Abstract: The present invention relates to a population of antibodies enriched from an antibody preparation, wherein the enriched population of antibodies has an altered amount of sialylation in the Fab region of the antibodies as compared to the antibody preparation prior to enrichment. Furthermore, the present invention relates to a method of enriching a population of antibodies from an antibody preparation, wherein the enriched population of antibodies has an altered amount of sialylation in the Fab region of the antibodies as compared to the antibody preparation prior to enrichment. The present invention also relates to the population of antibodies of the invention for use in medicine, a pharmaceutical composition comprising the populations of antibodies of the invention and the use of the population of antibodies of the invention in the prevention and/or treatment of atherosclerosis, cancer and infections such as bacterial, viral or fungal infections.

Abstract: A laser system is provided which selectively excites Raman active vibrations in molecules. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and binary pulse shaping (BPS). Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and remote sensing.

Abstract: Methods and systems for measuring particles within a flow are provided. An aircraft transports a high volume sample rate holographic measurement instrument through a particle-containing volume of interest along a reference axis X (time). As the instrument moves relative to the volume of interest, the holographic measurement instrument transmits a collimated light beam across the volume of interest along an optical axis Z. The light beam interacts with particles contained within the volume of interest, and a high-speed, one-dimensional detector array detects incident light reflecting patterns of light intensity levels that are associated with the interaction between the light beam and the particles.

Abstract: The present invention discloses a multilevel resistive memory having large storage capacity, which belongs to a field of a fabrication technology of a resistive memory. The resistive memory includes an top electrode and a bottom electrode, and a combination of a plurality of switching layers and defective layers interposed between the top electrode and the bottom electrode, wherein, the top electrode and the bottom electrode are respectively contacted with a switching layer (a film such as Ta2O5, TiO2, HfO2), and the defective layers (metal film such as Ti, Au, Ag) are interposed between the switching layers. By using the present invention, a storage capacity of a resistive memory can be increased.

Abstract: A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample.

Abstract: Various applications are directed to a material stack having a strained active material therein. In connection with an embodiment, an active material (e.g. a semiconductor material) is at least initially and partially released from and suspended over a substrate, strained, and held in place. The release and suspension facilitates the application of strain to the semiconductor material.

Abstract: A master key (K2,2) inputted by an input unit is stored in a storage unit. A matrix generating unit generates key element matrices (M1-M3) with respect to each of split keys (eR2, eR1, eR3) obtained by a key dividing unit dividing the master key (K2,2). To each coordinate entry of the key element matrices (M1-M3), operation data that successively obtained by repeating a hash operation with a one-way hash function is assigned, so as to maintain hierarchical nature of scalability (L). A key generating unit generates partial keys (K1,1-K2,2) corresponding to respective hierarchies of the scalabilities (R, L), on the basis of the key element matrices (M1-M3). These partial keys (K1,1-K2,2) are outputted to a coding unit or a decoding unit by an output unit.

Abstract: This invention provides an organic-inorganic hybrid material, which can exhibit high proton conductivity in a wide temperature range of a low temperature to a high temperature, a proton conductive material, which has a small particle diameter, that is, has a particle diameter capable of reaching pores of primary particles of carbon powder or the like, and has controlled particle diameters, a catalyst layer containing these materials for a fuel cell and an electrolyte film containing these materials for a fuel cell, and a fuel cell. The proton conductive hybrid material comprises proton conductive inorganic nanoparticles and a proton conductive polymer, wherein the Stokes particle diameter of the proton conductive hybrid material by dynamic light scattering is not more than 20 nm.

Abstract: The present invention provides a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject, and an evaluation method using the same. A cancer marker containing at least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as a marker for cancers excluding breast cancer. A method for evaluating the possibility of cancers excluding breast cancer includes the step of detecting the expression level of a cancer marker in a biological sample collected from a subject. In this method, the cancer marker contains at least one miRNA selected from hsa-miR-92 and hsa-miR-494.

Abstract: A system and method for Fourier encoding a nuclear magnetic resonance (NMR) signal is disclosed. A static magnetic field B0 is provided along a first direction. An NMR signal from the sample is Fourier encoded by applying a rotating-frame gradient field BG superimposed on the B0, where the BG comprises a vector component rotating in a plane perpendicular to the first direction at an angular frequency ? in a laboratory frame. The Fourier-encoded NMR signal is detected.

