Abstract: The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.

Abstract: A method of treating, reversing, or ameliorating type 2 diabetes (DM) includes administering to a host in need thereof a therapeutically effective amount of a mitochondria-targeted antioxidant, such as mito-TEMPO (2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride).

Abstract: The invention provides methods for diagnosing and treating asthma in subjects in need thereof but can be applied to other conditions where abnormal electrophysiology underlies dysfunctional organ contractility.

Abstract: In one embodiment, kicking training is provided to a kicker in real time by collecting data while the kicker kicks a ball toward a display screen, determining the trajectory of the ball from the collected data, and displaying to the kicker on the display screen a simulation of the flight of the ball within a virtual world.

Abstract: A bio-nanowire device includes a substrate having a first surface, a first conductor, a second conductor, and a bio-nanowire. The first and second conductors are disposed on the first surface of the substrate, and are spaced apart from each other. The bio-nanowire has two ends respectively connected to the first and second conductors, and includes a nucleic acid molecule having two nucleotide segments, and a plurality of metal ions bonded between the two nucleotide segments of the nucleic acid molecule. The two nucleotide segments form a double helix structure via base pairs. When a voltage or a current is applied to the bio-nanowire, the oxidation state of the metal ions can be changed such that the non-linear electroconductive characteristic of the bio-nanowire can be controlled.

Abstract: The invention concerns separation methods and systems including those comprising a continuous chromatographic simulated moving bed integrated with vapor compression distillation to create a high efficiency separations platform applicable to a broad range of separation functions.

Abstract: The disclosure relates generally to materials that comprise conductive covalent organic frameworks. The disclosure also relates to materials that are useful to store and separate gas molecules and sensors.

Abstract: Sulfonated silane ionomeric materials useful in electrodes of e.g., membrane electrode assemblies (MEA) of fuel cells can improve cell performance. MEAs prepared with CCE cathode catalyst layers and standard ELAT anode layers over a period of several start-stop cycles, as well as at multiple relative humidities were studied. The MEA performance was monitored using cyclic voltammetry, electrochemical impedance spectroscopy, and fuel cell polarization curves. The CCE cathode materials appeared to maintain performance and had improved water management capabilities at comparatively low relative humidities.

Abstract: A system and method for patient-adaptive hemodynamic management is described. One embodiment includes a system for hemodynamic management including transfusion, volume resuscitation with intravenous fluids, and medications, utilizing monitored hemodynamic parameters including the described dynamic predictors of fluid responsiveness, and including an intelligent algorithm capable of adaptation of the function of the device to specific patients.

Abstract: A disclosed chemical detection system for detecting a target material, such as an explosive material, can include a cantilevered probe, a probe heater coupled to the cantilevered probe, and a piezoelectric element disposed on the cantilevered probe. The piezoelectric element can be configured as a detector and/or an actuator. Detection can include, for example, detecting a movement of the cantilevered probe or a property of the cantilevered probe. The movement or a change in the property of the cantilevered probe can occur, for example, by adsorption of the target material, desorption of the target material, reaction of the target material and/or phase change of the target material. Examples of detectable movements and properties include temperature shifts, impedance shifts, and resonant frequency shifts of the cantilevered probe. The overall chemical detection system can be incorporated, for example, into a handheld explosive material detection system.

Abstract: Nano-graphene oxide sheets or nano-graphene sheets having a maximum average lateral dimension of about 50 nm and methods of making nano-graphene oxide sheets and nano-graphene sheets.

Abstract: A linear transform can be performed using a passive analog multi-stage charge re-use linear transform circuit. The passive analog multi-stage charge re-use linear transform circuit transforms an input analog circuit to generate a transformed analog output signal. The passive analog multi-stage charge re-use linear transform circuit may be included in a software defined radio (SDR), where the transformed analog output signal may be output to an analog-to-digital converter (ADC) of the SDR device so as to enable the ADC to perform wideband spectrum sensing. The passive analog multi-stage charge re-use linear transform circuit may also be included in a beamforming device so as to enable the device to perform spectral shifting and spatial shifting of signals. This passive analog multi-stage charge re-use linear transform circuit may promote reduced power consumption in comparison to other circuits while also supporting wideband applications at high sampling rates.

