Abstract: Vibratory feedback systems and methods are disclosed. A vibratory feedback system includes a shoe adapted to be secured to a user's foot, a plurality of force sensors and vibration actuators mounted on the shoe, and a microprocessor affixed to the shoe. The force sensors are configured to sense forces exerted by the user's foot. The vibration actuators are configured to provide vibrations to the user's foot. The microprocessor is coupled to receive data from the plurality of force sensors, and is programmed to actuate the plurality of vibration actuators to provide a first characteristic vibration to the user's foot based on the sensed forces. A method of improving the gait of a user includes enabling the user to ambulate with the vibratory feedback system secured to the user's foot, and providing a first characteristic vibration to the user's foot based on the sensed forces using the vibratory feedback system.

Abstract: A method for data encoding and associated decoding is based on the concept of batches that allows transmission of a large data file from a source node to multiple destination nodes through communication networks that may employ network coding wherein sparse matrix codes are employed in a network setting. A batch is a set of packets generated by a subset of the input packets using sparse matrix encoder. A sparse matrix encoder can be called repeatedly to generate multiple batches. The batches are generally independent of one another. During the transmission in a communication network, network coding can be applied to packets belonging to the same batch to improve the multicast throughput. A decoder recovers all or at least a fixed fraction of the input packets using received batches. The input packets can be pre-coded using a pre-code before applying sparse matrix codes. The data file can then be reconstructed by further decoding the pre-code.

Abstract: A buck-boost power converter switches the switches thereof with a novel sequence and extends the switching periods of the switches to reduce the switching loss and conduction loss when the input voltage thereof approaches the output voltage thereof. The influence of the load current of the power converter on the duty thereof is taken into account to switch the power converter between modes at correct time points, so as to prevent the output voltage from being affected by the mode switching.

Abstract: Methods and computer program products for quantitative three-dimensional (“3D”) image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography (“OCT”) dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image voxel can be iteratively computed. New refracted corrected voxel positions to an even sampling grid can be interpolated to provide corrected image data. In some embodiments, clinical outputs from the corrected image data can be computed.

Abstract: A pharmaceutical composition for inhibiting inflammation, comprising (a) hyaluronic acid, (b) a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, and (c) a pharmaceutically acceptable carrier, is provided. Also provided is a method for inhibiting inflammation in a mammal, comprising administrating to the mammal an effective amount of a composition comprising (a) hyaluronic acid and (b) an HMG-CoA reductase inhibitor.

Abstract: The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the invention concerns methods of inhibiting the growth of a tumor by administering a cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways in vitro or in vivo using cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the present invention concerns a method for screening candidate compounds for JAK and/or STAT3 inhibition and anti-tumor activity.

Abstract: Compounds comprising phosphorescent metal complexes comprising cyclometallated imidazo[1,2-f]phenanthridine and diimidazo[1,2-a:1?,2?-c]quinazoline ligands, or isoelectronic or benzannulated analogs thereof, are described. Organic light emitting diode devices comprising these compounds are also described.

Abstract: An apparatus and method for outputting high-frequency, high-power signals from low-frequency, low-power input is disclosed. The apparatus and method may provide a two-dimensional nonlinear lattice having a plurality of inductors and voltage-dependent capacitors intersecting at a plurality of nodes. Two or more adjacent boundaries of the nonlinear lattice may be provided with input signals which constructively interfere to output a signal of substantially higher amplitude and higher frequency than those of the input signals.

Abstract: The present invention relates to multi-phase self-stratifying coating systems, and in particular, to multi-phase self-stratifying coating systems having a substantially homogeneous composition of polymeric binder components that upon application and cure generates a multi-phase stratified coating wherein each phase is rich in a different polymeric binder component and wherein individual phases are separated by a diffuse interface, such that the stratified coating exhibits a gradient behavior wherein a given interface exhibits the attributes of the polymeric binder component that is rich at that interface, and wherein at least one phase is rich in a polymeric binder having a telechelic resin with reactive internal groups, reactive end groups, and an alkoxide oligomer, and at least one other phase is rich in a polymeric binder having a fluorinated polymer derived from fluorinated vinyl-based monomers.

Abstract: This invention has provided a direct manufacturing methodology of customized lingual orthodontic brackets by selective laser melting. The procedure is as follows. First of all, measure the dentition data and construct the 3D CAD model of the teeth through reverse engineering. Then a single soleplate of the lingual bracket contacting the tooth surface, as well as the ideal slot position is designed based on the teeth features. The designed models are later imported into the SLM machine and used to produce the brackets with desired materials directly. This method can actualize customized manufacture with highly accuracy, producing highly matched brackets all at once. The invention not only saves time and cost, but also has wide adaptation range and is able to adopt various raw materials. Different raw materials can be utilized in one step to accommodate specific capacity requirement of different parts of the brackets.

