Abstract: Methods and systems for acoustic multiple-input/multiple-output (MIMO) communication in an underwater environment. The method includes: a) receiving signals at multiple receivers representing transmitted signals from multiple transmitters, b) estimating channel responses between the multiple receivers and the multiple transmitters, c) performing an initial demodulation process on the received signals using the estimated channel responses to remove inter-symbol interference (ISI), and d) performing at least one subsequent demodulation process on the received signals. The subsequent demodulation process: i) removes co-channel interference (CoI) using the estimated channel responses and demodulated signals from an immediately preceding demodulation process to form interference cancelled signals and ii) removes ISI from the interference cancelled signals.

Abstract: Genetically engineered microorganisms have been constructed to produce succinate and malate in mineral salt media in pH-controlled batch fermentations without the addition of plasmids or foreign genes. The subject invention also provides methods of producing succinate and malate comprising the culture of genetically modified microorganisms.

Abstract: This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

Abstract: A method of maintaining an information rate of a Brain-computer interface (BCI) system, implanted in a patient's brain, by regulating arousal level in the patient's brain is disclosed. The method includes selecting a patient with the implanted BCI device configured to receive neuronal activity from one or more electrodes connected to the patient's brain and to establish a communication channel between the patient and an external device controlled by the patient. Accordingly, a rate of information passage through the communication channel from the BCI device is measured, and a region of the patient's brain involved in arousal regulation, is stimulated in response to said measuring, under conditions effective to adjust the rate of information passing from the BCI device through the communication channel. A computer medium for carrying out this method and a BCI Arousal Regulation system are also disclosed.

Abstract: A method of processing bundles of carbon nanotubes (CNTs). Bundles of CNTs are put into a solution and unbundled using sonication and one or more surfactants that break apart and disperse at least some of the bundles into the solution such that it contains individual semiconducting CNTs, individual metallic CNTs, and remaining CNT bundles. The individual CNTs are separated from each other using agarose bead column separation using sodium dodecyl sulfate as a surfactant. Remaining CNT bundles are then separated out by performing density-gradient ultracentrifugation.

Abstract: A flow cytometry system includes an inertial particle focusing device including a plurality of substantially parallel microchannels formed in a substrate, each microchannel having a width to height ratio in the range of 2:3 to 1:4, an analyzer disposed adjacent the inertial particle focusing device such that the analyzer is configured to detect a characteristic of particles in the inertial particle focusing device, and a controller connected to the analyzer and configured to direct the detection of the characteristic of the particles.

Abstract: A perpendicular magnetic recording medium according to which both the thermal stability of the magnetization is good and writing with a magnetic head is easy, and moreover the SNR is improved. In the case of a perpendicular magnetic recording medium comprising a nonmagnetic substrate (1), and at least a nonmagnetic underlayer (2), a magnetic recording layer (3), and a protective layer (4) formed in this order on the nonmagnetic substrate (1), the magnetic recording layer (3) comprises a low Ku region (31) layer having a perpendicular magnetic anisotropy constant (Ku value) of not more than 1×105 erg/cm3, and a high Ku region (32) layer having a Ku value of at least 1×106 erg/cm3. Moreover, the magnetic recording layer (3) is made to have therein nonmagnetic grain boundaries that contain a nonmagnetic oxide and magnetically isolate crystal grains, which are made of a ferromagnetic metal, from one another.

Abstract: The invention provides systems and methods for extracting and upgrading heavy hydrocarbons from substrates such as oil sands, oil shales, and tar sands in a unitary operation. The substrate bearing the hydrocarbon is brought into contact with a supercritical or near-supercritical fluid, a source of hydrogen such as hydrogen gas, and a catalyst. The materials are mixed and heated under elevated pressure. As a consequence of the elevated temperature and pressure, upgraded hydrocarbon-containing material is provided in a single or unitary operation. In some embodiments, sonication can be used to improve the upgrading process. Fluids suitable for use in the process include carbon dioxide, hexane, and water. It has been observed that upgrading can occur within periods of time of a few hours.

Abstract: Disclosed are conductive polymer inks and methods for forming the inks. The disclosed inks include a dispersion of conductive core/shell nanoparticles. The core/shell nanoparticles include a polymeric core and a shell formed of a conducting polymer. The inks can include a dispersion of the core/shell nanoparticles in a liquid carrier, such as an alcohol. The disclosed inks can be formulated to high viscosities and can be utilized in high-speed printing processes including rotogravure and flexographic printing processes. Products encompassed by the disclosure include polymer devices such as sensors, OFETs, RFID tags, printed circuit board, electrochromic devices, non-volatile memory devices, photovoltaics, and the like.

Abstract: Embodiments are directed to a ground reaction sensor cluster (GRSC) and to methods for precisely determining zero velocity points and bearing changes using a GRSC and for navigating using a GRSC and an inertial motion unit (IMU) in a global positioning satellite (GPS)-denied environment. The GRSC device itself includes an array of capacitive pressure and shear sensors. The array includes multiple flexible capacitive sensor cells that detect changes in capacitance in response to a footstep. Each cell of the array includes multiple overlapping, fingered capacitors that detect pressure and shear force by determining the change in capacitance in each fingered capacitor. The GRSC device also includes a multiplexing receiver that receives the capacitance inputs from each of the capacitive sensor cells. The multiplexing receiver and other electronic elements further process the received capacitance inputs to determine, based on the pressure and shear forces, the direction and bearing of the footstep.

