Patents Assigned to University
  • Compounds that inhibit NF?B and BACE1 activity
    Patent number: 8685963
    Abstract: The present invention relates to compounds with activity as BACE1 and NF?B modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: April 1, 2014
    Assignee: The Trustees of Columbia University in the city of New York
    Inventors: Donald W. Landry, Shi Xian Deng, Gangli Gong, Yuli Xie, Yidong Liu, K. Alison Rinderspacher
  • Retractor device with oximeter sensor and force sensor
    Patent number: 8688186
    Abstract: A retractor device has an oximeter sensor at its tip, which allows measuring of oxygen saturation of a tissue being retracted by the retractor. The retractor device also has a force sensor which can measure an amount of force that is applied to the retracted tissue by the tip of the retractor device. The tip includes one or more openings for at least one source and detector. A specific implementation is a spinal nerve root retractor with an oximeter sensor and a force sensor.
    Type: Grant
    Filed: January 18, 2010
    Date of Patent: April 1, 2014
    Assignees: ViOptix, Inc., Regents of the University of California
    Inventors: Jimmy Jian-min Mao, Robert E. Lash, Shane Burch
  • MACROCYCLIC THERAPEUTIC AGENTS AND METHODS OF TREATMENT
    Publication number: 20140088016
    Abstract: The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.
    Type: Application
    Filed: May 17, 2012
    Publication date: March 27, 2014
    Applicant: University of Florida Research Foundation, Inc.
    Inventor: Hendrik Luesch
  • FORWARD-IMAGING OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEMS AND PROBES
    Publication number: 20140083970
    Abstract: Provided are forward-imaging optical coherence tomography (OCT) systems and probes.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 27, 2014
    Applicant: Board of Regents, The University of Texas System
    Inventors: Karthik KUMAR, Jonathan C. CONDIT, Nathaniel J. KEMP, Thomas E. MILNER, Xiaojing ZHANG
  • METHODS OF DETECTING ANEUPLOIDY IN HUMAN EMBRYOS
    Publication number: 20140087376
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: February 23, 2012
    Publication date: March 27, 2014
    Applicant: The Board Of Trustees of the Leland Stanford Junior University
    Inventors: Shawn L. Chavez, Kevin E. Loewke, Barry Behr, Renee A. Reijo Pera
  • PHOSPHORUS-CONTAINING COMPOUNDS AND THEIR PREPARATION PROCESS AND USE
    Publication number: 20140088283
    Abstract: A series of novel phosphorus-containing compounds having the following formula is provided: in which: R1-R4, A, Q and m are as defined in the specification. A process for the preparation of the compound of formula (I) is also provided. A polymer of formula (PA), and preparation process and use thereof are further provided. A polymer of formula (PI), and preparation process and use thereof are also provided.
    Type: Application
    Filed: October 31, 2013
    Publication date: March 27, 2014
    Applicants: National Chung Hsing University, Chang Chun Plastics Co., Ltd.
    Inventors: Ching-Hsuan LIN, Tsung Li Lin, Yu-Ting Fang, Kuen-Yuan Hwang, An-Pang Tu
  • Modified siRNA Molecules Incorporating 5-Fluoro-2'-Deoxyuridine Residues to Enhance Cytotoxicity
    Publication number: 20140088300
    Abstract: A synthesized siRNA molecule having the sense strand with one or more uridine bases replaced by one or more respective nucleoside analogs, such as 5-fluoro-2?-deoxyuridine (FdU).
    Type: Application
    Filed: September 18, 2013
    Publication date: March 27, 2014
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, U.S. Department of Veterans Affairs
    Inventors: John C. SCHMITZ, SR., Edward Chu, William H. Gmeiner
  • GAMING MACHINE AND GAMING METHOD
    Publication number: 20140087812
    Abstract: A game is executed in a normal round, in a first-type free round, and in a second-type free round. The normal round is executed with a first symbol set including a plurality of symbols. The first-type free round is executed with a second symbol set that includes at least one first symbol in addition to the symbols in the first symbol set. The second-type free round is executed with a third symbol set that includes at least one second symbol in addition to the symbols in the first symbol set, the at least one second symbol being different from the at least one first symbol.
