Abstract: Isolated protein complexes are provided comprising keratinocyte growth factor and vitronectin, or at least domains thereof that enable binding to and activation of both a keratinocyte growth factor receptor and an integrin receptor for vitronectin. These protein complexes include synthetic proteins where the keratinocyte growth factor and vitronectin sequences are joined by a linker sequence. In particular forms, vitronectin sequences do not include a C-terminal heparin binding domain. Also provided are uses of these protein complexes for stimulating or inducing cell migration and/or proliferation in wound healing, tissue engineering, cosmetic and therapeutic treatments such as skin replacement, skin replenishment and treatment of burns where epithelial cell migration is required. In other embodiments, the invention provides inhibition of cancer cell metastasis, particularly in relation to breast cancer.

Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

Abstract: A rate based model predictive controller and method for air path control for a diesel engine regulates intake manifold pressure (MAP) and EGR valve flow rate to specified set points by coordinated control of a variable geometry turbine (VGT) and EGR valve position. A decay and a flexible Lyapunov function is enforced on the rate based model predictive controller for a single step prediction and control arisen.

Abstract: The invention provides electro-catalyst compositions for an anode electrode of a proton exchange membrane-based water electrolysis system. The compositions include a noble metal component selected from the group consisting of iridium oxide, ruthenium oxide, rhenium oxide and mixtures thereof, and a non-noble metal component selected from the group consisting of tantalum oxide, tin oxide, niobium oxide, titanium oxide, tungsten oxide, molybdenum oxide, yttrium oxide, scandium oxide, cooper oxide, zirconium oxide, nickel oxide and mixtures thereof. Further, the non-noble metal component can include a dopant. The dopant can be at least one element selected from Groups III, V, VI and VII of the Periodic Table. The compositions can be prepared using a surfactant approach or a sol gel approach. Further, the compositions are prepared using noble metal and non-noble metal precursors. Furthermore, a thin film containing the compositions can be deposited onto a substrate to form the anode electrode.

Abstract: Screening assays and methods of using same for screening to identify modulator agents or compounds that affect pcdh18 mediated inhibition of T cell effector function are described herein. Pharmaceutical and immunogenic compositions comprising agents or compounds that modulate pcdh18 mediated inhibition of T cell effector function are also encompassed. Methods for modulating pcdh18 mediated inhibition of T cell effector function using agents identified using assays described herein in pharmaceutical and immunogenic compositions are also envisioned. Adenocarcinoma is an exemplary tumor type that expresses pcdh18 and for which such pharmaceutical and immunogenic compositions would confer benefit to patients. Also encompassed are methods for reducing pcdh18 mediated inhibition of T cell effector function so as to achieve more effective T cell responses to pcdh18 expressing tumors.

Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.

Abstract: Disclosed are improved optical detection methods comprising multiplexed interferometric detection systems and methods for determining a characteristic property of a non-aqueous sample, together with various applications of the disclosed techniques.

Abstract: Sensors for target entities having functionalized thereon, at least one amine-terminated aptamer specific to the target entity, and methods of making and using the same are described.

Abstract: A nonbinary iterative detector-decoder (IDD) system. The IDD system comprises a detector, a decoder; and a nonbinary interface electrically connected between the detector and decoder. The interface is operative to convert a soft symbol and variance that is output by the detector into a corresponding nonbinary log likelihood ratio (LLR) vector that comprises one or more nonbinary LLRs, and to provide the LLR vector to the decoder. The interface is further configured to convert a nonbinary LLR vector comprised of one or more nonbinary LLRs that is output by the decoder into a corresponding soft symbol and variance, and to provide the soft symbol and variance to the detector.

Abstract: The present technology relates to systems, methods and devices for haptically-enabled virtual reality simulation of cerebral aneurysm clipping, wherein a user uses two physical stations during the simulation. The first station is a haptic and augmented reality station, and the second station is a haptic and virtual reality station.

Abstract: Provided are STAT3 inhibitors and methods of treating inflammation or a hyperproliferative disease such as, e.g., cancer. In some aspects, compounds may be used to treat breast cancer, a head/neck cancer, a lung cancer, a prostate cancer, or pancreatic cancer.

