Patents Assigned to University
  • Protein kinase targeted therapeutics
    Patent number: 8188096
    Abstract: The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1?, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1?, and upstream and downstream protein kinases).
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: May 29, 2012
    Assignee: Northwestern University
    Inventors: D. Martin Watterson, Linda J. Van Eldik
  • Opioid receptor subtype-selective agents
    Patent number: 8188128
    Abstract: Opioid receptor compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a condition mediated by an opioid receptor by administering an effective amount of the opioid receptor compound to a patient in need thereof.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: May 29, 2012
    Assignee: The University of Medicine and Dentistry of New Jersey
    Inventors: William J. Welsh, Youyi Peng, Qiang Zhang, Susan M. Keenan, Sonia Arora
  • Image processing apparatus, image processing program, storage medium and ultra-sonograph
    Patent number: 8187188
    Abstract: A computer 12 of an image processing apparatus 11 acquires ultrasound B-mode images of consecutive frames to estimate a carotid artery wall at a carotid artery minor axis cross section included in an ultrasound B-mode image of a predetermined frame. The computer 12 also uses, as a template image, the ultrasound B-mode image, which includes the estimated carotid artery wall and surrounding tissues of the carotid artery wall and estimates the size of the diameter of the carotid artery wall so as to minimize a margin of error between a transformed template image, which is created by transforming the template image, and the acquired ultrasound B-mode image of each frame, thereby acquiring the time change of the carotid artery wall.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: May 29, 2012
    Assignee: Gifu University
    Inventors: Yasunari Yokota, Fumio Nogata, Yoko Kawamura
  • High performance, crosslinked polymeric material for holographic data storage
    Patent number: 8187770
    Abstract: An optical recording material and methods of making such material is provided. The material comprises of a dewar benzene monomer, with at least two cross-linkable groups, a sensitizer, a cross-linker, and an initiator. The material does not require a binder or a co-sensitizer. The material can be fabricated by an exceedingly easy technique that offers high photosensitivity, high diffraction efficiency, millimeter thickness, and high dynamic range.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: May 29, 2012
    Assignee: The Regents of the University of California
    Inventors: Craig J. Hawker, Galen D. Stucky, Alexander Mikhailovsky, Anzar Khan
  • System for delivering conformal radiation therapy while simultaneously imaging soft tissue
    Patent number: 8190233
    Abstract: A device and a process for performing high temporal- and spatial-resolution MR imaging of the anatomy of a patient during intensity modulated radiation therapy (IMRT) to directly measure and control the highly conformal ionizing radiation dose delivered to the patient for the treatment of diseases caused by proliferative tissue disorders. This invention combines the technologies of open MRI, multileaf-collimator or compensating filter-based IMRT delivery, and cobalt teletherapy into a single co-registered and gantry mounted system.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: May 29, 2012
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: James F. Dempsey
  • Method and system for encoding multimedia content based on secure coding schemes using stream cipher
    Patent number: 8189776
    Abstract: Described herein are various embodiments of a coding technique that utilize a stream cipher for switching between first and second coding conventions for encoding a symbol sequence. The first coding convention specifies a first mapping between a symbol and a first codeword and the second coding convention specified a second mapping between the symbol and a second codeword. According to the invention, a key generated by the stream cipher is used to selected one of the first and second coding convention and the mapping of the selected coding convention is then utilized for encoding the symbol.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: May 29, 2012
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Oscar Chi Lim Au, Jiantao Zhou
  • Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
    Patent number: 8187878
    Abstract: The present invention provides compositions and methods for the production of differentiated mammalian cells. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a feeder layer or under feeder-free conditions in cell culture and further contacting the cells with an inhibitor of the PI3-kinase pathway and a member of the TGFb family for the generation of differentiated mammalian cells from pluripotent mammalian stem cells. Preferably, the differentiated cell is selected from the group consisting of a mesendodermal cell, a mesodermal cell, and an endodermal cell.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: May 29, 2012
    Assignees: University of Georgia Research Foundation, Inc., ViaCyte, Inc.