Abstract: It is an object of the present invention to provide a Type I-Type IV collagen hybrid gel, which maintains characteristics of a Type IV collagen and is superior in gel strength. It is the Type I-Type IV collagen hybrid gel obtained by mixing 100 to 500 parts by mass of the Type I collagen having fibrosis ability, relative to 100 parts by mass of the Type IV collagen having gelling ability. A three-dimensional structure is formed, where a membrane-like substance by the Type IV collagen is formed onto a fibrous substance by the Type I collagen, so as to be able to provide cell culture environment approximate to a basement membrane of a living body.

Abstract: Methods, media, and systems for detecting an anomalous sequence of function calls are provided. The methods can include compressing a sequence of function calls made by the execution of a program using a compression model; and determining the presence of an anomalous sequence of function calls in the sequence of function calls based on the extent to which the sequence of function calls is compressed. The methods can further include executing at least one known program; observing at least one sequence of function calls made by the execution of the at least one known program; assigning each type of function call in the at least one sequence of function calls made by the at least one known program a unique identifier; and creating at least part of the compression model by recording at least one sequence of unique identifiers.

Abstract: High-speed CMOS ring voltage controlled oscillators with low supply sensitivity have been disclosed. According to one embodiment, a CML ring oscillator comprises a CML negative impedance compensation circuit comprising two cross coupled transistors and a resistor connected to the two transistors for resistive biasing and a CML interpolating delay cell connected in parallel with the CML negative impedance compensation. An impedance change of the CML negative impedance compensation due to supply variation counteracts an impedance change of the CML interpolating delay cell.

Abstract: An event trigger data string is formulated and added to digital content for distribution to an audience via broadcast, satellite, cable or any other technology. The event trigger data string includes identification of an event source, identification of an operation to be performed, and a payload. A controller reads the data string and outputs a command to an appropriate event source for alteration of a digital content stream based upon the identified operation. The payload may, for example, identify an advertisement or notice to be spliced into or out of the digital content stream. Such event trigger data strings may be added to many different digital content streams, and a router or switching component may distribute the streams to systems that disseminate them to the audience. The technique enables interaction with different event sources, and allows command of multiple different operations by these event sources.

Abstract: To measure surface potentials in a liquid, the in-liquid potential measurement device according to the present invention includes: a cantilever having a probe at its free end; a displacement measurement unit that measures a voltage corresponding to a displacement of a tip of the cantilever; an AC source that applies an AC voltage between the probe and the sample; and a signal detection unit. A frequency of the AC voltage is 10 kHz or higher. The signal detection unit detects, from the voltage measured by the displacement measurement unit, an amplitude of a frequency component having the same frequency as that of the AC voltage, an amplitude of a frequency component having double frequency of that of the AC voltage, and a frequency component having the same phase as that of the frequency of the AC voltage.

Abstract: Disclosed herein are systems and methods for reducing effects of restless legs syndrome (RLS) in a subject. The method includes identifying, on the subject, a body region affected by RLS, placing an emitter unit in direct contact with skin of the body region, wherein the emitter unit includes at least one emitter that emits near-infrared light, and activating the emitter to emit an effective amount of near-infrared light for inducing release of nitric oxide from hemoglobin or generation in the endothelium. Also disclosed is an emitter unit that is placed in direct contact with a subject's skin associated with RLS to reduce the effects of RLS. The emitter unit emits an effective amount of near-infrared light directed to the subject's skin to induce release of nitric oxide from hemoglobin or generation in the endothelium, and a module configured to toggle the emitter unit between a transmitting and a nontransmitting mode.

Abstract: An electrode device for an electrochemical sensor chip includes an insulation sheet having an insulating property and including a top surface and a bottom surface opposite to each other in a thickness direction, and electrode members having a conductivity and held by the insulation sheet with the electrode members piercing the insulation sheet in a thickness direction, one ends of the electrode members located on the top surface side of the insulation sheet being connected to an analyte, the other ends located on the bottom surface side of the insulation sheet being connected to an electrodes of a transducer, at least the one ends of the electrode members being made of a mixture of conductive particles and an insulating material.

Abstract: The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI.

Abstract: A method for acquiring MRI signals includes: applying one or more than one RF pulse, which carries at least two frequency components, and a slice/slab selection gradient to a subject, so that at least two slices/slabs of the subject respectively corresponding to the at least two frequency components are excited simultaneously; applying a plurality of spatial encoding gradients; applying a plurality of separation gradients for separating the at least two slices/slabs; and applying at least one coherent refocusing gradient between the plurality of separation gradients.

Abstract: Embodiments of the present invention can resolve molecules beyond the optical diffraction limit in three dimensions. A double-helix point spread function can be used to in conjunction with a microscope to provide dual-lobed images of a molecule. Based on the rotation of the dual-lobed image, the axial position of the molecule can be estimated or determined. In some embodiments, the angular rotation of the dual-lobed imaged can be determined using a centroid fit calculation or by finding the midpoints of the centers of the two lobes. Regardless of the technique, the correspondence between the rotation and axial position can be utilized. A double-helix point spread function can also be used to determine the lateral positions of molecules and hence their three-dimensional location.