sequence comprising at least one aspartate or a homolog thereof, the peptide having an Insulin-Degrading Enzyme (IDE) inhibitory activity, for the manufacture of a medicament identified for treating a disease selected from the group consisting of diabetes, obesity, hyperglycemia, retinal damage, renal failure, nerve damage, microvascular damage and varicella-zoster virus (VZV) infection is disclosed.
Type:
Grant
Filed:
February 2, 2010
Date of Patent:
April 8, 2014
Assignee:
Ramot at Tel-Aviv University
Inventors:
Dan Frenkel, Adi Kopelevich, Veronica Lifshitz, Tali Benromano, Nofit Borenstein
Abstract: A method of preparing an ultra-nanoscale-LC monolithic separation medium for use in capillary columns, or channels in microfabricated devices (microchips), and capillaries prepared by the method are disclosed. The application of moderate positive pressure to both ends of the capillary during the monolith polymerization process permits the preparation of monolithic capillary columns having very low i.d., e.g., 25 ?m and smaller, with enhanced mass transfer properties and low back pressures, and excellent column-to-column reproducibility of retention times.
Type:
Grant
Filed:
April 21, 2006
Date of Patent:
April 8, 2014
Assignee:
Northeastern University
Inventors:
Alexander R. Ivanov, Li Zang, Barry L. Karger
Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
Type:
Grant
Filed:
November 26, 2012
Date of Patent:
April 8, 2014
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Abstract: A computerized method and system for determining an optimum amount of Internal Radionuclide Therapy (IRT) and External Radiation Therapy (XRT) to administer, comprising: obtaining activity image information for an imaged object from a detector; running a Monte Carlo simulation for the activity image information to obtain absorbed dose-rate image information at multiple times; adding the absorbed dose-rate image information from each time to obtain IRT total absorbed dose image information; and utilizing the IRT total dose image information to obtain total dose image information that is equivalent to XRT dose image information in terms of dose-rate, wherein the IRT dose information is converted to equivalent XRT dose information without having to generate BED dose maps.
Abstract: In various embodiments, electronic apparatus, systems, and methods include a unified compact spatiotemporal method that provides a process for machines to deal with space and time and to deal with sensors and effectors. Additional apparatus, systems, and methods are disclosed.
Type:
Grant
Filed:
May 28, 2010
Date of Patent:
April 8, 2014
Assignee:
Board of Trustees of Michigan State University
Inventors:
Juyang Weng, Zhengping Ji, Matthew Luciw, Mojtaba Solgi