    Inventors: Stephen Dalton, Allan Sheppard, Karen Jones, E. Edward Baetge, Kevin A. D'Amour, Alan D. Agulnick
  • Hydroamination of alkenes
    Patent number: 8188302
    Abstract: A method includes reacting an amino group, a composition including rhodium and an organic ligand, and a substrate having structural formula (I) in a reaction mixture. R1 is an organic group including a sp3 carbon atom bonded to CA. R2 is selected from the group consisting of hydrogen, methyl, and an organic group including a sp3 carbon atom bonded to CA. R3 and R4 independently are selected from the group consisting of hydrogen, methyl, and an organic group including a sp3 carbon atom bonded to CB. The method further includes forming a hydroaminated product in the reaction mixture.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: May 29, 2012
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Zhijian Liu, John F. Hartwig
  • Nicotine in therapeutic angiogenesis and vasculogenesis
    Patent number: 8188043
    Abstract: The present invention features methods for induction of angiogenesis by administration of nicotine or other nicotine receptor agonist. Induction of angiogenesis by the methods of the invention can be used in therapeutic angiogenesis in, for example, treatment of ischemic syndromes such as coronary or peripheral arterial disease.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: May 29, 2012
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: John Cooke, James Jang, Phillip Tsao, Christopher Heeschen
  • Detection method using nanoaggregate-embedded beads and system thereof
    Patent number: 8187820
    Abstract: The invention discloses a detection method using nanoaggregate-embedded beads and system thereof, which are characterized in that the nanoaggregate of Raman dye and metal nanoparticles is coated by an inorganic oxide to form a nanoaggregate-embedded bead, and which is then conjugated with a probe molecule to form a sensor bead. The Raman spectra of the product formed by binding of the sensor bead and an analyte in a sample is detected for determining whether the analyte exists in the sample. In embodiment, the pH of the solution of metal nanoparticles is controlled to keep at 10, and the concentration of the Raman dye is controlled to keep between 1×10?6 M and 2×10?6 M for reducing the size of the nanoaggregate.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: May 29, 2012
    Assignee: National Chung Cheng University
    Inventors: Laikwan Chau, Tzyy-Schiuan Yang, Ping-Ji Huang, Tai-Tsung Lin
  • Method of promoting olefin polymerization
    Patent number: 8188199
    Abstract: The method of promoting olefin polymerization uses a nanoparticle filler to increase the activity of a metallocene catalyst for in situ polymerization of polyolefins. The filler may be nanoparticles of manganese, or nanoparticles of manganese-doped titanium dioxide. The method includes the steps of (a) mixing a metallocene catalyst, e.g., zirconocene dichloride, with nanoparticles of the filler in an organic solvent, e.g., toluene, in a reactor to form a reaction mixture; (b) immersing the reactor in a temperature bath for a period of time sufficient to bring the mixture to an optimal polymerization reaction temperature; (c) adding monomer to the mixture in the reactor; (d) adding methylaluminoxane (MAO) as a co-catalyst to the reaction mixture to initiate polymerization; and (e) quenching the polymerization, e.g., by adding methanol containing 5% hydrochloric acid by volume to the reactor.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: May 29, 2012
    Assignees: King Fahd University of Petroleum & Minerals, King Abdulaziz City for Science & Technology
    Inventors: Mamdouh Ahmad Al-Harthi, Abdul Kaleel Sulaiman Haniffa, Bijal Kottukkal Bahuleyan, Sadhan Kumar De, Masihullah Jabarulla Khan
  • Poly-chromatic light-emitting diode (LED) lighting system
    Patent number: 8188683
    Abstract: The invention discloses a novel control system for a Poly-Chromatic light-emitting diode (LED) lighting system, and applies feed forward and feedback control techniques to regulate the color and luminous outputs. Also, the control system is proposed for achieving luminous and color consistency for Poly-Chromatic LED lighting.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: May 29, 2012
    Assignee: National Taiwan University
    Inventors: Bin-Juine Huang, Chun-Wen Tang, Fu-Cheng Wang
  • Cooling system for large power transformers
    Patent number: 8188822
    Abstract: A cooling system includes a housing having a compartment and an oil inlet. A transformer unit is disposed in the compartment and includes a plurality of large power transformers. A heat-dissipating unit is disposed in the compartment and includes a fluid inlet port member, a fluid outlet port member, a heat conductor, and a plurality of heat exchange pipes. The heat conductor is in thermal contact with the heat exchange pipes. The heat exchange pipes are arranged along a first direction. Each of the heat exchange pipes extends along a plane that is not parallel to the first direction. A cooling oil is introduced into the compartment through the oil inlet such that the transformer unit, the heat conductor, and the heat exchange pipes are immersed in the cooling oil.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: May 29, 2012
    Assignees: The Department of Electrical Engineering, National Chang-Hua University of Education University of Taiwan
    Inventors: Kuen-Cheng Wang, Tsair-Rong Chen, Jeen-Sheen Row
  • Hearing device improvements using modulation of acoustically coupled signals at middle ear resonance
