Abstract: A method for making epitaxial structure is provided. The method includes providing a substrate having an epitaxial growth surface, placing a carbon nanotube layer on the epitaxial growth surface, and epitaxially growing an epitaxial layer on the epitaxial growth surface. The carbon nanotube layer can be a carbon nanotube film drawn from a carbon nanotube array and including a plurality of successive and oriented carbon nanotubes joined end-to-end by van der Waals attractive force therebetween.
Type:
Grant
Filed:
October 18, 2011
Date of Patent:
January 21, 2014
Assignees:
Tsinghua University, Hon Hai Precision Industry Co., Ltd.
Abstract: The present invention includes compositions, methods and kits for the identification of a polypeptide that binds to a predetermined RNA sequence. The invention comprises, in part, a photoreactive moiety to aid in identification of such a polypeptide.
Type:
Grant
Filed:
June 20, 2006
Date of Patent:
January 21, 2014
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
James Eberwine, Ulo Langel, Kalle Kilk, Jennifer Zielinski
Abstract: A positioning system having a base, a manually movable end effector and a first joint interposed between the base and the end effector is disclosed. The first joint may comprise a proximal portion and a distal portion coupled together by magnetic attraction and configured to be intermittently separated by a pressurized gas cushion. The first joint may be configured to be changeable between a movable state and a fixed state. In the movable state, the proximal and distal portions are separated by the pressurized gas cushion and are movable relative to each other. In the fixed state, the proximal and distal portions contact each other and relative movement is thereby impeded. Methods of precisely positioning an end effector may include providing a device having a base, a first joint located distally from the base, and an end effector located distally from the first joint.
Type:
Grant
Filed:
July 15, 2009
Date of Patent:
January 21, 2014
Assignee:
The Board of Trustees of The Leland Stanford Junior University
Abstract: A light emitting diode includes a second electrode, a first semiconductor layer, an active layer, a second semiconductor layer, a reflector, and a first electrode. The second electrode, the first semiconductor layer, the active layer, the second semiconductor layer, and the reflector are stacked on the first electrode in that order. The first semiconductor layer defines a plurality of grooves on a surface contacting the second electrode. The plurality of grooves form a patterned surface used as the light extraction surface. A carbon nanotube layer is located on the patterned surface and embedded into the grooves.
Type:
Grant
Filed:
November 3, 2011
Date of Patent:
January 21, 2014
Assignees:
Tsinghua University, Hon Hai Precision Industry Co., Ltd.
Abstract: This invention provides a computational approach to identifying potential antibacterial drug targets based on a genomic sequence and its annotation. Starting from a fully sequenced genome, open reading frame assignments are made which determine the metabolic genotype for the organism. The metabolic genotype, and more specifically its stoichiometric matrix, are analyzed using flux balance analysis to assess the effects of genetic deletions on the fitness of the organism and its ability to produce essential biomolecules required for growth.
Type:
Grant
Filed:
October 29, 2007
Date of Patent:
January 21, 2014
Assignee:
The Regents of the University of California
Abstract: The present invention provides methods, apparatuses and kits for determining the presence and the concentration of nanoparticles in a given area, solution or region via cellular uptake and/or adsorption monitored through laboratory equipment. For example, the present invention provides a method of quantifying one or more nanoparticles by incubating a nanoparticle solution comprising one or more nanoparticles with one or more cells; isolating the one or more cells; lysing the one or more cells to release a cell lysate; separating the cell lysate electrophoretically on a gel; digitizing the gel to form a gel image; quantifying the nanoparticle intensity in the gel image; and correlating the nanoparticle intensity to a cell-associated nanoparticle concentration.
Type:
Grant
Filed:
October 2, 2009
Date of Patent:
January 21, 2014
Assignee:
Board of Regents, University of Texas System
Inventors:
Rockford K. Draper, Paul Pantano, Ru-Hung Wang, Carole Mikoryak
Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response.