Abstract: Generally, the subject matter disclosed herein relates to the fabrication of an RRAM cell using CMOS compatible processes. A resistance random access memory device is disclosed which includes a semiconducting substrate, a top electrode, at least one metal silicide bottom electrode formed at least partially in the substrate, wherein at least a portion of the at least one bottom electrode is positioned below the top electrode, and at least one insulating layer positioned between the top electrode and at least a portion of the at least one bottom electrode.

Abstract: According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light source configured to emit a beam of visible light; second light source configured to emit a beam of near-infrared light; a handheld probe optically coupled to the second light source; a second imaging device configured to detect visible light; a third imaging device configured to detect near-infrared light having a first predetermined wavelength; a fourth imaging device configured to detect near-infrared light having a second predetermined wavelength; a display for displaying at least one visual representation of data; and, a controller programmed to generate at least one real-time integrated visual representation of an area of interest and to display the real-time visual representation on the display for guidance during the diagnostic or therapeutic procedure.

Abstract: The disclosure provides a material with the general formula Sr1-xAxSi1-yGeyO3-0.5x, wherein A is K or Na, including mixtures thereof, and wherein 0?y?1 and 0?x?0.4. In a specific embodiment, 0?y?0.5. In another specific embodiment, 0?y?0.1 and 0?x?0.4. In another specific embodiment 0.9?y?1 and 0?x?0.25. The material may be a single-phase polycrystalline solid having a monoclinic crystal structure. The material may have an oxide-ion conductivity (?o) greater than or equal to 10?2 S/cm at a temperature of at least 500° C. The material may be formed into a planar or tubular membrane or a composite with another solid member. The material may be used as the electrolyte in a fuel cell or a regenerative or reverse fuel cell, as an oxygen sensor, or as an oxygen separation membrane. The material may also be used as a catalyst for oxidation of an olefin or for other purposes where oxide-ion conductivity is beneficial.

Abstract: During shock wave therapy, a determination is made that a kidney stone has begun to fracture, and then a progress of its fragmentation is assessed. This determination can reduce the number of shock waves used to disintegrate kidney stones, and thereby reduce dose-dependent tissue damage. The identification of fracture is possible through the detection and analysis of resonant acoustic scattering, which is the radiation caused by reverberations within a stone particle that is struck by a shock wave. The scattering frequency can provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Related concepts employ displacement measurements of kidney stones/fragments to provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Such techniques can be combined with vibro-acoustography based gating that better targets the stone.

Abstract: The present invention relates to a phosphopeptide-stabilized amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complex, wherein the complex is formed at a pH of below 7.0. Methods of making such complexes are also provided. The complexes are useful in dental applications, in particular in dental remineralisation.

Abstract: A system 120 for reflecting or redirecting incident light, microwave or sound energy includes a first substrate 144 configured to support an array of reflective elements 130 that can be angularly displaced through a range of substantially 90 degrees in response to a reflector angle control signal and a controller programmed to generate the reflector angle control signal to achieve desired incident energy beam or wavefront re-direction. The reflective elements 130 preferably comprise MEMS micro-reflector elements hingedly or movably attached to the first substrate 130 and define a reflective surface that is aimed at the source of incident light, microwave or sound energy.

Abstract: The present invention relates to a safe and effective way to deliver and express therapeutic compositions (e.g., transgenes) to the pancreas and lungs of a mammal.

Abstract: Provided herein are compositions and methods for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells, such as mesenchymal stem cells. One aspect provides a fibrochondrocyte culture medium including CTGF and TGF?3, optionally encapsulated by microspheres having different release profiles. Another aspect provides a method for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells by culturing with CTGF and TGF?3.