Patents Assigned to University
  • Patent number: 8638225
    Abstract: The present invention is directed to a circuit device configured to monitor a sensor device. The sensor device is configured to measure a predetermined physical parameter and provide a sensor output signal corresponding to the predetermined physical parameter. The circuit device includes a sampling circuit configured to sample the sensor output signal to obtain a predetermined number (N) of sensor output signal samples. an analog multiplication circuit to generate one of a plurality of predetermined digital sequences. and an analog integrator circuit. configured to add the N multiplication products to generate an analog signal power estimation value which corresponds to a degree of correlation between the sensor output signal and the selected predetermined digital sequence.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: January 28, 2014
    Assignee: University of Rochester
    Inventors: Mark F. Bocko, Zeljko Ignjatovic
  • Patent number: 8637556
    Abstract: Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: January 28, 2014
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Georgetown University
    Inventors: Steven J. Metallo, Edward V. Prochownik, Ariele Viacava Follis
  • Patent number: 8637233
    Abstract: A method of determining antimicrobial activity of an agent can include providing a well, wherein the well contains at least one antimicrobial agent, the well further including at least two electrodes. A sample of a microbe can be added into the well and a voltage pulsed between the electrodes. An electrical property can be sampled and recorded. In another aspect, a method of identifying at least one microbe includes taking a sample containing the at least one microbe, isolating the at least one microbe from the sample, dividing the at least one microbe into a at least one well, wherein each well contains at least one antimicrobial agent and at least two electrodes. A voltage is pulsed between the at least two electrodes, an electrical property is sampled during the pulsing and recorded. In another aspect, a diagnostic device for detecting at least one microbe is presented.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: January 28, 2014
    Assignees: Telemedicine Up Close, Inc., Texas State University
    Inventors: Cynthia S. Nickel, Clois E. Powell, James R. Biard, William A. Stapleton, Gary M. Aron, Jeanette Hill, Ray G. Cook, Daniel M. Justiss, Frederick J. Strieter, Wayne T. Kilian, Andrei M. Manoliu
  • Patent number: 8637582
    Abstract: A method of forming a porous material having improved compressive strength, includes forming an aerogel precursor that includes a polymer having a functional group capable of undergoing a crosslinking reaction dispersed in a dispersion medium. The precursor also includes a crosslinking agent. The aerogel precursor is frozen so that the dispersion is solidified, and freeze dried to sublime the dispersion medium and form the porous material. The crosslinking agent is reacted with the functional group to effect crosslinking, thus improving the compressive strength of the porous material.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: January 28, 2014
    Assignee: Case Western Reserve University
    Inventors: Matthew D. Gawryla, David A. Schiraldi
  • Patent number: 8638830
    Abstract: A semiconductor light emitting device, including: a heterojunction bipolar light-emitting transistor having a base region between emitter and collector regions; emitter, base, and collector electrodes for coupling electrical signals with the emitter, base, and collector regions, respectively; and a quantum size region in the base region; the base region including a first base sub-region on the emitter side of the quantum size region, and a second base sub-region on the collector side of the quantum size region; and the first and second base sub-regions having asymmetrical band structures.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: January 28, 2014
    Assignees: Quantum Electro Opto Systems Sdn. Bhd., The Board of Trustees of The University of Illinois
    Inventors: Nick Holonyak, Jr., Milton Feng, Gabriel Walter
  • Patent number: 8636660
    Abstract: A system and method for dynamic multi-stage test administration for detection of cardiovascular disease may include performing a first set of tests in a first stage of testing on a patient. Physiological results for each of the tests in the first stage may then be received. Then, based on the physiological results, dynamically determining a set of tests to perform on the subject in a second stage of testing. Additionally, the dynamically determined set of tests in the second stage of testing may be performed on the subject.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: January 28, 2014
    Assignee: Regents of the University of Minnesota
    Inventor: Jay N. Cohn
  • Patent number: 8637480
    Abstract: It is an object of the present invention to provide a novel mitochondrial function-improving agent and a novel PGC-1? expression inducing agent. The present invention provides a mitochondrial function-improving agent and a PGC-1? expression inducing agent each of which comprises a lysine-specific demethylase-1 (LSD-1) inhibitor.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: January 28, 2014
    Assignee: National University Corporation Kumamoto University
    Inventors: Mitsuyoshi Nakao, Shinjiro Hino
  • Patent number: 8639947
    Abstract: A database encryption system and method, the Structure Preserving Database Encryption (SPDE), is presented. In the SPDE method, each database cell is encrypted with its unique position. The SPDE method permits to convert a conventional database index into a secure one, so that the time complexity of all queries is maintained. No one with access to the encrypted database can learn anything about its content without the encryption key. Also a secure index for an encrypted database is provided. Furthermore, secure database indexing system and method are described, providing protection against information leakage and unauthorized modifications by using encryption, dummy values and pooling, and supporting discretionary access control in a multi-user environment.