Type:
Grant
Filed:
October 4, 2010
Date of Patent:
January 21, 2014
Assignees:
University of Massachusetts, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.
Inventors:
Thomas Tuschl, Phillip D. Zamore, Phillip A. Sharp, David P. Bartel
Abstract: A method and apparatus includes detecting lightning induced electromagnetic pulses and determining a physical property of an underground structure based on the lightning induced electromagnetic pulses. In some embodiments, an apparatus includes an antenna, a low noise amplifier, a processor, cable, and a transmitter. The antenna includes three substantively perpendicular loops of electrical conductors. The processor is configured to condition the amplified signal. The cable is about 100 meters in length and connects the low noise amplifier to the processor. The transmitter is configured to send conditioned data to a data aggregation system.
Type:
Grant
Filed:
August 26, 2010
Date of Patent:
January 21, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Ivan Richard Linscott, Timothy Chevalier, Umran S. Inan, David Strauss
Abstract: Disclosed is a method for printing an image, comprising a step of rasterizing an image to be printed in view of a first resolution to generate a first data bitmap; a step of splitting the first data bitmap according to a ratio of the first resolution to a second resolution to generate second data bitmaps; and a step of outputting the second data bitmaps to a printer with the second resolution for printing. Disclosed is also a device for printing images. The method and device for printing an image may solve the problem in the prior art that the definition of an image printed from a printer is too low and improve the definition of an image printed from a printer.
Type:
Grant
Filed:
February 27, 2009
Date of Patent:
January 21, 2014
Assignees:
Peking University Founder Group Co., Ltd., Beijing Founder Electronics Co., Ltd
Inventors:
Jinghua Shen, Yapeng Chen, Bin Yang, Lidong Wang
Abstract: A system and method for a Micro Electro-Mechanical System acoustic sensor, or MEMS acoustic sensor, to be used as an implanted microphone for totally implantable cochlear implants or middle ear implants is presented. The MEMS acoustic sensor comprises a coupler that attaches the sensor to an inner part of the ear, a MEMS acoustic sensor that converts acoustic vibrations into a change in capacitance, and a low-noise interface electronics circuit chip that detects the change in capacitance in the MEMS acoustic sensor, creates an signal representing a portion of the acoustic vibrations, and transmits the signal to one or more other devices, such as a cochlear implant. A method of fabrication enables the MEMS acoustic sensor to be fabricated as a small, less than 1 mm3, light weight, less than 30 mg, device suitable for implantation on a structure of the middle ear.
Type:
Grant
Filed:
May 18, 2010
Date of Patent:
January 21, 2014
Assignee:
Case Western Reserve University
Inventors:
Wen H. Ko, Darrin J. Young, Rui Zhang, Ping Huang, Jun Guo, Xuesong Ye, Cliff A. Megerian
Abstract: Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.
Type:
Grant
Filed:
April 4, 2007
Date of Patent:
January 21, 2014
Assignees:
Regents of the University of Minnesota, The United States of America as represented by Department of Veterens Affairs
Inventors:
Gary L. Nelsestuen, Ronald Bach, Matthew Stone, Stephen Barrett Harvey
Abstract: Some embodiments provide a method and system for efficiently transferring medical images. Some embodiments receive a medical image in a first platform dependent format of a Picture Archiving and Communication System (PACS). The first platform dependent format is one that is accessible by a first format compliant device that includes a library that specifies how to decode the first format. Some embodiments transform the medical image from the first format to a second format. The second format includes decoded content of the first format that is viewable on a first format non-compliant device. The transformed image is then passed to the device for viewing. Additionally, some embodiments efficiently transfer medical images by identifying image settings for one or more devices and by passing requested images that are optimized by resizing the images according to the image settings of the requesting device.
