Abstract: The present invention provides a self assembly molecule having an affinity for one or more target molecules, for use in formation of a heptameric complex, comprising: a) a monomer comprising a multimerization domain of Archaeal Sm1 (AF-Sm1) protein or SM-like ribonucleoprotein from other organisms, able to interact with other molecules of the same monomer comprising a multimerization domain of AF-Sm1 protein or SM-like ribonucleoprotein to self-assemble into a heptamer; and b) a target binding domain or peptide attached directly or via a linker to the monomer of (a). Also provided are heptamers comprising these self assembly molecules and methods for their use in therapy, imaging and diagnostics.

Abstract: Methods and compositions for treating and preventing toxic side effects of platinum-based chemotherapy agents are disclosed, in which transplatin is administered to a subject. Transplatin is shown to have protective effects against cisplatin-induced ototoxicity, nephotoxicity and neurotoxicity. Anti-inflammatory activity of transplatin is demonstrated and methods and compositions for treating and preventing inflammatory pain are described.

Abstract: A controller of a gaming machine executes a normal round of a game to spin reels of a first display, and triggers a chance round of the game when a result of the normal round satisfies a predetermined condition. The controller displays a wheel and a plurality of touch areas on a second display, and the wheel includes a plurality of areas, each of the plurality of areas corresponding to a number of free rounds. When any one of the touch areas is touched and slid by a player, the controller spinning the wheel in a direction corresponding to the slid touch area, and randomly determines a number of free rounds. The controller stops the wheel at a position of an area that corresponds to the determined number of free rounds among the plurality of areas, and provides free rounds having the determined number.

Abstract: In one embodiment according to the invention, there is provided a method of sensing a response of a living cell or virus to a change in conditions. The method comprises applying an essentially constant external electromotive force that causes oscillation of an acoustic wave device at essentially constant amplitude and frequency under steady state conditions. The acoustic wave device has attached at least one living cell or virus. A combined oscillating system including the acoustic wave device and the living cell or virus exhibits a fundamental frequency and at least one harmonic frequency of the combined oscillating system.

Abstract: The present disclosure relates, according to some embodiments, to methods, devices, and systems for fluid delivery to a subject using pumps, for example, non-gassing, direct current (DC), electro-osmotic pumps. In some embodiments, delivery of an aqueous fluid may be achieved by contacting the aqueous liquid with an electro-osmotic pump comprising (i) a cathode (e.g., a cathode comprising porous carbon coated with a cerium oxide-comprising coating), (ii) an anode (e.g., an anode comprising porous carbon coated with a cerium oxide-comprising coating), and (iii) a ceramic membrane (e.g., a ceramic membrane formed by fusing uncoated silica spheres, phosphosilicic-acid-coated fused silica spheres, or borosilicic-acid-coated fused silica spheres, wherein the fused spheres are randomly packed between the cathode and the anode) and/or optionally applying (a) a constant potential difference or constant voltage between the anode and the cathode of from about 0.

Abstract: Methods using solid-state shear pulverization and melt mixing and related polymer-carbon nanotube composites, as can be used to affect various mechanical and/or physical material properties.

Abstract: Disclosed is a method for highly efficiently obtaining an optically active alcohol from a carbonyl compound highly enantioselectively. Also disclosed is a ligand used in such a method. Specifically, an optically active alcohol is obtained by reacting a carbonyl compound and an organozinc compound by using a ligand (L) shown below.

Abstract: An apparatus for controlling propagation of an electromagnetic wave includes a metamaterial having an array of cells, each cell containing a metallic structure having a resonant frequency; a plurality of devices integrated in the metamaterial, each of said devices being in electrical communication with a metallic structure in a cell in the array of cells; and a controller for electrically activating each of said plurality of devices to cause said resonant frequency to change, thereby causing at least one of a permeability and permittivity of the metamaterial to change.

Abstract: This application provides transcription activator-like effector nucleases (TALENs), polynucleotide sequences encoding the TALENs, expression cassettes for producing TALENs to target cleavage of nucleic acids, and methods of producing and using the TALENs.

Abstract: Provided is a power converter 3 that directly converts polyphase AC power to AC power. A converter circuit has a plurality of first switching elements 311, 313 and 315 and a plurality of second switching elements 312, 314 and 316, both of which are connected to each phase R, S or T of the polyphase AC power to enable switching for turning on current-carrying bidirectionally. Condensers 821 to 826 are provided between phases. Input terminals of the first switching elements and those of the second switching elements are arranged to form respective lines. Some of the plurality of condensers 821 and 822 are arranged to be angled relative to the arrangement direction of the terminals. The wiring distance between the condensers and the switching elements can be shortened.