    Type: Grant
    Filed: May 30, 2005
    Date of Patent: January 28, 2014
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Yuval Elovici, Ronen Waisenberg, Erez Shmueli
  • Patent number: 8637493
    Abstract: Described are methods for treating cancers, e.g., glioblastoma, including administering an inhibitor of Notch signalling, e.g., a gamma secretase inhibitor, in combination with a chemotherapeutic agent.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: January 28, 2014
    Assignee: University of Massachusetts
    Inventors: Alonzo H. Ross, Candace Gilbert, Richard Moser
  • Patent number: 8639312
    Abstract: A system and method for electrically shielding a physiological pathway from electrical noise is disclosed. The method includes the operation of implanting at least one signal microelectrode into a patient such that the signal microelectrode is proximate to the physiological pathway. An additional operation includes substantially enclosing the microelectrode and a section of the physiological pathway with an electrical shielding wrap. The electrical shielding wrap includes a plurality of holes that enable fluid communication of physiological fluids between an inside and outside of the wrap.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: January 28, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Gregory Arthur Clark, David J. Warren, Noah M. Ledbetter
  • Patent number: 8636711
    Abstract: Stabilized glucagon solutions, methods of storing and using the stabilized glucagon solutions, and drug delivery devices containing the stabilized glucagon solutions. In some embodiments, the glucagon solutions may be alkaline, such as with a pH of at least about 9. The glucagon solutions may be resistant to aggregation of glucagon when the solutions are stored for a prolonged period, such as at least about three days, at room temperature and/or physiological temperature.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: January 28, 2014
    Assignees: Legacy Emanuel Hospital & Health Center, Indian University Research and Technology Corporation
    Inventors: W. Kenneth Ward, Richard D. DiMarchi
  • Patent number: 8637279
    Abstract: Disclosed herein is a recombinant Escherichia coli (E. coli) capable of producing D-xylonic acid from D-xylose and a method for producing D-xylonic acid using the same. The recombinant E. coli producing D-xylonic acid from D-xylose according to the present invention is a recombinant E. coli EWX4 (Microorganism deposition number KCTC11988BP) capable of producing D-xylonic acid from D-xylose. When utilizing the recombinant E. coli prepared by the method of the present invention, it is possible to produce D-xylonic acid from D-xylose with high yield while reducing production cost using sole carbon source.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: January 28, 2014
    Assignee: Myongji University Industry and Academia Cooperation Foundation
    Inventors: Wook-Jin Chung, Huaiwei Liu, Kris Niño Gomez Valdehuesa, Kristine Rose Medina Ramos, Mi-Deok Han
  • Patent number: 8637685
    Abstract: The invention provides fluorescent schweinfurthin analogs of formula (I) which are useful as probes and for the treatment of cancer and other diseases.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: January 28, 2014
    Assignee: University of Iowa Research Foundation
    Inventors: David F. Wiemer, Jeffrey D. Neighbors, Raymond J. Hohl, Craig Kuder
  • Patent number: 8636709
    Abstract: The invention relates to the treatment of wounds. In particular, the invention relates to systems, devices, and methods enabling pulse lavage irrigation of wounds in a non-controlled setting while providing containment of contaminated irrigation fluid, thereby preventing exposure of individuals and surfaces in proximity to the patient to infectious materials.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: January 28, 2014
    Assignee: Northwestern University
    Inventor: Elliot M. Hirsch
  • Patent number: 8637684
    Abstract: The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: January 28, 2014
    Assignees: Wisconsin Alumni Research Foundation, Indiana University Research and Technology Corporation
    Inventors: Ben Shen, Zhong-Yin Zhang
  • Patent number: 8637475
    Abstract: 2? and/or 3? prodrugs of 1?, 2?, 3? or 4?-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: January 28, 2014
    Assignees: Idenix Pharmaceuticals, Inc., University of Cagliari, The Centre National de la Recherché Scientifique, L'Universite Montpelier II
    Inventors: Richard Storer, Gilles Gosselin, Jean-Pierre Sommadossi
  • Patent number: 8637474
    Abstract: The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in treating central nervous system disorders by over-activation of NMDA and/or MC receptors. In one aspect, the present invention provides methods of enhancing brain's cognitive function and reducing neuronal cell death in mammals and humans.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: January 28, 2014
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Nancy Yuk-Yu Ip, Fanny Chui-Fun Ip, Yueqing Hu, Wen Cai Ye
  • Patent number: 8637042
    Abstract: Drug delivery compositions and methods of delivering compounds are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: January 28, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B Weiner, Karuppiah Muthumani, Donghui Zhang, Mathura Ramanathan
  • Patent number: 8637325
    Abstract: A method and apparatus for conducting the rapid pyrolysis of peptides, proteins, polymers, and biological materials. The method can be carried out at atmospheric pressures and takes only about 5 to 30 seconds. The samples are cleaved at the C-terminus of aspartic acid. The apparatus employs a probe on which the sample is heated and digested components analyzed.
    Type: Grant
    Filed: February 16, 2009
    Date of Patent: January 28, 2014
    Assignee: University of Wyoming
    Inventors: Franco Basile, Shaofeng Zhang
  • Patent number: 8638966
    Abstract: A sound enhancing system includes a haptic chair formed of a chair and plural speakers mounted to the chair. The speakers receive audio input from a subject audio source and generate corresponding sound vibrations. The chair is configured to deliver the generated sound vibrations to various body parts of a user seated in the chair through the sense of touch and by bone conduction of sound. A visual display viewable by the user corresponds to the generated sound vibrations and is indicative of the corresponding audio input. The sound enhancing system enhances user experience of the audio input by any one or combination of visually, by the sense of touch, and by bone conduction of sound.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: January 28, 2014
    Assignee: National University of Singapore
    Inventors: Oh Elizabeth Ann Taylor, Suranga Chandima Nanayakkara, Lonce Lamar Wyse, Sim Heng Ong, Kian Peen Yeo, Ghim Hui Tan