Abstract: Disclosed herein is an interface treatment method for germanium-based device, which belongs to the field of manufacturing technologies of ultra large scaled integrated (ULSI) circuits. In the method, the natural oxide layer on the surface of the germanium-based substrate is removed by using a concentrated hydrochloric acid solution having a mass percentage concentration of 15%˜36%, and dangling bonds of the surface are performed a passivation treatment by using a diluted hydrochloric acid solution having a mass percentage concentration of 5%˜10% so as to form a stable passivation layer on the surface. This method makes a good foundation for depositing a high-K (high dielectric constant) gate dielectric on the surface of the germanium-based substrate after cleaning and passivating, enhances quality of the interface between the gate dielectric and the substrate, and improves the electrical performance of germanium-based MOS device.
Type:
Grant
Filed:
June 14, 2012
Date of Patent:
January 21, 2014
Assignee:
Peking University
Inventors:
Ru Huang, Min Li, Xia An, Ming Li, Meng Lin, Xing Zhang
Abstract: When write data D is high rewritten data, a PC 10 controls a DRAM 24 to store the write data D (steps S100 and S110). When the write data D is not the high rewritten data, the PC 10 outputs an RRAM write request signal and the write data D to an SSD (step S100 and S120). A memory controller of the SSD input the RRAM write request signal controls the RRAM and an SRAM to store the write data D in the RRAM or the SRAM. This treatment enables data stored in the DRAM to be rewritten frequently. Therefore, the decrease of number of times of refresh operation of the DRAM and the decrease of power consumption are accomplished.
Abstract: System and method for loading the front line anticancer drug, doxorubicin (DOX) onto DNA-capped gold nanoparticles whose duplex DNA has been designed for specific DOX intercalation. Since each AuNP contains about 108 high affinity drug sites, this design allows for a high local DOX concentration on the particle. Drug binding was confirmed by monitoring the increase in DNA melting temperature, the shift in the plasmon resonance maximum, and the increase in the NP hydrodynamic radius as a function of [DOX]/[DNA] ratio. The feasibility of the nanoparticles as a drug delivery system was demonstrated by showing that particle-bound DOX could be transferred to a target DNA.
Type:
Grant
Filed:
November 1, 2011
Date of Patent:
January 21, 2014
Assignee:
Syracuse University
Inventors:
Mathew Maye, James Dabrowiak, Colleen Alexander
Abstract: The bacterium that can perform complete dechlorination of trichloroethene, and the bacteria consortium containing the bacterium are provided, and the method to dechlorinate soils or ground water contaminated with trichloroethene using the bacterium is also provide.
Type:
Grant
Filed:
September 23, 2011
Date of Patent:
January 21, 2014
Assignees:
PaGE Science Co., Ltd., National University Corporation Tokyo University of Agriculture and Technology
Abstract: An optical concentrator is disclosed which includes an imaging, aplanatic optical element having a front surface with a one-way light admitting portion, a back surface with a reflective portion, and an interior region of refractive material disposed between the front and backs surfaces.
Type:
Grant
Filed:
October 23, 2009
Date of Patent:
January 21, 2014
Assignee:
The Regents of the University of California
Abstract: A clay comprising a 2:1 aluminosilicate clay having negative charge sites, the 2:1 aluminosilicate clay containing subnano-sized zero valent iron (ZVI) particles distributed on clay surfaces is provided. In one embodiment, at least some or all of the particles have a cross-section of five (5) angstroms or less. Methods of synthesizing and the novel clays and the clay-templated subnano-scale ZVI particles themselves are also described. Such novel products are useful in a variety of remediation applications, including for reduction and dechlorination reactions.
Type:
Grant
Filed:
October 29, 2010
Date of Patent:
January 21, 2014
Assignee:
Board of Trustees of Michigan State University
Abstract: The present invention provides methods of achieving directed evolution of viruses by in vivo screening or “panning” to identify viruses comprising scrambled AAV capsids having characteristics of interest, e.g., tropism profile and/or neutralization profile (e.g., ability to evade neutralizing antibodies). The invention also provides scrambled AAV capsids and virus particles comprising the same.
Type:
Grant
Filed:
April 29, 2009
Date of Patent:
January 21, 2014
Assignee:
University of North Carolina at Chapel Hill