Abstract: A polymer is characterized by a repeat unit represented by Structural Formula (I): or a copolymer thereof. A crosslinked polymer characterized by a repeat unit represented by Structural Formula (II), (III), (IV) or (V): or a copolymer thereof, wherein at least one such repeat unit of a first polymer strand is crosslinked with at least one repeat unit of a second polymer strand by at least one bridging unit, the first and second polymer strands and the repeat unit being components of the crosslinked polymer.

Abstract: The present invention provides a frequency multiplier apparatus. The frequency multiplier apparatus includes an injection-locked frequency multiplier and a frequency-to-control signal converter. The injection-locked frequency multiplier outputs an output signal having a first frequency in response to an input signal having a first basic frequency. The frequency-to-control signal converter provides a first control signal to the injection-locked frequency multiplier in response to the input signal. The injection-locked frequency multiplier adjusts the first frequency to a second frequency in response to a change of the first control signal when the first basic frequency is changed to a second basic frequency.

Abstract: Methods and compositions for treating a mental condition in a subject in need thereof, includes administering to a subject in need thereof an effective amount of a CDD-102A compound [5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine], or a pharmaceutically acceptable salt or hydrate thereof pharmaceutically acceptable salt or hydrate thereof.

Abstract: The present disclosure relates generally to therapeutic compositions comprising recombinant bacteria. Further, the disclosure elaborates upon methods of utilizing the taught therapeutic compositions to treat autoimmune and inflammatory disease. The present teachings also relate to the disclosed recombinant bacteria and methods of producing the recombinant bacteria utilized in the compositions and methods. Further taught herein are dietary supplements and food additive compositions comprising the taught recombinant bacteria.

Abstract: The present invention relates to methods for treating TTK positive breast cancers or soft-tissue sarcomas in a mammalian subject by administering a therapeutically effective amount of a TTK antagonist. The invention also provides compositions comprising a TTK antagonist and a HER-2 antagonist, as well as methods of diagnosing a basal-like breast cancer and methods of determining the prognosis of a subject having a cancer by assessing expression of TTK in a tumor sample from a subject.

Abstract: In certain embodiments, the invention provides boron-nitrogen heterocycles having Formula (I): wherein one of the E1 and E2 is N, and one of the E1 and E2 is B; wherein E3 and E4 is carbon; wherein ring Y and ring Z are 5-membered or 6-membered carbocyclic or heterocyclic aromatic ring fused to ring X; wherein R2 and R3 represent mono, di, tri, tetra substitutions or no substitution; wherein R2 and R3 are each independently selected from various substituents; and wherein any two adjacent R2, and R3 are optionally joined to form a ring, which may be further substituted. In certain embodiments, the invention provides devices, such as organic light emitting devices, that comprise such boron-nitrogen heterocycles.

Abstract: A birefringent reflectarray having a planar metasurface containing metallic patches of subwavelength dimension is provided. The reflectarray is capable of simultaneously reflecting, concentrating, and splitting incident infrared light into two orthogonal linearly polarized reflections, and transforms the phase front of an incoming polarized light to a desired phase for the two reflections. Also provided is an optical modulator having a metasurface containing layers of nanoantennas of subwavelength dimension, and capable of modulating the phase and amplitude of light scattered from the modulator. The optical modulator has ability to perform computation through processing of light.

Abstract: The invention discloses a method of extracting nucleic acid analyte solution from biological sample, comprising: placing the biological sample into a heating container; optionally, adding solvent medium into the biological sample; heating the biological sample under high pressure; optionally, centrifuging the biological sample; and obtaining the solution including the nucleic acid analyte. The invention also discloses a method of detecting the nucleic acid analyte obtained by said extraction method.

Abstract: Vesicular Stomatitis Viruses expressing foreign nucleic acid sequences were highly attenuated but were lytic for abnormal cells, such as cancers, infected cells. Methods of treatment include the administration of these viruses.

Abstract: A micro-fluidic device operable to isolate target cells from a biological fluid comprises: an inlet operable to receive the biological fluid, the biological fluid comprising target cells and other components; a waste outlet operable to receive at least the other components of the biological fluid; a plurality of parallel arrays of cell isolation wells coupling the inlet with the waste outlet, each parallel array of cell isolation wells supporting a flow of the biological fluid from the inlet to the waste outlet in response to a pressure differential thereacross, each array of cell isolation wells comprising a plurality isolation wells, each isolation well being dimensioned to mechanically trap the target cells therein whilst permitting flow of other components of the biological fluid; and at least one pressure maintenance structure operable to assist in maintaining a predetermined pressure differential across each of the plurality of parallel arrays of cell isolation wells.