Abstract: A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under basic conditions to produce the metalloporphyrin. Products produced by such methods and intermediates useful for carrying out such methods are also described.

Abstract: A method for producing a GaN crystal capable of achieving at least one of the prevention of nucleation and the growth of a high-quality non-polar surface is provided. The production method of the present invention is a method for producing a GaN crystal in a melt containing at least an alkali metal and gallium, including an adjustment step of adjusting the carbon content of the melt, and a reaction step of causing the gallium and nitrogen to react with each other. According to the production method of the present invention, nucleation can be prevented, and as shown in FIG. 4, a non-polar surface can be grown.

Abstract: Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.

Abstract: Methods for rapid sensing of dissolved toxic heavy metals use a hybrid inorganic material (“HIM”), which is synthesized from hydrated iron oxide (“HFO”) and calcium magnesium silicate. HIM thus synthesized is used in sensing dissolved toxic heavy metals. Water containing toxic heavy metals (e.g., lead, copper, zinc, nickel, etc.) is passed through a sorbent bed of HIM, whereupon it shows a sharp drop in pH after a certain length of time. The presence of HFO and calcium magnesium silicates in HIM synergistically provide a precipitous drop in pH, which is characteristic of the concentration and type of toxic heavy metal. Therefore, observing a change in pH indicates the presence and identity of heavy metal ions in a test water sample.

Abstract: Processes for producing a microCT image for virtual histology using x-ray microscopic computed tomography are described along with processes for rapid and inexpensive high-throughput methods of high resolution imaging for screening an ex vivo embryo for phenotype using computed tomography imaging. Staining of particular components of specimens with one or more staining agents is described which contributes to high quality image generation and identification of anatomical structures as well as localization of molecular targets. Inventive animal and specimen holders are detailed which allow for reduced post-imaging processing of generated images. In particular, animal and specimen holders are provided which include a highly transparent bed or liner which separates the animal or specimen from a less transparent structure.

Abstract: A method for forming non-polar (Al,B,In,Ga)N quantum well and heterostructure materials and devices. Non-polar (11 20) a-plane GaN layers are grown on an r-plane (1 102) sapphire substrate using MOCVD. These non-polar (11 20) a-plane GaN layers comprise templates for producing non-polar (Al,B,In,Ga)N quantum well and heterostructure materials and devices.

Abstract: An optical adapter for an imaging system correcting images of spherical or near spherical bodies such as the earth during satellite image collection. An imaging system includes an image collector that collects a two-dimensional image of the body from a distance above the body such as from a satellite in geostationary orbit. The collected image is disk shaped and includes distortion due to earth curvature, primarily in the form of a loss of resolution due to the foreshortening of earth features in a radial direction extending outward from the center of the image disk. The optical adapter receives the collected image, transforms the collected image to correct the distortion, and outputs a corrected image with essentially uniform spatial resolution across the areas for which the correction is applied. An image sensor such as charge-coupled device array senses the corrected image and creates a digital representation of the corrected image.

Abstract: Novel bifunctional peptides useful in the treatment and/or diagnosis of EAE or MS. The peptides have a first peptide portion derived from an epitope of myelin proteolipid protein, myelin oligodendrocyte glycoprotein, or oligodendrocyte-specific peptide and a second peptide portion derived from CD11a (LFA-1 alpha subunit), CD18 (LFA-1 beta subunit), CD154 (CD40L), Fas-Ligand, or CTLA4. The carboxy and/or amino termini of the bifunctional peptides may be modified.

Abstract: The present invention relates to new penaeidin gene promoters found in tiger shrimps and applications thereof. The promoters of the invention are useful for the development of transgenic shrimps and valuable for the shrimp culture industry.

Abstract: An object of the present invention is to provide novel ribozyme systems capable of catalyzing tRNA acetylation using various carboxylic acids as acyl donors and uses thereof. Disclosed is a ribozyme catalyzing tRNA acetylation having a structure consisting of the RNA sequence represented by: (formula 1) P1-Z1Z2Z3Z4(N1)1(N1)2 . . . (N1)p-P2-(N2)1(N2)2 . . . (N2)q Y1Y2Y3-(N3)1(N3)2-N4GGN wherein (N1)1-(N1)p each independently represent any monoribonucleotide of U, C, A, and G; p represents 3 or 4; (N2)1-(N2)q each independently represent any monoribonucleotide of U, C, A, and G; q represents 5 or 6; (N3)1-(N3)2 each independently represent any monoribonucleotide of U, C, A, and G; N4 represents any monoribonucleotide of U, C, A, and G; Z1-Z4 each independently represent C or G; Y1-Y3 each independently represent C or G; N represents a monoribonucleotide complementary to A or G; and P1 and P2 represent a domain consisting of any RNA sequence capable of having a stem-loop structure.