Abstract: A magnetic platform is provided and includes a patterned array of discrete magnetic elements positioned on a substrate, a plurality of first electromagnets for creating a first magnetic field substantially in the plane of the substrate, an electromagnetic coil for creating a second magnetic field substantially perpendicular to the plane of the substrate, and a control device for controlling the application of the magnetic fields. Processes for manipulating, transporting, separating and sorting micro- or nano-scale particles and biomolecules are also described.

Abstract: The disclosure relates to methods of treating tuberous sclerosis in a subject, comprising administering a composition comprising an mTOR inhibitor and a tyrosine kinase inhibitor to a subject that is diagnosed with, suspected of, or exhibiting symptoms of cancer. In some embodiments, the cancer is tuberous sclerosis. In some embodiments, the mTOR inhibitor is sirolimus and the tyrosine kinase inhibitor is imatinib. In some embodiments, the disclosure relates to a composition comprising an mTOR inhibitor and a tyrosine kinase inhibitor. In some embodiments, the disclosure relates to a composition comprising sirolimus and imatinib.

Abstract: A system and method for cancellation of RF interference in the optical domain. The system and method utilize two Mach-Zehnder electrooptic modulators biased for parallel counter-phase modulation. The method of signal subtraction is referred to as incoherent optical subtraction, since two independent laser sources serve as the optical carrier waves. The system has produced the broadband cancellation result while simultaneously recovering a 50 dBm signal which was initially “buried” under the broadband interference. The cancellation depths achieved by the system are due to the accurate channel tracking and precise time delays attainable with modern optical devices—unattainable with state-of-the-art electronic devices at the time of this writing.

Abstract: Taught is a photonic crystal three-port circulator, which comprises a dielectric background material and a plurality of first air columns which are symmetrically arranged in the form of triangular lattice in the dielectric background material. The photonic crystal three-port circulator also comprises a magneto-optical cavity and three waveguides, wherein the magneto-optical cavity is arranged at the center of the photonic crystal three-port circulator; the three waveguides are symmetrically distributed around the magneto-optical cavity; and each waveguide comprises a waveguide port which is arranged at the position in the waveguide far away from the magneto-optical cavity. The photonic crystal three-port circulator realizes circular light transmission in single rotational direction from any one of the waveguide ports to another next to it, has a simple and compact structure, and can be easily integrated with other photonic crystal devices.

Abstract: A system and method for stabilizing a plurality of output frequencies (wavelengths) of a plurality of lasers (106). The laser beams are combined using optical multiplexer (110) and coupled into length-imbalanced (armlength-mismatched) Mach-Zehnder interferometer (MZI) (114) having an optical modulator (e.g. AOM) (122) in one of its arms. The output of the MZI is divided into corresponding beams via optical demultiplexer (128) and each beam is detected by a respective photo-diode (PD) (134). The individual electric signals, so generated, are demodulated using a corresponding plurality of phase-responsive devices (138) and the resulting phase-signals are directed to a plurality of servo-controllers (148) to control the central frequency of the respective lasers (106) via a corresponding plurality of feedback loop circuits (150). The lasers (106) can have different central frequencies which can also be individually tunned using offset modules (141) in the phase-responsive devices (138).

Abstract: Air bubbles may be used to reduce radiated underwater noise. Two modalities of sound attenuation by air bubbles were shown to provide a reduction in radiated sound: bubble acoustic resonance damping and acoustic impedance mismatching. The bubbles used for acoustic resonance damping were manifested using gas-filled containers coupled to a support, and the acoustic impedance mismatching bubbles were created using a cloud of freely-rising bubbles, which were both used to surround an underwater sound source.

Abstract: The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.

Abstract: The present invention relates to a compound of formula (I). Provided is also a method of killing a cell that comprises administering the compound of formula (I). Provided is also a method of treating cancer or diabetes in a mammal that comprises administering the compound of formula I and respective pharmaceutical compositions thereof.

Abstract: A motion state of a wearable motion-assist device of a doctor is sent to the wearable motion-assist device of a patient via a network. Then, this motion state is applied to the wearable motion-assist device of the patient, so that rehabilitation is conducted for the patient. Furthermore, the motion state of the wearable motion-assist device of the patient is sent from the wearable motion-assist device to the wearable motion-assist device. Then, the motion state of the wearable motion-assist device is applied to the wearable motion-assist device. Accordingly, the doctor can objectively sense the state of the patient.

Abstract: Vaccine compositions and methods for protecting a mammalian subject against infection with S. pneumoniae are disclosed. The vaccines and methods comprise an effective amount of one or more Streptococcus pneumoniae cell wall and/or cell membrane proteins and/or immunogenically-active fragments, derivatives or modifications thereof, wherein the proteins are selected from a defined group of proteins associated with age-dependent immunological responses.