Abstract: The present invention is directed to a circuit device configured to monitor a sensor device. The sensor device is configured to measure a predetermined physical parameter and provide a sensor output signal corresponding to the predetermined physical parameter. The circuit device includes a sampling circuit configured to sample the sensor output signal to obtain a predetermined number (N) of sensor output signal samples. an analog multiplication circuit to generate one of a plurality of predetermined digital sequences. and an analog integrator circuit. configured to add the N multiplication products to generate an analog signal power estimation value which corresponds to a degree of correlation between the sensor output signal and the selected predetermined digital sequence.
Abstract: Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell.
Type:
Grant
Filed:
January 15, 2010
Date of Patent:
January 28, 2014
Assignees:
University of Pittsburgh—Of the Commonwealth System of Higher Education, Georgetown University
Inventors:
Steven J. Metallo, Edward V. Prochownik, Ariele Viacava Follis
Abstract: A method of determining antimicrobial activity of an agent can include providing a well, wherein the well contains at least one antimicrobial agent, the well further including at least two electrodes. A sample of a microbe can be added into the well and a voltage pulsed between the electrodes. An electrical property can be sampled and recorded. In another aspect, a method of identifying at least one microbe includes taking a sample containing the at least one microbe, isolating the at least one microbe from the sample, dividing the at least one microbe into a at least one well, wherein each well contains at least one antimicrobial agent and at least two electrodes. A voltage is pulsed between the at least two electrodes, an electrical property is sampled during the pulsing and recorded. In another aspect, a diagnostic device for detecting at least one microbe is presented.
Type:
Grant
Filed:
May 4, 2012
Date of Patent:
January 28, 2014
Assignees:
Telemedicine Up Close, Inc., Texas State University
Inventors:
Cynthia S. Nickel, Clois E. Powell, James R. Biard, William A. Stapleton, Gary M. Aron, Jeanette Hill, Ray G. Cook, Daniel M. Justiss, Frederick J. Strieter, Wayne T. Kilian, Andrei M. Manoliu
Abstract: A method of forming a porous material having improved compressive strength, includes forming an aerogel precursor that includes a polymer having a functional group capable of undergoing a crosslinking reaction dispersed in a dispersion medium. The precursor also includes a crosslinking agent. The aerogel precursor is frozen so that the dispersion is solidified, and freeze dried to sublime the dispersion medium and form the porous material. The crosslinking agent is reacted with the functional group to effect crosslinking, thus improving the compressive strength of the porous material.
Abstract: A semiconductor light emitting device, including: a heterojunction bipolar light-emitting transistor having a base region between emitter and collector regions; emitter, base, and collector electrodes for coupling electrical signals with the emitter, base, and collector regions, respectively; and a quantum size region in the base region; the base region including a first base sub-region on the emitter side of the quantum size region, and a second base sub-region on the collector side of the quantum size region; and the first and second base sub-regions having asymmetrical band structures.
Type:
Grant
Filed:
January 7, 2010
Date of Patent:
January 28, 2014
Assignees:
Quantum Electro Opto Systems Sdn. Bhd., The Board of Trustees of The University of Illinois
Inventors:
Nick Holonyak, Jr., Milton Feng, Gabriel Walter
Abstract: A system and method for dynamic multi-stage test administration for detection of cardiovascular disease may include performing a first set of tests in a first stage of testing on a patient. Physiological results for each of the tests in the first stage may then be received. Then, based on the physiological results, dynamically determining a set of tests to perform on the subject in a second stage of testing. Additionally, the dynamically determined set of tests in the second stage of testing may be performed on the subject.
Abstract: It is an object of the present invention to provide a novel mitochondrial function-improving agent and a novel PGC-1? expression inducing agent. The present invention provides a mitochondrial function-improving agent and a PGC-1? expression inducing agent each of which comprises a lysine-specific demethylase-1 (LSD-1) inhibitor.
Type:
Grant
Filed:
March 29, 2010
Date of Patent:
January 28, 2014
Assignee:
National University Corporation Kumamoto University
Abstract: A database encryption system and method, the Structure Preserving Database Encryption (SPDE), is presented. In the SPDE method, each database cell is encrypted with its unique position. The SPDE method permits to convert a conventional database index into a secure one, so that the time complexity of all queries is maintained. No one with access to the encrypted database can learn anything about its content without the encryption key. Also a secure index for an encrypted database is provided. Furthermore, secure database indexing system and method are described, providing protection against information leakage and unauthorized modifications by using encryption, dummy values and pooling, and supporting discretionary access control in a multi-user environment.
Type:
Grant
Filed:
May 30, 2005
Date of Patent:
January 28, 2014
Assignee:
Ben Gurion University of the Negev Research and Development Authority
Abstract: Described are methods for treating cancers, e.g., glioblastoma, including administering an inhibitor of Notch signalling, e.g., a gamma secretase inhibitor, in combination with a chemotherapeutic agent.
Type:
Grant
Filed:
November 10, 2010
Date of Patent:
January 28, 2014
Assignee:
University of Massachusetts
Inventors:
Alonzo H. Ross, Candace Gilbert, Richard Moser
Abstract: A system and method for electrically shielding a physiological pathway from electrical noise is disclosed. The method includes the operation of implanting at least one signal microelectrode into a patient such that the signal microelectrode is proximate to the physiological pathway. An additional operation includes substantially enclosing the microelectrode and a section of the physiological pathway with an electrical shielding wrap. The electrical shielding wrap includes a plurality of holes that enable fluid communication of physiological fluids between an inside and outside of the wrap.