Abstract: The present invention relates to a method for microfluidic mixing in a “lab-on-a-chip” environment. The methodology focuses on constant acceleration and deceleration about a mean angular speed with a rotating disk serving as the mixing platform. The methodology results in good mixing between different fluids.

Abstract: The present invention relates to a tray for use with a walker. The tray includes a generally rigid tray base having an essentially rectangular shape with a front long side, a back long side, a first short side and a second short side, and wherein the tray has a length that extends to or past the essentially horizontal support member; a ridge extending along the sides of the tray, wherein the ridge has a height of at least about a ½ inch; a strap having a hook and loop fastener wherein the strap is positioned at or near the back long end; and a first hinge and a second hinge, the first and second hinges are positioned, when the tray is in use, at or near the front leg of the first and second support, respectively.

Abstract: An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk capacitance value is determined for a model circuit based on the impedance dataset. After a predetermined time period, a new bulk capacitance value is determined for on another portion of the sample. The difference between the new bulk capacitance and the initial bulk capacitance value is compared to a threshold value to determine if viable bacterial is present in the sample.

Abstract: Provided are methods of converting carbon dioxide to carbon nitrides. In a first reaction, carbon dioxide may be reacted with metal nitrides, such as Li3N, to form carbon nitrides in a fast and exothermic reaction. Also provided are methods of using product metal cyanamides from the first reaction to subsequently generate additional carbon nitrides.

Abstract: A method of determining common three-dimensional structural features of protein surfaces is provided, as is use of representations of these common structures in molecular database searching and in designing focused molecular libraries. The method is particularly concerned with the analysis and representation of protein surfaces such as b-turns, loops and contact surfaces. In one form, the method identifies common locations and orientations of amino acid side-chains, simplified as C?-C? vectors. In another form, the method identifies common regions of surface charge represented by grid points in three-dimensional space. Further provided are common three dimensional structural features of proteins that can be used to search molecular databases for the purposes of identifying molecules that match these common three dimensional structural features.

Abstract: Embodiments of the invention are directed to a new type of phase screen, i.e., an opto-electronic device that can convert a distorted incoming optical wavefront into a plane wave or, conversely, transform a plane wave into a prescribed varying output wavefront. The basic concept involves novel binary all-digital MEMS interferometer configurations that can be used to create controlled and arbitrary optical wavefront using only 0,1 amplitude changes followed by differential propagation distances to convert these amplitude variations into controllable and/or continuous phase variations. Clustered pixel notions, such as Floyd-Steinberg, Stucki or other algorithms useful in digital half-tone printing, are simultaneously employed to create controllable grey-level variations as well as continuous phase variations. Desired grey-levels can be obtained wherein each pixel is formed by, e.g., a 3×3 or 5×5 cluster of mirrors.

Abstract: Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof: (I) in which R1, R2, R3, and R4 are defined herein and pharmaceutical compositions thereof. Further provided is a method of treating various disorders, such as a disorder selected from the group consisting of a cardiovascular disorder, cancer, chronic pain, alcohol dependence, and inflammation in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt of formula (I).

Abstract: A system and method for monitoring personal protection items of a healthcare worker (gloves, gown, mask and respirator), using a user badge which stores data representing items worn by a worker, wirelessly communicating with the badge before the worker enters a patient zone (such as a patient room, bed area or exam table area), to see whether the worker has the required items. Patient beacons, located near patient room doors, near beds and other locations, store data representing the items required by workers who come in contact with, or close proximity to a patient, and wirelessly communicate with the badge. The patient beacon data can be set for the requirement of the patient, based on patient condition.

Abstract: An amplifier circuit includes an amplifier and a noise suppression block. The amplifier is arranged for receiving an input signal at an input port and generating an output signal at an output port according to the input signal. The noise suppression block is coupled between the input port and the output port of the amplifier, and arranged for receiving the input signal and the output signal and applying noise suppression to the output signal generated from the amplifier according to the received input signal and the received output signal.

Abstract: One aspect of the instant disclosure is to provide a sensorless adaptive safety actuator. The safety actuator comprises a driving unit, a transmission unit coupled to the driving unit, and an output unit coupled to the transmission unit. The transmission unit comprises a load-adaptable retracting mechanism. When the output unit experiences a mechanical load exceeding a critical value, the load-adaptable retracting mechanism causes the transmission unit to decouple from the driving unit. Thus, responding to an accident where the impact on the output unit causes a force/torque overload, the instant safety actuator is capable of effectively stopping the force/torque transmission to the work output device without the use of active sensors.