    Type: Application
    Filed: September 21, 2012
    Publication date: March 27, 2014
    Applicants: Aruze Gaming America, Inc., Universal Entertainment Corporation
    Inventors: Yoichi KATO, Hiroki NAKAMURA, Masumi FUJISAWA, Kazuo OKADA
  • QUATERNARY DATA-STORAGE MATERIALS AND THE PREPARATION METHOD THEREOF
    Publication number: 20140085771
    Abstract: An organic compound has the following chemical structure: wherein R is different from R*; R and R* are independently hydrogen, halogen, nitro or methoxyl; and R1 is a C1-C6 alkyl or a phenyl group. A quaternary data storage device includes a bottom electrode, a top electrode, and the organic film layer sandwiched between the bottom electrode and the top electrode.
    Type: Application
    Filed: December 12, 2012
    Publication date: March 27, 2014
    Applicant: Soochow University
    Inventors: Jian-Mei LU, Hua LI
  • METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY HCG ASSAY
    Publication number: 20140087393
    Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.
    Type: Application
    Filed: March 18, 2013
    Publication date: March 27, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: John O'Connor, Steven Birken, Galina Kovalevskaya
  • COMPOSITIONS AND METHODS FOR TREATMENT OF GYNECOLOGIC CANCERS
    Publication number: 20140088018
    Abstract: Molecules and compositions that can be used in the treatment of gynecologic cancers are described. ApoA-1, in particular, is demonstrated to inhibit the proliferation of cancer cells reduce tumor size in a mouse model of ovarian cancer.
    Type: Application
    Filed: October 4, 2011
    Publication date: March 27, 2014
    Applicant: The Regents of the University of California
    Inventors: Robin Farias-Eisner, Srinivasa T. Reddy
  • METHODS OF TREATING PRE-TERM LABOR
    Publication number: 20140088057
    Abstract: A method of treating pre-term labor in pregnant human patient expressing melatonin receptors in her myometrial cells comprises administering an inhibitor of MT2R, an inhibitor of protein kinase C, an inhibitor of phospholipase C, or a combination thereof to the patient.
    Type: Application
    Filed: May 17, 2013
    Publication date: March 27, 2014
    Applicant: The Florida State University Research Foundation, Inc.
    Inventor: James Olcese
  • Method for Estimating Flow Rates, Pressure Gradients, Coronary Flow Reserve, and Fractional Flow Reserve from Patient Specific Computed Tomography Angiogram-Based Contrast Distribution Data
    Publication number: 20140088414
    Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and/or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.
    Type: Application
    Filed: April 23, 2013
    Publication date: March 27, 2014
    Applicant: The Johns Hopkins University
    Inventors: Rajat Mittal, Albert C. Lardo, Jung Hee Seo
  • METHODS AND SYSTEMS FOR LINKING BUILDING INFORMATION MODELS WITH BUILDING MAINTENANCE INFORMATION
    Publication number: 20140089209
    Abstract: A computer-implemented method includes, in one aspect, receiving a request for a spatial analysis of building behavior of an entity within a building facility; retrieving building maintenance information about the entity within the building facility; accessing a building information model for the building facility; identifying a portion of the building information model that pertains to the entity; and based on the retrieved building maintenance information and the identified portion of the building information model, generating the spatial analysis of the building behavior for the entity within the building facility.
    Type: Application
    Filed: September 26, 2013
    Publication date: March 27, 2014
    Applicant: Carnegie Mellon University
    Inventors: Asli Akcamete, Burcu Akinci, Xuesong Liu, James H. Garrett, JR.