Type:
Grant
Filed:
December 10, 2009
Date of Patent:
January 28, 2014
Assignee:
University of Utah Research Foundation
Inventors:
Gregory Arthur Clark, David J. Warren, Noah M. Ledbetter
Abstract: Stabilized glucagon solutions, methods of storing and using the stabilized glucagon solutions, and drug delivery devices containing the stabilized glucagon solutions. In some embodiments, the glucagon solutions may be alkaline, such as with a pH of at least about 9. The glucagon solutions may be resistant to aggregation of glucagon when the solutions are stored for a prolonged period, such as at least about three days, at room temperature and/or physiological temperature.
Type:
Grant
Filed:
June 14, 2011
Date of Patent:
January 28, 2014
Assignees:
Legacy Emanuel Hospital & Health Center, Indian University Research and Technology Corporation
Abstract: Disclosed herein is a recombinant Escherichia coli (E. coli) capable of producing D-xylonic acid from D-xylose and a method for producing D-xylonic acid using the same. The recombinant E. coli producing D-xylonic acid from D-xylose according to the present invention is a recombinant E. coli EWX4 (Microorganism deposition number KCTC11988BP) capable of producing D-xylonic acid from D-xylose. When utilizing the recombinant E. coli prepared by the method of the present invention, it is possible to produce D-xylonic acid from D-xylose with high yield while reducing production cost using sole carbon source.
Type:
Grant
Filed:
August 21, 2012
Date of Patent:
January 28, 2014
Assignee:
Myongji University Industry and Academia Cooperation Foundation
Inventors:
Wook-Jin Chung, Huaiwei Liu, Kris Niño Gomez Valdehuesa, Kristine Rose Medina Ramos, Mi-Deok Han
Abstract: The invention provides fluorescent schweinfurthin analogs of formula (I) which are useful as probes and for the treatment of cancer and other diseases.
Type:
Grant
Filed:
June 25, 2009
Date of Patent:
January 28, 2014
Assignee:
University of Iowa Research Foundation
Inventors:
David F. Wiemer, Jeffrey D. Neighbors, Raymond J. Hohl, Craig Kuder
Abstract: The invention relates to the treatment of wounds. In particular, the invention relates to systems, devices, and methods enabling pulse lavage irrigation of wounds in a non-controlled setting while providing containment of contaminated irrigation fluid, thereby preventing exposure of individuals and surfaces in proximity to the patient to infectious materials.
Abstract: The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function.
Type:
Grant
Filed:
May 5, 2011
Date of Patent:
January 28, 2014
Assignees:
Wisconsin Alumni Research Foundation, Indiana University Research and Technology Corporation
Abstract: 2? and/or 3? prodrugs of 1?, 2?, 3? or 4?-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
Type:
Grant
Filed:
June 24, 2011
Date of Patent:
January 28, 2014
Assignees:
Idenix Pharmaceuticals, Inc., University of Cagliari, The Centre National de la Recherché Scientifique, L'Universite Montpelier II
Inventors:
Richard Storer, Gilles Gosselin, Jean-Pierre Sommadossi
Abstract: The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in treating central nervous system disorders by over-activation of NMDA and/or MC receptors. In one aspect, the present invention provides methods of enhancing brain's cognitive function and reducing neuronal cell death in mammals and humans.
Type:
Grant
Filed:
January 5, 2012
Date of Patent:
January 28, 2014
Assignee:
The Hong Kong University of Science and Technology
Inventors:
Nancy Yuk-Yu Ip, Fanny Chui-Fun Ip, Yueqing Hu, Wen Cai Ye
Abstract: Drug delivery compositions and methods of delivering compounds are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
Type:
Grant
Filed:
March 16, 2012
Date of Patent:
January 28, 2014
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
David B Weiner, Karuppiah Muthumani, Donghui Zhang, Mathura Ramanathan
Abstract: A method and apparatus for conducting the rapid pyrolysis of peptides, proteins, polymers, and biological materials. The method can be carried out at atmospheric pressures and takes only about 5 to 30 seconds. The samples are cleaved at the C-terminus of aspartic acid. The apparatus employs a probe on which the sample is heated and digested components analyzed.
Abstract: A sound enhancing system includes a haptic chair formed of a chair and plural speakers mounted to the chair. The speakers receive audio input from a subject audio source and generate corresponding sound vibrations. The chair is configured to deliver the generated sound vibrations to various body parts of a user seated in the chair through the sense of touch and by bone conduction of sound. A visual display viewable by the user corresponds to the generated sound vibrations and is indicative of the corresponding audio input. The sound enhancing system enhances user experience of the audio input by any one or combination of visually, by the sense of touch, and by bone conduction of sound.
Type:
Grant
Filed:
September 18, 2009
Date of Patent:
January 28, 2014
Assignee:
National University of Singapore
Inventors:
Oh Elizabeth Ann Taylor, Suranga Chandima Nanayakkara, Lonce Lamar Wyse, Sim Heng Ong, Kian Peen Yeo, Ghim Hui Tan