Abstract: The invention provides methods of detecting analytes of interest in a sample using electrogenerated chemiluminescence. The invention also provides compositions comprising at least one solid support that entraps or contains an electrogenerated chemiluminescent moiety.

Abstract: Provided are compositions and methods for inhibiting growth of cancer cells. The method of the invention relates to delivering to cells an effective amount of a composition that contains a polynucleotide having a Rad51 promoter or a polynucleotide having at least 95% similarity to a Rad51 promoter. The Rad51 promoter is operably linked to a coding region for a cytotoxic agent. In vitro and in vivo results demonstrating effectiveness of the polynucleotides of the invention are presented.

Abstract: A flex-rigid printed wiring board is provided which can retain flexibility of a flexible portion while increasing durability of the flexible portion against folding, and can ensure conduction in a rigid portion, and a method of manufacturing the printed wiring board. The flex-rigid printed wiring board includes a conductor layer provided on at least one face of a base film, one region of the wiring board containing the base film being a rigid region, an another region containing the base film being a flexible region. The average thickness “tf” of the conductor layer on the base film formed in the flexible region and the average thickness “tR” of the conductor layer on the base film formed in the rigid region satisfy the relationship of tf<tR.

Abstract: A laser diode having nano patterns is disposed on a substrate. A first conductive-type clad layer is disposed on the substrate, and a second conductive-type clad layer is disposed on the first conductive-type clad layer. An active layer is interposed between the first conductive-type clad layer and the second conductive-type clad layer. Column-shaped nano patterns are arranged at a surface of the second conductive-type clad layer to form a laser diode such as a distributed feedback laser diode.

Abstract: A method of providing provenance management for a pre-existing application is provided. A provenance data selection is received. The provenance data selection indicates provenance data to present to a user. The provenance data is presented to the user as a version tree comprising a plurality of connected nodes. A node selection is received. The node selection indicates a node selected from the version tree. One or more nodes from a root node of the plurality of connected nodes to the node selected from the version tree are identified. One or more action parameters associated with the identified one or more nodes are identified. An action parameter of the one or more action parameters is associated with a previous interaction with a pre-existing application. Presentation of a state of the pre-existing application associated with the node selected from the version tree is triggered.

Abstract: A method of determining endothelial dependent vasoactivity of a subject, the method is effected by recording pressure-related signals of a plurality of locations adjacent to at least one blood vessel; extracting at least one parameter from the pressure-related signals; and using the at least one parameter to determine a change of at least one characteristic of the at least one blood vessel, the change being representative of endothelial functioning; thereby determining the endothelial dependent vasoactivity of the subject.

Abstract: A foldable walker includes upstanding legs arranged in a generally square pattern, each of which is capped by a fixed joint member and each of which has a slider member slideably disposed on it. Two forward legs are interconnected by two rigid links arranged in a scissors arrangement with the uppermost end of each link pivotally connected to a fixed joint member and the lowermost end of each link pivotally connected to a slider. Each forward leg is interconnected to its associated rearward leg in the same way. Each pair of rigid links is interconnected to one another by a pivot pin. The linkage enables the width and the depth of the walker to be reduced to a very small space and telescoping legs reduce the height dimension of the walker. Handles are folded when the walker is stored and pivoted into their operable position when the walker is deployed.

Abstract: Telerobotic systems with integrated high frequency feedback to enhance users' telerobotic experience are provided. The controller of the telerobotic system is characterized by combining high frequency information with low frequency position or velocity information. The controller is useful for teleoperations with delay and no-delay between the communication channels of the master and slave device.

Abstract: The present invention provides novel markers and assays for autism based on the association of GSTM1 with autism. The invention relates to the use and application of as a susceptibility marker for autism. GSTM1 may be combined with other markers in methods and assays for diagnosis, prenatal diagnosis, and assessment of autism. The invention further relates to a likelihood ratio test. In addition, the present invention discloses a novel method for identifying individuals who are genetically susceptible to have offspring with autism wherein the genotype of GSTM1, alone or in combination with other genetic markers, is determined.

Abstract: The present invention is an apparatus and method for computing regional statistical distributions or characteristics of one or more quantitative measures over a mean anatomic space for one or more predefined populations and uses this statistical distributions/characteristics to study, research or understand the regional response of a disease or a treatment process and to regionally assess clinical status in patient data from an unknown population for diagnostic purposes.