  • MODULATORS OF HSP70/DNAK FUNCTION AND METHODS OF USE THEREOF
    Publication number: 20140087005
    Abstract: Compositions and methods for modulating HSP70 function, particularly for the targeted killing of cancer cells, are disclosed.
    Type: Application
    Filed: October 8, 2013
    Publication date: March 27, 2014
    Applicants: Fox Chase Cancer Center, The Trustees of the University of Pennsylvania
    Inventors: Donna L. George, Julia I-Ju Leu, Maureen Murphy
  • GENETIC CHANGES IN ATM AND ATR/CHEK1 AS PROGNOSTIC INDICATORS IN CANCER
    Publication number: 20140088169
    Abstract: The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation which could be overcome by inhibition of the ATR/CHEK1 pathway. It provides for methods of identifying patients unlikely to exhibit an adequate response to radiation therapy and/or chemotherapy who may benefit from ATR/CHEK1 pathway inhibition, as well as methods of treating said patients.
    Type: Application
    Filed: April 23, 2013
    Publication date: March 27, 2014
    Applicant: University of Pittsburgh - of the CommonWealth System of Higher Education
    Inventors: Susanne M. Gollin, Rahul Atul Parikh, Xin Hijang
  • Fluoride-Releasing Compositions
    Publication number: 20140088308
    Abstract: Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials, dental bonding agents or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capability. Such dental restorative materials may help reduce the level of dental caries in patients, particularly the level of caries occurring on the margins of the restorative materials.
    Type: Application
    Filed: November 12, 2013
    Publication date: March 27, 2014
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Xiaoming Xu, Shailaja Jayaramachandran
  • LYSM RECEPTOR-LIKE KINASES TO IMPROVE PLANT DEFENSE RESPONSE AGAINST FUNGAL PATHOGENS
    Publication number: 20140090106
    Abstract: Perception of chitin fragments (chitooligosaccharides) is an important first step in plant defense response against fungal pathogen. LysM receptor-like kinases (LysM RLKs) are instrumental in this perception process. LysM RLKs also play a role in activating transcription of chitin-responsive genes (CRGs) in plants. Mutations in the LysM kinase receptor genes or the downstream CRGs may affect the fungal susceptibility of a plant. Mutations in LysM RLKs or transgenes carrying the same may be beneficial in imparting resistance against fungal pathogens.
    Type: Application
    Filed: October 7, 2013
    Publication date: March 27, 2014
    Applicant: The Curators of the University of Missouri
    Inventors: Jinrong Wan, Gary Stacey, Minviluz Stacey, Xuecheng Zhang
  • METHOD AND APPARATUS FOR REALIZING ADAPTIVE QUANTIZATION IN PROCESS OF IMAGE CODING
    Publication number: 20140086313
    Abstract: A method for realizing adaptive quantization in image encoding and dequantization in image decoding is disclosed. In the adaptive quantization method, an image to be encoded is divided into one or more blocks, and each block is transformed to obtain one or more transform coefficients, the method comprising: acquiring parameter information of neighbor blocks of a current block; determining a quantization mode for the current block according to the parameter information of the neighbor blocks; and quantizing transform coefficients of the current block in the determined quantization mode. The quantization mode includes at least one of quantization matrix, quantization parameter and quantization step.
    Type: Application
    Filed: December 2, 2013
    Publication date: March 27, 2014
    Applicants: Tsinghua University, Huawei Technologies Co., Ltd.
    Inventors: Jianhua ZHENG, Yun HE, Jianwen CHEN
  • CONJUGATED POLYELECTROLYTE CAPSULES: LIGHT ACTIVATED ANTIMICROBIALS
    Publication number: 20140086795
    Abstract: Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicants: STC.UNM, University of Florida Research Foundation, Inc.
    Inventors: Kirk S. Schanze, Motokatsu Ogawa, Jonathan Robert Sommer, David G. Whitten, Thomas S. Corbitt