Abstract: The present disclosure provides a method and an apparatus for coding or decoding a matrix, includes: dividing a matrix into layers according to a preset quantity of divided layers, and grouping matrix elements into different layers; performing, according to a determined layer number of a highest layer to be coded and in an order of layers one by one, coding processing on matrix elements at each layer to be coded; for a layer having a layer number less than or equal to the layer number of the highest layer to be coded, writing residual data between an original matrix element value corresponding to the layer and a corresponding matrix element predicted value into a bit stream; for a layer having a layer number greater than the layer number of the highest layer to be coded, writing no coded data of the layer into the bit stream.

Abstract: A non-volatile SRAM cell comprises a first inverter, a second inverter, a first access transistor, a second access transistor, and a variable resistive element. The first inverter voltage is supplied by a first differential supply. The second inverter voltage is supplied by a second differential supply. The variable resistive element coupling with a third access transistor in series is coupled to the first output node. The non-volatile SRAM cell operates in a restore operation comprising a dual supply initialization phase and a pulse-overwrite phase. During the dual supply initialization phase, the first differential supply increases before the second differential supply so as to initialize the first output node to a logic state. During the pulse-overwrite phase, the third access transistor is turned on for a switch period in order to discharge/charge the first output node.

Abstract: A compound composed of a phospholipid and basic amino acid residues is provided as is a sterically stabilized phospholipid nanocarrier containing the compound and use of the same in passive and targeted delivery of negatively charged therapeutic agents encapsulated within the nanocarrier.

Abstract: A method of implementing a carbon nanotube thermal interface material onto a heat sink that includes growing carbon nanotubes on said heat sink by chemical vapor deposition and compressing the carbon nanotubes onto metallic surfaces to increase a contact surface area between the carbon nanotubes and the metallic surfaces. The increase in the contact surface area is the area of the carbon nanotubes that is in contact with the metallic surfaces.

Abstract: A method for making a lithium battery cathode composite is provided. A mixed solution including a solvent, an iron salt, and a phosphate is provided. An alkaline solution is added in the mixed solution until the mixed solution has a pH value in a range from about 1.5 to about 5. The mixed solution is stirred to react the iron salt with the phosphate to form a number of iron phosphate precursor particles. The iron phosphate precursor particles are heated. A lithium source solution, a reducing agent, and the iron phosphate precursor particles are mixed to form a lithium iron phosphate precursor slurry. Outer surfaces of the lithium vanadium phosphate particles are coated with the lithium iron phosphate precursor.

Abstract: Provided is an optical mode switch that can effect a more compact optical switch. The optical mode switch (100) is provided with: a single input port (1); a single output port (2); two waveguides (10) provided in parallel between the input port (1) and the output port (2); and a refractive index altering means (8) that alters the refractive index of the waveguides. Any given mode light input to the input port (1) is output as any given mode light from the output port (2) in accordance with the refractive index altered by the refractive index altering means (8).

Abstract: The ionophore and polymer membrane selective for aluminum (III) ion provide an ionophore that is selective for aluminum (III) ion [Al3+]. The ionophore may be used as a dopant in a polymer membrane formed from a polymer matrix, e.g., poly (vinyl chloride) (PVC), and that may also include a plasticizer, such as dioctylphthalate (DOP) and o-nitrophenylloctyl ether (o-NPOE). The polymer membrane may be incorporated into an ion selective electrode (ISE) that can be used as a potentiometric sensor for the detection of Al3+ ions in wastewater.

Abstract: Embodiments provided herewith relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant mesothelioma with antagonists of high-mobility group box 1 (HMGB1).

Abstract: An light emitting diode includes an insulating substrate, a P-type semiconductor layer, a semiconductor carbon nanotube layer, an MgO layer, a functional dielectric layer, and a first electrode, and a second electrode. The P-type semiconductor layer is located on the insulating substrate. The semiconductor carbon nanotube layer is located on the P-type semiconductor layer. The MgO layer is located on the semiconductor carbon nanotube layer. The functional dielectric layer covers the MgO layer. The first electrode is electrically connected to the P-type semiconductor layer. The second electrode is electrically connected to the semiconductor carbon nanotube layer.