    Patent number: 8189839
    Abstract: There is provided hearing device improvements using modulation techniques adapted to the characteristics of auditory and vestibular hearing. One embodiment provides for extending hearing to the infrasonic range by extracting sounds from the high ambient noise in this range and applying them to a carrier in the ultrasonic “quiet zone.” Further extension of hearing into the ultrasonic range is provided by a modulation scheme which uses a fluid conduction coupler to match impedance for a vibration transducer applied to the skin. A variation on this embodiment integrates this ultrasonic hearing extension with normal acoustic headphones. Another embodiment compensates for high frequency hearing loss by a modulation scheme which uses middle ear resonance as an amplifier. A further embodiment combines ultrasonic transposition with wireless modulation to obtain secure communication.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: May 29, 2012
    Assignee: Virginia Commonwealth University
    Inventors: Martin Lenhardt, Douglas Richards
  • Methods, systems, and computer program products for binary multiplexing x-ray radiography
    Patent number: 8189893
    Abstract: Methods, systems, and computer program products for binary multiplexing x-ray radiography are disclosed. According to one aspect, the subject matter described herein can include irradiating an object with composite x-ray beams including signals based on a predetermined binary transform. Further, the subject matter described herein can include detecting x-ray intensities associated with the signals of the composite x-ray beams. An inverse binary transform can be applied to the detected x-ray intensities associated with the signals of the composite x-ray beams to recover the signals of the composite x-ray beams.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: May 29, 2012
    Assignees: The University of North Carolina at Chapel Hill, North Carolina State University
    Inventors: Jian Zhang, Jianping Lu, Otto Z. Zhou, David Lalush
  • Dressing delivery system for internal wounds
    Patent number: 8187627
    Abstract: A dressing delivery system comprises an applicator for holding and positioning a wound dressing. The applicator comprises a sleeve having a distal spreading portion. The wound dressing is disposed on or adjacent the spreading portion. The applicator urges the dressing into contact with the wound. The sleeve is advanced to actuate the spreading portion, which increases the diameter of the applicator and preferably deploys the dressing.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: May 29, 2012
    Assignee: Loma Linda University Medical Center
    Inventors: Yong Hua Zhu, Wolff M. Kirsch
  • Prepared foods containing triglyceride-recrystallized non-esterified phytosterols
    Patent number: 8187657
    Abstract: A dietary supplement is provided which includes at least one triglyceride-based edible fat and between 3% and 50% by weight of triglyceride recrystallized phytosterols. The dietary supplement can be in the form of a capsule, pill or wafer. Additionally, the dietary supplement can be combined with protein, vitamins, minerals, or combinations thereof.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: May 29, 2012
    Assignee: Brandeis University
    Inventors: Daniel Perlman, Kenneth Hayes, Andrzej Pronczuk
  • Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke
    Patent number: 8187807
    Abstract: The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying individuals at risk of perioperative renal dysfunction. The present invention relates, in general, to perioperative stroke and, in particular, to methods of identifying individuals at risk of perioperative stroke.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: May 29, 2012
    Assignee: Duke University
    Inventors: Debra A. Schwinn, Ian Welsby, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Hilary P. Grocott, William D. White, Richard W. Morris, Joseph P. Mathew
  • Immobilized proteins and methods and uses thereof
    Patent number: 8188241
    Abstract: The invention relates to the field of covalently attaching proteins to a substrate, particularly to methods of immobilizing proteins by posttranslationally modifying a cysteine residue of said protein through the addition of functional groups. The invention also relates to biological molecules used in such techniques, including proteins, and detection methods and kits that utilize such immobilized proteins, such as a microdevice or “protein chip”, a high-throughput screening device, and for the microscopy of proteins on a surface.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: May 29, 2012
    Assignee: University of Utah Research Foundation
    Inventors: Charles Dale Poulter, Guillermo Roberto Labadie, Cecile Gauchet, Rochelle Frances Hawkins Bohaty
  • Fabrication of three-dimensional ion optics assemblies by metallization of non-conductive substrates
    Patent number: 8188422
    Abstract: A die assembly for creating a ring electrode including a cylindrically-shaped die base, two die walls and a die top sized to fit inside a cylindrical die housing. The die base and die top having a series of concentric elevations used as impressions to form on two ends of the ring electrode. A method of fabricating an LTCC ring electrode using the die assembly is also provided.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: May 29, 2012
    Assignee: University of South Florida
    Inventors: Friso van Amerom, Ashish Chaudhary, Shekhar Bhansali, Robert T. Short, George Steimle